bibliography scientist emeritus, clinical neuroscience...
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Profiles
September 3, 2015
BIBLIOGRAPHY
Irwin J. Kopin, M.D.
Scientist Emeritus, Clinical Neuroscience Section
National Institute of Neurological Disorders and Stroke
Bethesda, Maryland 20892
1959
1. Kopin, I.J.: Tryptophan loading and excretion of 5-hydroxy-indole-acetic acid in normal
and schizophrenic subjects. Science 129: 835-836, 1959.
2. Axelrod, J., Kopin, I.J. and Mann, J.D.: 3-Methoxy-4-hydroxy-phenylglycol sulfate, a
new metabolite of epinephrine and norepinephrine. Biochim Biophys Acta 36: 576-577, 1959.
3. Kopin, I.J.: Discussant of "Tryptophan metabolism in schizophrenics and in controls," by
E. A. Zeller. In Gibbs, F.A. (Ed.): Molecules and Mental Health. Philadelphia, J.B. Lippincot
Company, 1959 (pp. 65-67).
1960
4. Kopin, I.J. and Axelrod, J.: Presence of 3-methoxy-4-hydroxy-phenylglycol and
metanephrine in phaeochromocytoma tissue. Nature 185: 788, 1960.
5. Kopin, I.J.: Technique for the study of alternate metabolic pathways: Epinephrine
metabolism in man. Science 131: 1372-1374, 1960.
6. Kopin, I.J., Pare, C.M.B., Axelrod, J. and Weissbach, H.: 6-Hydroxylation, the major
metabolic pathway for melatonin. Biochim Biophys Acta 40: 377-378, 1960.
7. Kopin, I.J. and Axelrod, J.: 3,4-dihydroxyphenylglycol, a metabolite of epinephrine.
Arch Biochem Biophys 89: 148, 1960.
8. Kopin, I.J. and Rosenberg, I.N.: Idiopathic hypoparathyroidism: Report of a case with
autopsy findings. Ann Intern Med 53: 1238- 1249, 1960.
1961
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9. LaBrosse, E.H., Axelrod, J., Kopin, I.J. and Kety, S.S.: Metabolism of 7-H3-epinephrine-
D-bitartrate in normal young men. J Clin Invest 40: 253-260, 1961.
10. Hertting, G., Axelrod, J., Kopin, I.J. and Whitby, L.G.: Lack of uptake of catecholamines
after chronic denervation of sympathetic nerves. Nature 189: 66, 1961.
11. Kopin, I.J., Axelrod, J. and Gordon, E.: The metabolic fate of H3-epinephrine and C14-
metanephrine in the rat. J Biol Chem 236: 2109-2113, 1961.
12. Axelrod, J., Whitby, L.G., Hertting, G. and Kopin, I.J.: Studies on the metabolism of
catecholamines. Circ Res 9: 715-720, 1961.
13. Axelrod, J. and Kopin, I.J.: Estimation of 0-methylated metabolites of catecholamines.
In Quastel, J.H. (Ed.): Methods in Medical Research, Volume IX. Chicago: Year Book
Publishers, 1961 (pp. 153-158).
14. Kopin, I.J., Pare, C.M.B., Axelrod, J. and Weissbach, H.: The fate of melatonin in
animals. J Biol Chem 236: 3072-3075, 1961.
1962
15. Potter, L.T., Axelrod, J. and Kopin, I.J.: Differential binding and release of
norepinephrine and tachyphylaxis. Biochem Pharmacol 11: 254-256, 1962.
16. LaBrosse, E.H., Axelrod, J., Kopin, I.J. and Kety, S.S.: The metabolism of tritium-
labeled epinephrine in men. In: Tritium in the Physical and Biological Sciences, Volume II.
Vienna: International Atomic Energy Agency 1962 (pp.407-412).
17. Axelrod, J., Gordon, E., Hertting, G., Kopin, I.J. and Potter, L.T.: On the mechanism of
tachyphylaxis to tyramine in the isolated rat heart. Br J Pharmacol 19: 56-63, 1962.
18. Kopin, I.J., Hertting, G. and Gordon, E.K.: Fate of norepinephrine-H3 in the isolated
perfused rat heart. J Pharmacol Exp Ther 138: 34-40, 1962.
19. Kopin, I.J. and Gordon, E.K.: Metabolism of norepinephrine-H3 released by tyramine
and reserpine. J Pharmacol Exp Ther 138: 351-359, 1962.
1963
20. Kopin, I.J.: Estimation of relative magnitudes of alternative metabolic pathways. In
Glick, D. (Ed): Methods of Biochemical Analysis, Volume XI. New York: John Wiley and
Sons, Inc., 1963 (pp. 247-278).
21. Kopin, I.J. and Bridgers, W.: Differences in D- and L-norepinephrine-H3. Life Sci 5:
356-362, 1963.
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22. Kopin, I.J. and Gordon, E.: Metabolism of administered and drug-released
norepinephrine-7-H3 in the rat. J Pharmacol Exp Ther 140: 207-216, 1963.
23. Wurtman, R.J., Kopin, I.J. and Axelrod, J.: Thyroid function and the cardiac disposition
of catecholamines. Endocrinology 73: 63- 74, 1963.
24. Kopin, I.J. and Axelrod, J.: The role of monoamine oxidase in the release and
metabolism of norepinephrine. Ann N.Y. Acad Sci 107: 848-853, 1963.
25. Rosell, S., Kopin, I.J. and Axelrod, J.: Fate of H3-noradrenaline in skeletal muscle
before and following sympathetic stimulation. Am J Physiol 205: 317-321, 1963.
26. Kopin, I.J. and Wurtman, R.J.: Flow of uterine blood and the aestrous cycle. Nature
199: 386-387, 1963.
27. Baldessarini, R.J. and Kopin, I.J.: Assay of tissue levels of S-adenosyl-methionine. Anal
Biochem 6: 289-292, 1963.
28. Kopin, I.J. and Gordon, E.K.: Origin of norepinephrine in the heart. Nature 199: 1289,
1963.
29. Wurtman, R.J., Axelrod, J. and Kopin, I.J.: Uterine epinephrine and blood flow in
pregnant and postparturient rats. Endocrinology 73: 501-503, 1963.
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1964
30. Rosell, S., Axelrod, J. and Kopin, I.J.: Release of tritiated epinephrine following
sympathetic nerve stimulation. Nature 201: 301, 1964.
31. Kopin, I.J.: Storage and metabolism of catecholamines: The role of monoamine oxidase.
Pharmacol Rev 16: 179-191, 1964.
32. Fischer, J.E., Musacchio, J.M., Kopin, I.J. and Axelrod, J.: Effects of denervation on the
uptake and ß-hydroxylation of tyramine in the rat salivary gland. Life Sci 3: 413-419, 1964.
33. Musacchio, J.M., Kopin, I.J. and Snyder, S.: Effects of disulfiram on tissue
norepinephrine content and subcellular distribution of dopamine, tyramine and their ß-
hydroxylated metabolites. Life Sci 3: 769-775, 1964.
34. Kopin, I.J.: Metabolism of the catecholamines. Z Klin Chem 2: 115-123, 1964.
35. Fischer, J.E., Kopin, I.J. and Wurtman, R.J.: Effects of lumbar sympathectomy on the
uterine uptake of catecholamines. Nature 203: 938-939, 1964.
36. Kopin, I.J., Fischer, J.E., Musacchio, J. and Horst, W.D.: Evidence for a false
neurochemical transmitter as a mechanism for the hypotensive effect of monoamine oxidase
inhibitors. Proc Nat Acad Sci USA 52: 716-721, 1964.
37. Glowinski, J., Axelrod, J., Kopin, I.J. and Wurtman, R.J.: Physiological disposition of
H3-norepinephrine in the developing rat. J Pharmacol Exp Ther 146: 48-53, 1964.
38. Kopin, I.J.: Disposition and fate of catecholamine hormones. In Litwack, G. and
Kritchevsky, D. (Eds): Actions of Hormones on Molecular Processes. New York: John Wiley
and Sons, Inc., 1964 (pp. 257-267).
39. LaBrosse, E.H., Kopin, I.J., Felix, W.R., Jr. and Westlake, R.J.: Urinary tryptamine and
indole-3-acetic acid excretion by schizophrenic patients: Use of the tryptamine/indole acetic
acid ratio as an index of monoamine oxidase inhibition. J Psychiatr Res 2: 185-197, 1964.
40. Henkin, R.I. and Kopin, I.J.: Abnormalities of taste and smell thresholds in familial
dysautonomia: Improvement with methacholine. Life Sci 3: 1319-1325, 1964.
41. Wurtman, R.J., Kopin, I.J., Horst, W.D. and Fischer, J.E.: Epinephrine and organ blood
flow: Effect of hyperthyroidism, cocaine and denervation. Am J Physiol 207: 1247-1250, 1964.
1965
42. Fischer, J.E., Kopin, I.J. and Axelrod, J.: Evidence for extraneuronal binding of
norepinephrine. J Pharmacol Exp Ther 147: 181-185, 1965.
43. Kopin, I.J., Fischer, J.E., Musacchio, J.M., Horst, W.D. and Weise, V.K.: False
neurochemical transmitters and the mechanism of sympathetic blockade by monoamine oxidase
inhibitors. J Pharmacol Exp Ther 147: 186-193, 1965.
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44. Musacchio, J.M., Weise, V.K. and Kopin, I.J.: Mechanism of norepinephrine binding.
Nature 205: 606-607, 1965.
45. Bhagat, B., Gordon, E.K. and Kopin, I.J.: Norepinephrine synthesis and the pressor
responses to tyramine in the spinal cat. J Pharmacol Exp Ther 147: 319-323, 1965.
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46. Glowinski, J., Kopin, I.J. and Axelrod, J.: Metabolism of 7-3H-norepinephrine in the rat
brain. J Neurochem 12: 25-30, 1965.
47. Musacchio, J.M., Kopin, I.J. and Weise, V.K.: Subcellular distribution of some
sympathomimetic amines and their ß-hydroxylated derivatives in the rat heart. J Pharmacol Exp
Ther 148: 22-28, 1965.
48. Fischer, J.E., Horst, W.D. and Kopin, I.J.: ß-hydroxylated sympathomimetic amines as
false neurotransmitters. Br J Pharmacol 24: 477-484, 1965.
49. Kopin, I.J., Godon, E.K. and Horst, W.D.: Studies of uptake of 1-norepinephrine-14C.
Biochem Pharmacol 14: 753-759, 1965.
50. Musacchio, J.M., Fischer, J.E. and Kopin, I.J.: Effect of chronic sympathetic denervation
on subcellular distribution of some sympathomimetic amines. Biochem Pharmacol 14: 898-900,
1965.
51. Kopin, I.J.: Origin disposition and metabolic fate of catecholamines. In Roth, I.J. (Ed):
Isotopes in Experimental Pharmacology. Chicago: University of Chicago Press, 1965 (pp. 307-
313).
52. Fischer, J.E., Horst, W.D. and Kopin, I.J.: Norepinephrine metabolism in hypertrophied
rat hearts. Nature 207: 951-953, 1965.
53. Kopin, I.J.: Estimation of alternative metabolic pathways of catecholamines in man. In
Rothchild, S. (Ed): Advances in Tracer Methodology, Volume II. New York: Plenum Press,
1965 (pp. 237- 242).
1966
54. Poch, G.R. and Kopin, I.J.: The role of octopamine in tachyphylaxis to tyramine.
Biochem Pharmacol 15: 210-212, 1966.
55. Fischer, J.E., Weise, V.K. and Kopin, I.J.: Release of tritiated bretylium by sympathetic
nerve stimulation. Nature 209: 778-779, 1966.
56. Kopin, I.J.: Biochemical aspects of release of norepinephrine and other amines from
sympathetic nerve endings. Pharmacol Rev 18: 513-523, 1966.
57. Musacchio, J.M., Fischer, J.E. and Kopin, I.J.: Subcellular distribution and release by
sympathetic nerve stimulation of dopamine and a-methyl dopamine. J Pharmacol Exp Ther 152:
56-61, 1966.
58. Musacchio, J.M., Goldstein, M., Anagnoste, B., Poch, G. and Kopin, I.J.: Inhibition of
dopamine-ß-hydroxylase by disulfiram in vivo. J Pharmacol Exp Ther 152: 51-55, 1966.
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59. Musacchio, J.M., Bhagat, B., Jackson, C.J. and Kopin, I.J.: The effect of disulfiram on
the -methyl-dopa in the reserpine-
treated cat. J Pharmacol Exp Ther 152: 293-297, 1966.
60. Baldessarini, R.J. and Kopin, I.J.: Tritiated norepinephrine: Release from brain slices by
electrical stimulation. Science 152: 1630-1631, 1966.
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61. Kopin, I.J.: Biochemical aspects of storage and release of biogenic amines from
sympathetic nerves. In Euler, U.S. von, Rosell, S. and Uvnas, B. (Ed): Mechanism of Release
of Biogenic Amines. Oxford: Pergamon Press, 1966 (pp. 229-246).
62. Kopin, I.J.: Metabolism and disposition of catecholamines in the central and peripheral
nervous systems. In Levine, R. (Ed): Endocrines and the Central Nervous System, Res. Ner.
Men. Dis. Volume XLIII. Baltimore: The Williams and Wilkins Company 1966 (pp. 343-353).
63. Cohen, R.A., Kopin, I.J., Creveling, C.R., Musacchio, J.M., Fischer, J.E., Crout, J.R. and
Gill, J.R., Jr.: False neurochemical transmitters. Combined Clinical Staff Conference at the
National Institutes of Health. Ann Intern Med 65: 347-362, 1966.
64. Schildkraut, J.J., Scanberg, S.M. and Kopin, I.J.: The effects of lithium ion on H3-
norepinephrine metabolism in brain. Life Sci 5: 1479-1483, 1966.
65. Baldessarini, R.J. and Kopin, I.J.: S-adenosylmethionine in brain and other tissues. J
Neurochem 13: 769-777, 1966.
66. Fischer, J.E., Weise, V.K. and Kopin, I.J.: Interactions of bretylium and acetylcholine at
sympathetic nerve endings. J Pharmacol Exp Ther 153: 523-529, 1966.
67. Westlake, R.J. and Kopin, I.J.: Assessment of dopamine-ß-oxidase activity in the skin of
guinea pig in vivo. J Invest Dermatol 47: 169-179, 1966.
68. Masson, D.T., Kopin, I.J. and Braunwald, E.: Abnormalities in reflex control of the
circulation in familial dysautonomia. Effects of changes in posture on venous and arterial
constriction in normal subjects and patients with dysautonomia. Am J Med 41: 898-909, 1966.
1967
69. Sedvall, G.C. and Kopin, I.J.: Acceleration of norepinephrine synthesis in the rat
submaxillary gland in vivo during sympathetic nerve stimulation. Life Sci 6: 45-51, 1967.
70. Sedvall, G.C. and Kopin, I.J.: Influence of sympathetic denervation and nerve impulse
activity of tyrosine hydroxylase in the rat submaxillary gland. Biochem Pharmacol 16: 39-46,
1967.
71. Schanberg, S.M., Schildkraut, J.J. and Kopin, I.J.: The effects of psychoactive drugs on
norepinephrine-3H metabolism in brain. Biochem Pharmacol 16: 393-399, 1967.
72. Baldessarini, R.J. and Kopin, I.J.: The effects of drugs on the release of norepinephrine-
H3 from central nervous system tissues by electrical stimulation in vitro. J Pharmacol Exp Ther
156: 31-38, 1967.
73. Chase, T.N., Breese, G.R. and Kopin, I.J.: Serotonin release from brain slices by
electrical stimulation: Regional differences and effect of LSD. Science 157: 1461-1463, 1967.
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74. Schildkraut, J.J., Schanberg, S.M., Breese, G.R. and Kopin, I.J.: Norepinephrine
metabolism and drugs used in the affective disorders: A possible mechanism of action. Am J
Psychiatry 124: 600-608, 1967.
75. Schanberg, S.M., Schildkraut, J.J. and Kopin, I.J.: The effects of pentobarbital on the
fate of intracisternally administered norepinephrine-H3. J Pharmacol Exp Ther 157: 311-318,
1967.
76. Nyback, H., Sedvall, G. and Kopin, I.J.: Accelerated synthesis of dopamine-C14 from
tyrosine-C14 in rat brain after chlorpromazine. Life Sci 6: 2307-2312, 1967.
77. Kopin, I.J.: Acetylcholine, bretylium and release of norepinephrine from sympathetic
nerve endings. Ann NY Acad Sci 144: 588-592, 1967.
78. Kopin, I.J.: Relationship of psychotropic drug action to the metabolism and transport of
catecholamines. In Brill, H., Cole, J.O., Deniker, P., Hippius, H. and Bradley, P.B. (Eds.):
Neuropsychopharmacology. Amsterdam: Excerpta Medica Foundation, 1967 (pp. 330-334).
79. Kopin, I.J.: The adrenergic synapse. In Quarton, G.C., Melnechuk, T. and Schmitt, F.O.,
(Eds): The Neurosciences. New York: The Rockefeller University Press, 1967 (pp. 427-432).
1968
80. Sedvall, G.C., Weise, V.K. and Kopin, I.J.: The rate of norepinephrine synthesis
measured in vivo during short intervals; influence of adrenergic nerve impulse activity. J
Pharmacol Exp Ther 159: 274-282, 1968.
81. Chase, T.N. and Kopin, I.J.: Stimulus-induced release of substances from olfactory bulb
using the push-pull cannula. Nature 127: 466-467, 1968.
82. Schanberg, S.M., Schildkraut, J.J., Breese, G.R. and Kopin, I.J.: Metabolism of
normetanephrine-H3 in rat brain: Identification of conjugated 3-methoxy-4-hydroxyphenylglycol
as the major metabolite. Biochem Pharmacol 17: 247-254, 1968.
83. Fischer, J.E., Weise, V.K. and Kopin, I.J.: False adrenergic transmitter release from the
isolated cat heart. Am J Med Sci 255: 158-162, 1968.
84. Kopin, I.J.: False adrenergic transmitters. Annu Rev Pharmacol 8: 377-394, 1968.
85. Kopin, I.J., Breese, G.R., Krauss, K.R. and Weise, V.K.: Selective release of newly
synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation. J
Pharmacol Exp Ther 161: 271-278, 1968.
86. Schildkraut, J.J., Kopin, I.J., Schanberg, S.M. and Durell, J.: Norepinephrine metabolism
and psychoactive drugs in the endogenous depressions. Pharmakopsychiatr
Neuropsychopharmakol 1: 69-92, 1968.
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87. Chase, T.N., Breese, G.R., Carpenter, D.O., Schanberg, S.M. and Kopin, I.J.:
Stimulation-induced release of serotonin. Adv Pharmacol 6: 351-364, 1968.
88. Kopin, I.J.: Monoamine oxidase inhibitors and false neurochemical transmitters. In
Cheymol, J. and Boissier, J.R. (Eds.): Monoamine Oxidase Inhibitors: Relationship between
Pharmacological and Clinical Effects. Oxford: Pergamon Press, 1968 (pp. 83-89).
89. Kopin, I.J.: Biosynthesis and metabolism of catecholamines. Anesthesiology 29: 654-
660, 1968.
90. Kopin, I.J. and Weise, V.K.: Effect of reserpine and metaraminol on excretion of
homovanillic acid and 3-methoxy-4-hydroxyphenolglycol in the rat. Biochem Pharmacol 17:
1461-1464, 1968.
91. Schanberg, S.M., Breese, G.R., Schildkraut, J.J., Gordon, E.K. and Kopin, I.J.: 3-
methoxy-4-hydroxyphenylglycol sulfate in brain and cerebrospinal fluid. Biochem Pharmacol
17: 2006-2008, 1968.
92. Schanberg, S.M., Schildkraut, J.J., Krivanek, J. and Kopin, I.J.: Effect of cortical
spreading depression on norepinephrine-H3 metabolism in brain stem. Experientia 24: 909,
1968.
93. Horst, W.K., Kopin, I.J. and Ramey, E.R.: Influence of sodium and calcium on
norepinephrine uptake by isolated perfused rat hearts. Am J Physiol 215: 817-822, 1968.
94. Katz, R.I., Chase, T.N. and Kopin, I.J.: Evoked release of norepinephrine and serotonin
from brain slices: Inhibition by lithium. Science 162: 466-467, 1968.
95. Kopin, I.J.: Identification of "True" and "False" transmitters. In Efron, D.H. (Ed):
Psychopharmacology, A Review of Progress 1957-1967. U.S. Department of Health, Education
and Welfare, Public Health Service Publication No. 1836. Washington: U.S. Government
Printing Office, 1968 (pp. 57-60).
96. Kopin, I.J.: The influence of false adrenergic transmitters on adrenergic
neurotransmission. In Wolstenholme, G.E.W. and O’Connor, M. (Ed) Adrenergic
Neurotransmission. Boston: Little, Brown and Company, 1968 (pp. 95-104).
1969
97. Kopin, I.J.: How does lithium work: (Editorial). New Engl J Med 280: 560-561, 1969.
98. Goodwin, J.S., Katz, R.I. and Kopin I.J.: Effect of bromide on evoked release of
monoamines from brain slices and intact atria. Nature 221: 556-557, 1969.
99. Breese, G.R., Chase, T.N. and Kopin, I.J.: Metabolism of some phenylethylamines and
their ß-hydroxylated analogs in brain. J Pharmacol Exp Ther 165: 9-13, 1969.
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100. Chase, T.N., Katz, R.I. and Kopin, I.J.: Release of 3H serotonin from brain slices. J
Neurochem 16: 607-615, 1969.
101. Kopin, I.J.: Biogenic amines and drugs action. In Black, P. (Ed): Drugs and the Brain.
Baltimore: The Johns Hopkins Press, 1969 (pp. 3-15).
102. Axelrod, J. and Kopin, I.J.: The uptake, storage, release and metabolism of noradrenaline
in sympathetic nerves. In Akert, K. and Waser, P.G. (Ed): Progress in Brain Research, Volume
XXXI. Amsterdam: Elsevier Publishing Company, 1969 (pp. 21-32).
103. Breese, G.R., Chase, T.N. and Kopin, I.J.: Metabolism of tyramine-3H and octopamine-
3H by rat brain. Biochem Pharmacol 18: 863-869, 1969.
104. Katz, R.I., Goodwin, J.S. and Kopin, I.J.: Disposition of neurotransmitters in
experimental mouse glioma. Life Sci 8: 561-569, 1969.
105. Katz, R.I. and Kopin, I.J.: Release of norepinephrine-3H and serotonin-3H evoked from
brain slices by electrical-field stimulation - calcium dependency and the effects of lithium,
ouabain and tetrodotoxin. Biochem Pharmacol 18: 1935-1939, 1969.
106. Katz, R.I. and Kopin, I.J.: Electrical field-stimulated release of norepinephrine-H3 from
rat atrium: Effects of ions and drugs. J Pharmacol Exp Ther 169: 229-236, 1969.
107. Katz, R.I., Chase, T.N. and Kopin, I.J.: Effect of ions on stimulus-induced release of
amino acids from mammalian brain slices. J Neurochem 16: 961-967, 1969.
108. Katz, R.I. and Kopin, I.J.: Effect of D-LDS and related compounds on release of
norepinephrine-H3 and serotonin-H3 evoked from brain slices by electrical stimulation.
Pharmacol Res Commun 1: 54-62, 1969.
109. Schildkraut, J.J., Schanberg, S.M., Kopin, I.J. and Durell, J.: Affective disorders and
norepinephrine pharmacology. Int Psychiatr Clin 6: 83-141, 1969.
110. Schildkraut, J.J., Schanberg, S.M., Breese, G.R. and Kopin, I.J.: Effects of psychoactive
drugs on the metabolism of intracisternally administered serotonin in rat brain. Biochem
Pharmacol 18: 1971- 1978, 1969.
