berks landfill · groundwater. approximately 26,495 residents within three miles of the site use...

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BERKS LANDFILL s-X -:'i\ r3$£NNSYLtAN SINKING SPRINGS, BERKS COTNTY,«$JENNSYLtANIA i..i.::ncvr ^br Toxic Substancesand Disease Registry 5. .3. Fr.blic Health Service •!•••«•••••••••••••••••• ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^* ' "*-(*..;•:--•"*.p-^ r - , •:-nv]K'n?s I\;riod Ends: ^:-;: :"-^ DEC 17

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Page 1: BERKS LANDFILL · groundwater. Approximately 26,495 residents within three miles of the site use both public and private groundwater veils for their potable supply. There are no known

BERKS LANDFILLs-X -:'i\r3$£NNSYLtANSINKING SPRINGS, BERKS COTNTY,«$JENNSYLtANIA

i..i.::ncvr br Toxic Substances and Disease Registry5. .3. Fr.blic Health Service•!•••«••••••••••••••••••^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ * ' "*-(*..;•:--•"*.p- r - ,

•:-nv]K'n?s I\;riod Ends: :-;: :"-

DEC 17

Page 2: BERKS LANDFILL · groundwater. Approximately 26,495 residents within three miles of the site use both public and private groundwater veils for their potable supply. There are no known

SUMMARY

The U.S. Environmental Protection Agency (EPA) has proposed that BerksLandfill, located in Sinking Springs, Berks County, Pennsylvania, be addedto the National Priorities List (NPL) . Volatile organic compounds (VOC's)and inorganic compounds have been released from the landfill into thegroundwater. Approximately 26,495 residents within three miles of thesite use both public and private groundwater veils for their potablesupply. There are no known populations that would be at special risk foradverse health effects from exposure to site-related contamination.

The potential human exposure pathways of concern at the Berks LandfillSite are ingest ion, inhalation, and dermal contact with contaminatedgroundwater; and, inadvertent ingestion, inhalation, and dermal contactwith potentially contaminated soil/sediment. Further sampling andevaluation is needed to further address the potential exposure tocontaminated soil/sediment. - Surface water on and in the vicinity of thesite is not presently contaminated with site-related compounds; however,there is the potential that this environmental media could be contaminatedin the future. If it becomes contaminated, this pathway should bereevaluated for potential health related implications .

Based on the available information, this site is considered to be ofpotential public health concern because of the risk to human health causedby the possibility of exposure to hazardous substances.

BACKGROUND

-A. SITE DESCRIPTION AND HISTORY

The U.S. Environmental Protection Agency (EPA) has proposed that BerksLandfill, located in Sinking Springs, Berks County, Pennsylvania, be addedto the National Priorities List (NPL). Appendix A contains diagrams ofthe site, the surrounding area, and the location of monitoring wells.Berks Landfill began operations about 1960 and consists of two areastotalling approximately 58 acres. The site operated for approximately 15years (1960-1975) before becoming a permitted facility; there are norecords to indicate waste types or quantity of waste disposed during thisperiod. Illegal dumping may have also occurred; however, no documentationof this exists. Prior to landfilling activities, the site was used formining. -...:-.' - •;

The permitted 48 -acre, active landfill receives 300 to 500 tons per day ofmunicipal refuse and demolition debris. The 10 -acre, old, inactivelandfill accepted municipal refuse; however, it also received an estimated5,000 cubic yards of alkali sludges. The sludges, which contained heavymetal constituents .such as barium, cadmium, and chromium, were dumped inthe unlined landfill for approximately one year (1979-1980).

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Page 3: BERKS LANDFILL · groundwater. Approximately 26,495 residents within three miles of the site use both public and private groundwater veils for their potable supply. There are no known

In 1975, the site was granted a water quality management permit by thePennsylvania Department of Environmental Resources (PADER) , to dischargetreated leachate from the solid waste operation into the unnamed tributaryto Cacoosing Creek. However in 1979, the site was in violation fornoncompliance of water quality standards; as a result, dischargingpractices were halted. Four surface impoundments, with a capacity of 2.6million gallons, are located at the base of the northwestern portion ofthe active landfill. These surface impoundments collect leachate from thelandfills via leachate collection system. The leachate is transported offsite for treatment and disposal.

