Bhahwal Ali Shah

Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu-180001, J&K, India. Office: +91-191-2569000-06 Ext. 211. E-mail: bashah@iiim.ac.in; bashah@iiim.res.in; bhahwal@gmail.com;

Scientist, Natural Product Chemistry (Microbes) Division, CSIR-Indian Institute of Integrative Medicine (May

2011 onwards).

Jr. Scientist, Natural Product Chemistry (Microbes) Division, CSIR-Indian Institute of Integrative Medicine

(April 2008 – April 2011).

Assistant Professor in Academy of Scientific and Innovative Research (AcSIR) from 2012 onwards

Members of different Doctoral Advisory Committees and active participant in the framework of AcSIR

chemistry course work, lectures, conducting exam etc.

INDO-US Research Science and Technology Forum Fellowship for the year 2011.

Fast Track Research Grant awarded by DST (2010)

Qualified for Senior Research Fellowship-2008 awarded by Council of Scientific and Industrial Research,

New Delhi, India.

Best paper award of the Institute (2007-2008) for “A facile approach towards enantiomerically pure

masked β-amino alcohols; P. Gupta, Bhahwal Ali Shah, R. Parshad, G.N. Qazi and S.C. Taneja, Green

Chemistry, 2007, 9, 1120-1125”

2nd best paper award of the Institute (2006-2007) for “Formation of 1,3-dioxalanes: a typical Baylis-

Hillman reaction of sesquiterpene lactone parthenin; Bhahwal Ali Shah, S.C. Taneja, V.K. Sethi, P.

Gupta, S.S. Andotra, S.S. Chimni and G.N. Qazi Tetrahedron. Lett., 2007, 48, 955-960.”

Best paper award of the Institute (2013) for “Tubulin Inhibitors from an Endophytic Fungus Isolated

from Cedrus deodara; M. Kumar, M. Qadri, P. R. Sharma, A. Kumar, S. S. Andotra,T. Kaur, K. Kapoor, V.

K. Gupta, R. Kant, A. Hamid, S. Johri, S. C. Taneja, R. A. Vishwakarma, S. Riyaz-Ul-Hassan, Bhahwal Ali

Shah, J. Nat. Prod., 2013, 76, 194-199.

Best paper award of the Institute (2011) for “Tandem Catalysis by Lipase in a Vinyl Acetate-Mediated

Cross-Aldol Reaction; M. Kumar, Bhahwal Ali Shah, S. C. Taneja, Adv. Synth. Cat., 2011, 353, 1207-

1212

Positions Held

Awards and Honors

Isolation of Natural Products

Research Area

Structural modifications of Naturally Occurring Molecules

Development of synthetic methodologies

Papers:

2015 1. R. Deshidi, S. Devari, Bhahwal Ali Shah, Metal free access to quinolines via C–C bond cleavage of

styrenes; Org. Chem. Front., 2015, 2, 515-519. 2. S. Devari, A. Kumar, Bhahwal Ali Shah, C–H functionalization of terminal alkynes towards

stereospecific synthesis of (E) or (Z) 2-methylthio-1,4-ene-diones; Chem. Commun., 2015, 51, 5013-5016.

3. M. Kumar, S. Devari, A. Kumar, S. Sultan, Q. N. Ahmed, M. Rizvi, Bhahwal Ali Shah, Copper (II)‐Triflate‐Catalyzed Oxidative Amidation of Terminal Alkynes: A General Approach to α‐Ketoamides; Asian J. Org. Chem., 2015, doi: 10.1002/ajoc.201500022.

4. S. Bhushan, S. Guru, A. Pathania, S.Kumar, A. Kumar, F. Malik, D. Ramesh, M. Kumar, Bhahwal Ali Shah, S. Jaglan, A. Faruk, S. Tasduq, R. A. Vishwakarma, S. Lattoo, S. Rana, Secalonic acid-D, a mycotoxin from a novel endophytic source, represses HIF-1α/VEGF arbitrated angiogenesis via Akt/mTOR/p70S6K signalling cascade; Cell Death & Disease, 2015, (accepted).