111. Kopin, I.J., Weise, V. and Sedvall, G.C. Effect of false transmitters on norepinephrine
synthesis. J Pharmacol Exp Ther 170: 246-252, 1969.
112. Chase, T.N., Katz, R.I. and Kopin, I.J.: Effect of anticonvulsants on brain serotonin.
Trans Am Neurol Assoc 94: 236-238, 1969.
1970
113. Chase, T.N., Katz, R.I. and Kopin, I.J.: Effect of diazepam on fate of intracisternally
injected serotonin-C14. Neuropharmacology 9: 103-108, 1970.
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114. Krauss, K.R., Kopin, I.J. and Weise, V.K.: The effect of bretylium on amine retention in
rat heart. J Pharmacol Exp Ther 172: 282- 288, 1970.
115. Krauss, K.R., Carpenter, D.O. and Kopin, I.J.: Acetylcholine-induced release of
norepinephrine in the presence of tetrodotoxin. J Pharmacol Exp Ther 173: 416-421, 1970.
116. Breese, G.R., Chase, T.N. and Kopin, I.J.: Effect of monoamine oxidase inhibitors on the
disposition of intracisternally administered metaraminol-3H. Biochem Pharmacol 19: 525-532,
1970.
117. Breese, G.R., Kopin, I.J. and Weise, V.K.: Effects of amphetamine derivatives on brain
dopamine and noradrenaline. Br J Pharmacol 38: 537-545, 1970.
118. Gewirtz, G.P. and Kopin, I.J.: Release of dopamine-ß-hydroxylase with norepinephrine
during cat splenic nerve stimulation. Nature 227: 406-407, 1970.
119. Kvetnansky, R., Weise, V.K. and Kopin, I.J.: Elevation of adrenal tyrosine hydroxylase
and phenylethanolamine-N-methyl transferase by repeated immobilization of rats.
Endocrinology 87: 744-749, 1970.
120. Lemberger, L., Witt, E.D., Davis, J.M. and Kopin, I.J.: The effects of haloperidol and
chlorpromazine on amphetamine metabolism and amphetamine stereotype behavior in the rat. J
Pharmacol Exp Ther 174: 428-433, 1970.
121. Louis, W.J., Krauss, K.R., Kopin, I.J. and Sjoerdsma, A.: Catecholamine metabolism in
hypertensive rats. Circ Res 27: 589- 594, 1970.
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122. Ng, K.Y., Chase, T.N., Colburn, R.W. and Kopin, I.J.: L-dopa-induced release of
cerebral monoamines. Science 170: 76-77, 1970.
123. Ng, K.Y., Chase, T.N. and Kopin, I.J.: Drug-induced release of 3H- norepinephrine and
3H-serotonin from brain slices. Nature 228: 468-469, 1970.
124. Parks, L.C., Watanabe, A.M. and Kopin, I.J.: Prevention or reversal of levodopa-induced
cardiac arrhythmias by decarboxylase inhibitors. Lancet II: 1014-1015, 1970.
125. Gewirtz, G.P. and Kopin, I.J.: Effect of intermittent nerve stimulation on norepinephrine
synthesis and mobilization in the perfused cat spleen. J Pharmacol Exp Ther 175: 514-520,
1970.
126. Lemberger, L., Silberstein, S.D., Axelrod, J. and Kopin, I.J.: Marihuana: Studies on the
disposition and metabolism of delta-9-tetra-hydrocannabinol in man. Science 170: 1320-1322,
1970.
127. Kvetnansky, R., Gewirtz, G.P., Weise, V.K. and Kopin, I.J.: Effect of hypo-physectomy
on immobilization-induced elevation of tyrosine hydroxylase and phenylethanolamine-N-methyl
transferase in the rat adrenal. Endocrinology 87: 1323-1329, 1970.
128. Kopin, I.J. and Baldessarini, R.J.: Assay of tissue levels of S- adrenosylmethionine. In
Tabor, C.W. and Tabor, H. (Ed): Amino Acids and Amines. New York: Academic Press, Inc.,
1970 (pp. 397- 400).
129. Kopin, I.J.: Catecholamines in blood pressure regulation. In Barbeau, A. and
McDowell, F.H. (Ed): L-Dopa and Parkinsonism. Philadelphia: F.A. Davis Company, 1970
(pp. 277-280).
1971
130. Kvetnansky, R., Gewirtz, G.P., Weise, V.K. and Kopin, I.J.: Enhanced synthesis of
adrenal dopamine-ß-hydroxylase induced by repeated immobilization in rats. Mol Pharmacol 7:
81-86, 1971.131. Paul, M.I., Kvetnansky, R., Cramer, H., Silbergeld, S. and Kopin, I.J.:
Immobilization stress-induced changes in adrenocortical and medullary cyclic-AMP content in
the rat. Endocrinology 88: 338- 344, 1971.
132. Wender, P.H., Epstein, R.S., Kopin, I.J. and Gordon, E.K.: Urinary monoamine
metabolites in children with minimal brain dysfunction. Am J Psychiatry 127: 1411-1415, 1971.
133. Chase, T.N., Breese, G.R., Gordon, E.K. and Kopin, I.J.: Catecholamine metabolism in
the dog: Comparison of intravenously and intraventricularly administered 14C-dopamine and
3H-norepinephrine. J Neurochem 18: 135-140, 1971.
134. Silbergeld, S., Kvetnansky, R., Sigalso, G.L., Weise, V.K. and Kopin, I.J.: Levels of
adrenal catecholamine-synthesizing enzymes after postmortem treatment in rats and after
necropsy in human beings. J Lab Clin Med 77: 290-297, 1971.
14
135. Gewirtz, G.P., Kvetnansky, R., Weise, V.K. and Kopin, I.J.: Effect of hypophysectomy
on adrenal dopamine-ß-hydroxylase activity in the rat. Mol Pharmacol 7: 163-168, 1971.
136. Kvetnansky, R., Gewirtz, G.P., Weise, V.K. and Kopin, I.J.: Catechol-amine-synthesizing
enzymes in the rat adrenal gland during exposure to cold. Am J Phychiatry 220: 928-931, 1971.
137. Kopin, I.J.: Unnatural amino acids as precursors of false transmitters. Fed Proc 30: 904-
907, 1971.
15
138. Johnson, D.G., Thoa, N.B. and Kopin, I.J.: Inhibition of norepinephrine biosynthesis by
chlorpromazine in the guinea pig vas deferens. J Pharmacol Exp Ther 177: 146-154, 1971.
139. Lemberger, L., Axelrod, J. and Kopin, I.J.: The disposition and metabolism of
tryptamine and the in vivo formation of 6-hydroxy-tryptamine in the rabbit. J Pharmacol Exp
Ther 177: 169-176, 1971.
140. Silberstein, S.D., Johnson, D.G., Jacobowitz, D.M. and Kopin, I.J.: Sympathetic
reinnervation of the rat iris in organ culture. Proc Natl Acad Sci USA 68: 1121-1124, 1971.
141. Kvetnansky, R., Silbergeld, S., Weise, V.K. and Kopin, I.J.: Effects of restraint on rat
adrenomedullary response to 2-deoxyglucose. Psycho-pharmacologia 20: 22-31, 1971.
142. Ng, K.Y., Colburn, R.W. and Kopin, I.J.: Effects of L-dopa on efflux of cerebral
monoamines from synaptosomes. Nature 230: 331- 332, 1971.
143. Thoa, N.B., Johnson, D.G., Kopin, I.J. and Weiner, N.: Acceleration of catecholamine
formation in the guinea pig vas deferens after hypogastric nerve stimulation: Roles of tyrosine
hydroxylase and new protein synthesis. J Pharmacol Exp Ther 178: 442-449, 1971.
144. Silbergeld, S., Kvetnansky, R., Weise, V.K. and Kopin, I.J.: Effect of repeated
administration of 2-deoxy-D-glucose or insulin on catecholamine-synthesizing enzymes in rat
adrenals. Biochem Pharmacol 20: 1763-1769, 1971.
145. Weinshilboum, R.M., Kvetnansky, R., Axelrod, J. and Kopin, I.J.: Elevation of serum
dopamine-ß-hydroxylase activity with forced immobilization. Nat New Biol 230: 287-288,
1971.
146. Carpenter, D., Breese, G., Schanberg, S., and Kopin, I.J.: Serotonin and dopamine:
Distribution and accumulation in aplysia nervous and non-nervous tissue. Int J Neurosci 2: 49-
56, 1971.
147. Kopin, I.J.: Discussion of panel on amine metabolism. In Williams, T.A., Katz, M.M.
and Shield, J.A., Jr. (Ed): Recent Advances in the Psychobiology of the Depressive Illnesses.
Washington: U.S. Government Printing Office, 1971 (pp. 43-47).
148. Thoa, N.B., Johnson, D.G. and Kopin, I.J.: Selective release of newly synthesized
norepinephrine in the guinea pig vas deferens during hypogastric nerve stimulation. Eur J
Pharmacol 15: 29-35, 1971.
149. Gewirtz, G.P., Kvetnansky, R., Weise, V.K. and Kopin, I.J.: Effect of ACTH and
dibutyryl cyclic AMP on catecholamine synthesizing enzymes in the adrenals of
hypophysectomized rats. Nature 230: 462-463, 1971.
150. Ng, K.Y., Chase, T.N., Colburn, R.W. and Kopin, I.J.: Dopamine: Stimulation-induced
release from central neurons. Science 172: 487-489, 1971.
151. Watanabe, A.M., Parks, L.C. and Kopin, I.J.: Modification of the cardiovascular effects
of L-dopa by decarboxylase inhibitors. J Clin Invest 50: 1322-1328, 1971.
16
152. Lemberger, L., Tamarkin, N.R., Axelrod, J. and Kopin, I.J.: Delta-9-
tetrahydrocannabinol: Metabolism and disposition in long-term mari-huana smokers. Science
173: 72-74, 1971.
153. Kvetnansky, R., Weise, V.K., Gewirtz, G.P. and Kopin, I.J.: Synthesis of adrenal
catecholamines in rats during and after immobilization stress. Endocrinology 89: 46-49, 1971.
154. Kvetnansky, R., Gewirtz, G.P., Weise, V.K. and Kopin, I.J.: Effect of dibutyryl cyclic-
AMP on adrenal catecholamine-synthesizing enzymes in repeatedly immobilized
hypophysectomized rats. Endo-crinology 89: 50-55, 1971.
155. Dubois, A., Watanabe, A. and Kopin, I.J.: Postoperative gastric ileus. Experimental
study and treatment. Rendic R. Gastroenterology 3: 116-117, 1971.
156. Kopin, I.J.: Accumulation of drugs at sympathetic nerve endings. In Brodie, B.B. and
Gillette, R.J. (Ed): Handbook of Experimental Pharmacology, Volume XXVIII/I (Concepts in
Biochemical Pharmacology). New York: Springer/Verlag, 1971 (pp. 317-327).
157. Johnson, D.G., Thoa, N.B., Weinshilboum, R., Axelrod, J. and Kopin, I.J.: Enhanced
release of dopamine-ß-hydroxylase from sympathetic nerves by calcium and phenoxybenzamine
and its reversal by prostaglandins. Proc Natl Acad Sci USA 68: 2227-2230, 1971.
158. Davis, J.M., Kopin, I.J., Lemberger, L. and Axelrod, J.: Effects of urinary pH on
amphetamine metabolism. Ann N.Y. Acad Sci 179: 493-501, 1971.
159. Johnson, D.G., Gorden, P. and Kopin, I.J.: A sensitive radioimmuno-assay for 7S nerve
growth factor antigens in serum and tissues. J Neurochem 18: 2355-2362, 1971.
160. Kopin, I.J.: The chemical nature, biosynthesis and metabolism of the catecholamines. In
Sunderman, F.W. and Sunderman, F.W., Jr. (Ed): Laboratory Diagnosis of Endocrine Disease.
St. Louis: Warren H. Green, Inc. 1971 (pp. 423-427).
161. Lemberger, L., Axelrod, J. and Kopin, I.J.: Metabolism and disposi-tion of D-9-
tetrahydrocannabinol in man. Pharmacol Rev 23: 371-380, 1971.
162. Kopin, I.J.: Effects of drugs on catecholamine synthesis. In Ho, B.T. and McIsaac,
W.M. (Ed): Advances in Behavioral Biology, Volume I (Brain Chemistry and Mental Disease).
New York: Plenum Press, 1971 (pp. 73-82).
163. Kopin, I.J.: False neurotransmitters in the mechanism of action of central nervous system
and cardiovascular drugs. In Biel, J.H. and Abood, L.G. (Ed): Medicinal Research Series,
Volume 5/B (Biogenic Amines and Physiological Membranes in Drug Therapy). New York:
Marcel Dekker, Inc., 1971 (pp. 329-353).
164. Weinshilboum, R.M., Thoa, N.B., Johnson, D.G., Kopin, I.J. and Axelrod, J.:
Proportional release of norepinephrine and dopamine-ß-hydroxylase from sympathetic nerves.
Science 174: 1349-1351, 1971.
17
165. Lemberger, L., Axelrod, J. and Kopin, I.J.: Metabolism and dispo-sition of
tetrahydrocannabinols in naive subjects and chronic marihuana users. Ann N.Y. Acad Sci 191:
142-154, 1971.
1972
166. Thoa, N.B., Johnson, D.G. and Kopin, I.J.: Inhibition of norepinephrine bio-synthesis by
a-methyl amino acids in the guinea pig vas diferens. J Pharmacol Exp Ther 180: 71-77, 1972.
167. Kopin, I.J.: Introduction. In Rall, J.E. and Kopin, I.J. (Ed): Methods in Investigative and
Diagnostic Endocrinology, Volume II (Thyroid and Biogenic Amines). Amsterdam: North-
Holland Publishing Company, 1972 (pp. 309-317).
18
168. Kopin, I.J.: Separation and estimation of radioactively labelled catecholamines and their
metabolites. In Rall, J.E. and Kopin, I.J. (Ed): Methods in Investigative and Diagnostic Endo-
crinology, Volume II (Thyroid and Biogenic Amines). Amsterdam: North-Holland Publishing
Company 1972 (pp. 489-496).
169. Thoa, N.B., Wooten, G.F., Axelrod, J. and Kopin, I.J.: Inhibition of release of dopamine-
ß-hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or
cytochalasin-B. Proc Natl Acad Sci USA 69: 520-522, 1972.
170. Kopin, I.J. and Silberstein, S.D.: Axons of sympathetic neurons: Transport of enzymes in
vivo and properties of axonal sprouts in vitro. Pharmacol Rev 24: 245-254, 1972.
171. Colburn, R.W. and Kopin, I.J.: Effects of reserpine and tyramine on release of
norepinephrine from synaptosomes. Biochem Pharmacol 21: 733-736, 1972.
172. Kopin, I.J.: False transmitters. In Snyder, S.H. (Ed): Perspectives in Neuropharmacology.
Cambridge: Oxford University Press, Inc., 1972 (pp. 339-348).
173. Kopin, I.J.: Metabolic degradation of catecholamines. The relative importance of
different pathways under physiological conditions and after administration of drugs. In
Blaschko, H. and Muscholl, E. (Eds): Handbook of Experimental Pharmacology, Volume
XXXIII (Catecholamines). New York: Springer/Verlag, 1972 (pp. 270-282).
174. Silberstein, S.D., Johnson, D.G., Hanbauer, I., Bloom, F.E. and Kopin, I.J.: Axonal
sprouts and 3H norepinephrine uptake by superior cervical ganglia in organ culture. Proc Natl
Acad Sci USA 69: 1450-1454, 1972.
175. Ng, L.K.Y., Chase, T.N., Colburn, R.W. and Kopin, I.J.: L-dopa in parkinsonism.
Neurology 22: 688-696, 1972.
176. Johnson, D.G., Silberstein, S.D., Hanbauer, I. and Kopin, I.J.: The role of nerve growth
factor in the ramification of sympathetic nerve fibres into the rat iris in organ culture. J
Neurochem 19: 2025-2029, 1972.
177. Lamprecht, F., Eichelman, B., Thoa, N.B., Williams, R.B. and Kopin, I.J.: Rat fighting
behavior: Serum dopamine-ß-hydroxylase and hypothalamic tyrosine hydroxylase. Science 177:
1214-1215, 1972.
178. Thoa, N.B., Weise, V.K. and Kopin, I.J.: Effect of L-dihydroxy- phenylalamine on
methylation of 3H-norepinephrine and 3H-histamine. Biochem Pharmacol 21: 2345-2350,
1972.
179. Ng, L.K.Y., Chase, T.N., Colburn, R.W. and Kopin, I.J.: Release of [3H]-dopamine by L-
5-hydroxytryptophan. Brain Res 45: 499-505, 1972.
180. Kopin, I.J.: Aminergic neurons and substitute transmitters in brain. In Kopin, I.J. (Ed):
Research Publications: Association for Research in Nervous and Mental Disease, Volume 50
(Neurotransmitters). Baltimore: Williams and Wilkins Company, 1972 (pp. 207-215).
19
181. Kopin, I.J., Silberstein, S.D., Johnson, D.G., Hanbauer, I. and Jacobowitz, D.M.:
Sympathetic reinnervation of the rat iris in vitro. In Costa, E., Iversen, L.L. and Paoletti, R.
(Eds): Advances in Biochemical Psychopharmacology, Volume 6 (Studies of Neurotransmitters
at the Synaptic Level). New York: Raven Press, 1972 (pp. 89-92).
182. Silberstein, S.D., Lemberger, L., Klein, D.C., Axelrod, J. and Kopin, I.J.: Induction of
adrenal tyrosine hydroxylase in organ culture. Neuro-pharmacology 11: 721-726, 1972.
20
183. Ng, L.K.Y., Colburn, R.W. and Kopin, I.J.: Effects of L-dopa on accumulation and
efflux of monoamines in particles of rat brain homogenates. J Pharmacol Exp Ther 168: 316-
325, 1972.
184. Hanbauer, I., Johnson, D.G., Silberstein, S.D. and Kopin, I.J.: Pharmacological and
kinetic properties of uptake of [3H]-norepine-phrine by superior cervical ganglia of rats in organ
culture. Neuropharmacology 11: 857-862, 1972.
185. Murphy, D.L. and Kopin, I.J.: The transport of biogenic amines. In Hokin, L.E. (Ed):
Metabolic Pathways, Volume VI (Metabolic Transport). New York: Academic Press, Inc., 1972
(pp 503-542).
186. Vogel, S.A., Silberstein, S.D., Berv, K.R. and Kopin, I.J.: Stimu-lation-induced release
of norepinephrine from rat superior cervical ganglia in vitro. Eur J Pharmacol 20: 308-311,
1972.
1973
187. Dubois, A., Watanabe, A.M. and Kopin, I.J.: Postoperative gastric ileus. Am J Dig Dis
18: 39-42, 1973.
188. Lamprecht, F., Kvetnansky, R., Ng, L.K.Y., Williams, R.B. and Kopin, I.J.: Effect of -9-
tetrahydrocannabinol on immobilization-induced changes in rat adrenal medullary enzymes. Eur
J Pharmacol 21: 249-251, 1973.
189. Williams, R. B., Ng, L.K.Y., Lamprecht, F., Roth, K. and Kopin, I.J.: -9-
tetrahydrocannabinol: A hypotensive effect in rats. Psychopharmacologia 28: 269-274, 1973.
190. Kvetnansky, R. and Kopin, I.J.: Activity of adrenal catecholamine- producing enzymes
and their regulation after stress. In Kovach, A.G.B. (Ed): Advances in Experimental Medicine
and Biology Volume 33 (Neurohumoral and Metabolic Aspects of Injury). New York: Plenum
Publishing Corporation, 1973 (pp. 517-533).
191. Lamprecht, F., Williams, R.B. and Kopin, I.J.: Serum dopamine-beta-hydroxylase during
development of immobilization-induced hypertension. Endocrinology 92: 953-956, 1973.
192. Maengwyn-Davies, G.D., Johnson, D.G., Thoa, N.B., Weise, V.K. and Kopin, I.J.:
Influence of isolation and fighting on adrenal tyrosine hydroxylase and phenylethanolamine-N-
methyltransferase activities in three strains of mice. Psychopharmacologia 28: 339- 350, 1973.
193. Kopin, I.J.: Modification by inhibition of decarboxylase of the cardio-vascular effects of
L-dopa in animals. In Yahr, M.P. (Ed): Advances in Neurology, Volume 2 (Treatment of
Parkinsonism the Role of Dopa Decarboxylase Inhibitors). New York: Raven Press, 1973 (pp.
137-148).
194. Weir, R.L., Chase, T.N., Ng, L.K.Y. and Kopin, I.J.: 5-hydroxy-indoleacetic acid in
spinal fluid: Relative contribution from brain and spinal cord. Brain Res 52: 409-412, 1973.
21
195. Moss, J., Kazic, T., Henry, D.P. and Kopin, I.J.: Scorpion venom-induced discharge of
catecholamines accompanied by hypertension. Brain Res 54: 381-385, 1973.
196. Johnson, D.G., Weise, V.K., Hanbauer, I., Silberstein, S.D. and Kopin, I.J.: Dopamine-ß-
hydroxylase activity during sympathetic reinnervation of rat iris in organ culture. Neurobiology
3: 88- 90, 1973.
197. Wooten, G.F., Thoa, N.B., Kopin, I.J. and Axelrod, J.: Enhanced release of dopamine-ß-
hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3’,5’-
monophosphate and theophylline. Mol Pharmacol 9: 178-183, 1973.
198. Cramer, H., Johnson, D.G., Hanbauer, I., Silberstein, S.D. and Kopin, I.J.: Accumulation
of adenosine 3’,5’-monophosphate induced by catechol-amines in the rat superior cervical
ganglion in vitro. Brain Res 53: 97-104, 1973.
199. Kopin, I.J.: Control of synthesis, transport and release of dopamine-beta-hydroxylase
and tyrosine hydroxylase. In Mandell, A.J. (Ed): New Concepts on Neurotransmitter
Regulation. New York: Plenum Publishing Cor-poration, 1973 (pp. 21-31).
200. Hanbauer, I., Kopin, I.J., Maengwyn-Davies, G.D., Thoa, N.B. and Weise, V.K.: Effects
of vinblastine on catecholamine-biosynthetic enzymes in heart, sympathetic ganglion and adrenal
glands of rats. Br. J Pharmacol 48: 106-112, 1973.
201. Ng, L.K.Y., Lamprecht, F., Williams, R.B. and Kopin, I.J: D9-tetrahydro-cannabinol and
ethanol: Differential effects on sympathetic activity in differing environmental setting. Science
180: 1368-1369, 1973.
202. Hanbauer, I. and Kopin, I.J.: Mechanism involved in the trans-synaptic increase of
tyrosine hydroxylase and dopamine-ß-hydroxy-lase activity in sympathetic ganglia. Naunyn-
Schmiedeberg’s Arch Pharmacol 280: 39-48, 1973.
203. Dubois, A., Weise, V.K. and Kopin, I.J.: Postoperative ileus in the rat: Physiopathology,
etiology and treatment. Ann Surg 178: No. 6, 1973.
204. Thomas, J.A., Van Orden, L.S., III, Redick, J.A. and Kopin, I.J.: Immunological
localization of dopaminie-ß-hydroxylase on the chromaffin granule membrane. Frontiers in
Catecholamines Research. New York and Oxford: Pergamon Press, 1973 (pp. 79-81), also in J.
Psychiatr Res 11: 317-319, 1974.
205. Kopin, I.J., Berv, K.R. and Webb, J.G.: Sympathetic ganglia in culture. Frontiers in
Catecholamine Research. New York and Oxford: Pergamon Press, 1973 (pp. 239-244).