In September 1935, NUS Field Investigation Team III (FIT) conducted a siteinspection. The total number of samples taken were 21 aqueous and sevensolid (soil/sediment and waste). During the FIT inspection, sevenmonitoring wells, natural drainage areas, and the leachate collectionsystem were tested for contamination. No remedial actions have takenplace to date.

Access to the site is not restricted. A cable/chain is located at themain access road to limit vehicle access.

B. SITE VISIT

On March 14, 1989, ATSDR personnel, along with a Pennsylvania Departmentof Health representative, visited the Berks Landfill Site. The purpose ofthe visit was to verify information present in the Site InvestigationReport and to note any additional concerns that the community may haveconcerning the contamination at the site. The information obtained duringthe visit is present in the appropriate sections of this PreliminaryHealth Assessment.

C. COMMUNITY HEALTH CONCERNS

ATSDR is not aware of any particular concerns that the residents living inthe vicinity of the site may have.

DEMOGRAPHICS. LAND. AND RESOURCE USB

'The area surrounding the site consists of uninhabited woodlands to thesouth, east, and west, with some residential homes to the north alongWheatfield Road. The estimated populations within three miles of the siteare 413, 3,861, and 13,752 within one, two, and three miles,respectively.

According to PADER representatives, the unnamed tributary to CacoosingCreek is not used for drinking, fishing, or recreational purposes.However, according to a local resident, the tributary runs through theOlive Leaf playground, located approximately 1-1/4 miles northwest of thesite and children do play in the water. In addition, cattle, steer, andsheep drink from the tributary.

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ENVIRONMENTAL CONTAMINATION AND OTHER HAZARDS

A. ON-SITE CONTAMINATION

Table 1, Appendix B, lists the on-site contaminants of concern, theenvironmental media affected, and the range of concentrations found foreach contaminant. Significant contamination was detected in the on-sitemonitoring wells and on-site leachate seeps.

B. OFF-SITE CONTAMINATION

Table 2, Appendix B, lists the off-site contaminants of concern, theenvironmental media affected, and the range of concentrations found foreach contaminant. The only off-site private well that was found to becontaminated was the Lombardo well, which is located northwest of the site\See Appendix A for diagram). Off-site surface water was contaminatedwith manganese, chromium, and lead at low concentrations.

C. QUALITY ASSURANCE AND QUALITY CONTROL

The conclusions in this Preliminary Health Assessment are based on theinformation reviewed by ATSDR. The validity of these conclusions isdetermined by the reliability of the data reviewed and the informationobtained from sources Interviewed by ATSDR.

D. PHYSICAL AND OTHER HAZARDS -• - -

There are no known physical hazards located at the Berks Landfill Siteother than those normally associated with a landfill operation.

PATHWAYS ANALYSES

A. ENVIRONMENTAL PATHWAYS (FATE AND TRANSPORT)

CroundwaterThere are 781 homes (approximately 2,968 people), located within threemiles of the site, that draw from the aquifer of concern (Hammer CreekFormation) and are served by private wells. Also located within threemiles of the site, but not drawing from the aquifer of concern, are six ofthe ten wells of the Citizen's Utility Water Company. The water companysupplies a total population of approximately 20,400, including thepopulations of the towns of Springmont, West Lawn, Sinking Springs, andWest Wyomissing. There are no known uses of groundwater for irrigation ofCrops. , : • • ' . , • : - ' • " • • • v

A potential exists for continued groundwater contamination as well asmigration of carcinogenic pollutants to downgradient private wells.Secondary openings such as bedding plane partings, joints, fractures, andfaults provide the main pathways for groundwater transmission. These

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openings provide an interconnection series of channels. The Hammer CreekFormation is lens shaped, overlapping, and discontinuous. Shallowgroundwater underlying the site appears to flow in a northerly direction.

