1

INDUSTRY ROUND TABLEBETTER FOOD FOR BETTER HEALTH MERIEUX FONDATION 2016

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Innovative all-round premium nutrition and care provider for the entire family (cont’d)

2 RESTRICTED

Wide range of products targeting different age groups

Pregnancy Infants

Biostime

ADiMIL

Biostime

ADiMIL

Adults

Healthy Times

Swisse Wellness

BM Care

ADIMAMA Premium Nutritional Milk

Milk Calcium Chewable Tablet

Premium Nutritional Milk

Premium formula

Specialty formula Baby diapers Baby shower care Baby wipes

Baby

cerealTeddy puffs

Baby biscuits

Baby food

Ultivite multivitamin

Ultiboost

Superfoods

Active Skincare

Probiotic sachetsBaby food supplement

Swisse Wellness

Note:

1. To be launched in March 2016

Swisse

Pregnancy

ultivite

Baby care Kids supplements – only after launch

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5,9%

8,5%

6,1%

1,5%

Total Baby stores Supermarkets E-commerce

Strong footprint across China

Source: Nielsen

As of 31 December 2015, we have

728 regional distributors

Over 40,684 points of sale, including 28,785 specialty stores, 6,695 supermarkets and 5,204 VIP Pharmacies

Beijing

Shanghai

Guangzhou

Headquarter

21.8% 20.2%

48.1%68.8%

7.6%30,1%

3.4%

IMF Industry average Biostime

Supermarkets Baby specialty stores

VIP Pharmacies E-commerce

Sales by channel in 2015

#10

Biostime’s market share by channel in 2015

Diversified Sales Channels

#6#2#6

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Biostime’s extensive nationwide network

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Microbiota research & application group

Conduct scientific research projects

Clinical trail management

Innovative ingredient research

Probiotics/prebiotics -related product

development

Personalized nutrition solution

Infant microbiota and health

Skin microbiota

Human breast milk microbiota and nutritional

component

Functions and mechanisms of

probiotics/prebiotics

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技术引进

前期培训- 阶段1， 2015.03

Biofortis 中心实验室，法国南特

前期培训- 阶段2， 2015.10

合生元实验室，中国广州

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研究平台Research Platform-Funding Project

会议平台Offline Communication-Conference Platform

媒介平台Online Communication-Media Platform

智库平台Think-Tank Platform-Expert Panel

Biostime Institute of Nutrition and Care

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5000+ Registered Professionals

Have published 300+ articles

Update articles regularlyEnglish Version will be launched in May 2016

Including Doctors, Dietitians, Scholars

BINC Academic Communication (Online

Media)

http://www.binc.com.cn/

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Microbiota research & application group

Scientific research:

1. Database of infant gut microbiota development. Biobank of infant stool samples Analyse microbiota composition Collaborators:

Changsha maternal and child care service centreJiangnan University…..

2. Correlation between the skin Characteristic and microflora of infants Comparison between healthy infant with those who have atopic dermatitis. Analyse microbiota composition Collaborators:

Beijing Children’s Hospital, Capital Medical University

3. The effect of maternal secretor status and breast milk profile on infant health Genotyping of the key SNP on the gene that determine the secretor status. Analyse the breast milk HMO profiling Collaborators:

To be decided..

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Scientific basis

Regulations

Manufacturing process

Formulation

Ingredient evaluation

Microbiota research & application group

Ongoing projects:

Probiotic delivery system

Strain selection

Clinical research on digestion and

immunity

Probiotics-related product development:

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n=0-15

b1-3

b1-4

b1-3

b1-6

a1-2

a1-3

a1-4

a2-3

a2-6

b1-4

lactoselacto-N-biose

N-acetyllactosamine

b1-4 b1-4

a1-2 a1-3

2’-fucosyllactose

(2’FL)

3-fucosyllactose

(3FL)

b1-4

a2-3b1-4a2-6

3’-sialyllactose

(3’SL)

6’-sialyllactose

(6’SL)

b1-4

b1-3

b1-3

Lacto-N-tetraose (LNT)

(type 1 chain)

b1-4

b1-3

b1-4

Lacto-N-neotetraose (LNnT)

(type 2 chain)

b1-4

b1-3

b1-3

b1-4

b1-6

Lacto-N-hexaose (LNH)

b1-4

b1-3

b1-3

b1-4

b1-6

b1-3

iso-Lacto-N-octaose

b1-4

b1-3

b1-4

b1-3

para-Lacto-N-octaose

b1-3

b1-3

b1-4

b1-3

b1-4

b1-3

b1-3

b1-4

b1-6

b1-3

iso-Lacto-N-neooctaose

b1-4

a1-2

b1-4

b1-3

b1-3

Lacto-N-fucopentaose I

(LNFP I)

b1-4

b1-3

b1-3

Lacto-N-fucopentaose II

(LNFP II)

a1-4

b1-4

b1-3

a1-3

Lacto-N-fucopentaose III

(LNFP III)

b1-4

b1-4

b1-3

b1-3

Lacto-N-fucopentaose V

(LNFP V)

a1-3

Glucose (Glc) Galactose (Gal) N-acetylglucosamine (GlcNAc) Fucose (Fuc) N-acetylneuraminic acid (NeuAc)

a2-3

b1-4

b1-3

b1-3

LS-Tetrasaccharide a

(LST a)

a2-6

b1-4

b1-3

b1-3

LS-Tetrasaccharide b

(LST b)

a2-6

b1-3

b1-4

b1-4

LS-Tetrasaccharide c

(LST c)

a2-6

b1-4

b1-3

b1-3

a2-3

Disialyllacto-N-tetraose

(DSLNT)

HMO Blueprint and Structural Diversity

150 – 200 different HMO

11Kunz C et al. (2000) Ann Rev Nutr 20:699-722

b1-3/4

Antiadhesive Antimicrobials

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Microbiota research & application group

Personalized nutrition project

A global trend: Choose the foods that are right for you!

We all respond differently to the same food.

Discover the right foods for you, by measuring your genetics & microbes

Tailor your food choices to your unique genetic makeup

"We found that people who receive DNA-based advice improve their diet to a greater extent than those who receive the standard dietary advice.” Dr. El-Sohemy, Canada Research Chair in Nutrigenomics