1974
206. Dubois, A., Kopin, I.J., Pettigrew, K.D. and Jacobowitz, D.M.: Chemical and
histochemical studies of postoperative sympathetic activity in the digestive tract in rats.
Gastroenterology 66: 403-407, 1974.
22
207. Moss, J., Colburn, R.W. and Kopin, I.J.: Scorpion toxin-induced catechol-amine release
from synaptosomes. J Neurochem 22: 217-221, 1974.
208. Hanbauer, I., Jacobowitz, D.M. and Kopin, I.J.: Effects of vinblastine on noradrenergic
axons. Br J Pharmacol 50: 219-225, 1974.
209. Thoa, N.B., Costa, J.L., Moss, J. and Kopin, I.J.: Mechanism of release of
norepinephrine from peripheral adrenergic neurones by the calcium ionophores X 537A and A
23187. Life Sci 14: 1705- 1719, 1974.
210. Colburn, R.W., Ng, L.K.Y., Lemberger, L. and Kopin, I.J.: Subcellular distribution of
D9-tetrahydrocannabinol in rat brain. Biochem Pharmacol 23: 873-877, 1974.
211. Kobayashi, R.M. and Kopin, I.J.: The effects of stress and environ-mental lighting on
histamine in the rat brain. Brain Res 74: 356-359, 1974.
212. Hanbauer, I., Kopin, I.J. and Jacobowitz, D.M.: Effects of vinblastine on peripheral
autonomic nerves: Degeneration and formation of new nerve fibers. In Fuxe, K., Olson, L. and
Zotterman, Y. (Eds): Dynamics of Degeneration and Growth in Neurons. Oxford and New
York: Pergamon Press, 1974 (pp. 485-497).
213. Moss, J., Thoa, N.B. and Kopin, I.J.: On the mechanism of scorpion toxin-induced
release of norepinephrine from peripheral adrenergic neurons. J Pharmacol Exp Ther 190: 39-
48, 1974.
214. Kobayashi, R.M., Palkovits, M., Kopin, I.J. and Jacobowitz, D.M.: Bio-chemical
mapping of noradrenergic nerves arising from the rat locus coeruleus. Brain Res 77: 269-279,
1974.
215. Kizer, J.S., Palkovits, M., Zivin, J., Brownstein, M., Saavedra, J.M. and Kopin, I.J.: The
effect of endocrinological manipulations on tyrosine hydroxylase and dopamine-ß-hydroxylase
activities in individual hypothalmic nuclei of the adult male rat. Endocrinology 95: 799-812,
1974.
216. Gordon, E.K., Oliver, J., Black, K. and Kopin, I.J.: Simultaneous assay by mass
fragmentography of vanillyl mandelic acid homovanillic acid and 3-methoxy-4-hydroxy-
phenethylene glycol in cerebrospinal fluid and urine. Biochem Med 11: 32-40, 1974.
217. Kopin, I.J., Palkovits, M., Kobayashi, R.M. and Jacobowitz,D.M.: Quantitative
relationship of catecholamine content and histofluorescence in brain of rats. Brain Res 80: 229-
235, 1974.
218. Redick, J.A., Thomas, J.A., Van Orden, L.S., III, Van Orden, D.E. and Kopin, I.J.:
Immunocytochemical localization of dopamine-ß-hydroxylase in adrenal chromaffin granules.
Neuropharmacology 13: 1005-1014, 1974.
219. Roizen, M.F., Moss, J., Henry, D.P. and Kopin, I.J.: Effects of halothane on plasma
catecholamines. Anesthesiology 41: 432-439, 1974.
23
220. Reid, J.L. and Kopin, I.J.: Significance of plasma dopamine-ß-hydroxylase activity as an
index of sympathetic neuronal function. Proc Natl Acad Sci USA 71: 4392-4394, 1974.
221. Hawks, R.L., Kopin, I.J., Colburn, R.W. and Thoa, N.B.: Norcocaine: A
pharmacologically active metabolite of cocaine found in brain. Life Sci 15: 2189-2195, 1974.
222. Kopin, I.J.: Regulation of catecholamine-synthesizing enzymes. J Psychiatr Res 11:
335-338, 1974.
223. Lamprecht, F., Ebert, M.H., Turek, I. and Kopin, I.J.: Serum dopamine-beta-hydroxylase
in depressed patients and the effect of electroconvulsive shock treatment. Psychopharmacologia
40: 241- 248, 1974.
224. Lamprecht, F., Eichelman, B.S., Williams, R.B., Wooten, G.F. and Kopin, I.J.: Serum
dopamine-beta-hydroxylase (DBH) activity and blood pressure response of rat strains to shock-
induced fighting. Psychosom Med 36: 298-303, 1974.
225. Kopin, I.J.: Drugs that act at sympathetic nerve endings. Intra-Science Chem Rept 8: 13-
22, 1974.
226. Kopin, I.J.: Neurotransmitters: Basic concepts, development and role in neurological
disorders. In: Biologic and Clinical Aspects of Brain Devel-opment, Volume 6. Mead Johnson
Symposium on Perinatal Developmental Medicine, 1974.
226a. Thomas, J.A., Van Orden, L.S., III, Redick, J.A. and Kopin, I.J.: Immunological
localisation of dopamine---hydroxylase on the--chromaffin granule membrane. J Psychiatr Res
11: 317-319, 1974.
1975
227. Reid, J.L., Zivin, J.A., Foppen, F.H. and Kopin, I.J.: Catecholamine neuro-transmitters
and synthetic enzymes in the spinal cord of the rat. Life Sci 16: 975-984, 1975.
228. Thoa, N.B., Wooten, G.F., Axelrod, J. and Kopin, I.J.: On the mechanism of release of
norepinephrine from sympathetic nerves induced by depolarizing agents and sympathomimetic
drugs. Mol Pharmacol 11: 10-18, 1975.
229. Kobayashi, R.M., Palkovits, M., Jacobowitz, D.M. and Kopin, I.J.: Biochemical mapping
of the noradrenergic projection from the locus coeruleus. Neurology 25: 223-233, 1975.
230. Roizen, M.F., Weise, V., Moss, J. and Kopin, I.J.: Plasma catechol-amines: Arterial
venous differences and the influence of body temperature. Life Sci 16: 1133-1144, 1975.
231. Dubois, A., Henry, D.P. and Kopin, I.J.: Plasma catecholamines and postoperative
gastric emptying and small intestinal propulsion in the rat. Gastroenterology 68: 466-469, 1975.
232. Kizer, J.S., Zivin, J.A., Jacobowitz, D.M. and Kopin, I.J.: The nyctohemeral rhythm of
plasma prolactin: Effects of ganglionectomy, pinealectomy, constant light, constant darkness or
6-OH-dopamine administration. Endocrinology 96: 1230-1240, 1975.
24
233. Roizen, M.F., Thoa, N.B., Moss, J. and Kopin, I.J.: Inhibition by halothane of release of
norepinephrine, but not of dopamine---hydroxylase from guinea-pig vas deferens. Eur J
Pharmacol 31: 313-318, 1975.
234. Hanbauer, I., Kopin, I.J., Guidotti, A. and Costa, E.: Induction of tyrosine hydroxylase
elicited by beta adrenergic receptor agonists in normal and decentralized sympathetic ganglia:
Role of cyclic 3’5-adenosine monophosphate. J Pharmacol Exp Ther 193: 95-104, 1975.
235. Gordon, E.K., Oliver, J. and Kopin, I.J.: The effect of probenecid on catecholamine
metabolites in human cerebrospinal fluid analyzed by mass fragmentography. Life Sci 16:
1527-1532, 1975.
236. Webb, J.G., Moss, J., Kopin, I.J. and Jacobowitz, D.M.: Biochemical and
histofluorescence studies of catecholamines in superior cervical ganglia in organ culture. J
Pharmacol Exp Ther 193, 489-505, 1975.
237. Reid, J.L. and Kopin, I.J.: The effects of ganglionic blockade, reserpine and vinblastine
on plasma catecholamines and dopamine---hydroxylase in the rat. J Pharmacol Exp Ther 193:
748-756, 1975.
238. Roizen, M.F., Weise, V., Grobecker, H. and Kopin, I.J.: Plasma catecholamines and
dopamine-ß-hydroxylase activity in spontaneously hypertensive rats. Life Sci 17: 283-288,
1975.
239. Gordon, E., Perlow, M., Oliver, J., Ebert M. and Kopin, I.J.: Origins of catecholamine
metabolites in monkey cerebrospinal fluid. J Neurochem 25: 347-349, 1975.
240. Wooten, G.F., Kopin, I.J. and Axelrod, J.: Effects of colchicine and vinblastine on
axonal transport and transmitter release in sympathetic nerves. Ann N.Y. Acad Sci 253: 528-
534, 1975.
241. Kizer, J.S., Kopin, I.J. and Zivin, J.A.: Estimates of catecholamine turnover rates in
individual hypothalamic nuclei of the rat by use of alpha-methyl-para-tyrosine. Br J Pharmacol
54: 243, 1975.
242. Palkovits, M., Kobayashi, R.M., Kizer, J.S., Jacobowitz, D.M. and Kopin, I.J.: Effects
of stress on catecholamines and tyrosine hydroxylase activity of individual hypothalamic nuclei.
Neuroendo-crinology 18: 144-153, 1975.
243. Webb, J.G., Berv, K.R. and Kopin, I.J.: Induction of dopamine-ß-hydroxylase in superior
cervical ganglia in organ culture. Neuro-pharmacology 14: 643-648, 1975.
244. Lamprecht, F., Andres, R. and Kopin, I.J.: Plasma dopamine-ß-hydroxylase: Constance
of levels in normotensive adults and decreases with development of blood pressure elevation.
Life Sci 17: 749-754, 1975.
25
245. Grobecker, H., Roizen, M.F., Weise, V., Saavedra, J.M. and Kopin, I.J.:
Sympathoadrenal medullary activity in young, spontaneously hypertensive rats. Nature 258:
267, 1975.
246. Reid, J.L., Zivin, J.A. and Kopin, I.J.: Central and peripheral adrenergic mechanisms in
the development of deoxycorticosterone saline hypertension in rats. Circ Res 37: 569-579, 1975.
247. Zivin, J.A., Reid, J.L., Saavedra, J.M. and Kopin, I.J.: Quanti-tative localization of
biogenic amines in the spinal cord. Brain Res 99: 293-301, 1975.
248. Lamprecht, F., Jacobowitz, D.M., Richardson, J.S. and Kopin, I.J.: Central adrenergic
neurons in DOCA-salt hypertension. J Neurosci Res 1: 227-234, 1975.
249. Colburn, R.W., Thoa, N.B. and Kopin, I.J.: Influence of ionophores which bind calcium
on the release of norepinephrine from synaptosomes. Life Sci 17: 1395-1400, 1975.
250. Roizen, M.F., Kopin, I.J., Palkovits, M., Brownstein, M., Kizer, J.S. and Jacobowitz,
D.M.: The effect of two diverse inhalation anesthetic agents on serotonin in discrete regions of
the rat brain. Exp Brain Res 24: 203-207, 1975.
251. Ng, L.K.Y. and Kopin, I.J.: Striatal monoamines and false trans-mitters. In
Hornykiewicz, O. (Ed.): International Encyclopedia of Pharmacology and Therapeutics.
Oxford, England, Pergamon Press Ltd., 1975 (pp. 685-694).
252. Ebert, M.H. and Kopin, I.J.: Differential labelling of origins of urinary catecholamine
metabolites by dopamine-C14. Trans Assoc of Am Physicians 1: (xxxviii) 1975 (pp. 256-264).
1976
253. Roizen, M.F., Thoa, N.B., Moss, J. and Kopin, I.J.: Inhibition by cyclopropane of release
of norepinephrine, but not dopamine-ß-hydroxylase, from the guinea-pig vas deferens.
Anesthesiology 44: 54-56, 1976.
254. Zivin, J.A., Doppman, J.L., Reid, J.L., Tappaz, M.L., Saavedra, J.M., Kopin, I.J. and
Jacobowitz, D.M.: Biochemical and histo-chemical studies of biogenic amines in spinal cord
trauma. Neurology 26: 99-107, 1976.
255. Ziegler, M., Lake, C.R. and Kopin, I.J.: Deficient sympathetic nervous responses in
familial dysautonomia. N Engl J Med 294: 630-633, 1976.
256. Kopin, I.J.: Catecholamines, adrenal hormones and stress. Hosp Pract 11: 49-55, 1976.
26
257. Reid, J.L., Zivin, J.A. and Kopin, I.J.: The effects of spinal cord transection and
intracisternal 6-hydroxydopamine on phenyle-thanolamine-N-methyl transferase (PNMT)
activity in rat brain cord. J Neurochem 26: 629-631, 1976.
258. Kizer, J.S., Palkovits, M., Kopin, I.J., Saavedra, J.M. and Brownstein, M.J.: Lack of
effect of various endocrine manipulations on trytophan hydroxylase activity of individual nuclei
of the hypothalamus, limbic system and midbrain of the rat. Endocrinology 98: 743-747, 1976.
259. Zivin, J.A., Reid, J.L., Tappaz, M.L. and Kopin, I.J.: Quantitative localization of tyrosine
hydroxylase, dopamine-ß-hydroxylase, phenolethanolamine-N-methyl transferase, and glutamic
acid decarboxylase in spinal cord. Brain Res 105: 151-156, 1976.
260. Ziegler, M.G., Lake, C.R. and Kopin, I.J.: Plasma noradrenaline increases with age.
Nature 261: 333-334, 1976.
261. Kessler, J.A., Gordon, E.K., Reid, J.L. and Kopin, I.J.: Homovanillic acid and 3-
methoxy-4-hydroxyphenylethyleneglycol production by the monkey spinal cord. J Neurochem
26: 1057-1061, 1976.
262. Ziegler, M.G., Lake, C.R. Fappen, F.H., Shoulson, I. and Kopin, I.J.: Norepinephrine in
cerebrospinal fluid. Brain Res 108: 436-440, 1976.
263. Lake, C.R., Ziegler, M.G. and Kopin, I.J.: Use of plasma norepine-phrine for evaluation
of sympathetic neuronal function in man. Life Sci 18: 1315-1326, 1976.
264. Gordon, E.K., Markey, S.P., Sherman, R.L. and Kopin, I.J.: Con-jugated 3,4-
dihydroxyphenylacetic acid (DOPAC) in human and monkey cerebrospinal fluid and rat brain
and the effects of pro-benecid treatment. Life Sci 18: 1285-1292, 1976.
265. Roizen, M.F., Kopin, I.J., Thoa, N.B., Zivin, J., Muth, E.A. and Jacobowitz, D.M.: The
effect of two anesthetic agents on norepine-phrine and dop-amine in discrete brain nuclei, fiber
tracts, and terminal regions of the rat. Brain Res 110: 515-522, 1976.
266. Ziegler, M.G., Lake, C.R., Eldridge, R. and Kopin, I.J.: Plasma norepinephrine and
dopamine-ß-hydroxylase in dystonia. In Eldridge, R. and Fahn, S. (Eds.): Advances in
Neurology, Vol. 14. New York, Raven Press, 1976 (pp. 307-318).
267. Tappaz, M.L., Zivin, J.A. and Kopin, I.J.: Intraspinal glutamic decarboxylase distribution
after transection of the cord at the thoracic level. Brain Res 111: 220-223, 1976.
268. Kopin, I.J., Kaufman, S., Viveros, H., Jacobowitz, D.M., Lake, C.R., Ziegler, M.,
Lovenberg, W.M. and Goodwin, F.K.: Dopamine-ß-hydroxylase: Basic and Clinical Studies.
Ann Intern Med 85: 211- 223, 1976.
269. Weise, V.K. and Kopin, I.J.: Assay of catecholamines in human plasma: Studies of a
single isotope radioenzymatic procedure. Life Sci 19: 1673-1686, 1976.
27
270. Thoa, N.B., Tizabi, Y., Kopin, I.J. and Maengwyn-Davies, G.D.: Alterations of mouse
adrenal medullary catecholamines and enzymes in response to attack: Effect of pre- and post-
treatment with phenobarbital. Psycho-pharmacology 51: 53-57, 1976.
271. Tizabi, Y., Kopin, I.J., Maengwyn-Davies, G.D. and Thoa, N.B.: Attack-induced changes
in response to decapitation of plasma catecholamines of victim mice. Psychopharmacol
Commun 2: 391-402, 1976.
272. Kopin, I.J.: Catecholamines and stress. In Usdin, E., Kvetnansky, R. and Kopin, I.J.
(Eds): Catecholamines and Stress. Pergamon Press, Ltd., Oxford, England 1976 (pp. 1-5).
28
273. Kobayashi, R.M., Palkovits, M., Kizer, J.S., Jacobowitz, D.M. and Kopin, I.J.: Selective
alterations of catecholamines and tyrosine hydroxylase activity in the hypothalamus following
acute and chronic stress. In Usdin, E., Kvetnansky, R. and Kopin, I.J. (Eds.): Catecholamines
and Stress. Pergamon Press Ltd., Oxford, England, 1976 (pp. 29-38).
274. Palkovits, M., Brownstein, M.J., Kizer, J.S., Saavedra, J.M. and Kopin, I.J.: Effect of
stress on serotonin and tryptophan hydroxy-lase activity of brain nuclei. In Usdin, E.,
Kvetnansky, R. and Kopin, I.J. (Eds.): Catecholamines and Stress. Pergamon Press Ltd.,
Oxford, England 1976 (pp. 51-59).
275. Palkovits, M., Brownstein, M.J., Kizer, J.S., Saavedra, J.M. and Kopin, I.J.: Effect of
stress on serotonin concentration and tryptophan hydroxylase activity of brain nuclei.
Neuroendro-crinology 22: 298-304, 1976.
276. Markey, S.P., Colburn, R.W. and Kopin, I.J.: Synthesis and puri-fication of 2-Bromo-a-
ergocryptine-Br82 Br J Labelled Compd Radiopharm 12: 627-630, 1976.
277. Grobecker, H., Saavedra, J.M., Roizen, M.F., Weise, V., Kopin, I.J. and Axelrod, J.:
Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in
rats. Clin Sci Mol Med 51: 377s-380s, 1976.
1977
278. Lake, C.R., Ziegler, M.G., Coleman, M.D. and Kopin, I.J.: Age-adjusted plasma
norepinephrine levels are similar in normotensive and hypertensive subjects. N Engl J Med 296:
208-209, 1977.
279. Ziegler, M.G., Lake, C.R. and Kopin, I.J.: The sympathetic nervous system defect in
primary orthostatic hypotension. N Engl J Med 296: 293-297, 1977.
280. Grobecker, H., Roizen, M.F. and Kopin, I.J.: Effect of tyramine and guan-ethidine on
dopamine-ß-hydroxylase activity and norepine-phrine concen-trations in vesicular fraction of the
heart and plasma of rats. Life Sci 20: 1009-1016, 1977.
281. Tappaz, M.L., Brownstein, M.J. and Kopin, I.J.: Glutamate decar-boxylase (GAD) and
Y-aminobutyric acid (GABA) in discrete nuclei of gypothalamus and substantia nigra. Brain
Res 125: 108-121, 1977.
282. Ziegler, M.G., Wood, J.H., Lake, C.R. and Kopin, I.J.: Norepine-phrine and 3-methoxy-
4-hydroxyphenylglycol gradients in human cerebrospinal fluid. Am J Psychiatry 134: 565-568,
1977.
283 Liuzzi, A., Foppen, F.H., Saavedra, J.M., Jacobowitz, D. and Kopin, I.J.: Effect of NGF
and dexamethasone on phenylethanolamine-N-methyl transferase (PNMT) activity in neonatal
rat superior cervical ganglia. J Neurochem 28: 1215-1220, 1977.
284. Foppen, F.H., Liuzzi, A. and Kopin, I.J.: Gas chromatographic-mass spectrometric
identification of epinephrine in rat superior cervical ganglia and formation in vivo. Experientia
33: 596-598, l977.
29
285. Lamprecht, F., Richardson, J.S., Williams, R.B. and Kopin, I.J.: 6-Hydroxy-dopamine
destruction of central adrenergic neurones prevents or reverses developing DOCA-salt
hypertension in rats. J Neural Transm 40: 149-158, 1977.
30
286. Popper, C.W., Chiueh, C.C. and Kopin, I.J.: Plasma catecholamine concen-trations in
unanesthetized rats during sleep, wakefulness, immobilization and after decapitation. J
Pharmacol Exp Ther 202: 144-148, 1977.
287. Liuzzi, A., Foppen F.H., Saavedra, J.M., Levi-Montalcini, R. and Kopin, I.J.: Gas
Chromatographic-mass spectrometric assay of serotonin in rat superior cervical ganglia. Effects
of nerve growth factor and 6-hydroxydopamine. Brain Res 133: 354-357, 1977.
288. Wooten, G.F., Weise, V.K. and Kopin, I.J.: Norepinephrine synthesis con-tributes to the
accumulation of catecholamines after ligation of rat sciatic nerves. Brain Res 136: 174-177,
1977.
289. Kopin, I.J.: Catecholamine metabolism (and the biochemical assessment of sympathetic
activity). Clin Endocrinol Metab 6: 525-549, 1977.
290. Kopin, I.J.: Methods for measuring brain amine metabolism from blood and urinary
amine metabolites. In Usdin, E., Weiner, N. and Youdim, M. (Eds): Structure and Function of
monoamine Enzymes. Marcel Dekker, Inc., New York 1977 (pp. 467-476).
291. Grobecker, H., McCarty, R., Saavedra, J.M., Chuieh, C.C. and Kopin,-I.J.: Dopamine---
hydroxylase activity and catecholamine-concentrations in plasma: experimental and essential
hypertension. -Postgraduate Med J 53(3): 43-48, 1977.
292. Grobecker, H., Roizen, M.F., Jacobowitz, D.M. and Kopin, I.J.: Effect of prolonged
treatment with adrenergic neuron blocking drugs on sympatho-adrenal reactivity in rats. Eur J
Pharmacol 46: 125- 133, 1977.
293. Lake, C.R., Major, L.F., Ziegler, M.G. and Kopin, I.J.: Increased sympathetic nervous
system activity in alcoholic patients treated with disulfiram. Am J Psychiatry 134: 1411-1414,
1977.
294. Chase, T.N. and Kopin, I.J.: Drug-induced disorders of movement. In Goldensohn, S. and
Apel, S.H. (Eds.): Scientific Approaches to Clinical Neurology. Lea and Febiger, Philadelphia,
Pa., Chapter 72, 1977 (pp. 1190-1211).
295. Liuzzi, A., Foppen, F.H. and Kopin, I.J.: Stimulation and maintenance by nerve growth
factor of phenylethanolamine-N-methyl-transferase in superior cervical ganglia of adult rats.
Brain Res 138: 309-315, 1977.
296. Lake, C.R., Ziegler, M.G., Coleman, M. and Kopin, I.J.: Lack of correlation of plasma
norepinephrine and dopamine-ß-hydroxylase in hypertensive and normotensive subjects. Cir
Res 41: 865-869, 1977.
1978
297. Kopin, I.J.: Noradrenergic neurotransmission. In Lipton, M.A., DiMascio, A. and
Killam, K.F. (Eds.): Psychopharmacology: A Generation of Progress. Raven Press, New York,
1978 (pp. 217-219).
31
298. Kopin, I.J.: Measuring turnover of neurotransmitter in human brain. In: Lipton, M.A.,
DiMascio, A. and Killam, K.F. (Eds.): Psychopharmacology: A generation of Progress. Raven
Press, New York, 1978 (pp. 933-942).
299. Roizen, M.F., Moss, J., Henry, D.P., Weise, V. and Kopin, I.J.: Effect of general
anesthetics on handling- and decapitation-induced increases in sympathoadrenal discharge. J
Pharmacol Exp Ther 204: 11-18, 1978.