On the basis of the hydrological information related to the site, the sixpublic water supply wells, located to the north and northeast of the site,do not appear to be at probable risk of contamination. However, thebedding, planing, and faults introduce unpredictability with respect togroundwater flow. The small community of Olive Leaf Chapel, locatedapproximately one mile northwest of the site, appears to betopographically downgradient and private wells between the site and thiscommunity could possibly be at risk of degradation.

Filtered groundwater samples showed little metal contamination. Thisindicates that the metals are associated with suspended particulates andare not readily dissolved in water. Generally, metals are not regarded asmobile in groundwater, since they tend to sorb to soil particles ascontaminated water percolates through the pore spaces in the saturatedzone.

Surface WaterThe site is situated on a hillside with areas of higher elevation to thesouth, east, and west. An unnamed tributary to Cacoosing Creek is locatedto the north and west of the active landfill and appears to receive sitedrainage. The tributary flows in a northwesterly direction forapproximately 1-1/2 miles before entering the creek. The tributary wassampled during the site investigation and no contamination was detected.It is possible that contaminated surface soil can be transported to thetributary at some time in the future, since it does receive runoff fromthe site.

Four surface impoundments are situated at the base of the northwesternportion of the active landfill. These Impoundments are located adjacentto the unnamed tributary.

Soil/SedimentThe landfill, situated in the Triassic Lowlands Section of the PiedmontPhysiographic Province, is generally underlain by rocks of the NewarkGroup, specifically, the Hammer Creek Formation. Neither the on-site nor-the off-site soils and sediment were sampled during the siteinvestigation. Therefore, this environmental pathway cannot be adequatelyaddressed without further sampling. Based on the information reviewed,there is reason to believe that at least on-site soils have beencontaminated by contaminants emanating from the landfills.

Air,No readings were recorded above background with either the HNu orradiation mini-alert during the Site Investigation; however, extensive airmonitoring has not been conducted at the site. Air quality is notexpected to be affected by contamination emanating from the site.

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Food ChainFood chain contamination has not been reported. Hunting and fishing werenot observed during the site visit and crops are not being grown in thearea; therefore, the potential for food chain contamination seems to beminimal.

B. HUMAN EXPOSURE PATHWAYS

Both organic and inorganic compounds, have been identified at the BerksLandfill Site. On the basis of the characteristics of the populationspotentially affected and the reported contaminant levels in the variousenvironmental media, the human exposure pathways of concern at this siteinclude:

1. Ingestion, inhalation, and dermal contact with contaminatedgroundwater. ., • ;

2. Inadvertent ingestion, inhalation, and dermal contact with potentiallycontaminated soil/sediment.

PUBLIC HEALTH IMPLICATIONS

In the following section, the health Implications of the contaminants ofconcern detected at the site are addressed based on the environmentalmedia in which .they were found and the human exposure pathway.associatedwith that media. - . . • • ' • • Y

The presence of a large number of volatile organic compounds (VOC's) wasdetected in groundwater and leachate samples at the site. A sample fromthe Lombardo well also revealed similar VOC contamination. Among theVOC's reported, vinyl chloride and benzene are recognized as humancarcinogens, TCE is classified as a probable, human carcinogen, andtrans-l,2-dichloroethene and methylene chloride are classified as possiblehuman carcinogens. All of the,reported organic contaminants arerelatively well absorbed <Jermally.

Benzene was detected at 35 ppb in the on-site groundwater monitoringwells. Acute (short-term) exposure to benzene may result in centralnervous system depression. Headache, dizziness, nausea, and coma may alsoresult; however, acute exposures to contaminants found at the BerksLandfill site are not expected. Chronic exposure is well documented tocause blood changes. Benzene is basically a myelotoxic agent.