5. R. Deshidi, S. Devari, Bhahwal Ali Shah, Iodine promoted oxidative amidation of terminal alkene; Synthesis of α-ketoamides, Benzothiazoles and Quinozolines; Eur. J. Org. Chem., 2015, 2015, 1428–1432.

6. A. K. Qazi, A. Hussain, S. Khan, M. A. Aga, A. Behl, S. Ali, S. K. Singh, S. C. Taneja, Bhahwal Ali Shah, A. K. Saxena, D. M. Mondhe, A. Hamid, Quinazoline based small molecule exerts potent tumor suppressive properties by inhibiting PI3K/akt/FoxO3a signalling in experimental colon cancer; Cancer Letters, 2015, 2015, 1428–1432.

Publications

7. M. A. Rizvi, M. Zaki, M. Afzal, M. Mane, M. Kumar, Bhahwal Ali Shah, S. Srivastav, S. Srikrishna, G. M. Peerzada, S. Tabassum, Nuclear blebbing of biologically active organoselenium compound towards human cervical cancer cell (HeLa): In vitro DNA/HSA binding, cleavage and cell imaging studies; Eur. J. Med. Chem., 2015, 90, 876-888.

8. A. Kumar, M. Kumar, S. Sharma, S. Guru, S. Bhushan, Bhahwal Ali Shah, Design, Synthesis and Bio-evaluation of Cryptophycins Based Tubulin Inhibitors; Eur. J. Med. Chem. 2015, 93, 55–63.

2014

9. S. Devari, M. Kumar, R. Deshidi, M. Rizvi, Bhahwal Ali Shah, A general metal-free approach for the stereoselective synthesis of C-glycals from unactivated alkynes; Beilstein J. org. chem., 2014, 10, 2649-2653.

10. R. Deshidi, M. Kumar, S. Devari, Bhahwal Ali Shah, A general metal free approach to α-ketoamides via oxidative amidation–diketonization of terminal alkynes; Chem. Comm., 2014, 50, 9533-9535.

11. B. Kumar, M.A. Aga, A. Rouf, Bhahwal Ali Shah, S.C. Taneja, Common precursor strategy for the synthesis of bestatin, amprenavir intermediate and syn-4-hydroxy-5-phenyl-γ-lactam; RSC Advances, 2014, 4, 17206-17209.

12. R. Chib, M. Kumar, M. Rizvi, S. Sharma, A. Pandey, S. Bani, S. S. Andotra, S. C. Taneja, Bhahwal Ali Shah, Anti-inflammatory terpenoids from Boswellia ovalifoliolata; RSC Advances, 2014 , 4, 8632-8637.

13. S. Devari, S. Jaglan, M. Kumar, R. Deshidi, S. Guru, S. Bhushan, M. Kushwaha, A. P. Gupta, S. G. Gandhi, J. P. Sharma, S. C. Taneja, R. A. Vishwakarma, Bhahwal Ali Shah, Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis; Phytochemistry, 2014, 98, 183-189.

14. M. Kumar, A. Kumar, M. Rizvi, M. Mane, K. Vanka, S. C. Taneja, Bhahwal Ali Shah, Synthesis of α, β‐Unsaturated δ‐Lactones by Vinyl Acetate Mediated Asymmetric Cross‐Aldol Reaction of Acetaldehyde: Mechanistic Insights; Eur. J. Org. Chem., 2014, 5247-5255.

15. P. Gupta, A. Rouf, Bhahwal Ali Shah, N. Mahajan, A. Chaubey, S.C. Taneja, Arthrobacter sp. lipase catalyzed kinetic resolution of BINOL: The effect of substrate immobilization; J. Mol. Catal. B: Enzym., 2014, 101, 35-39.

16. M. A. Aga, B. Kumar, A. Rouf, Bhahwal Ali Shah, S. C. Taneja, Vasicine as tridentate ligand for enantioselective addition of diethylzinc to aldehydes; Tetrahedron Lett., 2014, 55, 2639-2641.

17. M. A. Rizvi, S. Guru, T. Naqvi, M. Kumar, N. Khumbhar, S. Akhoon, S. Banday, S. K. Singh, S. Bhushan, G. M. Peerzada, Bhahwal Ali Shah, An Investigation of in vitro Cytotoxicity and apoptotic potential of aromatic diselenides; Bioorg. Med. Chem. Lett., 2014, 24, 3440-3446.