32
300. Lake, C.R., Wood, J.H., Ziegler, M.G., Ebert, M.H. and Kopin, I.J.: Probenecid-induced
norepinephrine elevations in plasma and cerebrospinal fluid. Arc Gen Psychiatry 35: 237-240,
1978.
301. Weinstock, M., Thoa, N.B. and Kopin, I.J.: a-Adrenoceptors modulate noradrenaline
release from axonal sprouts in cultured rat superior cervical ganglia. Eur J Pharmacol 47: 297-
302, 1978.
302. McCarty, R., Chiueh, C.C. and Kopin, I.J.: Behavioral and cardio-vascular responses of
spontaneously hypertensive and normotensive rats to inescapable footshock. Behav Biol 22:
405-410, 1978.
303. McCarty, R. and Kopin, I.J.: Alterations in plasma catecholamines and behavior during
acute stress in spontaneously hypertensive and Wistar-Kyoto normotensive rats. Life Sci 22:
997-1006, 1978.
304. Chiueh, C.C. and Kopin, I.J.: Centrally mediated release by cocaine of endogenous
epinephrine and norepinephrine from the sympathoadrenal medullary system of unanesthetized
rats. J Pharmacol Exp Ther 205: 148-154, 1978.
305. Chiueh, C.C., Sun, C.L., Kopin, I.J., Fredericks, W.R. and Rapoport, S.I.: Entry of [3H]
norepinephrine, [125] albumin and Evans blue from blood into brain following unilateral
osmotic opening of the blood-brain-barrier. Brain Res 145: 291-301, 1978.
306. Blitzer, B.L., Waggoner, J.G., Jones, E.A., Gralnick, H.R., Towne, D., Butler, J., Weise,
V., Kopin, I.J., Walters, I., Teychenne, P.F., Goodman, D.G. and Berk, P.D.: A model of
fulminant hepatic failure in the rabbit. Gastro-enterology 74: 664-671, 1978.
307. Kopin, I.J., Lake, C.R. and Ziegler, M.G.: Plasma levels of norepinephrine. Ann Intern
Med 88: 671-680, 1978.
308. McCarty, R., Chiueh, C.C. and Kopin, I.J.: Spontaneously hyper-tensive rats: Adrenergic
hyperresponsivity to anticipation of electric shock. Behav Biol 23: 180-188, 1978.
309. Chiueh, C.C. and Kopin, I.J.: Hyper-responsivity of spontaneously hyper-tensive rat to
indirect measurement of blood pressure. Am J Physiol 234: H690-H695, 1978.
310. McCarty, R. and Kopin, I.J.: Pregnancy: Its effects on blood pressure, heart rate and
sympatho-adrenal activity in spontaneously hypertensive rats. Proc Soc Exp Biol Med 158:
242-244, 1978.
311. Weinstock, M., Zavadil, A.P., Rosin, A.J., Chiueh, C.C. and Kopin, I.J.: The role of
peripheral catecholamines in oxotremorine tremor in the rat and its antagonism by beta
adrenoceptor blocking agents. J Pharmacol Exp Ther 206: 91-96, 1978.
312. Kopin, I.J.: Section I Summary - Birth Defects: Original article series. In Bergsma, D.
and Goldstein, A. (Eds.): Neurochemical and Immunologic Components in Schizophrenia, Vol.
XIV. Alan R. Liss, Inc., New York, 1978 (pp 75-77).
33
313. Chiueh, C.C. and Kopin, I.J.: Radioenzymatic paper-chromatographic assay for
dopamine and norepinephrine in cerebroventricular cisternal perfusate of cat following
administration of cocaine or d-amphetamine. J Neurochem 31: 561-564, 1978.
34
314. Gottesfeld, Z., Kvetnansky, R., Kopin, I.J. and Jacobowitz, D.M.: Effects of repeated
immobilization stress on glutamate decarboxylase and Choline acetyltransferase in discrete brain
regions. Brain Res 152: 374-378, 1978.
315. Kopin, I.J.: The role of calcium in neurosecretion. In Deniker, P., Radouco-Thomas, C.,
Villeneuve, A., Baronet-Lacroix, D. and Garcin, F. (Eds.): Neuropsychopharmacology, Vol 1.
Pergamon Press, New York 1978 (pp. 357-361).
316. Kvetnansky, R., Kopin, I.J. and Saavedra, J.M.: Changes in epinephrine in individual
hypothalamic nuclei after immobilization stress. Brain Res. 155: 387-390, 1978.
317. McCarty, R. and Kopin, I.J.: Sympatho-adrenal medullary activity and behavior during
exposure to footshock stress: A comparison of seven rat strains. Physiol Behav 21: 567-572,
1978.
318. Kvetnansky, R., Sun, C.L., Lake, C.R., Thoa, N., Torda, T. and Kopin, I.J.: Effect of
handling and forced immobilization on rat plasma levels of epinephrine, norepinephrine, and
dopamine-ß-hydroxylase. Endocrinology 103: 1868-1874, 1978.
319. Rapoport, J.L., Mikkelsen, E.J., Ebert, M.H., Brown, G.L., Weise, V.K. and Kopin, I.J.:
Urinary catecholamines and amphetamine excretion in hyper-active and normal boys. J Nerv
Ment Dis 166: 731-737, 1978.
320. Elchisak, M.A., Polinsky, R.J., Ebert, M.H., Powers, K.J. and Kopin, I.J.: Contribution
of plasma homovanillic acid (HVA) to urine and cerebrospinal fluid HVA in the monkey and its
pharmacokinetic disposition. Life Sci 23: 2339-2348, 1978.
321. McCarty, R., Kvetnansky, R., Lake, C.R., Thoa, N.B. and Kopin, I.J.: Sympatho-adrenal
activity of SHR and WKY rats during recovery from forced immobilization. Physiol Behav 21:
951-955, 1978.
322. McCarty, R. and Kopin, I.J.: Changes in plasma catecholamines and behavior of rats
during the anticipation of footshock. Horm Behav 11: 248-257, 1978.
1979
323. Kopin, I.J.: Plasma catecholamines in human and experimental hyper-tension. In Meyer,
P. and Schmitt, H. (Eds.): Nervous System and Hyper-tension. John Wiley & Sons, New York,
1979 (pp. 267- 276).
324. Saavedra, J.M., Kvetnansky, R. and Kopin, I.J.: Adrenaline, noradrenaline and dopamine
levels in specific brain stem areas of acutely immobilized rats. Brain Res 160: 271-280, 1979.
325. Weinstock, M., Zavadil, III, A.P., Chiueh, C.C. and Kopin, I.J.: The effect of
oxotremorine on blood pressure and plasma catecholamines in conscious and anesthetized rats.
Life Sci 24: 301-310, 1979.
35
326. Kopin, I.J.: Biochemical assessment of peripheral adrenergic activity. In Paton, D.M.
(Ed.): The Release of Catecholamines from Adrenergic Neurons. Pergamon Press, New York,
1979 (pp. 355- 372).
327. Tizabi, Y., Thoa, N.B., Maengwyn-Davies, G.M., Kopin, I.J. and Jacobowitz, D.M.:
Behavioral correlation of catecholamine concentration and turnover in discrete brain
areas of three strains of mice. Brain Res 166: 199-205, 1979.
328. Lake, C.R., Davis, P.B., Zeigler, M. and Kopin, I.J.: Electrolytes and norepinephrine
levels in blood of patients with cycstic fibrosis. Clin Chim Acta 92: 141-146, 1979.
329. Kvetnansky, R., McCarty, R., Thoa, N.B., Lake, C.R., and Kopin, I.J.: Sympatho-adrenal
responses of spontaneously hypertensive rats to immobilization stress. Am J Physiol 236:
H457-H462, 1979.
330. Elchisak, M.A., Polinsky, R.J., Ebert, M.H., Modlin, L.T. and Kopin, I.J.: Kinetics of
homovanillic acid and determination of its production rate in the rhesus monkey. Life Sci 24:
1493-1501, 1979.
331. Brown, G.L., Hunt, R.D., Ebert, M.H., Bunney, Jr., W.E. and Kopin, I.J.: Plasma levels
of d-amphetamine in hyperactive children. Serial behavior and motor responses.
Psychopharmacology 62: 133- 140, 1979.
332. McCarty, R. and Kopin, I.J.: Patterns of behavioral development in spontaneously
hypertensive rats and Wistar-Kyoto normotensive controls. Dev Psychobiol 12: 239-243, 1979.
333. Kvetnansky, R., Weise, V.K., Thoa, N.B. and Kopin, I.J.: Effects of chronic guanethidine
treatment and adrenal medullectomy on plasma levels of catecholamines and corticosterone in
forcibly immobilized rats. J Pharmacol Exp Ther 209: 287-291, 1979.
334. Lake, C.R., Ziegler, M.G., Coleman, M. and Kopin, I.J.: Evaluation of the sympathetic
nervous system in trisomy-21 (Down’s Syndrome). J Psychiatr Res 15: 1-6, 1979.
335. Sun, C.L., Thoa, N.B. and Kopin, I.J.: Comparison of the effects of 2-deoxyglucose and
immobilization on plasma levels of catecholamines and corticosterone in awake rats.
Endocrinology 105: 306-311, 1979.
336. McCarty, R., Giland, G.M., Weise, V.K. and Kopin, I.J.: Strain differences in rat adrenal
biosynthetic enzymes and stress-induced increases in plasma catecholamines. Life Sci 25: 747-
754, 1979.
337. Kvetnansky, R., Kopin, I.J. and Klein, D.C.: Stress increases pineal epinephrine.
Psychopharmacol Commun 3: 69-72, 1979.
338. Gilad, G.M., Gilad, V.H. and Kopin, I.J.: Reaction of the mutant mouse nude to axonal
injuries of the central nervous system. Exp Neurol 65: 87-98, 1979.
36
339. Kopin, I.J.: Plasma catecholamines: A brief overview. In Usdin, E., Kopin, I.J. and
Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol 1. Pergamon Press, New
York, 1979 (pp. 897-902).
340. Sun, C.L. and Kopin, I.J.: Plasma catecholamines and direct stimulation of rat
hypothalamus. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and
Clinical Frontiers. Vol 2. Pergamon Press, New York, 1979. (pp. 1422- 1424).
341. Sisak, M.E., Markey, S.P., Colburn, R.W., Zavadil, A.P. and Kopin, I.J.: Identification of
6-hydroxymelatonin in normal human urine by gas chromatography-mass spectrometry. Life Sci
25: 803-806, 1979.
342. Yamaguchi, I. and Kopin, I.: Plasma catecholamine and blood pressure responses to
sympathetic stimulation in pithed rats. Am J Physiol 237(3): H305-H310, 1979.
343. Gilad, G.M., McCarty, R., Weise, V.K. and Kopin, I.J.: Strain differences in the
regulation of the sympatho-adrenal system. Brain Res 176: 380-384, 1979.
344. Kim, Y.D., Lake, C.R., Lees, D.E., Schuette, W.H., Bull, J.M., Weise, V.K., and Kopin,
I.J.: Hemodynamic and plasma catecholamine responses to hyperthermic cancer therapy in
humans. Am J Physiol 237(5): H570-H574, 1979.
345. Lake, C.R., Ziegler, M., Coleman, M.D. and Kopin, I.J.: Plasma levels of norepinephrine
and dopamine-ß-hydroxylase in CRF patients treated with dialysis. Cardiovasc Med 4(10):
1099-1111, 1979.
346. McCarty, R. and Kopin, I.J.: Stress-induced alterations in plasma catechol-amines and
behavior of rats: Effects of chlorisondamine and bretylium. Behav Neural Biol 27: 249-265,
1979.
347. Kvetnansky, R., Weise, V.K. and Kopin, I.J.: The origins of plasma epinephrine,
norepinephrine and dopamine levels in stressed rats. In Usdin, E., Kopin, I.J. and Barchas, J.
(Eds.): Catechol-amines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press, New York,
1979 (pp. 684-686).
348. Ebert, M., Elchisak, M., Zavadil, A., Polinsky, R. and Kopin, I.J.: Use of deuterium-
labelled methionine and HVA to study dopamine metabolism in vivo. In Usdin, E., Kopin, I.J.
and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press,
New York, 1979 (pp. 889-891).
349. Grobecker, H., Saavedra, J.M., McCarty, R., Weise, V.K. and Kopin, I.J.: Role of
noradrenergic nerves and adrenal medulla during the development of genetic and experimental
hypertension in rats. In Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and
Clinical Frontiers. Vol. 1. Pergamon Press, New York, 1979 (pp. 906-908).
350. Yamaguchi, I., and Kopin, I.J.: Direct stimulation of sympathetic outflow and plasma
levels of norepinephrine and epinephrine of pithed rats. In Usdin, E., Kopin, I.J. and Barchas, J.
(Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press, New York, 1979
(pp. 924-926).
37
351. Jimerson, D.C., Sun, C.L., Yamaguchi, I. and Kopin, I.J.: Plasma levels of glycol
metabolites and presynaptic metabolism of nore-pinephrine (NE). In Usdin, E., Kopin, I.J. and
Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers. Vol. 1. Pergamon Press, New
York, 1979 (pp. 927-929).
352. McCarty, R. and Kopin, I.J.: Plasma catecholamines and behavior of rats during stress. In
Usdin, E., Kopin, I.J. and Barchas, J. (Eds.): Catecholamines: Basic and Clinical Frontiers.
Vol. 2. Pergamon Press, New York, 1979 (pp. 1789-1791).
353. Blombery, P., Kopin, I.J., Gordon, E.K. and Ebert, M.H.: Metabolism and turnover of
MHPG in the monkey. In Usdin, E., Kopin, I.J., and Barchas, J. (Eds.): Catecholamines: Basic
and Clinical Frontiers. Vol. 2. Pergamon Press, New York, 1979 (pp. 1875-1877).
354. Markey, S.P., Powers, K. Dubinsky, D. and Kopin, I.J.: General methods for the
synthesis of methyl isotope labelled catecholamine metabolites. Preparation of 4-hydroxy-3-
methoxy-d3-mandelic acid, phenylacetic acid, and phenylethylene glycol. Journal Labelled
Compounds Radiopharma-ceuticals 17(1): 103-113, 1979.
355. Weinstock, M., Zavadil, III, A.P. and Kopin, I.J.: Differential effects of d-and 1-
propranolol on dopamine turnover stimulated by oxotremorine in striatal and mesolimbic areas
of rat brain. Eur J Pharmacol 59(3-4): 187-193, 1979.
356. McCarty, R., Chiueh, C.C., and Kopin, I.J.: Differential behavioral responses of
spontaneously hypertensive (SHR) and normotensive (WKY) rats to d-amphetamine. Pharmacol
Biochem Behav 12: 53-59, 1979.
357. Gilad, G.M. and Kopin, I.J.: Neurochemical aspects of neuronal ontogenesis in the
developing rat cerebellum: Changes in neuro-transmitter and polyamine synthesizing enzymes. J
Neurochem 33: 1195-1204, 1979.
358. Gross, H.A., Lake, C.R., Ebert, M.H., Ziegler, M.G., and Kopin, I.J.: Catecholamine
metabolism in primary anorexia nervosa. J Clin Endocrinol Metab 49(6): 805-809, 1979.
359. Markey, S.P., Colburn, R.W., Kopin, I.J., and Aamodt, R.L.: Distribution and excretion
in the rat and monkey of 82Br Bromocriptine. J Pharmacol Exp Ther 211: 31-35, l979.
360. Lake, C.R., Ziegler, M.G., Coleman, M.D. and Kopin, I.J.: Hydro-chlorothiozide-induced
sympathetic hyperactivity in hypertensive patients. Clin Pharmacol Ther 26:4: 428-432, 1979.
361. Davis, G.C., Williams, A.C., Markey, S.P., Ebert, M.H., Caine,-E.D., Reichert, C.M. and
Kopin, I.J.: Chronic parkinsonism-secondary to intravenous injection in meperidine analogues.--
Psychiatry Res 1: 249-254, 1979.
1980
38
362. Kopin, I.J., McCarty, R., Torda, T. and Yamaguchi, I.: Catechol-amines in plasma and
responses to stress. In Usdin, E., Kvetnansky, R. and Kopin, I.J. (Eds.): Catecholamines and
Stress: Recent Advances, Vol 8. New York, Elsevier/North Holland, 1980, pp. 197-204.
363. Lake, C.R., Sternberg, D.E., VanKammen, D.P., Ballenger, J.C., Ziegler, M.G., Post,
R.M., Kopin, I.J. and Bunney, W.E.: Schizo-phrenia: Elevated cerebrospinal fluid
norepinephrine. Science 207: 331-333, 1980.
364. Gilad, G.M., Gagnon, C., and Kopin, I.J.: Protein carboxymethylase activity in the rat
superior cervical ganglion during development and after axonal injury. Brain Res 183: 393-
402, 1980.
365. Yamaguchi, I. and Kopin, I.J.: Blood pressure, plasma catechol-amines and sympathetic
outflow in pithed SHR and WKY rats. Am Physiol Soc 238: (Heart Circ Physiol 7): H365-
H372, 1980.
366. Tetsuo, M., Markey, S.P., and Kopin, I.J.: Measurement of 6-hydroxy-melatonin in
human urine and its diurnal variations. Life Sci 27: 105-109, 1980.
367. Yamaguchi, I. and Kopin, I.J.: Differential inhibition of Alpha-1 and Alpha-2
adrenoceptor-mediated pressor responses in pithed rats. J Pharmacol Exp Ther 214: 275-281,
1980.
368. Lake, C.R., Ziegler, M.G., Coleman, M.D., and Kopin, I.J.: Fen-fluramine potentiation of
anti-hypertensive effects of thiazides. Clin Pharmacol Ther 28: 22-27, 1980.
369. Oertel, W.H., Tappaz, M.L., Kopin, I.J., Ransom, D.H., and Schmechel, D.E.:
Production of an antiserum to rat brain glutamate (GAD)/cysteine sulfinate (CSD)
decarboxylase. Brain Res Bull 5(2): 713-719, 1980.
370. Kopin, I.J., McCarty, R., and Yamaguchi, I.: Plasma catecholamines in human and
experimental hypertension. Clin Exp Hypertens 2(3&4): 379-394, 1980.
371. Blombery, P.A., Kopin, I.J., Gordon, E.K., Markey, S.P. and Ebert, M.H.: Conversion of
MHPG to vanillylmandelic acid. Arch Gen Psychiatry 37: 1095-1098, 1980.
372. Oertel, W.H., Schmechel, D.E., Daly, J.W., Tappaz, M.L. and Kopin, I.J.: Localization
of glutamate decarboxylase on line-immunoelectro-phoresis and two-dimensional
electrophoresis by use of the radioactive suicide substrate [2-3H]-y-acetylenic GABA. Life Sci
27: 2133-2141, l980.
373. Fuerstein, G., Torda, T. and Kopin I.J.: Effect of indomethacin on cardiac --adrenergic
receptors. Eur J Pharmacol 67: 469-472, 1980.
374. Polinsky, R.J., Kopin, I.J., Ebert, M.H. and Weise, V.: Pharmacologic distinction of
different orthostatic hypotension syndromes. Neurology 31: 1-7, 1980.
39
375. Lake, C.R., Polinsky, R.J., Gullner, H.G., Ebert, M.H., Ziegler, M.G., Barter, F.C. and
Kopin, I.J.: Dissociation between central and peripheral noradrenergic activity in essential
hypertension. Clin Sci 59: 229-233, 1980.
376. Weinstock, M., Zavadil, A.P., Muth, E.A., Crowley, W.R., O’Donohue, T.L., Jacobowitz,
D.M. and Kopin, I.J.: Evidence that noradrenaline modulates the increase in striatal dopamine
metabolism induced by muscarinic receptor stimulation. Eur J Pharmacol 68: 427-435, 1980.
377. Polinsky, R.J., Kopin, I.J., Ebert, M.H. and Weise, V.: The adrenal medullary response to
hypoglycemia in patients with orthostatic hypotension. J Clin Endocrinol Metab 51(6): 1401-
1406, l980.
1981
378. Eisler, T., Teravainen, H., Nelson, R., Krebs, H., Weise, V., Lake, C.R., Ebert, M.H.,
Whetzel, N., Murphy, D.L., Kopin, I.J. and Calne, D.B.: Deprenyl in Parkinson Disease.
Neurology 31: 19-23, 1981.
379. Tetsuo, M., Markey, S.P., Colburn, R.W. and Kopin, I.J.: Quantitative analysis of 6-
hydroxymelatonin in human urine by gas chromatography-negative chemical ionization mass
spectrometry. Anal Biochem 110: 208-215, 1981.
380. Torda, T., Yamaguchi, I., Hirata, F., Kopin, I.J. and Axelrod, J.: Mepacrine treatment
prevents immobilization-induced desensi-tization of beta-adrenergic receptors in rat hypothalmus
and brain stem. Brain Res 205: 441-444, 1981.
381. Elkins, R.N., Rapoport, J.L., Zahn, T.P., Buchsbaum, M.S., Weingartner, H., Kopin, I.J.,
Langer, D. and Johnson, C.: Acute effects of caffeine in normal prepubertal boys. Am J
Psychiatry 138(2): 178-183, 1981.
382. Goldstein, D.S., Feuerstein, G., Izzo, J.L., Kopin, I.J. and Keiser, H.,R.: Validity and
reliability of liquid chromatography with electro-chemical detection for measuring plasma levels
of norepinephrine and epinephrine in man. Life Sci 28: 467-475, 1981.
383. McCarty, R., Kvetnansky, R. and Kopin, I.J.: Plasma catecholamines in rats: Daily
variations in basal levels and increments in response to stress. Physiol Behav 26: 27-31, 1981.
384. Torda, T., Yamaguchi, I., Hirata, F., Kopin, I.J. and Axelrod, J.: Quinacrine-blocked
desensitization of adrenoceptors after immobilization stress or repeated injection of isoproterenol
in rats. J Pharmacol Exp Ther 216(2): 334-338, 1981.
40
385. Feuerstein, G. and Kopin, I.J.: Effect of PGD2, PGE2, PGF2-, and PGI2 on blood
pressure, heart rate and plasma catecholamine responses to spinal cord stimulation in the rat.
Prostaglandins 21(2): 189-206, 1981.
386. Feuerstein, G., Jimerson, D.C. and Kopin, I.J.: Prostaglandins, catecholamines, and
cardiovascular responses to hemorrhage. Am J Physiol 240: R166-R174, 1981.
387. Feuerstein, G., Adelberg, S.A., Kopin, I.J. and Jacobowitz, D.M.: Cardio-vascular and
sympathetic responses to PGF2- injection into hypothalamus nuclei. Brain Res Bull 6: 203-207,
1981.
388. Feuerstein, G., Yamaguchi, I., and Kopin, I.J.: Effect of GABA agonist and antagonists
on cardiovascular and sympathetic responses in SHR and WKY rats. Clin Exp Hypertens 3(2):
207-218, 1981.
389. Kopin, I.J.: Catecholamines and blood pressure regulation. In Soffer, R.N. (Ed.):
Biochemical Regulation of Blood Pressure. John Wiley & Sons, 1981 (pp. 266-279).
390. Tappaz, M.L., Aguera, M., Belin, M.F., Oertel, W.H., Schmechel, D.E., Kopin, I.J., and
Pujol, J.F.: GABA markers in the hypo-thalamic median eminence. In Costa, E., DiChiara, G.,
and Gessa, G.L. (Eds.): GABA and Benzodiazepine Receptors. New York, Raven Press, 1981
(pp. 229-236).
391. Yamaguchi, I., Torda, T., Hirata, F. and Kopin, I.J.: Adrenoceptor desensitization after
immobilization stress or repeated injection of isoproterenol. Am J Physiol 240: (Heart Circ.