Trans-l,2-dichloroethene was detected at concentrations up to 88 ppb(parts per billion; ug/1) In on-site monitoring wells. The ProposedMaximum Contaminant Level (FMCL) for this compound in drinking water is 70ppb. In order to protect human health, concentrations of . . '.'trans-l,2-dichloroethene should be kept at or preferably.below thislevel. Trans-l,2-dichloroethene can act as a primary irritant producing

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dermatitis and irritation of mucous membranes. It can also act as anarcotic, causing central nervous syrtem depression. Symptoms of acuteexposures include dizziness, nausea end frequent vomiting. Renal effects,when they do occur, are transient.

Groundwater monitoring wells and landfill leachate samples contained up to75 ppb of trichloroethylene (TCE), which is well above the MaximumContaminant Level (MCL) of 5 ppb. TCE is a known human carcinogen whichcauses an additional lifetime cancer risk of 1 in 100,000 at 27 ppb indrinking water. Exposure to TCE vapor during normal domestic activities(i.e., showering, dishwashing, bathing) may cause irritation of the eyes,nose, and throat. Repeated or prolonged skin contact may causedermatitis. Although acute exposure to high concentrations of TCE maydepress the central nervous system causing such symptoms as headache,dizziness, vertigo, tremors, nausea and vomiting, irregular heartbeat,sleepiness, and fatigue, these effects are not expected at the levelsfound at this site.

An additional lifetime cancer risk of 1 in 100,000 is posed by aconcentration of 20 ppb of vinyl chloride in drinking water. Vinylchloride was detected at concentrations as high as 32 ppb in groundwatermonitoring wells on site. It was also detected at 21 ppb in the Lombardodomestic well. The water in this well is sufficiently contaminated thatit should not be used for potable purposes unless it is treated prior touse. Light-headedness, some nausea, and dulling of visual and auditoryresponses may develop in acute exposures. Chronic exposure to vinylchloride may cause hepatic damage, angiosarcoma of the liver, and excesscancer of the lung and lymphatic and nervous systems.

Methylene chloride was detected in on-site leachate samples at levels thatmay be harmful to human health. Repeated contact may cause dermatitis.Methylene chloride is a mild narcotic. Effects from intoxication includeheadache, giddiness, stupor, irritability, and numbness of the limbs.

Metal contaminants detected in the environmental media absorb poorlythrough the skin; however, compromises in the skin barrier, such as, cutsand other breaks in the skin, increase transdermal absorption and maycause contaminants to enter the body more readily.

Arsenic is a carcinogen. The principal routes of entry into the body areInhalation and ingestion of arsenic dust or fumes. Arsenic was detectedat 139 ppb in on-site groundwater. The permissible concentration ofarsenic in water for the protection of human health is 50 ppb (EPA, MCL).Prolonged dermal contact with arsenic contaminated environmental mediacould cause local hyperemla and later vesicular or pustular eruption.Conjunctiva are vulnerable to the irritant effects of arsenic.

Chronic arsenical poisoning due to ingestion is rare and generallyconfined to patients taking prescribed medications. However, it can be anassociate of inhaled inorganic arsenic from swallowed sputum and Improper

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k , eating habits. Symptoms are weight loss, nausea, and diarrhea alternating^^ with constipation, loss of hair, and pigmentation and eruption of the

skin.

Lead can produce a variety of systemic (noncarclnogenic) toxicities Thereported lead levels (ND- 1,740 ppb) are sufficiently high to pose a riskof chronic lead toxicity (via incidental ingestion) in persons engaged infrequent on-site activities . The MCL for lead in drinking water is 50ppb. Chronic lead toxicity consists of a variety of neurological, renaland/or hematological effects. Neurological effects are characterized byencephalopathy and degeneration of sensory and motor nerve function; renaleffects are characterized by Interstitial nephritis; hematological effectsare characterized by alterations in heme synthesis and frank hypochromic,microcytic anemia. The neonate and young are particularly sensitive tothe neurological effects of lead, with one of the most sensitive clinicaleffects being subtle deficiencies in learning ability.