18. S. Sharma, M. Ahmad, J. A. Bhat, A. Kumar, M. Kumar, M. A. Zargar, A. Hamid, Bhahwal Ali Shah, Design, synthesis and biological evaluation of β-Boswellic acid based HDAC inhibitors as inducers of cancer cell death; Bioorg. Med.Chem. Lett., 2014, 24, 4729-4734.

2013

19. M. Kumar, M. Qadri, P. R. Sharma, A. Kumar, S. S. Andotra,T. Kaur, K. Kapoor, V. K. Gupta, R. Kant, A. Hamid, S. Johri, S. C. Taneja, R. A. Vishwakarma, S. Riyaz-Ul-Hassan, Bhahwal Ali Shah, Tubulin Inhibitors from an Endophytic Fungus Isolated from Cedrus deodara; J. Nat. Prod., 2013, 76, 194-199.

20. A. S. Pathania, A. Joshi, S. Kumar, S. K. Guru, S. Bhushan, P. R. Sharma, W. W. Bhat, A. K. Saxena, J. Singh, Bhahwal Ali Shah, S. S . Andotra, S. C. Taneja, F. A. Malik, A. Kumar, Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059; Apoptosis, 2013, 18, 1561-1573.

21. Y. Qurishi, A. Hamid, P.R. Sharma, Z.A. Wani, D.M. Mondhe, S.K. Singh, M.A. Zargar, S.S. Andotra, Bhahwal Ali Shah, S.C. Taneja, A.K. Saxena. NFκB Down-regulation and PARP Cleavage by Novel 3-α-Butyryloxy-β-boswellic Acid Results in Cancer Cell Specific Apoptosis and in vivo Tumor Regression; Anticancer Agents Med. Chem., 2013, 13, 777-790.

22. S. Devari, R. Deshidi, M. Kumar, A. Kumar, S. Sharma, M. Rizvi, M. Kushwaha, A. P. Gupta, Bhahwal Ali Shah, Osmium (VI) catalyzed chemoselective oxidation of allylic and benzylic alcohols; Tetrahedron Lett., 2013, 54, 6407–6410.

23. R. Mehra, A. Nargotra, Bhahwal Ali Shah, S. C. Taneja, R. A. Vishwakarma, S. Koul, Pro-apoptotic properties of parthenin analogs: a quantitative structure–activity relationship study; Med. Chem. Res., 2013, 22, 2303-2311.

24. M.A. Aga, B. Kumar, A. Rouf, Bhahwal Ali Shah, S.S. Andotra, S.C. Taneja, Natural (−)‐Vasicine as a

Novel Source of Optically Pure 1‐Benzylpyrrolidin‐3‐ol; Helvetica Chimica Acta, 2013, 96, 969-977. 25. R. Chib, Bhahwal Ali Shah, S.S. Andotra, V. Bharadwaj, R. K. Gupta, S.C. Taneja, R. K. Khajuria,

Quantification of Sesquiterpene Lactones in Parthenium hyterophorous by Normal-Phase HPLC; J. Chromatogr. Sci., 2013, 51, 950-953.

26. M. Qadri, S. Johri, Bhahwal Ali Shah, A. Khajuria, T. Sidiq, S. K. Lattoo, M. Z. Abdin, S. Riyaz-Ul-Hassan, Identification and bioactive potential of endophytic fungi isolated from selected plants of the Western Himalayas; Springer Plus, 2013, 2, 1-14.

2012

27. P. Gupta, A. Rouf, Bhahwal Ali Shah, D. Mukherjee, S. C. Taneja, Efficient Preparation of Biologically Important 1, 2-Amino Alcohols; Syn. Commun., 2013, 43, 505-519.

28. S. Khan, R. Kaur, Bhahwal Ali Shah, F. Malik, A. Kumar, S. Bhushan, S. K. Jain, S. C. Taneja, J. Singh, A

Novel cyano derivative of 11‐Keto‐β‐Boswellic acid causes apoptotic death by disrupting

PI3K/AKT/Hsp‐90 cascade, mitochondrial integrity, and other cell survival signaling events in HL‐60 cells; Mol. Carcinog. 2012, 51, 679–695.