Physiol. 9:) H691-H696, 1981.
392. Kopin, I.J., Goldstein, D.S. and Feuerstein, G.Z.: Position Paper: The Sympathetic
Nervous System and Hypertension. In Laragh, J.J., Buhler, F.R. and Seldin, D.W. (Eds.):
Frontiers in Hypertension Research. New York, Springer-Verlag, 1981 (pp. 283- 289).
393. Jimerson, D.C., Markey, S.P., Oliver, J.A. and Kopin, I.J.: Simultaneous measurement of
plasma 4-hydroxy-3-methoxyphenyl-ethylene glycol and 3,4-dihydroxyphenylethylene glycol by
gas chromatography mass spec-trometry. Biomed Mass Spectrom 8(6): 256-259, 1981.
394. Kopin, I.J.: Mode of action of antidepressants and central stimulants. In van Praag, H.M.,
Lader, M.H., Rafaelsen, O.J., and Sachar, E.J. (Eds.): Handbook of Biological Psychiatry - Part
IV Brain Mechanisms and Abnormal Behavior. New York, Marcel Dekker 1981 (pp. 741-766).
395. Oertel, W.H., Schmechel, D.E., Brownstein, M.J., Tappaz, M.L., Ransom, D.H. and
Kopin, I.J.: Decrease of glutamate decarboxylase (GAD)-immuno-reactive nerve terminals in the
substantia nigra after kainic acid lesion of the striatum. J Histochem Cytochem 29(8): 977-980,
1981.
396. Zerbe, R.L., Feuerstein, G. and Kopin, I.J.: Effect of captopril on cardio-vascular,
sympathetic and vasopressin responses to hemorrhage. Eur J Pharmacol 72: 391-395, 1981.
41
397. Tetsuo, M., Polinsky, R.J., Markey, S.P. and Kopin, I.J.: Urinary 6-hydroxymelatonin
excretion in patients with orthostatic hypotension. J Clin Endocrinol Metab. 53: 607, 1981.
398. Polinsky, R.J., Kopin, I.J., Ebert, M.H., Weise, V. and Recant, L.: Hormonal responses to
hypoglycemia in orthostatic hypotension patients with adre-nergic insufficiency. Life Sci 29:
417-425, 1981.
399. Kopin, I.J.: Assessing norepinephrine metabolism in human brain: Past, present, and
future. In Matthysse, S. (Eds.): Psychiatry and the Biology of the Human Brain. New York,
Elsevier North Holland, 1981 (pp. 89-101)
400. Saller, C.F. and Kopin, I.J.: Glucose potentiates haloperidol induced catalepsy. Life Sci
29(22): 2337-2342, 1981.
401. Feuerstein, G., DiMicco, J.A., Ramu, A. and Kopin, I.J.: Effect of indomethacin on the
blood pressure and plasma CA responses to acute endotoxaemia. J Pharm Pharmacol 33: 576-
579, 1981.
402. Helke, C.J., DiMicco, J.A., Jacobowitz, D.M. and Kopin, I.J.: Effect of capsaicin
administration to neonatal rats on the Substance P content of discrete CNS regions. Brain Res
222: 428-431, 1981.
403. Feuerstein, G., Chiueh, C.C. and Kopin, I.J.: Effect of naloxone on the cardiovascular and
sympathetic response to hypovolemic hypotension in the rat. Eur J Pharmacol 75: 65-69, 1981.
404. Feuerstein, G., Adelberg, S., Kopin, I.J. and Jacobowitz, D.M.: Central cardiovascular
effects of prostacyclin. Neuropharmacology, 20: 1085-1090, 1981.
405. Lozovsky, D., Saller, C. and Kopin, I.J.: Dopamine receptor binding is increased in
diabetic rats. Science 214: 1031-1032, 1981.
406. Feuerstein, G., Zukowska-Grojec, Z. and Kopin, I.J.: Cardiovascular effects of
leukotriene D4 in SHR and WKY rats. Eur J Pharmacol 76: 107-110, 1981.
407. Kopin, I.J.: Neurotransmitters and the Lesch Nyhan Syndrome. N Engl J Med 305: 1148-
1150, 1981.
408. Jimerson, D.C., Nurnberger, J.I., Post, R.M., Gershon, E.S. and Kopin, I.J.: Plasma
MHPG in rapid cyclers and healthy twins. Arch Gen Psychiatry 38: 1287-1290, 1981.
409. Oertel, W.H., Schmechel, D.E., Weise, V.K., Ransom, D.H., Tappaz, M.L., Krutzsch,
H.C. and Kopin, I.J.: Comparison of cycteine sulphinic acid decarboxylase isoenzymes and
glutamic acid decar-boxylase in rat liver and brain. Neuroscience 6(12): 2701-2714, 1981.
410. Oertel, W.H., Schmechel, D.E., Mugnaini, E., Tappaz, M.L. and Kopin, I.J.:
Immunocytochemical localization of glutamate decar-boxylase in rat cerebellum with a new
antiserum. Neuroscience 6(12): 2715-2735, 1981.
42
411. Oertel, W.H., Schmechel, D.E., Tappaz, M.L. and Kopin, I.J.: Production of a specific
antiserum to rat brain glutamic acid decarboxylase by injection of an antigen-antibody complex.
Neuro-science 6(12): 2689-2700, 1981.
412. Feuerstein, G., Zerbe, R.L., Ben-Ishay, D., Kopin, I.J. and Jacobowitz, D.M.:
Catecholamines and vasopressin in forebrain nuclei of hypertension prone and resistant rats.
Brain Res Bull 7: 671-676, 1981.
413. Kopin, I.J.: False transmitters revisited: Their role in the hypotensive action of MAO
inhibitors. In Kamijo, K., Usdin, E. and Nagatsu, T. (Eds.): Monamine Oxidase. Basic and
Clinical Frontiers. Amsterdam-Oxford-Princeton, Excerpta Medica 1981 (pp. 321-327).
43
413a Kim, Y.D., Jones, M., Hanowell, S.T., Koch, J.P., Lees, D.E., Weise, V. and Kopin, I.J.:
Changes in peripheral vascular and cardiac sympathetic activity before and after coronary artery
bypass surgery: Interrelationships with hemodynamic alterations. Am Heart J 102(6): 972-979,
1981.
1982
414. Feuerstein, G., Adelberg, S.A., Kopin, I.J. and Jacobowitz, D.M.: Hypothalamic sites for
cardiovascular and sympathetic modulation by prostaglandin E2. Brain Res 231: 335-342,
1982.
415. Elchisak, M.A., Polinsky, R.J., Ebert, M.H. and Kopin, I.J.: Kinetics of homovanillic acid
and determination of its production rate in humans. J Neurochem 38: 380-385, 1982.
416. Feuerstein, G., Zerbe, R.L., Meyer, D.K. and Kopin, I.J.: Alteration of cardiovascular,
neurogenic and humoral responses to acute hypovolemic hypotension by administered
prostacyclin. J Cardiovasc Pharmacol 4: 246-253, 1982.
417. Oertel, W.H., Mugnaini, E., Tappaz, M.L., Weise, V.K., Dahl, A.L., Schmechel, D.E. and
Kopin, I.J.: Central GABAergic innervation of neurointermediate pituitary lobe: Biochemical
and Immunocytochemical study in the rat. Neurobiology 79: 675-679, 1982.
418. Polinsky, R.J., Taylor, I.L., Weise, V., and Kopin, I.J.: Pancreatic polypeptide responses
to hypoglycemia in chronic autonomic failure: J Clin Endocrinol Metab 54: 48-52, 1982.
419. Feuerstein, G., Helke, C.J., Zerbe, R.L., Jacobowitz, D.M. and Kopin, I.J.: Mechanisms
involved in central cardiovascular effects of prostaglandin F2. Am J Physiol 242: (Regulatory
Integrative Comp Physiol 11): R545-R551, 1982.
420. Cohen, R.M., Campbell, I.C., Yamaguchi, I., Pickar, D. and Kopin, I.J.: Cardiovascular
changes in response to selective monoamine oxidase inhibition in the rat. Eur J Pharmacol 80:
155-160, 1982.
421. Oertel, W.H., Mugnaini, E., Schmechel, D.E., Tappaz, M.L. and Kopin, I.J.: The
immunocytochemical demonstration of Gamma-aminobutyric acid-ergic neurons -- Methods and
Application. Chan-Palay,V. and Palay, S.L. (Eds.): Cytochemical Methods in Neuroanatomy.
New York, Liss, Inc. 1982 (pp. 297-329).
422. Feuerstein, G., Zukowska-Grojec, Z., Krausz, M.M., Blank, M.L., Snyder, F. and Kopin,
I.J.: Cardiovascular and sympathetic effects of 1-0-hexadecyl-2-acetyl-sn-glycero-3-
phosphocholine in conscious SHR and WKY rats. Clin Exper Hypertens--A- 4(8): 1335-1350,
1982.
423. Bybee, D.E., Wiesen, M., Aronin, N., Krieger, D.T., Frohman, L.A. and Kopin, I.J.:
Failure of bromocriptine to lower plasma catecholamines in normal men and women. J Clinl
Endocrinol Metab 53(3): 648-650, 1982.
424. Poddubiuk, Z.M., Blumberg, J.B. and Kopin, I.J.: Brain prosta-glandin content in rats
sacrificed by decapitation vs focused microwave irradiation. Experientia 15(38): 987-988, 1982.
44
425. Zerbe, R.L., Feuerstein, G., Meyer, D.K. and Kopin, I.J.: Cardio-vascular, sympathetic,
and renin-angiotensin system responses to hemorrhage in vasopressin-decifient rats.
Endocrinology III(2): 608-613, 1982.
426. Feuerstein, G., Zerbe, R., Ben-ishay, D., Kopin, I.J. and Jacobowitz, D.M.:
Catecholamines and vasopressin hindbrain nuclei of hyper-tension prone and resistant rats.
Brain Res 251: 169-173, 1982.
427. Saller, C., Zerbe, R., Bayorh, M., Lozovsky, D. and Kopin, I.J.: Phencyclidine suppresses
plasma prolactin levels. Eur J Pharmacol 83: 309-311, 1982.
428. Zukowska-Grojec, Z., Bayorh, M., Kopin, I.J. and Feuerstein, G.: Leukotriene D4:
Cardiovascular and sympathetic effects in spon-taneously hypertensive rats (SHR) and Wistar-
Kyoto (WKY) rats. J Pharmacol Exp Ther 223: 183-189, 1982.
429. Bayorh, M. and Kopin, I.J.: Effect of phencyclidine (PCP) on adrenergic responses to
spinal cord stimulation in pithed rats. Eur J Pharmacol 85: 15-21, 1982.
430. Kopin, I.J.: Evolving views of the metabolic fate of norepine-phrine. Endocrinol Exp 16:
291-300, 1982.
431. Linnoila, M., Karoum, F., Calib, H.M., Kopin, I.J. and Potter, W.Z.: Alteration of
norepinephrine metabolism with desipramine and zimelidine in depressed patients. Arch Gen
Psychiatry 39: 1025-1028, 1982.
432. Pfeiffer, A., Feuerstein, G., Faden, A.I. and Kopin, I.J.: Evidence for an involvement of -
but not delta or kappa opiate receptors in sympa-thetically and parasympathetically mediated
cardiovascular responses to opiate upon intra-hypothalamic microinjection. Life Sci 31: 1279-
1282, 1982.
1983
433. Kopin, I.J., Gordon, E.K., Jimerson, D.C. and Polinsky, R.J.: Relation between plasma
and cerebrospinal fluid levels of 3-methoxy-4-hydroxy-phenyl-glycol. Science 219: 73-75,
1983.
434. Jimerson, D.C., Insel, T.R., Reus, V.I. and Kopin, I.J.: Increased plasma MHPG in
dexamethasone-resistant depressed patients. Arch Gen Psychiatry 40: 173-176, 1983.
435. Bayorh, M.A., Zukowska-Grojec, Z. and Kopin, I.J.: Effect of Desipramine and cocaine
on plasma norepinephrine and pressor responses to adrenergic stimulation in pithed rats. J Clin
Pharmacol 23: 24-31, 1983.
436. Zerbe, R.L., Bayorh, M.A., Quirion, R. and Kopin, I.J.: The role of vasopressin
suppression in phencyclidine-induced diuresis. Pharmacology 26: 73-78, 1983.
45
437. Zukowska-Grojec, Z., Bayorh, M.A., Yaar, I., Kopin, I.J. and Feuerstein, G.: Lukotriene
D4: Divergent cardiovascular and sympathetic effects in spon-taneously hypertensive and
normotensive Wistar-Kyoto rats. Adv Prostaglandin Thromboxane Res 11: 407-412, 1983.
438. Martin, P.R., Ebert, M.H., Gordon, E.K. and Kopin, I.J.: Urinary catecholamine
metabolites and effects of clonidine in patients with alcohol amnestic disorder. Clin Pharmacol
Ther 33(1): 19-27, 1983.
439. Bayorh, M.A., Zukowska-Grojec, Z., Ezra, D., Feuerstein, G.Z. and Kopin, I.J.:
Cardiovascular and sympathetic responses to chronic arachidonate in SHR and WKY rats.
Hypertension 5: 172-179, 1983.
440. Zukowska-Grojec, Z., Bayorh, M.A. and Kopin, I.J.: Effect of desipramine on the effects
of --adrenoceptor inhibitors on pressor responses and release of norepinephrine into plasma of
pithed rats. J Cardiovasc Pharmacol 5: 297-301, 1983.
441. Lozovsky, D., Saller, C.F., Bayorh, M.A., Chiueh, C.C., Rice, K.C., Burke, T.R., Jr. and
Kopin, I.J.: Effects of phencyclidine on rat prolactin, dopamine receptor and locomotor activity.
Life Sci 32: 2725-2731, 1983.
442. Lozovsky, D., Saller, C.F. and Kopin, I.J.: Lithium and the prevention of dopamine
receptor supersensitivity in diabetic rats. Am J Psychiatry 140(5): 613-614, 1983.
443. Goldstein, D.S., Lake, C.R., Chernow, B., Ziegler, M.G., Coleman, M.D., Taylor, A.A.,
Mitchell, J.R., Kopin, I.J. and Keiser, H.R.: Age-dependence of hypertensive-normotensive
differences in plasma norepinephrine. Hypertension 5: 100-104, 1983.
444. Chiueh, C.C., Zukowska-Grojec, Z., Kirk, K.L. and Kopin, I.J.:6-Fluorocatecholamines
as false adrenergic neurotransmitters. J Pharmacol Exp Ther 225: 529-533, 1983.
445. Burns, R.S., Chiueh, C.C., Markey ,S.P., Ebert, M.H., Jacobowitz, D.M. and Kopin, I.J.:
A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars
compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl
Acad Sci USA 80: 4546-4550, 1983.
446. Polinsky, R.J., Samaras, G.M., and Kopin, I.J.: A sympathetic neural prosthesis for
managing orthostatic hypotension. Lancet 1: 901-904, 1983.
447. Goldstein, D.S., McCarty, R., Polinsky, R.J. and Kopin, I.J.: Relationship between
plasma norepinephrine and sympathetic neural activity. Hyper-tension 5: 552-558, 1983.
448. Oertel, W.H., Graybiel, A.M., Mugnaini, E., Elde, R.P., Schmechel, D.E. and Kopin, I.J.:
Coexistence of glutamic acid decarboxylase- and somatostatin-like immunoreactivity in neurons
of the feline nucleus retricularis thalami. J Neurosci 3(6): 1322-1332, 1983.
449. Kopin, I.J., Polinsky, R.J., Oliver, J.A., Oddershede, I.R. and Ebert, M.H.: Urinary
catecholamine metabolites distinguish different types of sympathetic neuronal dysfunction in
patients with orthostatic hypotension. J Clin Endocrinol Metab 57(3): 632- 637, 1983.
46
450. Williford, D.J., Zavadil, A.P., Walsh, R.A., Weise, V., Kopin, I.J. and Gillis, R.A.:
Influence of vagotomy on changes in feline plasma catecholamine levels induced by occlusion of
either the left or right coronary vessel. Cardiovas Res 17: 568-576, 1983.
451. Zukowska-Grojec, Z., Bayorh, M.A., Zerbe, R.L., Palkovits, M. and Kopin, I.J.: Role of
catecholamines and vasopressin in cardio-vascular responses to bilateral dorsolateral transection
of the medulla oblongata in the rat. Hypertension 5(6): 908-915, 1983.
452. Jimerson, D.C., Rubinow, D.R., Ballenger, J.C., Post, R.M. and Kopin, I.J.: Peripheral
contribution to cerebrospinal fluid MHPG: Studies in depressed patients. Psychopharmacol Bull
19(4): 665-668, 1983.
453. Pfeiffer, A., Feuerstein, G., Kopin, I.J. and Faden, A.I.: Cardio-vascular and respiratory
effects of Mu-, Delta- and Kappa-opiate agonists micro-injected into the anterior hypothalamic
brain area of awake rats. J Pharmacol Exper Ther 225(3): 735-741, 1983.
454. Pfeiffer, A., Feuerstein, G., Zerbe, R.L., Faden, A.I. and Kopin, I.J.: m-Receptors mediate
opioid cardiovascular effects at anterior hypothalamic sites through sympatho-adrenomedullary
and parasympathetic pathways. Endocrinology 113(3): 929-938, 1983.
455. Zukowska-Grojec, Z., Bayorh, M., Faden, A.I., Kopin, I.J. and Feuerstein, G.:
Pharmacological intervention in the cardiovascular effects of leukotriene D4 in pithed
spontaneous hypertensive rats. In Piper, P.J. (Ed.): Leukotrienes and Other Lipoxygenase
Products. Chichester, England, John Wiley and Sons, 1983 (pp. 113-120).
456. Feuerstein, G., Zukowska-Grojec, Z., Bayorh, M., Kopin, I.J. and Faden, A.I.:
Leukotriene D4-induced hypotension is reversed by thyrotropin-releasing hormone.
Prostaglandins 26(5): 711-724, 1983.
457. Goldstein, D.S., Horwitz, D., Keiser, H.R., Polinsky, R.J. and Kopin, I.J.: Plasma --[3H]-
norepinephrine, d-[14C]-norepinephrine, and d,-,-[3H]-isoproterenol - kinetics in essential
hypertension. J Clin Invest 72: 1748-1758, 1983.
458. Bayorh, M.A., Lozovsky, D., Rice, K.C., Burke, T.R. Jr. and Kopin, I.J.: Cardio-vascular
and plasma prolactin responses to stereoisomers of phencyclidine. Pharmacol Biochem Behav
19: 365-367, 1983.
459. Ezra, D., Bayorh, M.A., Zukowska-Grojec, Z., Lazar, J.D. and Kopin, I.J.: Effects of
chronic arachidonate on blood pressure of spon-taneously hypertensive rats. Clin Exp Hypertens
5: 1485-1499, 1983.
460. Ross, R.J., Zavadil, A.P., Calil, H.M., Linnoila, M., Kitanaka, I., Blombery, P. and
Kopin, I.J.: Effects of desmethylimipramine on plasma norepinephrine, pulse, and blood
pressure. Clin Pharmacol Ther 33(4):-429-437, 1983.
1984
47
461. Angus, J.A., Bobik, A., Jackman, G.P., Kopin, I.J. and Korner, P.I.: Role of auto-
inhibitory feed-back in cardiac sympathetic transmission assessed by simultaneous
measurements of changes in [3H]-efflux and atrial rate in guinea-pig atrium. Br J Pharmacol
81: 201-214, 1984.
462. Kopin, I.J.: Plasma catecholamines as an index of a neuroendocrine response. In Shah,
N.S. and Donald, A.G. (Eds.): Psychoneuro-endocrine Dysfunction. New York, Plenum
Publishing Corporation, (pp. 157-171), 1984.
463. Martin, P.R., Weingartner, H., Gordon, E.K., Burns, R.S., Linnoila, M., Kopin, I.J. and
Ebert, M.H.: Central nervous system catechol-amine metabolism in Korsakoff’s psychosis. Ann
Neurol 15: 184-187, 1984.
464. Kopin, I.J.: Avenues of investigation for the role of catecholamines in anxiety.
Psychopathology 17(1): 83-97, 1984.
465. Solomon, S.L., Wallace, E.M., Ford-Jones, E.L., Baker, M., Martone, W. J., Kopin, I.J.,
Critz, A.D. and Allen, J.R.: Medication errors with inhalant epinephrine mimicking an epidemic
of neonatal sepsis. New Engl J Med 310: 166-170, 1984.
466. Kopin, I.J., Jimerson, D.C., Markey, S.P., Ebert, M.H. and Polinsky, R.J.: Disposition
and metabolism of MHPG in humans: Application to studies in depression. Pharmacopsychiatry
17: 3-8, 1984.
467. Feuerstein, G., Bayorh, M.A., Zerbe, R.L. and Kopin, I.J.: Peripheral pressor effects of
sympathetic stimulation, noradrenaline, angiotensin II and vasopressin in Brattleboro rats.
Naunyn Schmiedebergs Arch Pharmacol 325: 247-250, 1984.
468. Martin, P.R., Ebert, M.H., Gordon, E.K. Linnoila, M. and Kopin, I.J.: Effects of clonidine
on central and peripheral catecholamine metabolism. Clin Pharmacol Ther 35: 322-327, 1984.
469. Brown, R.T., Oliver, J., Kirk, K.L. and Kopin, I.J.: Determination of urinary 4-hydroxy-
3-methoxyphenylethylene glycol in man by high performance liquid chromatography with
electrochemical detection. Life Sci 34: 2313-2318, 1984.
470. Ward, C.D., Trombley, I.K., Calne, D.B. and Kopin, I.J.: L-Dopa decarboxy-lation in
chronically treated patients - Brief Communi-cations. Neurology 34: 198-201, 1984.
471. Kopin, I.J., Zukowska-Grojec, Z., Bayorh, M.A. and Goldstein, D.S.: Estimation of
intrasynaptic norepinephrine concentrations at vascular neuroeffector junctions in vivo. Naunyn-
Schmiedebergs Arch Pharmacol 325: 298-305, 1984.
472. Pfeiffer, A., Pfeiffer, D.G., Feuerstein, G., Faden, A.I. and Kopin, I.J.: An increase in
opiate receptor-sites is associated with enhanced cardiovascular depressant, but not respiratory
depressant action of morphine. Brain Res 296: 305-3ll, 1984.
473. Chiueh, C.C., Markey, S.P., Burns, R.S., Johannessen, J.N., Pert, A. and Kopin, I.J.:
Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4-
phenyl-1,2,3,6-tetrahydro-pyridine in the rat. Eur J Pharmacol 100: 189-194, 1984.
48
474. Kopin, I.J.: Catecholamines and the cardiovascular system: Recent advances in
biochemical evaluation of adrenergic activity. In Usdin, E., Carlsson, A. Dahlstrom, A. and
Engel, J. (Eds.): Catecholamines Part A: Basic and Peripheral Mechanisms. New York, Alan
R. Liss, Inc. 1984, pp. 347-355.
475. Polinsky, R.J., Jimerson, D.C. and Kopin, I.J.: Chronic autonomic failure: CSF and
plasma 3-methoxy-4-hydroxypenylglycol. Neurology 34: 979-983, 1984.
476. Kopin, I.J., Blombery, P., Ebert, M.H., Gordon, E.K., Jimerson, D.C., Markey, S.P. and
Polinsky, R.J.: Disposition and metabolism of MHPG-CD3 in humans: Plasma MHPG as the
principal pathway of norepinephrine metabolism and as an important determinant of CSF levels
of MHPG. In Usdin, E., Sjoqvist, F. and Bertilsson, L. (Eds.): Frontiers in Biochemical and
pharmacological Research in Depression. New York, Raven Press, 1984, 57-68.
