beyond asthma and copd
TRANSCRIPT
Beyond Asthma and COPD Challenges and Opportunities
Dry Powder Inhalers
Management Forum - 19 & 20 June 2012
David Harris, John Burke
Presentation_ManagementForum-DPIs_v1-0.ppt
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Catch twenty-two? The vast majority of dry powder inhalers are used to treat asthmatic and COPD patients...
They’re powered by the impaired organ!
Confidential © Team Consulting 2012
Pain relief How many tonnes of OTC analgesics are produced globally per year? 185,000 tonnes! If all analgesic tablets were placed end-to-end, how many times would they pass around the Earth?
140 times!
How many analgesic tablets are taken globally every second? >14,800!
2. http://www.in-pharmatechnologist.com/Ingredients/Univar-steps-into-paracetamol-breach
4. http://www.rsc.org/chemistryworld/Issues/2009/February/BusinessRoundup.asp
3. Warner TD, Mitchell JA (2002); Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?
Proc Natl Acad Sci USA 99 (21): 13371–3
1. Richard L Myers; The 100 Most Important Chemical Compounds, ISBN-13: 978-0-313-33758-1, p151
1, 2, 3, 4
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What’s the cost? 468,000,000,000 analgesic tablets are taken every year.
If it takes around 30 minutes for the tablets to kick-in.
Working at 75% productivity during this time amounts to: 29,302,884,615 hours! Which equates to 16,987,179 years!
The average cost of time per hour is around $10.
The total cost per year is a staggering: $293,028,846,154
5. http://www.bbc.co.uk/news/magazine-17512040
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What are the challenges?
Current analgesics are large doses need more potent drugs
Tablet blister packs are simple, effective and inexpensive need simple devices!
Delivering drugs with much narrower therapeutic indices accurate and repeatable delivered dose
no pain
no cold chain
stable formulation
less fear
no needlestick
faster delivery
shorter queues
Can DPIs deliver
vaccinations successfully?
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What are the challenges?
• Delivery of dose needs to be as accurate as a needle and syringe
• Usability
many users will never have seen an
inhaler before!
• Majority of vaccinations given to infants or children
• Very low cost
on par with a needle and syringe
Excellent DCU
Perfectly intuitive
Works for children & adults
Very low cost
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Some exciting developments
• Inhaled insulin – Mannkind Corporation
• Nasal migraine relief – Sumatriptan
• Breakthrough cancer pain – inhaled Fentanyl, Akela Pharma
• Inhaled tuberculosis vaccine
6. http://www.mannkindcorp.com/product-pipeline-diabetes-afrezza.htm
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7. http://www.akelapharma.com/products.html
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8. http://www.pnas.org/content/105/12/4656.full.pdf
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The future for DPIs? simple low cost
accurate low
wastage
high payload
intuitive desirable
safe
efficient