29. Y. Qurishi, A. Hamid, P. R. Sharma, Z.A. Wani, D.M. Mondhe, Shashank K Singh, M. A. Zargar, S. S Andotra, Bhahwal Ali Shah, S. C. Taneja, A. K. Saxena, PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models; Future Oncol., 2012, 8, 867-881.

30. A. Kumar, Bhahwal Ali Shah, S. Singh, A. Hamid, S.K. Singh, V.K. Sethi, A.K. Saxena, J. Singh, S.C. Taneja, Acyl derivatives of bowswellic acids as inhibitors of NF-kappa β and STATs; Bioorg. Med. Chem. Lett., 2012, 22, 431-435.

31. R. Kant, V. K Gupta, K. Kapoor, R. Chib, Bhahwal Ali Shah, S. C Taneja, 1, 2, 3, 4, 5, 6-Hexa-O-acetyl-scyllo-inositol; Acta Cryst. Sec. E., 2012, E(68), o2594-o2594.

2011

32. M. Kumar, Bhahwal Ali Shah, S. C. Taneja, Tandem Catalysis by Lipase in a Vinyl Acetate-Mediated Cross-Aldol Reaction; Adv. Synth. Cat., 2011, 353, 1207-1212.

33. N. Anand, Bhahwal Ali Shah, M. Kapoor, R. Parshad, R.L. Sharma, M.S. Hundal, A.P. S. Pannu, P.V. Bharatam, S.C. Taneja, Entrapment and Kinetic Resolution of Stabilized Axial and Equatorial Conformers of Spiro-β-lactams; J. Org. Chem., 2011, 76, 5999-6006.

34. B. Kumar, M.A. Aga, A.R. Dar, Bhahwal Ali Shah, S.C. Taneja, 2,3-Unsturated allyl glycosides as glycosyl donors for selective α-glycosylation, J. Org. Chem., 2011, 76, 3506-3510.

35. R. Kaur, S. Khan, R. Chib, T. Kaur, P.R. Sharma, J. Singh, Bhahwal Ali Shah, S.C. Taneja, A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid; Eur. J. Med. Chem., 2011, 46, 1356-1366.

36. A. Kumar, F. Malik, S. Bhushan, Bhahwal Ali Shah, S. C. Taneja, H. C. Pal, Z. A. Wani, D. M. Mondhe, J. Kaur, J. Singh, A novel parthenin analog exhibits anti-cancer activity: Activation of apoptotic signaling events through robust NO formation in human leukemia HL-60 cells; Chem. Biol. Interact., 2011, 193, 204–215.

37. G. Chashoo, S. K. Singh, P.R. Sharma, D.M. Mondhe, A. Hamid, A. Saxena, S.S. Andotra, Bhahwal Ali Shah, N.A. Qazi, S.C. Taneja, A.K. Saxena, A propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition; Chem. Biol. Interact., 2011, 189, 60-71.

38. A.F. Raja, F. Ali, I.A. Khan, A.S. Shawl, D.S. Arora, Bhahwal Ali Shah, S.C. Taneja, Antistaphylococcal

and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata; BMC

Microbiol., 2011, 11, 54.

39. S. Khan, R. Chib, Bhahwal Ali Shah, Z. A. Wani, N. Dhar, D. M. Mondhe, S. Lattoo, S. K. Jain, S. C. Taneja,

J. Singh, A cyano analogue of boswellc acid induces crosstalk between p53/PUMA/Bax and

telomerase that stages the human papilloma virus type 18 positive HeLa cells to apoptotic death;

Eur. J. Pharm. 2011, 660, 241-248.

40. G. Chashoo, S.K. Singh, D.M. Mondhe, P.R. Sharma, S.S. Andotra, Bhahwal A. Shah, S.C. Taneja,

A.K.Saxena, Potentiation of antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexonyloxy

derivative; Eur. J. Pharm., 2011, 668, 390-400.