477. Jimerson, D.C., Rubinow, D.R., Ballenger, J.C., Post, R.M. and Kopin, I.J.:
Cerebrospinal fluid norepinephrine metabolites in depressed patients: New methodologies. In
Usdin, E., Carlsson, A., Dahlstrom, A. and Engel, J. (Eds.): Catecholamines: Neuro-
pharmacology and Central Nervous System -Therapeutic Aspects. New York, Alan R. Liss, Inc.
1984, pp. 123-129.
478. Kafka, M.S., Polinsky, R.J., Williams. A., Kopin, I.J., Lake, C.R., Ebert, M.H. and
Tokola, N.S.: Alpha-adrenergic receptors in ortho-static hypotension syndromes. Neurology 34:
1121-1125, 1984.
479. Zamir, N., Bannon, M.J., Helke, C.J., Kopin, I.J. and Jacobowitz, D.M.: Primate Model
of Parkinson’s Disease: alterations in multiple opioid systems in the basal ganglia. Brain Res
322:356-360, 1984.
480. Kopin, I.J.: Neurotransmitters and neuropsychopharmacology in Stetten, Jr., D., (Ed.) and
Carrigan, W. T., (Assoc. Ed.), NIH: An Account of Research in its Laboratories and Clinics.
New York, Academic Press, 1984, 34-45.
481. Angus, J.A., Korner, P.I., Jackman, G.P., Bobik, A. and Kopin, I.J.: Role of
autoinhibitory feedback in cardiac sympathetic transmission. Clin Exp Hypertens (A) 6(1-2):
371-385, 1984.
482. DeQuattro, V., Sullivan, P., Minagawa R., Kopin, I., Bornheimer, J., Foti, A., and Barndt,
R.: Central and peripheral noradrenergic tone in primary hypertension. Fed Proc 43(1): 47-51,
1984.
483. Chiueh, C.C., Burns, R.S., Markey, S.P., Jacobowitz, D.M. and Kopin, I.J.: Primate
model of parkinsonism: Selective lesion of nigro-striatal neurons by 1-methyl-4-phenyl-1,2,3,6-
tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys: Life Sci 36: 213-
218, 1984.
484. Bayorh, M.A., Zukowska-Grojec, Z., Palkovits, M. and Kopin, I.J.: Effect of
phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei. Brain
Res 321: 315-318, 1984
49
485. Chiueh, C.C., Markey, S.P., Burns, R.S., Johannessen, J.N., Jacobowitz, D.M. and Kopin,
I.J.: Selective neurotoxic effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in
subhuman primates and man: A new animal model of parkinson’s disease. Psychopharmacol
Bull 20: 548-553, 1984.
486. Zavadil, A.P., Ross, R.J., Calil, H.M., Linnoila, M., Blombery, P., Jimerson, D.C., Kopin,
I.J. and Potter, W.Z.: The effect of desmethylimipramine on the metabolism of norepinephrine.
Life Sci 35(10): 1061-1068, 1984.
487. Bayorh, M.H., Zukowska-Grojec, Z., Kopin, I.J. and Feuerstein, G: Leukotriene D4
inhibits cardiovascular responses to sympathetic stimu-lation, angiotensin and vasopressin in the
pithed spontaneously hypertensive rat. J Pharmacol Exp Ther 231(1): 85-90, 1984.
488. Jacobowitz, D.M., Burns, R.S., Chiueh, C.C. and Kopin, I.J.: N-methyl-4- phenyl-
1,2,3,6-tetra-hydropyridine (MPTP) causes destruction of the nigrostriatal but not the
mesolimbic dopamine system in the monkey. Psychopharmacol Bull, 20:(3):416-422, 1984.
489. Feuerstein, G., Lozovsky, D., Cohen, L.A., Labroo, V.M., Kirk, K.L., Kopin, I.J. and
Faden, A.I.: Differential effect of fluorinated analogs of TRH on the cardiovascular system and
prolactin release. Neuropeptides 4(4): 303-310, 1984.
1985
490. Zukowska-Grojec, Z., Zerbe, R.L., Jimerson, D.C., Bayorh, M.A., Palkovits, M. and
Kopin, I.J.: Catecholaminergic activity of the baroreceptor areas of the brain in response to
bilateral dorsolateral transection of medulla oblongata in rats. Brain Res 325: 231-240, 1985.
491. Kopin, I.J.: Biochemical evaluation of sympatho-adrenal medullary activity - An
overview. In Ben-Jonathan, N., Bahr, J.M. and Weiner, R.I. (Eds): Catecholamines as hormone
regulators, Vol. 18. Serono Symposia. New York, Raven Press, 1985, 175-188.
492. Torda, T. and Kopin, I.J.: Lack of preventive effect of 6-hydroxy-dopamine on a
decrease of beta-adrenergic receptors induced by repeated stress in the heart of rats. Endocrinol
Exp (Bratisl) 19(1): 47-51, 1985.
493. Bayorh, M.A. and Kopin, I.J.: Effect of phencyclidine (PCP) on adrenergic responses to
spinal cord stimulation in pithed rats. Eur J Pharmacol 85: 15-21, 1985.
494. Burns, R.S., LeWitt, P.A., Ebert, M.H., Pakkenberg, H. and Kopin, I.J.: The clinical
syndrome of striatal dopamine deficiency. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-
tetrahydropyridine (MPTP). N Engl J Med 312(22): 1418-1421, 1985.
495. Goldstein, D.S., Zimlichman, R., Stull, R., Folio, J., Levinson, P.D., Keiser, H.R. and
Kopin, I.J.: Measurement of regional neuronal removal of norepinephrine in man. J Clin Invest
76: 15-21, 1985.
50
496. Zukowska-Grojec, Z., Bayorh, M.A., Kopin, I.J. and Feuerstein, G.: Overall and regional
hemodynamic effects of leukotriene D4 in spontaneously hypertensive rats. Hypertension 7(4):
507-513, 1985.
497. Polinsky, R.J., Goldstein, D.S., Brown, R.T., Keiser, H.R. and Kopin, I.J.: Decreased
sympathetic neuronal uptake in idiopathic orthostatic hypotension. Annals of Neurology: 18(1):
48-53, 1985.
498. Lozovsky, D., Kopin, I.J. and Saller, C.F.: Modulation of dopamine receptor
supersensitivity by chronic insulin: implication in schizophrenia. Brain Res 343(1): 190-193,
1985.
499. Haass, M., Kopin, I.J., Goldstein, D.S. and Zukowska-Grojec, Z.: Differential inhibition
of alpha adrenoceptor-mediated pressor responses by rat atrial natriuretic peptide in the pithed
rat. J Pharmacol Exp Ther 235(1): 122-127, 1985.
500. Weise, V.K., Palkovits, M. and Kopin, I.J.: Effect of ventral noradrenergic bundle
transection and locus coeruleus lesions on urinary 3-methoxy-4-hydroxyphenylethylenglycol
(MHPG) excretion in the rat. Brain Res 359(1-2): 239-245, 1985.
501. Kopin, I.J.: Catecholamine metabolism: Basic aspects and clinical significance.
Pharmacol Rev 37: 333-364, 1985.
502. Corsini, G.U., Pintus, S., Chiueh, C.C., Weiss J.F. and Kopin, I.J.: 1-Methyl-4-phenyl-
1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with
diethyldithiocaramate. Eur J Pharmacol 119(1-2): 127-128 1985.
503. Bayorh, M.A., Zukowska-Grojec, Z., Ezra, D., Kopin, I.J. and Feuerstein, G: Leukotriene
D4 reduces pressor responses to sympathetic stimulation, angiotensin, and vasopressin. Adv
Prostaglandin Thromboxamane Leukotriene Res 13:51-54, 1985.
1986
504. Fournier, R.D., Chiueh, C.C., Kopin, I.J., Knapka, J.J., DiPette, D. and Preuss, H.G.:
Refined carbohydrate increases blood pressure and catecholamine excretion in SHR and WKY.
Am J Physiol 250: E381-E385, 1986.
505. Goldstein, D.S., Zimlichman, R., Stull, R., Keiser, H.R. and Kopin, I.J.: Estimation of
intrasynaptic norepinephrine concentrations in humans. Hypertension 8(6): 471-475, 1986.
506. Finberg, J.P.M. and Kopin, I.J.: Chronic clorgyline treatment enhances release of
norepinephrine following sympathetic stimulation in the rat. Naunyn-Schmiedeberg’s Arch
Pharmacol 332: 236-242, 1986.
507. Bankiewicz, K.S., Oldfield, E.H., Chiueh, C.C., Doppman, J.L., Jacobowitz, D.M. and
Kopin, I.J.: Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-
methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci 39: 7-16, 1986.
51
508. Joyce, J.N., Marshall, J.F., Bankiewicz, K.S., Kopin, I.J. and Jacobowitz, D.M.:
Hemiparkinsonism in a monkey after unilateral internal carotid artery infusion of 1-methyl-4-
phenyl-1,2,3,6-tetrahydropyridine (MPTP) is asso-ciated with regional ipsilateral changes in
striatal dopamine D2 receptor density. Brain Res 382(2): 360-364, 1986.
509. Preuss, H.G., Fournier, R.D., Chiueh, C.C., Kopin, I.J., Knapka, J.J., DiPette, D., More,
N.W. and Rao, N.A.: Refined carbohydrates affect blood pressure and retinal vasculature in
spontaneously hypertensive and Wistar Kyoto rats. J. Hypertens [Suppl] 4: S459-S462, 1986.
52
510. Kopin, I.J., Burns, S.R., Chiueh, C.C. and Markey, S.: MPTP-induced parkinsonian
syndromes in humans and animals. In: Fisher, A., Hanin I. and Lachman, C. (Eds.) Alzheimer’s
and Parkinson’s Diseases New York, Plenum Publishing Corporation, 519-530, 1986.
511. Zukowska-Grojec, Z., Haass, M., Kopin, I.J. and Zamir, N.: Interactions of artial
natriuretic peptide with the sympathetic and endocrine systems in the pithed rat. J Pharmacol
Exp Ther 239(2): 480-487, 1986.
512. Eisenhofer, G., Goldstein, D.S., Stull R., Keiser, H.R., Sunderland T., Murphy, D.L. and
Kopin, I.J.: Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol,
catecholamines, and 3,4-dihydroxypheyl-alanine in plasma, and their responses to inhibition of
monoamine oxidase. Clin Chem 32(11): 2030-2033, 1986.
513. Siever, L.J., Uhde, T.W., Jimerson, D.C., Lake, C.R., Kopin, I.J. and Murphy D.L.:
Indices of noreadrenergic output in depression. Psychiatry Res 19(1): 59-73, 1986.
514. Kopin, I.J.: Toxins and Parkinson’s Disease: MPTP Parkinsonism in Humans and
Animals. In: Yahr, M.D., Bergmann, K.J. (Eds.) Advances in Neurology, New York, Raven
Press, 137-144, 1986.
515. Chiueh, C.C., Firnau, G., Burns, R.S., Nahmias, C., Chirakal, R., Kopin, I.J. and Garnett,
E.S.: Determination and visualization of damage to striatal dopaminergic terminals in 1-Methyl-
4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism by [18F]-labeled 6-fluoro-L-dopa and
positron emission tomography. Adv. Neurol. 45:167-169, 1986.
516. Chiueh, C.C., Burns, R.S., Kopin, I.J. and Kirk, K.L.;6-18F-DOPA/Position emission
tomography visualized degree of damage to brain dopamine in basal ganglia of monkeys with
MPTP-induced parkinsonism. In: Markey, S.P., Castagnoli, N., Jr., Trevor, A.J. and Kopin, I.J.
(Eds.) MPTP: A Neurotoxin Producing a Parkinsonian Syndrome, Orlando, Florida, Academic
Press, 327-338, 1986.
1987
517. Corsini, G.U., Zuddas, A., Bonuccelli, U. Schnelli, S. and Kopin, I.J.: 1-Methyl-4-
phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhan-ced by ethanol or
acetaldehyde. Life Sci. 40: 827-832, 1987.
518. Polinsky, R.J., Brown, R.T., Lee, G.K., Timmers, K., Culman, J., Foldes, O., Kopin, I.J.
and Recant, L.: Endorphin, ACTH, and catecholamine responses in chronic autonomic failure.
Ann. Neur. 22:573-577, 1987.
519. Kopin, I.J.: Toxins and Parkinson’s disease: MPTP parkinsonism in humans and animals.
Adv. Neurol. 45:137-144, 1987.
520. Pohl, R., Ettedgui, E., Bridges, M., Lycaki, H., Jimerson, D., Kopin, I., and Rainey, J.M.:
Plasma MHPG levels in lactate and isoproterenol anxiety states. Biol. Psychiatry 22:1127-1136,
1987.
53
521. Porrino, L.J., Burns, R.S., Crane, A.M., Palombo, E., Kopin, I.J., and Sokoloff, L.:
Changes in local cerebral glucose utilization associated with Parkinson’s syndrome indiced by 1-
methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the primate. Life Sci. 40:1657-1664,
1987.
522. Kopin, I.J.: MPTP-induced neurotoxicity. In: Peter Jenner, (Ed): Neurotoxins and Their
Pharmacological Implications, New York, Raven Press, 163-178, 1987.
523. Chiueh, C.C., Firnau, G., Burns, R.S., Nahmias, C., Chirakal, R., Kopin, I.J., and Garnett,
E.S.: Determination and visualization of damage of striatal dopaminergic terminals in 1-methyl-
4-phenyl-1,2,3,6-tetrahydropyridine-induced parkin-sonism by [18F]-labelled 6-fluoro-L-dopa
and positron emission tomo-graphy. Adv. Neurol. 45:167-169, 1987.
524. Goldstein, D.S., Udelsman, R., Eisenhofer, G., Stull, R., Keiser, H.R., and Kopin, I.J.:
Neuronal source of plasma dihydroxyphenylalanine. J. Clin. Endocrinol. Metab. 64:856-861,
1987.
525. Eisenhofer, G., Ropchak, T.G., Stull, R.W., Goldstein, D.S., Keiser, H.R., and Kopin,
I.J.: Dihydroxyphenylglycol and intraneuronal metabolism of endogenous and exogenous
norepinephrine in the rat vas deferens. J. Pharmacol. Exp. Ther. 241:547-553, 1987.
526. Goldstein, D.S., Eisenhofer, G., Sax, F.L., Keiser, H.R., and Kopin, I.J.: Plasma
norepinephrine pharmacokinetics during mental challenge, Psychosomatic Medicine: 49:591-
605, 1987.
527. Eisenhofer, G., Goldstein, D.S., Stull, R.W., Gold, P.W., Keiser, H.R., and Kopin, I.J.:
Short Communication. Dissociation between corticotrophin and catecholamine responses to
isoprenaline in humans, Clin. and Exp. Pharmacol. & Physiol. 14:337-341, 1987.
528. Brown, R.T., Polinsky, R.J., and Kopin, I.J.: Interconversion of O-methylated
norepinephrine metabolites in humans. J. Lab. Clin. Med. 110:119-124, 1987.
529. Haass, M., Zukowska-Grojec, Z, Kopin, I.J., and Zamir, N.: Role of autonomic nervous
system and vasoactive hormones in the release of atrial natriuretic peptides in conscious rats. J.
Cardiovasc. Pharmacol. 10:424-432, 1987.
530. Barone, P., Bankiewicz, K.S., Corsini, G.U., Kopin, I.J., and Chase, T.N.: Dopaminergic
mechanisms in hemiparkinsonian monkeys. Neurology 37:1592-1595, 1987.
531. Finberg, J.P., and Kopin, I.J.: Chronic clonidine treatment produces desensitisation of
post- but not presynaptic alpha 2-adrenoceptors. Eur. J. Pharmacol. 138:95-100, 1987.
532. Porrino, L.J., Burns, R.S., Carne, A.M., Palombo, E., Kopin, I.J., Sokoloff, L.: Local
cerebral metabolic effects of L-dopa therapy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-
induced parkinsonism in monkeys. Proc. Natl. Acad. Sci. 84:5995-5999, 1987.
533. Eisenhofer, G., Goldstein, D.S., Stull, R., Ropchak, T.G., Keiser, H.R., Kopin, I.J.:
Dihydroxyphenylglycol and dihydroxymandelic acid during intravenous infusions of
noradrenaline. Clin. Sci. 73:123-127, 1987.
54
534. Kopin, I.J.: MPTP: An industrial chemical and contaminant of illicit narcotics stimulates
a new era in research on Parkinson’s Disease. Environ.Health Perspect. 75:45-51, 1987.
534a. Schuette, W.H., Bankiewicz, K.S., Markowitz, A., Plowman, F.A., Kopin, I.J.: A system
for measuring the angular response of hemiparkinsonian monkeys to a food stimulus. Med.
Instrum. 21: 314-316, 1987.
1988
535. Kopin, I.J. and Schoenberg, D.G.: MPTP in animal models of Parkinson’s disease: Mt.
Sinai J. Med. 55:43-49, 1988.
536. Kopin, I.J. and Markey, S.P.: MPTP Toxicity: Implications for research in Parkinson’s
disease. Am. Rev. Neurosci. 11:81-96.
55
537. Kopin, I.J.: New opportunities for Parkinson’s disease research: The MPTP-induced
parkinsonian syndrome in humans and animals. In: Jack D. Barchas, William E. Bunney, Jr.,
(Eds.), Perspectives in Psychopharmacology; A Collection of Papers in Honor of Earl Usdin.
Neurology and Neurobiology, Vol. 40. New York, Alan R. Liss, Inc., 249-262, 1988.
538. Polinsky, R.J., Taylor, I.L., Weise, V., Kopin, I.J.: Gastrin responses in patients with
adrenergic insufficiency. J. Neurol. Neurosurg. Psychiatry. 51:67-71, 1988.
539. Kopin, I.J., Bankiewicz, K., Harvey-White, J: Assessment of brain dopamine metabolism
from plasma HVA and MHPG during debrisoquin treatment: Validation in monkeys treated with
MPTP. Neuropsychopharmacology 1(2):119-125, 1988.
540. Brücke, T., Bankiewicz, K., Harvey-White, J., Kopin, I.J.: The partial dopamine receptor
agonist terguride in the MPTP-induced hemiparkinsonian monkey model. Eur. J. Pharmacol.
148:445-448, 1988.
541. Eisenhofer, G., Ropchak, T.G., Kopin. I.J., Goldstein, D.S.: Release, metabolism, and
intraneuronal disposition of newly synthesized norepinephrine in rat vas deferens. J. Pharmacol.
Exp. Ther. 245:81-88, 1988.
542. Goldstein, D.S., Eisenhofer, G., Stull, R., Folio, C.J., Keiser, H.R., Kopin, I.J.: Plasma
dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans. J. Clin.
Invest. 81:213-220, 1988.
543. Schinelli, S., Zuddas, A., Kopin, I.J., Barker, J.L., di Porzio, U.: 1-Methyl-4-phenyl-
1,2,3,6-tetrahydropyridine metabolism and 1-methyl-4-phenylpyridinium uptake in dissociated
cell cultures from the embryonic mesencephalon. J. Neurochem. 50:1900-1907, 1988.
544. Kopin, I.J., Oliver J.A., Polinsky, R.J.: Relationship between urinary excretion of
homovanillic acid and norepinephrine metabolites in normal subjects and patients with
orthostatic hypotension. Life Sci. 43:125-131, 1988.
545. Kopin, I.J., Bankiewicz, K., Harvey-White, J.: Effect of MPTP-induced parkinsonism in
monkeys on the urinary excretion of HVA and MHPG during debrisoquin administration. Life
Sci. 43:133-141, 1988.
546. Szemeredi, K., Zukowska-Grojec, Z., Bagdy, G., Hill, J., Kopin, I.J.: Evidence for a
direct peripheral effect of clonidine on the norepinephrine release in vivo in pithed rats. Eur. J.
Pharmacol. 145(3):251-255, 1988.
547. Ho, V.W., Porrino, L.J., Crane, A.M., Burns, R.S., Kopin, I.J., Sokoloff, L.: Metabolic
mapping of the oculomotor system in MPTP-induced parkinsonian monkeys. Ann. Neurol.
23:86-89, 1988.
548. Kopin, I.J., Harvey-White, J, Bankiewicz, K.: A new approach to biochemical evaluation
of brain dopamine metabolism. Cell Mol. Neurobiol. 8(2):171-179, 1988.
56
549. Polinsky, R.J., Brown, R.T., Burns, R.S., Harvey-White, J., Kopin, I.J.: Low lumbar CSF
levels of homovanillic acid and 5-hydroxyindoleacetic acid in multiple system atrophy with
autonomic failure. J. Neurol. Neurosurg. Psychiatry. 51:914-919, 1988.
550. Szemeredi, K., Bagdy, G., Stull, R., Keiser, H.R., Kopin, I.J., Goldstein, D.S.:
Sympathoadrenomedullary hyper-responsiveness to yohimbine in juvenile spontaneoulsy
hypertensive rats. Life Sci. 43:1063-1068, 1988.
551. Duncan, M.W., Kopin, I.J., Garruto, R.M., Lavine L., Markey, S.P.: 2-Amino-
3(methylamino)-propionic acid in cycad-derived foods is an unlikely cuase of amyotrophic
lateral sclerosis/parkinsonism. Lancet, September 10, 1988, p 631, 1988.
552. Eisenhofer, G., Goldstein, D.S., Ropchak, T.G., Nguyen, H.Q., Keiser, H.R., Kopin, I.J.:
Source and physiological significance of plasma 3,4-dihydroxyphenylglycol and 3-methoxy-4-
hydroxyphenylglycol. J. Auton. nerv. Syst., 24:1-14, 1988.
553. Szemeredi, K., Bagdy, G., Stull, R., Calogero, A.E., Kopin, I.J., Goldstein, D.S.:
Sympathoadrenomedullary inhibition by chronic glucocorticoid treat-ment in conscious rats.
Endocrinology 123:2585-2590, 1988.
554. Hovevey-Sion, D., Harvey-White, Kopin, I.J.: Measurement of homovanillic acid in
small volumes of plasma using liquid chromatography with electrochemical detection. J.
Chromatog. 426:141-147.
555. Palombo, E., Porrino, L.J., Bankiewicz, K.S., Crane, A.M., Kopin, I.J., Sokoloff, L.:
Administration of MPTP acutely increases glucose utilization in the substantia nigra of primates.
Brain Res. 453:227-234, 1988.
556. Eisenhofer, G., Kirk, K.L., Kopin, I.J., Goldstein, D.S.: Simultaneous determination of
endogenous catechols and exogenous 2- and 6-fluorinated catechols in tissue and plasma using
liquid chromatography with electrochemical detection. J. Chromatog. 431:156-162, 1988.
557. Eisenhofer, G., Ropchak, T., Nguyen H., Keiser, H.R., Kopin, I.J., Goldstein, D.S.:
Source and physiological significance of plasma 3,4-dihydroxyphenylalanine in the rat. J.
Neurochem. 51:1204-1213, 1988.
558. Goldstein, D.S., Kopin, I.J.: Plasma norepinephrine as an index of sympathetic neuronal
function in health and disease. In Saito E. (Ed.), Progress in Hypertension. (Vol. I).
Neurotransmitters as Modulators of Blood Pressure. Utrecht, Holland; VNU Science Press,
1988, pp. 65-87.
559. Bankiewicz, K.S., Plunkett, R.J., Kopin, I.J., Jacobowitz, D.M., London, W.T., Oldfield,
E.H.: Transient behavioral recovery in hemiparkinsonian primates after adrenal medullary
allografts. Progress in Brain Research 78:543-549. In: D.M. Gash and J.R. Sladek, Jr., (Eds.)
