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Outlasts,Outperforms,Outnumbers™

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Table of ContentsTable of Contents

• The Silverlon® Advantage slide 3• The Negative Pressure Innovation slides 4-5• What Silverlon® Has slides 6-7• How To Use slides 8-10• Five Case Studies slides 11-22• 90 Day Value Analysis slide 23-24• One Year Value Analysis Projection slides 25-27• Savings Calculator – hospital slide 28• Savings Calculator – home healthslide 29• Contact Information slide 30

The Silverlon® AdvantageThe Silverlon® Advantage

• Silverlon® is the most cost effective silver product on the market and is the most versatile.

• Silverlon® can be rinsed to remove excess exudate and reapplied for up to 7 day use.

Silverlon® Negative Pressure DressingsSilverlon® Negative Pressure Dressings

Award Winning InnovationAward Winning Innovation

Combine Silverlon® NPD with NPWT

Accelerates Healing Potential. Proven in over 300 patient trials to enhance and accelerate granulation and wound closure by 20% to 40% vs. Conventional protocols.

Reduces Overall Cost of NPWT. Wounds heal quicker, saving rental charges, kit costs, and nursing time.

Lowers Infection. Proven in over 300 patient trials to lower the risk of the media re-infecting the wound bed.

Silverlon® Negative Pressure DressingsSilverlon® Negative Pressure DressingsAward Winning InnovationAward Winning Innovation

Combine Silverlon® NPD with NPWT: (Continued)

Reduces Foam Sticking to the Wound. Silverlon® not only reduces the incidence of foam adhering to the granulation bed, but it also eliminates the need to pick the foam out of the wound.

Safe and Easy to Use. Silverlon® is not known to interact with any drug and is bactericidal to all clinically relevant pathogens. It will not shed metallic silver into tissue, nor will it tattoo or stain the skin.

Silverlon® Negative Pressure DressingsClinical Investigations

Silverlon® Negative Pressure DressingsSustained Strength & Easy to Use

SilverlonSilverlon®® Negative Pressure DressingsNegative Pressure Dressings

SimpleSimple Technique Means Easy to UseTechnique Means Easy to Use

Silverlon® Negative Pressure Dressings Silverlon® Negative Pressure Dressings

Professional Guidelines For Use

Moisten dressing with sterile or clean water. Saline may be used for irrigation, but should be avoided as the primary wetting agent.

Apply either side of dressing in direct contact with wound bed and walls, and overlap wound edges onto healthy skin.

Cover Silverlon® NPD with negative pressure foam or fill media ( if using Versatile 1) and drape per manufacturer’s instructions.

Change Silverlon® NPD when you change foam or fill media.

Silverlon® NPD may be used for up to 7 days.

SilverlonSilverlon® Negative Pressure Dressings® Negative Pressure Dressings

Frequently Asked Questions

Can these dressings handle highly exudative wounds ? The unique dual “flow ports” allow for rapid fluid passage into the media,

making it an ideal dressing over highly exudative wounds, with or without the use of NPWT.

Can these dressings be rinsed and reused ? Based on professional discretion, all these dressings may be rinsed and

reused, provided they are substantially free of debris and exudate.

Can these dressings also be used without negative pressure therapy ?

Absolutely, simply follow Silverlon® wound contact protocol.

See dressing package for Indications and Caution.

Five Clinical CasesFive Clinical Cases

Combining Negative Pressure Therapy Combining Negative Pressure Therapy with Silverlonwith Silverlon® Negative Pressure ® Negative Pressure

Dressings, and BilaDressings, and Bilayered Living Skin yered Living Skin EquivalentEquivalent

Case Study 1Case Study 1

• 82 y/o woman with diabetes, peripheral vascular disease, and neuropathy

• Ulcer developed from thermal injury (electric blanket). Failed to respond to conventional treatment.

Case Study 1Case Study 1 (Continued)(Continued)

1/12/02

Necrotic Diabetic Heel Ulcer

5.1 x 7.0cm

1/12/02

s/p debridement, pre-Apligraft®, Silverlon®, KCI

Wound Vac®

Case Study 1Case Study 1 (Continued)(Continued)

85% Wound Volume Reduction in 90 days85% Wound Volume Reduction in 90 days

1/14/02

2 days s/p Apligraft®, Silverlon®, Wound Vac®

4/10/02

2 days s/p 2nd apligraft®, Silverlon®, Wound Vac®

2.1 x 2.0cm

Case Study 2Case Study 2Rapid Healing in 90 daysRapid Healing in 90 days

12/31/01

Healed at 3 months

10/3/01

Admit

4.7 x 6.0 x 1.8cm

Case Study 3Case Study 3Rapid Healing In 30 DaysRapid Healing In 30 Days

11/12/01

Silverlon® & Wound Vac®

4.0 x 4.7 x 0.7 cm

12/10/01

s/p Silverlon®, Vac®, & Apligraft®

0.6 x 1.0 cm

Case Study 4Case Study 4

• 73 y/o woman with chronic steroid dependent asthma, hypertension bilateral venous stasis disease and hx of phlebitis.