A criterion of 1000 ppb barium was set by EPA for domestic water supplieson a health basis. The concentrations detected in the on-site groundwatermonitoring wells were at levels high enough to potentially cause adversehuman health effects, such as increased muscle contractility, ifinadvertently ingested or inhaled for long periods of time. Contact withbarium may also cause some local irritation to the eyes, nose, throat, andskin.

, . Other metals that were detected during the site investigation were nickel,V_y chromium, zinc, manganese, and vanadium. These metals can cause skin

sensitization and dermatitis if contacted for long periods of time. Theymay also cause irritation to the conjunctiva of eyes and mucous membranesof the upper respiratory tract. Concentrations of contaminants detectedin off -site surface waters were not at levels expected to cause anyadverse human health effects.

CONCLUSIONS

From the available information, the Berks Landfill Site is considered tobe of potential public health concern because of the risk to human healthcaused by the possibility of exposure to hazardous substances at levelsthat may potentially result in adverse human health effects over time. As'noted in the Human Exposure Pathways Section of this Preliminary HealthAssessment, human exposure to both organic and inorganic compounds mayoccur or may be occurring and may have occurred in the past via ingestion,inhalation, dermal contact with contaminated groundwater; and, potentialinadvertent ingestion, inhalation, or dermal contact with contaminatedsoils/sediment. Surface water on and in the vicinity of the site is notpresently contaminated with site -related compounds; however, there is thepotential that this environmental media could be contaminated in thefuture. If it becomes contaminated, this pathway should be reevaluatedfor potential health related implications.

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** To be approved by EPI-MED branch **The Berks Landfill Site has been evaluated for appropriate follow-up withrespect to health effects studies. Inasmuch as there is no extantdocumentation or indication in the information and data reviewed for thisPreliminary Health Assessment that significant human exposure toon- site/off -site contaminants is currently occurring or has occurred inthe past, this site is not being considered for follow-up health studiesat this time. However, if data become available suggesting that humanexposure to significant levels of hazardous substances is currentlyoccurring or has occurred in the past, ATSDR will reevaluate this site forany indicated follow-up.

RECOMMENDATIONS

ATSDR recommends the following for the protection of human health:

1. Sample on-site and off-site soil and sediment for potentialsite-related contamination so that these media can be adequately addressed•for potential associated health implications.

\

2. i Access should be restricted to the landfill area to limit exposure toleachate and potentially contaminated soils.

3. Adequate dust control should be used if remedial activities areinitiated at the site in the future.

4. Workers involved in remedial activities, as well as those involved inthe pumping of leachate from the surface impoundments for shipment tooff -site treatment facilities, should be equipped with proper protectivegear. All remedial activities should comply with Occupational Safety andHealth Administration (OSHA) standards and National Institute ofOccupational Safety and Health recommendations.

5. Continue monitoring of wells that may be used as potable watersupplies that are located downgradient of the site to insureconcentrations of contaminants remain below drinking water standards. Ifconcentrations of contaminants in the drinking water are found to exceedacceptable health based levels, alternate water should be supplied.

6. Water fron the Lombardo private well should not be used for potablepurposes unless it is treated prior to use. The levels of vinyl chloridedetected in the well could cause significant adverse health effects if thewater is used for long periods of time.

7. The unnamed tributary to Cacoosing Creek should continue to bemonitored for site-related contamination.

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PREPARERS OF REPORT

Environmental Reviewer: Chebryll J. CarterEnvironmental Health EngineerEnvironmental Engineering Branch

Typist: Charlotta V. GavinClerk/TypistEnvironmental Engineering Branch

ATSDR REGIONAL REPRESENTATIVES

Region III Representatives: Charles Walters and Lynn WilderField Operations BranchRegion III

REFERENCES

1. Hazardous Ranking System for Berks Landfill, Prepared for theHazardous Site Control Division, U.S. EPA by NUS Corporation, SuperfundDivision, September 1986.