Transplantation into the Mamalian CNA: Preclinical and Postclinical Studies. Elsevier,
Amsterdam, 1988.
560. Kopin, I.J.: MPTP effects on dopamine neurons. In: The Mesocorticolimbic Dopamine
System. Vol. 537, Annals of the New York Academy of Sciences, 1988.
57
561. Kopin, I.J., Eisenhofer, G., Goldstein, D.S.: Adrenergic response following recognition of
stress. in G.P. Chrousos, D. L. Loriaux, P.W. Gold (Eds.), Mechanisms of Physical and
Emotional Stress. Plenum Press, New York, 1988.
562. Kopin, I.J., Bankiewicz, K.S., Plunkett, R.J., Porrino, L., Jacobowitz, D.M., London,
W.T., Oldfield, E.H.: Recent Advances in dopaminergic implants. In Hefti, F., and Weiner, W.J.
(Eds.), Progress in Parkinson Research. Plenum Publishing Corporation, 1988, pp. 205-210.
563. Kopin, I.J., Bankiewicz, K.S., Palombo, E., Porrino, L.: Nonmotor aspects of chronic 1-
methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in primates. In Sandler, M., Dahlstrom, A.,
Belmaker, R.H. (Eds.), Progress i Catecholamine Research, Part B: Central Aspects. Alan R.
Liss, New York, NY, 1988, pp. 109-112.
58
1989
564. Kopin, I.J., Eisenhofer, G., Goldstein, D.: Adrenergic response following recognition of
stress. In S. Breznitz and O Zinder (Eds.), Molecular Biology of Stress. Alan R. Liss, Inc., New
York, 1989, pp. 123-132.
565. Kopin, I.J.: Plasma levels of catecholamines and dopamine---hydroxylase. In: U.
Trendelenburg and N. Weiner (Eds.) Handbook of Experimental Pharmacology, Vol. 90/III.
Springer-Verlag, Heidelberg, Germany, 1989.
566. Szemeredi, K., Zukowska-Grojec, Z., Bagdy, G., Feketes, M.I., Kopin, I.J.: Opposite
effects of chronic cortisol treatment on pre- and postsynaptic actions of clonidine in pithed rats.
J. Auton. Pharmac. 9:35-43, 1989.
567. Eisenhofer, E., Hovevey-Sion, D., Kopin, I.J., Miletich, R., Kirk, K.L., Finn, R.,
Goldstein, D.S.: Neuronal uptake and metabolism of 2- and 6-fluorodopamine: False
neurotransmitters for positron emission tomographic imaging of sympathetically innervated
tissues. J. Pharmacol. Exp. Ther. 248:419-427, 1989.
568. Eisenhofer, E., Brush, J.E., Cannon, R.O., Stull, R., Kopin, I.J., Goldstein, D.S.: Plasma
dihydroxyphenylalanine and total body and regional noradrenergic activity in humans. J. Clin.
Endocrin. Metab., 68:247-255, 1989.
569. Eisenhofer, E., Goldstein, D.S., Kopin, I.J.: Plasma dihydroxyphenylglycol for estimation
of noradrenaline neuronal re-uptake in the sympathetic nervous system in vivo. Clinical Sci.,
76:171-182, 1989.
570. Duncan, M.W., Kopin, I.J., Crowley, J.S., Jones, S.M., Markey, S.P.: Quantification of
the putative neurotoxin 2-amino-3-(methylamino) propanoic acid (BMAA) in cycadales:
Analysis of the seeds of some members of the family Cycadaceae. J. Anal. Toxicol., 13:169-
175, 1989.
57l. Deka-Starosta, A., Garty, M., Zukowska-Grojec, Z., Keiser, H.R., Kopin, I.J., Goldstein,
D.S.: Renal sympathetic nerve activity and norepinephrine release in rats. Am. J. Physiol.
257:R229-R236, 1989.
572. Johannessen, JN, Chiueh, CC, Bacon, JP, Garrick, NA, Burns, RS, Weise, VK, Kopin, IJ,
Parisi, JE, Markey, SP. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the Dog:
Effect of Pargyline Pretreatment. J Neurochem 1989 582-589.
573. Zuddas, A., Corsini, G.U., Schinelli, S., Barker, J.L., Kopin, I.J., diPorsio, U.:
Acetaldehyde directly enhances MPP+ neurotoxicity and delays its elimination from the
striatum. Brain Res, 501:11-22, 1989.
574. Zuddas, A., Corsini, G.U., Schinelli, S., Johannessen, J.N., diPorzio, U., Kopin, I.J.;
MPTP treatment combined with ethanol or acetaldehyde selectively destroys dopaminergic
neurons in mouse substantia nigra. Brain Res, 501:1-10, 1989.
59
575. Goldstein, D.S., Polinsky, R.J, Garty, M., Robertson, D., Brown, R.T., Biaggioni, I.,
Stull, R., Kopin, I.J.: Patterns of plasma levels of catechols in neurogenic orthostatic
hypotension. Ann. Neurol. 26:558-563, 1989.
576. Goldstein, D.S., Eisenhofer, G., Garty, M, Sax, F.L., Keiser, H.R., Kopin, I.J.:
Pharmacologic and tracer methods to study sympathetic function in primary hypertension. Clin.
Exp. Hypertens. 11:173-189, 1989.
577. Garty, M., Deka-Starosta, A., Stull, R., Kopin, I.J., Goldstein, D.S. Plasma levels of
catechols after fasting in intact or adrenal-demedullated rats. J. Auton. Nerv. Syst., 26:181-184.
578. Goldstein, D.S., Eisenhofer, G., Garty, M., Folio, C.J., Stull, R., Brush, J.E., Sax, F.L.,
Keiser, H.R., Kopin, I.J. Implications of plasma levels of catechols in the evaluation of
sympathoadrenomedullary function. Am. J. Hypertens., 2:133S-139S, 1989.
579. Garty, M., Stull, R., Kopin, I.J., Goldstein, D.S., Skin color, aging, and plasma L-dopa
levels. J. Auton. Nerv. Syst., 26:261-263, 1989.
580. Garty, M., Deka-Starosta, A., Chang, P.C., Eisenhofer, G., Zukowska-Grojec, Z., Stull,
R., Kopin, I.J., Goldstein, D.S. Plasma levels of catechols during reflexive changes in
sympathetic nerve activity. Neurochem. Res., 14:523-531, 1989.
581. Hovevey-Sion, D., Kopin, I.J., Stull, R.W., Goldstein, D.S., Effects of monoamine
oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma.
Neuropharmacology 28:791-797, 1989.
582. Szemeredi, K., Stull, R., Kopin, I.J., Goldstein, Effects of a peripherally acting -2-
adrenoceptor antagonist (L-659, 066) on hemodynamics and plasma levels of catechols in
conscious rats. E. J. Pharmacol. 170:53-59, 1989.
583. Marini, A.M., Schwartz, J.P., Kopin, I.J., The neurotoxicity of 1-methyl-4-
phenylpyridinium in cultured cerebellar granule cells, J. Neurosci., 9:3665-3672, 1989.
584. Kopin, I.J. Reflections of the role of Adrenergic mechanisms in ventricular arrhythmias,
In: J. Brachmann, A. Schomig (Eds.) Adrenergic System and Ventricular Arrhythmias in
Myocardial Infarction, Springer-Verlag, New York, pp. 123-1133, 1989.
585. Goldstein, D.S., Kopin, I.J., The autonomic nervous system and catecholamines in
normal blood pressure control and in hypertension, in: J.H.Laragh, B.M. Brenner, (Eds.),
Hypertension: Pathophysiology, Diagnosis, and Management. Raven Press, New York, p. 711,
1989.
586. Szemeredi, K., Bagdy, G., Kopin, I.J., Goldstein, D.S., Neurocirculatory regulation in
cortisol-induced hypertension, Clin. Exper. Hyper., A11:1425-1439, 1989.
587. Culman, J., Chiueh, C.C., Foldes, O., Kopin, I.J.: Circulating catecholamines are not
involved in immobilization stress-induced plasma ACTH rise in rats with transection of the
pituitary stalk. In: G.R. Van Loon, R. Kvetnansky, R. McCarty and J. Axelrod. (Eds.) Stress:
60
Neurochemical and Humoral Mechanisms. Gordon and Breach Science Publishers, S.A., New
York, 425-436, 1989.
1990
588. Bankiewicz, K.S., Plunkett, R.J., Jacobowitz, D.M., Porrino, L., di Porzio, U., London,
W.T., Kopin, I.J., and Oldfield, E.H., The effect of fetal mesencephalon implants on primate
MPTP-induced parkinsonism: Histochemical and behavioral studies, J. Neurosurg., 231-144,
1990.
589. Kopin, I.J.: False Adrenergic transmitters and positron emission tomographic imaging of
myocardial sympathetic innervation. Circulation, 82:646-648, 1990.
590. Szemeredi, K., Komoly, S., Kopin, I.J., Bagdy, G., Keiser, H.R., Goldstein, D.S.:
Simultaneous measurement of plasma and brain extracellular fluid concentrations of catechols
after yohimbine administration in rats. Brain Research, 542:8-14, 1990.
591. Kopin, I.J.: In-vivo quantitative imaging of catecholaminergic nerve terminals in brain
and peripheral organs using positron emission tomography (PET). J. Neural Transm. 32:19-27,
1990.
592. Garty, M., Deka-Starosta, Chang, P., Kopin, I.J., Goldstein, D.S.: Effects of clonidine on
renal sympathetic nerve activity and norepinephrine spillover, J. Pharmacol. Exp. Therap.
254:1068-1075, 1990.
593. Bankiewicz, K.S., Plunkett, R.I., Mefford, I., Kopin, I.J., Oldfield, E.H., Behavioral
recovery from MPTP-induced parkinsonism in monkeys after intracerebral tissue implants is not
related to CSF concentrations of dopamine metabolites. Prog. Brain Res. 82:561-5671, 1990.
594. Garty, M., Deka-starosta, A., Stull, R., Kopin, I.J., Goldstein, D.S., Effects of general
anesthetics on plasma levels of catechols in intact and in adrenal-demedulated rats. Biogenic
Amines, 5:435-443, 1990.
595. Szemeredi, K., Bagdy, G., Stull, R., Kopin, I.J., Goldstein, D.S., Cortisol and alpha-2
adrenergic regulation of sympathoneural activity, Biogenic Amines, 5:445-454, 1990.
596. Hovevey-Sion, D., Eisenhofer, G., Kopin, I.J., Kirk, K.I., Szemeredi, K., Goldstein, D.S.
Metabolic fate of injected radiolabelled dopamine and 2-fluorodopamine in rats,
Neuropharmacol. 29:881-887, 1990.
597. Goldstein, D., Chang, P.C., Eisenhofer, G., Miletich, R., Finn, R., Bacher, J., Kirk, K.L.,
Bacharach, S., Kopin, I.J. Positron emission tomographic imaging of cardiac sympathetic
innervation and function. Circulation 81(5):1606-1621, 1990.
598. Duncan, M.W., Steele, J.C., Kopin, I.J., Markey, S.P. 2-Amino-3-(methylamino)-
propanoic acid (BMAA) in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and
parkinsonism-dementia of Guam. Neurology 40:767-772, 1990.
61
599. Chang, P.C., Szemeredi, K., Grossman, E., Kopin, I.J., Goldstein, D.S. Fate of tritiated 6-
fluorodopamine in rats: a false neurotransmitter for positron emission tomographic imaging of
sympathetic innervation and function. J. Pharmacol. Exp. Ther. 255:809-817, 1990.
600. Palombo, E., Porrino, L.J., Bankiewicz, K.S., Crane, A.M., Sokoloff, L., Kopin, I.J.
Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid
infusion of the neurotoxin MPTP. J. Neurosci. 10:860-869, 1990.
1991
601. Bankiewicz, K.S., Plunkett, R.J., Jacobowitz, D.M., Kopin, I.J., Oldfield, E.H. Fetal
nondopaminergic neural implants in parkinsonian primates. J. Neurosurgery 74:97-104, 1991.
602. Goldstein, D.S., Chang, P.C., Smith, B., Herscovitch, P., Austin, S.M., Eisenhofer,
Kopin, I.J. Dosimetric estimates for clinical positron emission tomographic scanning after
injection of [18F]-6-fluorodopamine. J. Nuclear Med. 32:102-110, 1991.
603. Bankiewicz, K.S., Oldfield, E.H., Plunkett, R.J., Schuette, W.H., Cogan, D.G., Hogan,
N., Zuddas, A., Kopin, I.J. Apparent unilateral visual neglect in MPTP-hemiparkinsonian
monkeys is due to delayed initiation of motion. Brain Res. 541:98-102, 1991.
604. Goldstein, D.S., Grossman, E., Tamrat, M., Chang, P.C., Eisenhofer, G., Bacher, J., Kirk,
K.L., Bacharach, S., Kopin, I.J. Positron emission imaging of cardiac sympathetic innervation
and function using 18F-6-fluorodopamine: Effects of chemical sympathectomy by 6-
hydroxydopamine. J. Hypertens. 9:417-423, 1991.
605. Zudas, A., Corsini, G.U., Barker, J.L., Kopin, I.J., di Porzio, U. Specific reinnervation of
lesioned mouse striatum by grafted mesencephalic dopaminergic neurons. Eur. J. Neurosci. 3:72-
85, 1991.
606. Grossman, E., Chang, P.C., Hoffman, A., Tamrat, M., Kopin, I.J., Goldstein, D.S. Tracer
norepinephrine kinetics: dependence on regional blood flow and the site of infusion. Am. J.
Physiol. 260:R946-R952, 1991.
607. Szemeredi, K., Pacak, K., Kopin, I.J., Goldstein, D.S., Sympathoneural and skeletal
muscle contributions to plasma DOPA responses in pithed rats. J. Autonom. Nerv. Sys. 35:169-
174, 1991.
608. Duncan M.W., Villacresses N.E., Pearson P.G., Waytt L., Rapoport S.I., Kopin I.J.,
Markey S.P., Smith O.R. 2-Amino-3-(methylamino)-propanoic acid (BMAA) pharmacokinetics
and blood-brain barrier permeability in the rat. J Pharmacol Exp Ther, 258:27-35, 1991.
609. Palombo E., Porrino L.J., Crane A.M., Bankiewicz K.S., Kopin I.J., Sokoloff L. Cerebral
metabolic effects of monoamine oxidase inhibition in normal and 1-methyl-4-phenyl-1,2,3,6-
tetrahydropyridine acutely treated monkeys. J Neurochem, 56(5):1639-1646, 1991.
610. Szemeredi K., Komoly S., Kopin I.J., Bagdy G., Keiser H.R., Goldstein D.S.
Simultaneous measurement of plasma and brain extracellular fluid concentrations of catechols
after yohimbine administration in rats. Brain Research, 542:8-14, 1991.
62
611. Eisenhofer G., Esler M.D., Goldstein D.S., Kopin I.J. Neuronal uptake, metabolism, and
release of tritium-labeled norepinephrine during assessment of its plasma kinetics. Am J
Physiol, 269:E505-E515, 1991.
612. Culman, J., Kopin, I.J., Saavedra, J.M. Regulation of corticotropin-releasing hormone in
pituitary-adrenocortical response during acute and repeated stress in the rat. Endocrine
Regulations, 25:151-158, 1991.
612a Zuddas A, Corsini GU, Barker JL, Kopin IJ, Di Porzio U. Specific Reinnervation of
Lesioned Mouse Striatum by Grafted Mesencephalic Dopaminergic Neurons. Eur J Neurosci.
3:72-85,1991
1992
613. Duncan M.W., Markey S.P., Weick B.G., Pearson P.G., Ziffer H., Hu Y., Kopin I.J. 2-
Amino-3-(methylamino)propanoic acid (BMAA) bioavailability in the primate. Neurobiol
Aging, 13:333-337, 1992.
614. Pacak K., Armando I., Komoly S., Fukuhara K., Weise V.K., Holmes C., Kopin I.J.,
Goldstein D.S. Hypercortisolemia inhibits yohimbine-induced release of norepinephrine in the
posterolateral hypothalamus of conscious rats. Endocrinology, 131:1369-1376, 1992.
615. Kvetnansky R., Goldstein D.S., Weise V.K., Holmes C., Szemeredi K., Bagdy G., Kopin
I.J. Effects of handling or immobilization on plasma levels of dopa, catecholamines, and
metabolites in rats. J Neurochem 58:2296-2302, 1992.
616. McMahon A., Kvetnansky R., Fukuhara K., Weise V.K., Kopin I.J., Sabban E.L.
Regulation of tyrosine hydroxylase and dopamineß-ß-hydroxylase mRNA levels in rat adrenals
by a single and repeated immobilization stress. J Neurochem, 58:2124-2130, 1992.
617. Kopin I.J. Origins and significance of dopa and catecholamine metabolites in body
fluids. Pharmacopsychiat, 24:33-36, 1992.
618. Marini A.M., Lipsky R.H., Schwartz J.P., Kopin I.J. Accumulation of 1-methyl-4-phenyl-
1,2,3,6-tetrahydropyridine in cultured cerebellar astro-cytes. J Neurochem, 58:1250-1258, 1992.
619. Pacak K., Armando I., Fukuhara K., Kvetnansky R., Kopin I.J., Goldstein D.
Noradrenergic activation in the paraventricular nucleus during acute and chronic immobilization
stress in rats. Brain Research, 589:91-96, 1992.
620. Kopin I.J. Mechanisms of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced
destruction of dopaminergic neurons: in Selective Neurotoxicity H. Herken, F. Hucho, Eds.,
Springer-Verlag, Heidelberg Germany, 1992, pp. 333-356.
621. Kopin I.J. Features of the Dopaminergic Neurotoxin MPTP: in: Neurotoxins and
Neurodegenerative Disease, J.W. Langston, Anne Young, eds. Ann NY Acad Sci, 648:96-104,
1992.
63
622. Grossman E., Hoffman A., Armando I., Abassi Z., Kopin I.J., Goldstein D.S.
Sympathoadrenal contribution to plasma dopa (3,4-dihydroxyphenylalanine) in rats. Clin Sci,
83:65,74, 1992.
1993
623. Kopin I.J., Bankiewicz K.S., Plunkett R.F., Jacobowitz D.M., Oldfield E.H. Tissue
implants in treatment of parkinsonian syndromes in animals and implications for use of tissue
implants in humans. Advances in Neurology, 60:707-714, 1993.
624. Lenders J.W., Eisenhofer G., Aramando I., Keiser H. R., Goldstein D.S., Kopin I.J.
Determination of metanephrines in plasma by liquid chromotography with electrochemical
detection. Clin Chem, Jan;39(1):97-103, 1993.
625. Kopin I.J. The pharmacology of Parkinson’s disease therapy: an update. Annu Rev
Pharmacol Toxicol 33:467-497, 1993.
626. Wolfovitz E., Grossman E., Folio C.J., Keiser H.R., Kopin I.J., Goldstein D.S.
Derivation of urinary dopamine from plasma dihydroxyphenylalanine in humans. Clin Sci,
May;84(5):549-557, 1993.
627. Finberg J.P., Pacak K., Kopin I.J., Goldstein D.S. Chronic inhibition of monoamine
oxidase type A increases noradrenaline release in rat frontal cortex. Naunyn Schmiedergs Arch
Pharmacol, May;347(5):500-505, 1993.
628. Lenders J.W., Kvetnansky R., Pacak K., Goldstein D.S., Kopin I.J., Eisenhofer G.
Extraneuronal metabolism of endogenous and exogenous norepinehprine and epinehprine in rats.
J Pharmacol Exp Ther, Jul;266(1):288-293, 1993.
629. Nankova B., Devlin D., Kvetnansky R., Kopin I.J., Sabban E.L. Repeated
immobilization stress increases the binding of c-Fos-like proteins to a rat dopamine beta-
hydroxylase promoter enhancer sequence. J Neurochem Aug;61(2):776-779, 1993.
630. Kopin I.J. Clinical Evaluation of Tyrosine Hydroxylase Activity in Brain and Peripheral
Organs. Tyrosine Hydroxylase Activity in Brain and Peripheral Organs. In: Naoi M, ed.
Tyrosine Hydroxylase, 1993, 195-216.
631. Miletich RS, Comi G, Bankiewicz K, Plunkett R, Adams R, Di Chiro G, Kopin IJ. 6-
[18F]Fluoro-L-dihydroxyphenylalanine Metabolism and Positron Emission Tomography after
Catechol-O-methyltransferase Inhibition in Normal and Hemiparkinsonian Monkeys. Brain
Research, 626:1-13, 1993.
632. Goldstein DS, Eisenhofer G, Dunn BB, Armando I, Lenders J, Grossman E, Holmes C,
Kirk KL, Bacharach S, Adams R, Herscovitch P, Kopin IJ. Positron emission tomographic
imaging of cardiac sympathetic innervation using 6-[18F]fluorodopamine: initial findings in
humans. J Am Coll Cardiol 22:1961-71, 1993.
64
633. Goldstein DS, Garty M, Bagdy G, Szemeredi K, Sternberg EM, Listwak S, Deka-
Starosta A, Hoffman A, Chang PC, Stull R, Gold PW, Kopin IJ. Role of CRH in glucopenia-
induced adrenomedullary activation in rats. J Neuroendocrinology 5:475-86, 1993.
634. Kvetnansky R, Fukuhara K, Pacak K, Cizza G, Goldstein DS, Kopin IJ. Endogenous
glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization
stress in rats. Endocrinology 133:1411-9, 1993.
635. Pacak K, Kvetnansky R, Palkovits M, Fukuhara K, Yadid G, Kopin IJ, Goldstein DS.
Adrenalectomy augments in vivo release of norepinephrine in the paraventricular nucleus during
immobilization stress. Endocrinology 133:1404-10, 1993.
636. Pacak K, Yadid G. Jakab G, Lenders JW, Kopin IJ, Goldstein DS. In vivo hypothalamic
release and synthesis of catecholamines in spontaneously hypertensive rats. Hypertension
22:467-78, 1993.
637. Pacak K, Palkovits M, Kvetnansky R, Fukuhara K, Armando I, Kopin IJ, Goldstein DS.
Effects of single or repeated immobilization on release of norepinephrine and its metabolites in
the central nucleus of the amygdala in conscious rats. Neuroendocrinology 57:626-33, 1993.
638. Pacak K, Palkovits M, Kvetnansky R, Kopin IJ, Goldstein DS. Effects of brainstem
hemisections on in vivo synthesis and release of catecholamines in the paraventricular nucleus of
the hypothalamus. Neuroendocrinology 58:196-201, 1993.
639. Pacak K, Yadid G, Jakab J, Lenders JW, Kopin IJ, Goldstein DS. In vivo hypothalamic
release and synthesis of catecholamines in spontaneously hypertensive rats. Hypertension
22:467-78, 1993.
640. Yadid G, Pacak K, Golomb E, Harvey-White JD, Lieberman DM, Kopin IJ, Goldstein
DS. Glycine stimulates striatal dopamine release in conscious rats. Br J Pharmacol 110:50-3,
1993.
641. Yadid G, Pacak K, Kopin IJ, Goldstein DS. Modified microdialysis probe for sampling
extracellular fluid and administering drugs in vivo. Am J Physiol 265:R1205-11, 1993.
642. Kopin IJ. Monoamine oxidase (MAO): Relationships to foods, poisons and medicines.
Biogenic Amines 9:355-65, 1993.
643. Sheng JG, McShane LM, Plunkett RJ, Cummins AC, Oldfield EH, Kopin IJ, Palmatier
MA. Dopaminergic neuronal sprouting and behavioral recovery in hemi-parkinsonian rats after
implantation of amnion cells. Exp Neurol, 123(2):192-203, Oct, 1993.