41. R. Chib, Bhahwal Ali Shah, N. Anand, A. Pandey, K. Kapoor, S. Bani, V.K. Gupta, Rajnikant, V.K. Sethi,

S.C.Taneja, Psilostachyn, acetylated pseudoguainolides and their analogues: preparation and

evaluation of their anti-inflammatory potential; Bioorg. Med. Chem. Lett., 2011, 21, 4847-4851.

42. K. Kapoor, V.K. Gupta, Rajnikant, Bhahwal Ali Shah, S.S. Andotra, S.C. Taneja, 3,8-Dibromo-3-

(bromomethyl)-3,3a,4,5,6,6a-hexahydro-6a-hydroxy-6,9a-dimethylazuleno[4,5-b]furan-2,9-dione - a

sesquiterpene lactone; X-ray Structural Analysis Online, 2011, 27, 67-68.

43. K. Kapoor, V.K. Gupta, Rajnikant, R. Chib, Bhahwal Ali Shah, S.C. Taneja, Crystal structure of methyl-

2-cyano-3,11-dioxurs-1,12-dien-24-oate; X-ray Structural Analysis Online, 2011, 27, 43-44.

2009

44. Bhahwal Ali Shah, R. Chib, P. Gupta, V.K. Sethi, S. Koul, S.S. Andotra, A. Nargotra, S. Sharma, A. Pandey,

S. Bani, B. Purnima and S.C. Taneja, Saponins as novel TNF-α inhibitors: Isolation of saponins and a

nor-pseudoguaianolide from Parthenium hysterophorus; Org. Biomol. Chem., 2009, 7, 3230-3235.

45. Bhahwal Ali Shah, R. Kaur, P. Gupta, A. Kumar, V.K. Sethi, S.S. Andotra, J. Singh, A.K. Saxena and S.C.

Taneja, Structure activity relationship (SAR) of parthenin analogues with pro-apoptotic activity:

Development of novel anticancer leads; Bioorg. Med. Chem. Lett., 2009, 19, 4394–4398.

46. K.A. Bhat, Bhahwal Ali Shah, K.K. Gupta, A. Pandey, S. Bani, S.C. Taneja, Semi-synthetic analogs of

pinitol as potential inhibitors of TNF-a cytokine expression in human neutrophils; Bioorg. Med.

Chem. Lett., 2009, 19, 1939-1943.

2008 47. P. Gupta, S. C. Taneja, Bhahwal Ali Shah, D. Mukherjee, R. Parshad, S. S. Chimnib, G. N. Qazi, An

expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino

alcohols; Tetrahedron: Asymmetry, 2008, 19, 1898-1903.

2007

48. Bhahwal Ali Shah, A. Kumar, P. Gupta, M. Sharma, V. K. Sethi, A. K. Saxena, J. Singh, G. N. Qazi, S. C.

Taneja, Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids; Bioorg. Med.

Chem. Lett., 2007, 17, 6411-6416.

49. Bhahwal Ali Shah, S.C. Taneja, V.K. Sethi, P. Gupta, S.S. Andotra, S.S. Chimni and G.N. Qazi, The

formation of novel 1,3-dioxolanes: a typical Baylis-Hillman reaction of a sesquiterpene lactone

parthenin; Tetrahedron Lett., 2007, 48, 955-960.

50. D. Mukherjee, Bhahwal Ali Shah, P. Gupta, S.C. Taneja, Tandem acetalation-acetylation of sugars and

related derivatives with enolacetates under solvent free conditions; J. Org. Chem. 2007, 72, 8965-

8968.

51. P. Gupta, Bhahwal Ali Shah, R. Parshad, G.N. Qazi , S.C. Taneja, A facile approach towards

enantiomerically pure masked β–amino alcohols; Green Chem., 2007, 9, 1120-1125.

52. P. Gupta, S.C. Taneja, Bhahwal Ali Shah, V.K. Sethi , G.N. Qazi, Lipase catalysed separation

geometrical isomers: Geraniol-Nerol; Chem. Lett., 2007, 36, 1110-1111.

53. P. Gupta, V.K. Sethi, S.C. Taneja, Bhahwal Ali Shah, S.S. Andotra, S.S. Chimni, S. Koul, G.N. Qazi,

Odoriferous cyclic ethers via cohalogenation reaction: facile synthesis of nerol oxide, florol, florol

methyl ether and pityol methyl ether; Helv. Chim. Acta, 2007, 90, 196-204.