2. Site Inspection of Berks Landfill, Prepared for the Hazardous SiteControl Division, U.S. EPA by NUS Corporation, Superfund Division,September 22, 1986.

3. Sittig, Marshall, Handbook of Toxic and Hazardous Chemicals andCarcinogens, Second Edition, Noyes Publications, New Jersey, 1985.

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TABLE 1: ON-SITE CONTAMINANTS OF CONCERNBerks Landfill Site

Sinking Springs, Berks County, Pennsylvania1985 Sampling Data

Media Contaminant Concentrations Found (ppb)

GroundwaterMonitoring Wells vinyl chloride ND-32

trans-l,2-dichloroethene ND-38trichloroethene (TCE) ND-34manganese 320-67,300nickel ND-660vanadium ND 1,650zinc ND-27,600arsenic ND-139barium 430-2,980chromium 130-910copper ND-4,580lead 95-1,740

Leachate lead 24-91chromium 47-290arsenic ND-57methylene chloride ND-3,800vinyl chloride ND-18TCE ND-75benzene ND-35manganese 17,200-23,500nickel 29-240

Notes:ND-not detectedppb-parts per billion (ug/1)

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TABLE 2: OFF-SITE CONTAMINANTS OF CONCERNBerks Landfill Site

Sinking Springs, Berks County, Pennsylvania1985 Sampling Data

Media Contaminant Concentrations Found (ppb)

GroundwaterLombardo Private Well vinyl chloride ND-21

Notes:ND-not detectedppb-parts per billion (ug/1)

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BND250 2-BROMO-l>OtAMlNO-4 -DlHYDROXYANTHRAQUINONE 564

TOXICITY DATA: CODEN: THR: May ignite violently on exposure to air. When heateddnd-ese 30 mg/L • MUREAV 108,13,33 to decomposition it emits toxic fumes of Br~. See alsrmnt-hnm:fbr 82 junoI/L MUREAV 4.333,67 BORANES and BORON COMPOUNDScyt-hmn:fbf 82 |uno!/L MUREAV 4,353,67cyt-hmn:lett 200 mg/L ECREAL 34,182,64 „»,««»» »» *sce-hmn:lym 20 junol/L HEREAY 83,163.76 BND5W HR: 2msc-hmn:fbr 15 mg/L CSHSAZ 29,151, 65 BROMODICHLOROMETHANEsce-dmg-orl2Smg/L GENTAE 100,259,82 CAS: 75-27-4 NIOSH: PA 5310000sce-dmg:och250|ig/L GENTAE 100,259,82 mf: CHBrCfe mw: 163.83dnd-hma:fbr 10 junol/L BLFSBY 29A.69.84 *cyt-hmn:lum 13 mg/L CYTOAN 46,387,81 PROP: Colorless liquid. Bp: 89.2-90.6°, d: 1.971 @ 25°/sce-hmn:lum 20 junol/L HEREAY 83,163,76 25*sce-hnm:leu 10 mg/L AGTQAH 19,225,76sce-hmn:fbrlOmg/L CYTBAI 38,159,83 . SYNS:sce-hmn:ovr 20 mg/L CYTBAI 38,159,83 BDCM NCI-CSJMJsce-hran:oth 15 mg/L CYTBAI 38,159,83 DICHLOROBROMOMETHANBmsc-hmn:fbr 15 mg/L CSHSAZ 29.151,65dnd-mus:lum 10 junoW. BLESBY 29A.69.84 TOXICITY DATA: CODEN:cyt-hara:kdy 20 junol/L CGCGBR 38,21 1,84 mmo-sat 50 |iL/plate DHEFDK FDA-78-cyt-mus-lpr 20 mg/kg (10D DABBBA 39,3688.79 rCJ* / 1046.78preg):REP sce-hmn:lyn»400|imoI/L!O< 1/i- ENVRAL 32,72,83