• 3 month old painful leg wound that originated from an insect bite and has failed conventional therapy

Case Study 4 Case Study 4 (Continued)(Continued)

Admit

s/p debridement s/p 12 of Wound Vac®

6/11/01

application of Apligraf® continue Vac® and

Silverlon® reduced pain

Case Study 4 Case Study 4 (Continued)(Continued)

7/2/01

s/p Apligraf® & Vac Continue Silverlon® and

Dynaflex®

8/28/01

Healed in less than 3 months

Case Study 5Case Study 5

• 63 y/o woman with chronic steroid dependent rheumatoid arthritis, Sjogren Syndrome, osteoporosis and iron deficiency anemia present with a a traumatic painful leg Ulcer.

Case Study 5 Case Study 5 (Continued)(Continued)

11/26/01

Admit

9.9 x 8.5cm

11/29/01

s/p debridement application Apligraf®

Case Study 5Case Study 5 (Continued)(Continued)

11/29/01

Apligraf®, Silverlon®, Vac®

12/03/01

1st dressing change, reduced pain, went on to

rapid healing

COMPARATIVE STUDY OF COMBINATION THERAPYCOMPARATIVE STUDY OF COMBINATION THERAPY

SILVERLON®NPD with VAC® VS. VAC® ALONESILVERLON®NPD with VAC® VS. VAC® ALONE

Non-Healing Chronic Wounds Associated With Tissue Defects of the Legs and Feet,Stanley N. Carson, M.D.; Fountain Valley Regional Hospital. Presented at SAWC, 2005

Efficacy and Cost Savings Analysis at 90 days of Treatment.

Patient Population VAC® Alone N=40 Silverlon® NPD & VAC® N=40

Age 16 – 90 years 15 – 89 yearsMale 21 21Female 19 19Diabetes 18 18Tobacco Use 7 7Renal Failure 5 5Ischemia ABI 0.5-0.8 12 12Wound Areas Avg. = 10cc Avg. = 12cc

COMPARATIVE STUDY OF COMBINATION THERAPYCOMPARATIVE STUDY OF COMBINATION THERAPY

SILVERLON®NPD with VAC® VS. VAC® ALONE SILVERLON®NPD with VAC® VS. VAC® ALONE (Continued)(Continued)

RESULTS VAC® Alone Silverlon® NPD & VAC®

Percent healed at 90 days 50% 87.5%

Infection 15% 0

No. of kits/patient 30 18

Nurse time/ patient 17.5 hrs. 10.5 hrs.

Savings per patient

w/ Silverlon® NPD - $ 3,073.50

__________________________________________________________________

Protocol:

VAC® alone: VAC® dressings changed every 3 days.

Silverlon® & VAC®: VAC® dressings changed every 5 days.

One Year Value Analysis Projection One Year Value Analysis Projection Using SilverlonUsing Silverlon® with® with

Negative Pressure Wound TherapyNegative Pressure Wound Therapy

• Expected Annual Cost Savings Analysis Using Medicare Reimbursement Pricing

• 2003 actual utilization at 800 bed teaching hospital with an average of 18 active VAC’s

• Silverlon® Negative Pressure Dressing with VAC® vs. VAC® with Standard Kit

One Year Value Analysis ProjectionOne Year Value Analysis Projection

Negative Pressure Wound TherapyNegative Pressure Wound Therapy (Continued)(Continued)VAC® Alone --- Standard KCI Protocol

3 Dressing Changes Per WeekCosts

Actual NPT Patient Days - 2003 6,570 Actual Rental Charge (Per Day Per Machine) $ 70.00 $ 459,900 Actual Kit Usage - 3 kits/wk/patient (total units) 2,190 Avg.Kit Cost (foam/drape) – avg. of all sizes $ 28.00 $ 61,320 Avg. Nursing Time Per Kit Change - 38 min. each 1,387hrs. @ $ 27/hr $ 37,449 Avg. Infection Rate: NPT Related 12%

Total $558,669

VAC® Combined with Silverlon® NPD --- Silverlon® Protocol1 Dressing Change Per Week

Costs Est. NPT Patient Days with Silverlon® - 2003 5,256 Est. NPT Rental Charge (Per Day Per Machine) $ 70.00 $ 367,920 Est. Kit Usage – 1 kit/wk/patient (total units) 938 Avg. Kit Cost $ 28.00 $ 26,264 Avg. Nursing Time for 938 kits @ 38 min. each 594 hrs. @ $27/hr $ 21,411

Total $ 415,595

Expected Savings: $ 558,669 - $ 415,595 = $ 143,074 or 25 %

One Year Value Analysis Projection One Year Value Analysis Projection Negative Pressure Wound TherapyNegative Pressure Wound Therapy (Continued)(Continued)

Expected Annual Savings

Rental Savings from fewer rental days needed: $ 459,900 - $ 367,920 = $ 91,980 or 20%

Disposable Kit Savings from fewer kits used: 2,190 – 938 = 1,254 saved $ 35,056 or 57%

Nursing Time Savings from fewer kit changes: 1,254 kits @ 38 minutes = 793 hrs. or 57%

Payroll Dollars Saved: (793 nurse hours x $ 27 avg.) = $ 21,411

Overall Expected Annual Savings: $ 143,074 or 25%

Can your silver dressing do this ?