Book chapters and reviews 1. Bhahwal Ali Shah and Subhash Chandra Taneja. In Compendium of bioactive natural products; “Structural

modifications of parthenin; a sesquiterpene lactone of immense biological potential” Eds. S.C. Taneja, V.K. Gupta & B.D. Gupta, Studium Press, USA, 2010, Vol. 7, p45-76.

2. Bhahwal Ali Shah and Subhash Chandra Taneja. In Compendium of bioactive natural products; “Biological prospective of pinitol and its structurally modified products” Eds. S.C. Taneja, V.K. Gupta & B.D. Gupta, Studium Press, USA, 2010, Vol. 7, p247-266.

3. Bhahwal Ali Shah, G.N. Qazi and S.C. Taneja. Boswellic acids: a group of medicinally important compounds; Nat. Prod. Rep., 2009, 26, 72-89.

4. B. Kumar, M.A. Aga, A. Rouf, Bhahwal Ali Shah, S.C. Taneja, Tetrahydropyranyl ether (THPE) formation in hydroxyl group protection and conversion to other useful functionalities; RSC Advances, 2014, 4, 21121-21130.

5. S. Rasool, V. Rasool, T. Naqvi, B.A. Ganai, Bhahwal Ali Shah, Genetic unraveling of colorectal cancer; Tumor Biology, 2014, 35, 5067-5082.

Patents: 1. A novel formulation useful in cancer chemotherapy, D. M. Mondhe; S. C. Taneja; S. Koul; J. K. Dhar; A. K.

Saxena; R. K. Johri; Z. A. Wani; S. S. Andotra; S. C Sharma; S. Singh; P. N. Gupta; Bhahwal Ali Shah; R. A. Vishwakarma. (Indian Patent Filed: 2554DEL2012).

2.G. N. Qazi; S. C. Taneja; J. Singh; A. K. Saxena; V. K. Sethi; Bhahwal Ali Shah; , A. Kumar; S. S. Andotra; F. Malik; S. Muthiah; S. K. Agrawal; semi-synthetic sesquiterpene lactone parthenin compound useful for cytotoxicity against cancer cell lines and anticancer activity (WO Patent Application No. PCT/IN2009/000218)

3. G. N. Qazi; S. C. Taneja; J. Singh; A. K. Saxena; V. K. Sethi; Bhahwal Ali Shah; B. K. Kapahi; S. S. Andotra; A. Kumar; S. Bhushan; F. Malik; D. M. Mondhe; M. Shanmugavel; S. Singh; M. Verma; S. K. Singh; cytotoxicity and induction of apoptosis in cancer cells by semi-synthetic analogues of boswellic acids for their use as anti-cancer agents (US Patent Application No. 12/401337)

4. G. N. Qazi; S. C. Taneja; J. Singh; A. K. Saxena; V. K. Sethi; Bhahwal Ali Shah; A. Kumar; S. S. Andotra; F. Malik; S. Muthiah; S. K.. Agrawal; semi-synthetic sesquiterpene lactone parthenin compound useful for cytotoxicity against cancer cell lines and anticancer activity (Indian Patent Filed: 0840DEL2008)

5. G. N. Qazi; S. C. Taneja; J. Singh; A. K. Saxena; V. K. Sethi; Bhahwal Ali,Shah; A. Kumar; S. S. Andotra; F. Malik; S. Muthiah; S. K.. Agrawal; semi-synthetic sesquiterpene lactone parthenin compound useful for anti-cancer activity (Indian Patent Filed: 0839DEL2008)

6. G. N. Qazi; S. C. Taneja; J. Singh; A. K. Saxena; V. K. Sethi; Bhahwal Ali Shah; B. K. Kapahi; S. S. Andotra; A. Kumar; S. Bhushan; F. Malik , D. M. Mondhe; M. Shanmugavel; S. Singh ; M. Verma; S. K. Singh; in vitro and in vivo anti-cancer activity of semi-synthetic compound (Indian Patent Filed: 0606DEL2008).