1994
644. Goldstein DS, Coronado L, Kopin IJ. 6-[Fluorine-18] Fluorodopamine Pharmacokinetics
and Dosimety in Humans. J Nucl Med 35:964-73, 1994.
65
645. Miletich R, Bankiewicz KS, Quarantelli M, Plunkett RJ, Frank J, Kopin IJ, Di Chiro G.
MRI detects acute degeneration of the nigrostriatal dopamine system after MPTP exposure in
hemiparkinsonian monkeys. Ann Neurol 35:689-97, 1994.
646. Nankova B, Kvetnansky R, McMahon A, Viskupic E, Hiremagalur B, Frankle G,
Fukuhara K, Kopin IJ, Sabban EL. Induction of tyrosine hydroxylase gene expression by a
nonneuronal nonpituitary-mediated mechanism in immobilization stress. Proc Nat Acad Sci
USA 91:5937-41, 1994.
647. Kopin IJ: Monoamine oxidase and catecholamine metabolism. J Neural Transm 41:57-
67, 1994.
648. Viskupic E, Kvetnansky R, Sabban EL, Fukuhara K, Weise VK, Kopin IJ, Schwartz JP:
Increase in rat adrenal phenylethanolamine N-methyltransferase mRNA level caused by
immobilization stress depends on intact pituitary-adrenocortical axis. J Neurochem 63:808-14,
1994.
649. Yadid G, Pacak K, Kopin IJ, Goldstein DS. Modified microdialysis probe for sampling
extracellular fluid and administering drugs in vivo. Am J Physiol 265(5 Pt 2):R1205-11,
November, 1993.
650. Kopin IJ: Tips from Toxins: the MPTP Model of Parkinson’s Disease.
Neurodegnerative Diseases. Academic Press. Ltd., 1994.
651. Finberg JP, Pacak K, Goldstein DS, Kopin IJ. Modification of cerebral cortical
noradrenaline release by chronic inhibition of MAO-A. J Neural Transm Supply 41:123-5, 1994.
652. Yadid G, Pacak K, Kopin IJ, Goldstein DS. Endogenous serotonin stimulates striatal
dopamine release in conscious rats. J pharmacol Exp Ther 270(3):1158-65, Sept, 1994.
653. Kopin IJ: Neurotransmitters and Disorders of the Basil Ganglia. Basic Neurochemistry:
Molecular, Cellular, and Medical Aspects, 5th Edition, ed. GJ Siegel, Raven Press, Ltd., New
York, 1994.
654. Chang PC, Grossman E, Kopin IJ, Goldstein DS. On the existence of functional beta-
adrenoceptors on vascular sympathetic nerve endings in the human forearm. J
Hypertens;12(6):681-90, June,1994.
655. Eisenhofer G, Pecorella W, Pacak K, Hooper D, Kopin IJ, Goldstein DS. The neuronal
and extraneuronal origins of plasma 3-methoxy-4-hydroxyphenylglycol in rats. J Auton Nerv
Syst, 1;50(1):93-107, Dec, 1994.
1995
656. Cizza G, Pacak K, Kvetnansky R, Palkovits M, Goldstein DS, Brady LS, Fukuhara K,
Bergamini E, Kopin IJ, Blackman MR, Chrousos GP, Gold PW: Decreased stress responsivity
of central and peripheral catecholaminergic systems in aged 344/N fischer rats. J Clin Invest
95:1217-24, 1995.
66
657. Pacak K, Palkovits M, Kopin IJ, Goldstein DS: Stress-induced norepinephrine release in
the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal
activity: in vivo microdialysis studies. Frontiers in Neuroendocrinology 16:89-150, 1995.
658. Pacak K, McCarty R, Palkovits M, Cizza G, Kopin, IJ, Goldstein, DS,
Chrousos GP: Decreased Central and Peripheral Catecholaminergic Activation in Obese Zucker
Rats. Endocrinology 136 (10):4360-7, 1995.
659. Yadid G, Goldstein, DS, Pacak K, Kopin IJ, Golomb E. Functional alpha 3-glycine
receptors in rat adrenal. Eur J Pharmacol 15;288(3):399-401, Feb, 1995.
660. Finberg JP, Wang J, Goldstein DS, Kopin IJ, Bankiewicz KS. Influence of selective
inhibition of monoamine oxidase A or B on striatal metabolism of L-DOPA in hemiparkinsonian
rats. J Neurochem; (3):1213-20, Sept, 1995.
661. Higgins JJ, Harvey-White JD, Kopin IJ. Low lumbar CSF concentrations of homovanillic
acid in the autosomal dominant ataxias [letter]. J Neurol Neurosurg Psychiatry; 58(6):760,
June,1995.
662. Eisenhofer G, Rundquist B, Aneman A, Friberg P, Dakak N, Kopin IJ, Jacobs MC,
Lenders JW. Regional release and removal of catecholamines and extraneuronal metabolism to
metanephrines. J Clin Endocrinol Metab, 80(10):3009-17, Oct, 1995.
663. Pacak K, Palkovits M, Kventnansky R, Matern P, Hart C, Kopin IJ, Goldstein DS.
Catecholaminergic inhibition by hypercortisolemia in the paraventricular nucleus of conscious
rats. Endocrinology 136(11):4814-9, NOV, 1995.
664. Wolfovitz E, Pacak K, Abassi Z, Kopin IJ, Goldstein DS. Effects of Hypercortisolemia or
hyperinsulinemia on neurochemical indices of catecholamine release and synthesis in conscious
rats. J Auton Nerv Syst 4;54(2):104-12, Aug, 1995.
665. Pacak K, McCarty R, Palkovits M, Kopin IJ, Goldstein DS. Effects of immobilization on
in vivo release of norepinephrine in the bed nucleus of the stria terminalis in conscious rats.
Brain Res, 688(1-2):242-6, Aug,1995.
666. Kopin, IJ. Definitions of Stress and Sympathetic Neuronal Responses, In: B. Boland, Ed.
Ann N Acad Sci, New York, NY, Vol 771, pp 19-30, 1995.
667. Kvetnansky R, Pacak K, Fukuhara K, Viskupic E, Hiremagalur B, Nankova B, Goldstein
D S, Sabban L, Kopin I J, Sympathoadrenal System in Stress, In: B. Boland, Ed. Ann N Acad Sci,
New York, NY, Vol 771, pp 131-158, 1995.
668. Pacak K, Palkovits M, Kvetnansky R, Yadid G, Kopin I J, Goldstein D S, Effects of
Various Stressors on In Vivo Norepinephrine Release in the Hypothalamic Paraventricular
Nucleus and on the Pituitary-Adrenocortical Axis, In: B. Boland, Ed. Ann N Acad Sci, New
York, NY, Vol 771, pp 115-139, 1995.
1996
67
669. Al-Damluji S, Kopin IJ. Functional properties of the uptake of amines in immortalised
peptidergic neurones (transport-P). Brit J Pharm 117:111-8, 1996.
670. Kvetnansky R, Nankova B, Viskupic E, Vietor I, Rusnak M, McMahon A, Kopin IJ,
Sabban EL. Induction of adrenal tyrosine hydroxylase mRNA by single immobilization stress
occurs even after splanchnic transection and in the presence of cholinergic antagonists. J
Neurochem, 66(1):138-46, Jan, 1996.
671. Lenders WM, Eisenhofer G, Abeling NGGM, Berger W, Murphy DL, Konings
CH,Wagemakers LMB, Kopin IJ, Karoum F, Van Gennip AH, Brunner HG. Specific
Genetic Deficiencies of the A and B Isoenzymes of Monoamine Oxidase are Characterized by
Distinct Neurochemical and Clinical Phenotypes. J of Clin Inv, 97:1010-19, 1996.
672. Al-Damluji S, Kopin IJ. Binding and competitive inhibition of amine uptake at
postsynaptic neurones (transport-P) by tricyclic antidepressants. British J of Pharm,117:811-
816, 1996.
673. Fukuhara K, Kvetnansky R, Weise VK, Ohara H, Yoneda R, Goldstein DS, Kopin IJ.
Effects of Continuous and Intermittent Cold (SART) Stress on Sympathoadrenal System
Activity in Rats. J Neuroendocrinology,8:65-72,1996.
674. Kopin, IJ. Dopaminergic Neurotransmission, In: D Robertson (Ed) Primer on the
Autonomic Nervous System, Academic Press, New York, pp. 87-90,1996. 675. Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, Kopin IJ,
Goldstein DS, Murray DE. Cardiac Sympathetic Nerve Function in Congestive Heart Failure. Circulation, 93:1667-1676,1996.
676. Eisenhofer G, Lenders JWM, Harvey-White J, Ernst M, Zametkin A, Murphy DL, Kopin
IJ. Differential Inhibition of Neuronal and Extraneuronal Monoamine Oxidase. Neuropsychopharm 15:296-301,1996.
677. Fukuhara K, Kvetnansky R, Cizza G, Pacak K, Ohara H, Goldstein DS, Kopin IJ.
Interrelations between sympathoadrenal system and hypothalamo-pituitary-adorenocortical/thyroid systems in rats exposed to cold stress. Neuroendocrinology, 8:533-541(1996).
678. Pacak K, Palkovits M, Makino S, Kopin IJ, Goldstein D. Brainstem hemisection decrease
corticotropin-releasing hormone mRNA in the paraventricular nucleus but not in the central amygdaloid nucleus. J of Neuroendocrinology, 8:543-551 (1996)
679 Yamamoto T, Polinsky RJ, Goldstein DS, Baucom CE, Kopin IJ. Plasma sulfoconjugated
dopamine levels are normal in patients with autonomic failure. J Lab Clin Med. 128; 488-491,1996.
680. Higgins JJ; Harvey-White JD; Nee LE; Colli MJ; Grossi TA; Kopin IJ Brain MRI,
lumbar CSF monoamine concentrations, and clinical descriptors of patients with spinocerebellar ataxia mutations. J Neurol Neurosurg Psychiatry 61:591-5, 1996
681. Axelrod FB; Goldstein DS; Holmes C; Berlin D; Kopin IJ Pattern of plasma levels of
catecholamines in familial dysautonomia. Clin Auton Res 6(4):205-9, 1996
68
682. Goldstein DS, Pacak K, Kopin IJ Nonspecificity versus Prmitive Specificity of Stress Responses. in Stress: Molecular Genetic and Neurobiological Advances Ed by McCarty R, Aguuilers, G. Sabban, E. Kvetnansky R. Gordon and Breach (1996) pp 3-19
683. Pacak K, Makino S, Palkovits M, Kvetnansky R , Kopin IJ, Goldstein DS.
Immobilizatiop- induced Norepinephrine Release in the Paraventricular Nucleus and the Central Nucleus of the Amygdala; Associaton with Corticotropin-Releasing Hormone Gene-Expression in Stress: Molecular Genetic and Neurobiological Advances Ed by McCarty R, Aguuilers, G. Sabban, E. Kvetnansky R. Gordon and Breach (1996) pp 49-66.
684. Kvetnansky R , Pacak K,Nankova B, Fukuhara K, Goldstein DS, Saban EL, Kopin IJ Peripheral Catecholamine Synthesis, ReleAse, and Metabolism during Stress: Acute
versus Chronic effects of Hepercortisolemia in Stress: Molecular Genetic and Neurobiological Advances Ed by McCarty R, Aguuilers, G. Sabban, E. Kvetnansky R. Gordon and Breach (1996) pp 243-265.
69
1997 685. Goldstein DS, Holmes C, Cannon RO,III, Eisenhofer G, Kopin IJ. Sympathetic
cardioneuropathy in dysautonomias. N Engl J Med 1997;336:696-702. 686. Herzberg U, Elilav E, Bennett GJ, Kopin IJ. The analgesic effects of R(+)-WIN 55,212-2
mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain. Neurosci Lett 1997;221:157-160.
687. Al-Damluji S, Porter D, Krsmanovic LZ, Knutson JR, Kopin IJ. Visual detection of
transport-P in peptidergic neurones. Br J Pharmacol 120:876-882.1997. 688. Goldstein DS, Holmes C, Stuhlmuller JE, Lenders JWM, Kopin IJ. 6-
[18F]Fluorodopamine positron emission tomographic scanning in the assessment of cardiac sympathoneural function--studies in normal humans. Clin Auton Res 1997;7:17-29.
689. Herzberg U, Eliav E, Dorsey JM, Gracely RH, Kopin IJ. NGF involvement in pain
induced by chronic constriction injury of the rat sciatic nerve. Neuroreport 1997; 8:1613-8.
690. Hooper D. Kawamura M. Hoffman B, Kopin IJ, Hunyady, Mezey E, Eisenhofer G
Tyrosine hydroxylase assay for detection of low levels of enzyme activity in peripheral tissues. J Chromatogr B Biomed Sci Appl 694:317-24, 1997
691. Kawamura M, Kopin IJ, Kador PF, Sato S; Tjurmina O,; Eisenhofer G. Effects of
aldehyde/aldose reductase inhibition on neuronal metabolism of norepinephrine. J Auton Nerv Syst 66:145-8, 1997
1998 692. Kvetnansky R, Pacak K,; Sabban EL, Kopin IJ, Goldstein DS Stressor specificity of
peripheral catecholaminergic activation. Adv Pharmacol 42:556-60, 1998 693. Goldstein DS, Holmes C, Cannon RO III, Eisenhofer G, Kopin IJ Sympathetic
cardioneuropathy in dysautonomias. Adv Pharmacol 42:615-9, 1998 694. Axelrod FB, Goldstein DS, Holmes C, Kopin IJ Genotype and phenotype in familial
dysautonomia.Adv Pharmacol 42:925-8, 1998 695. Kvetnansky R, Pacak K, Sabban EL, Kopin IJ, Goldstein DS. Stressor specificity of
peripheral catecholaminergic activation. Adv Pharmacol. 42: 556-560, 1998 696. Kopin IJ, Rundqvist B, Friberg P, Lenders J, Goldstein DS, Eisenhofer G Different
relationships among norepinephrine release, uptake and spillover in Human heart, kidneys and forearm. Am J Physiol 275: R165-R173, 1998
697. Al-Damluji S, Kopin IJ. structural properties of phenylethylamine derivatives which
inhibit transport-P in peptidergic neurones. Br J Pharmacol 124: 693-702, 1998 698. Pacak K, Palkovits M, Yadid G, Kvetnansky R, Kopin IJ, Goldstein DS Heterogeneous
Neurochemical Responses to Different Stressors: A Test of Selye’s Doctrine of Nonspecificity. Am J Physiol 275: R1247-R1255,1998
70
699. Finberg JP; Wang J; Bankiewicz K; Harvey-White J; Kopin IJ; Goldstein DS. Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey. J Neural Transm Suppl 52:279-85, 1998
700. Castillo SO; Baffi JS; Palkovits M; Goldstein DS; Kopin IJ; Witta J; Magnuson MA;
Nikodem VM. Dopamine Biosynthesis Is Selectively Abolished in Substantia Nigra/Ventral Tegmental Area but Not in Hypothalamic Neurons in Mice with Targeted Disruption of the Nurr1 Gene. Mol Cell Neurosci 11:36-46, 1998
1999
701. Lamensdorf I, Meiri N, Harvey-White J, Jacobowitz DM, Kopin IJ Oligoantisense for
Kir6.2 diminished contralateral turning induced by apomorphine in the 6-hydroxy-dopamine hemiparkinsonian rat model. Brain Research 818:,275-284, 1999
702. Kawamura M, Eisenhofer G, Kopin IJ, Kador P, Lee YS, Tsai J-Y, Fujisawa S, Lizak
MJ, Sato,S. Aldose Reductase: a key enzyme in norepinephrine metabolism in rats. Biochem Pharm 58:517-524,1999
703. Duan Y-F, Kopin IJ, Goldstein DS. Stimulation of the hypothalamic paraventricular
nucleus modulates firing of barosensitive neurons in the nucleus of the solitary tract in rabbits. Am J Physiol. 277:R404-R411,1999.
701. Tjurmina OA , Goldstein DS, Palkovits M, Kopin
2-Adrenoceptor-Mediated Restraintof Norepinephrine Synthesis, Release, and Turnover during Immobilization in Rats Brain Res 826:243-252,1999
702. Kawamura M, Schwartz JP, Nomura T, Kopin IJ, Goldstein DS, Huynh TT, Hooper DR, Harvey-White J, Eisenhofer G. .Differential effects of chemical sympathectomy on
expression and activity oftyrosine hydroxylase and levels of catecholamines and DOPA
in peripheral tissues of rats. Neurochem Res. 24:25-32, 1999.
2000
703. Sato S, Kawamura M, Eisenhofer G, Kopin IJ, Fujisawa S, Kador PF. Aldo-keto
reductases in norepinephrine metabolism. Adv Exp Med Biol.463:459-63, 1999.
704. Lamensdorf I, He L, Nechushtan A, Harvey-White J, Eisenhofer G, Milan R, Rojas E,
Kopin IJ. Effect of glipizide on dopamine synthesis, release and metabolism in PC12
cells.Eur J Pharmacol 388:147-54, 2000.
705. Lamensdorf I, Eisenhofer G, Harvey-White J, Hayakawa Y, Kirk K, Kopin IJ. Metabolic
stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin,
+3,4-dihydroxyphenylacetaldehydeJ Neurosci Res. 60:552-8, 2000.
706. Lamensdorf I, Eisenhofer G, Harvey-White J, Nechustan A, Kirk K, Kopin IJ. 3,4-
Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12
cells. Brain 868:191-20,2000.
71
707. Lamensdorf I, Hrycyna C, He LP, Nechushtan A, Tjurmina O, Harvey-White J,
Eisenhofer G, Rojas E, Kopin IJ. Acidic dopamine metabolites are actively extruded from
PC12 cells by a novel sulfonylurea-sensitive transporter. Naunyn Schmiedebergs Arch
Pharmacol. 2000 Jun;361(6):654-64.
708. Yadid G, Harvey-White JD, Kopin IJ, Goldstein DS. Estimation of striatal dopamine
spillover and metabolism in vivo. Neuroreport. 11:3367-73, 2000
2001
709. Goldstein DS, Li ST, Kopin IJ Sympathetic neurocirculatory failure in Parkinson disease:
Evidence for an etiologic role of alpha-synuclein. Ann Intern Med. 135:1010-1, 2001
2002
710. Goldstein DS, Katzper M, Linares O, Kopin IJ. Kinetic model for the fate of 6-
[18F]fluorodopamine in the human heart: a novel means to examine cardiac sympathetic
neuronal function. Naunyn Schmiedebergs Arch Pharmacol. 365:38-49, 2002.
711. Kawamura M, Eisenhofer G, Kopin IJ, Kador PF, Lee YS, Fujisawa S, Sato S.Aldose
reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of
norepinephrine in human sympathetic ganglia. Auton Neurosci. 96:131-9,2002.
2003
712. Goldstein DS, Holmes C, Patronas N, Kopin IJ. Cerebrospinal fluid levels of catechols in
patients with neurogenic orthostatic hypotension. Clin Sci (Lond). 2003;104:649-54.
713. Goldstein DS, Eisenhofer G, Kopin IJ. Sources and significance of plasma levels of
catechols and their metabolites in humans. J Pharmacol Exp Ther. 2003 ;305:800-11.
714. Eisenhofer G, Goldstein DS, Kopin IJ, Crout JR. Pheochromocytoma: rediscovery as
a catecholamine-metabolizing tumor. Endocr Pathol. 2003;14:193-212.
715. Li ST, Holmes C, Kopin IJ, Goldstein DS. Aging-related changes in cardiac sympathetic
function in humans, assessed by 6-18F-fluorodopamine PET scanning. J Nucl Med.
2003;44:1599-603.
2004
716. Eldadah BA, Pacak K, Eisenhofer G, Holmes C, Kopin IJ, Goldstein DS.
Cardiac uptake-1 inhibition by high circulating norepinephrine levels in patients with
pheochromocytoma. Hypertension. 2004 ;43:1227-32
717. Eisenhofer G, Kopin IJ, Goldstein DS. Leaky catecholamine stores: undue waste or a
stress response coping mechanism? Ann N Y Acad Sci. 2004;1018:224-30.
718. Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: a contemporary view
with implications for physiology and medicine.
72
Pharmacol Rev. 2004 ;56:331-49.
719. Kopin IJ. Psychpharmacology Research in the 1950’s in Mind, Body and Behavior.
Foundations of Neuroscience and Behavioral Research at the National Institutes of
Health. Ed Farreras, IG, Hannaway C, and Harden VA IOS Press Washington, D.C.
(2004) pp 267-280
2006
720. Goldstein DS, Eisenhofer G, Kopin IJ. Clinical catecholamine neurochemistry: a legacy of
Julius Axelrod. Cell Mol Neurobiol. (2006) 26:693-700.
721. Kopin IJ. The relationship of early studies of monoamine oxidase to present concepts. J
Neural Trans (2006) [Suppl} 71:79-86.
2007
722. Goldstein DS, Kopin IJ. Evolution of concepts of stress Stress. (2007)10:109-20
2008
723. Goldstein DS, Kopin IJ. Adrenomedullary, adrenocortical, and sympathoneural responses
to stressors: a meta-analysis. Endocr Regul. 2008 (4):111-9.
724. Goldstein DS, Holmes C, Sewell L, Kopin IJ. Hypertension increases cerebral 6-18F-
fluorodopa-derived radioactivity J Nucl Med. 2009 (9):1479-82.
725. Goldstein DS, Holmes C, Sewell L, Pechnik S, Kopin IJ. Effects of Carbidopa and
Entacapone on the Metabolic Fate of the Norepinephrine Prodrug L-DOPS J Clin
Pharmacol. 2010;51:66-74
726. Goldstein DS, Sullivan P, Holmes C, Kopin IJ, Basile MJ, Mash DC. Catechols in post-
mortem brain of patients with Parkinson disease. Eur J Neurol. 2010: 10.1468-1331
727. Goldstein DS, Holmes C, Kopin IJ, Sharabi Y. Intra-neuronal vesicular uptake of
catecholamines is decreased in patients with Lewy body diseases. J Clin Invest. 2011:
121:3320-30
728. Goldstein DS, Sullivan P, Cooney A, Jinsmaa Y, Sullivan R, Gross DJ, Holmes C, Kopin
IJ, Sharabi Y. Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-
dihydroxyplenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson’s
disease. J Neurochem. 2012;123(6):932-43.
729. Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong R, Mash DC, Kopin IJ,
Sharabi Y. Determinants of buildup of the toxic dopamine metabolite DOPAL in
Parkinson's disease.. J Neurochem. 2013;126(5):591-603.
730. Goldstein DS, Sullivan P, Holmes C, Miller GW, Sharabi Y, Kopin IJ. A vesicular
sequestration to oxidative deamination shift in myocardial sympathetic nerves in
Parkinson's disease. J Neurochem. 2014:
73
731. Goldstein DS, Kopin IJ, Sharabi Y. Catecholamine autotoxicity. Implications for
pharmacology and therapeutics of Parkinson disease and related disorders. Pharmacol
Ther. 2014 Dec;144(3):268-82
732. Goldstein DS, Kopin IJ, Sharabi Y, Holmes C Plasma biomarkers of decreased vesicular
storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian
form of multiple system atrophy. Clin Auton Res. 2015;26:61-67
733. Goldstein DS, Sullivan P, Cooney A, Jinsmaa Y, Kopin IJ, Sharabi Y. Rotenone
Decreases Intracellular Aldehyde Dehydrogenase Activity: Implications for the
Pathogenesis of Parkinson Disease. J Neurochem. 2015;133:14-25
734. Goldstein DS, Sullivan P, Holmes C, Kopin IJ, Sharabi Y, Mash DC. Decreased vesicular
storage and aldehyde dehydrogenase activity in multiple system atrophy. Parkinsonism
Relat Disord. 2015;21:567-72.
Irwin J. Kopin
September 3, 2015