ipr-haraTDLo:400mgfcg(9or JEEMAF 43,47,78 sce-mus-orl 200 mg/kg/4D-I ENVRAL 32.72,83lODpreg):TER ort-rat LD50:916 mg/kg TXAPA9 52.35 1,80

ivn-hamTDLo:200 mg/kg <8D UFSAK 4,633,65 orl-mus LD50:450 mg/kg TXAPA9 44,213.78

ori<afLD50:8400 mg*g IYKEDH 4,467,73 A Genetk Toxicology Program. Community Right Toscu-rat LD50:3900 mg/kg TAKHAA 30,530,71 Know List. Reported in EPA TSCA Inventory.unr-ratLD50:2300 mg/kg NI1RDN 6,721,82 _._ . , . , . . . . . .ipr-mui LD50:3050 mVkg TAKHAA 30.530.71 TH Moderately toxic by ingestion. Human mutagemcscu-mus LD50:3500 mg/kg TAKHAA 30,530,71 data. When heated to decomposition it emits very toxicivn-n»usLDSO:2500rog/kg TAKHAA 30.530,71 fumes of Br~ and CT. See also CHLORINATED HYDRO-EPA Genetic Toxicology Program. CARBONS. ALIPHATIC and BROMIDES. For furthc

information, see Vol. 6, No. 3 of DP1M Report.THR: Moderately toxic by subcutaneous, intravenous, in- 'traperitoneal and possibly other routes. Mildly toxic by BND750 HR:3 'ingestion. An experimental teratogen. Other experimental oK4-BROMO-2,5-DICHLOROPHENYL)-o-ETHYL ireproductive effects. Human mutagenic data. When heated PHENYLPHOSPHONOTHIOATE ito decomposition it emits very toxic fumes of Br~ and CAS: 13936-66-8 NIOSH: TB 1717500 iNO,. mf: C BrazOaPS mw:426.10 ?BND250 HR:1 SYN: VELSKOLPCS-SOO !2-BROMO-l,8-DIAMINO-4,5.DIHYDROXYAN. VT«WI. 1 ™n™THRAQUINONE TOMCITY DATA: CODEN: j

rA«- «r»tAr-i Kin u- m s<mvn orl-mus LD50:75 mg/kg JAFCAU 27.1197.79 ICAS. 65235-63-4 NIOSR CB 5975500 .gpg LDLO; 100 mgfltg JEENA1 61.1261,68mf: C|4H9BrN204 mw: 349.16 scu-gpgLDLo:lOOmgflcg JEENAI 61.1261.68 ISYN: MOD* OSTACETOVA uo (CZECH) THR: Poison by ingestion and subcutaneous routes. When '•royrnTYDATA. CODEN- heated to decomposition it emits very toxic fumes of S04. i1UAJX.11 I LIA1A. CUUCTI. __ _._ . _ _ _ , CCTCDG$kn.rbi500mg«4HMLD 28ZPAK -.244.72 PO,. Q and Br . See also ESTERS.eye-rbt 500 mg/24H MLD 28ZPAK - 44.72od-ratLD50: 12500 mg/kg 28ZPAK -.244.72 BNE250 HR:3 (Reported in EPA TSCA Inventory.THR: Mildly toxic by ingestion. A ' ' * ' ' ~ ' -: 53581-53-6 NIOSH: SH 0300000When heated to decomposition it er jHisBtOj'BrH mw: 341.10of Br~ and NO..

: <fl-4-BROMO-I,5-D!METKOXY-a-METHYLPHENETMYlAMINEKV.BND325 n«;j --OBROMIDBBROMODmORANE TOXICITY DATA:; CODEN: ,CAS: 23834-96-0 ipr-ral LD50: 50 mg/kg ' TXAPA9 45(1),49,7S ^mf:B2BrH3 mw: 106.56 ivn-mus LD50:80 mgAg TXAPA9 45(1).49.78

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