Savings Calculator – HospitalSavings Calculator – Hospital(file on this CD as NPD Savings Calculator – Hospital.xls(file on this CD as NPD Savings Calculator – Hospital.xls))

Negative Pressure Therapy Estim. National Plug In YourDirect Cost Per Patient Week Averages Costs

AssumptionsDaily Pump Rental Cost $70.00 $65.00

Avg. Disposable Kit Cost $28.00 $28.00Avg. Hourly Nursing Cost $27.00 $27.00

Avg. Cost of SilverlonØ Negative Pressure Dressing $25.00 $25.00Avg. Number of Active NPWT Patients Per Week 10

Weekly Cost of Care - Conventional Protocol - 3 Changes

Weekly Pump Rental $490.00 $455.00Kit Costs Per Week with 3 Changes $84.00 $84.00

Labor Per Week (30 min. per Kit Change - 3 changes) $40.50 $40.50Estimated Weekly Cost Per Patient $614.50 $579.50

Weekly Cost of Care - SilverlonØ NPD Protocol - 1.5 Changes

Weekly Pump Rental $490.00 $455.00Kit Costs Per Week with 1.5 Kit Changes $42.00 $42.00

Labor Cost Per Week (30 min. per Kit Change - 1.5 changes) $20.25 $20.25SilverlonØ Cost $37.50 $37.50

Estimated Weekly Cost Per Patient $589.75 $554.75

Estimated Weekly Savings Per Patient $24.75 $24.75Estimated Weekly Savings --- All Patients $247.50

Estimated Annual Savings --- All Patients 10 $12,870.00

Additional Weekly Savings - Patient Days Reduced 20% With Silverlon Ø NPD ProtocolWeekly Pump Rental $392.00 $364.00

Kit Costs Per Week with 1.5 Kit Changes $33.60 $33.60Labor Cost Per Week (30 min. per Kit Change - 1.5 Changes) $20.25 $16.20

Silverlon CostØ $37.50 $30.00Estimated Weekly Cost Per Patient $483.35 $443.80

Estimated Savings With SilverlonØ ----- Per Patient Per Week $135.70Estimated Savings With SilverlonØ ----- All Patients 31% $1,357.00

Expected Annual Savings --- Reduced Patient Days --- All Patients $70,564Total Direct Annual Savings All Patients 10 $83,434.00

Savings Calculator – Home HealthSavings Calculator – Home Health( file on this CD as NPD Savings Calculator – Home Health.xls( file on this CD as NPD Savings Calculator – Home Health.xls))

Negative Pressure Wound Therapy Estim. National Plug In Your Home HealthCost Per Patient Week Averages Costs Agency Savings

with SilverlonØAssumptions

Daily Pump Rental Cost $70.00 $60.00Avg. Disposable Kit Cost $28.00 $28.00Avg. Nursing Visit Cost $100.00 $100.00

Avg. Cost of SilverlonØ Negative Pressure Dressing $30.00 $24.00Annual Average Total Number of NPWT Patients 50

Weekly Cost of Care - Conventional Protocol - 3 Visits Per WeekWeekly Pump Rental $490.00 $420.00 Medicare

Kit Costs Per Week with 3 Changes $84.00 $84.00 MedicareLabor Per Week with 3 Changes $300.00 $300.00 your cost

Estimated Weekly Cost Per Patient - Conventional Protocol $874.00 $804.00

Weekly Cost of Care - SilverlonØ NPD Protocol - 1.5 Visits Per Week

Weekly Pump Rental $490.00 $420.00 MedicareKit Costs Per Week with 1.5 Kit Changes $42.00 $42.00 Medicare

Labor Cost Per Week with 1.5 Kit Changes $150.00 $150.00 $150.00SilverlonØ NPD Cost $45.00 $36.00 ($36.00)

Estimated Weekly Cost Per Patient - Silverlon Ø NPD Protocol $727.00 $648.00

Estimated Weekly Savings --- Conventional Protocol vs SilverlonØ NPD Protocol $147.00 $156.00 $114.00

Additional Agency Savings From Faster Healing Using Silverlon Ø NPD Protocol Estim. National Your

Average AgencyEstimated Savings Per Week of Care Saved --- Silverlon Ø NPD Protocol --- Per Patient $147.00 $114.00

average duration of care - Conventional Protocol - days * 97average days saved with SilverlonØ NPD Protocol - assuming 30% * * 29

Your Estimated Savings - Per Patient $611.10 $473.91 Annual Average Number of NPWT Patients 50

Your Estimated Total Annual Savings $78,985.71

Source: * KCI, Ostomy Wound Management 1999, Nov:45(11) 41-50Source: * * Carson, SN et al, Silver Dressings Used with VACØ: Is There An Advantage ?

SilverlonSilverlon®®ContactContact InformationInformation

Argentum Medical, LLC.

(Customer Service) 1-888-551-0188

More information is available at SILVERLON.COM

Silverlon® Outlasts, Outperforms, Outnumbers™