big data, computational biology & the future of strategic planning for research
TRANSCRIPT
BIG DATA, COMPUTATIONAL BIOLOGY & THE FUTURE OF STRATEGIC PLANNING FOR RESEARCH
Image: r2hox/Flickr
TODAY’S TRANSLATIONAL RESEARCH
Computation and large dataset analysis are challenging the nature and processes of translational research.
The increase in computation has a significant impact on how organizations plan and program for translational research activities.
The links between strategic planning, programming and design are dynamic and require faster feedback to drive value creation.
TODAY’S TRANSLATIONAL RESEARCH
This presentation explores the new paradigm of translational research andhow it is challenging conventional assumptions about physical space.
We introduce new tools and techniques for rapidly evaluating the spatialimpact of strategic plans to address changing practices.
THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN’S HOSPITAL COLUMBUS, OH
The research programs here illustrate how computational biology is already impacting strategic facility planning decisions.
NCH RESEARCH INSTITUTE: MISSION
“…dedicated to enhancing the health of children by engaging in high-quality, cutting-edge research according to the highest scientific and ethical standards.”
Research informs the best clinical care.
RESEARCH AT NCH PAST, PRESENT, FUTURE
Independent nonprofit/affiliate of hospital
Staff = ~1,000 employees / hospital ~10,000
Research = ~$130M / hospital ~$2B
~600,000 SF of research space in 3+ buildings
~130 faculty
NCH RESEARCH INSTITUTE: FACTS
Transforming discoveries into cures and treatments.Clinical challenges inform research questions.
TRANSLATIONAL RESEARCH
Basic Science Clinical Studies
RESEARCH IS DIVERSIFYING Translational science is diversifying. Beyond drug discovery and stem cell work, researchers are also designing modified spray nozzles for higher levels of safety and for protection from use by children.
NCH RESEARCH INSTITUTE: FACULTY GROWTH
1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
140
120
100
80
60
40
20
0
Approximates hospital revenue growth
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
70
60
50
40
30
20
10
0
80
90
($ in
Mill
ions
)
20.0
24.1
30.2
33.531.2
36.1
41.7
49.4 49.4
64.8
69.4
57.9
83.7
66.3
70.2
NCH’S FUNDING FROM NIH HAS QUADRUPLED OVER THE LAST DECADE
DATA GROWTH: 2 REMARKABLE FACTS
We create as much information in two days as we did from the dawn of civilization through 2003.
Ninety percent of all the data in the world has been created in the last two years.
NCH RESEARCH INSTITUTE: HEALTHCARE DATA GROWTH
1 million patient electronic medical records (EMR)EMRs accessed 14 billion times
7.7 million records in an injury prevention database
Database with 50 million clinical notes
Genomic medicine…
GENOMICS & PERSONALIZED MEDICINE
The customization of healthcare—medical decisions, treatments, and drugs— for each patient based on their unique DNA sequence.
A single human genome has 3 billion base pairs.
NCBI GENBANK ENTRIES
1982 1985 1988 1991 1993 1996 1999 2002 2007 2010 2013
140
120
100
80
60
40
20
0
140
2004
Bas
e Pai
rs (
Bill
ions
)
DATA & GENOME SEQUENCING
We can sequence 18,000 patient genomes/year...which generates 1.8 petabytes of data.
1.8 petabyte = 1.8 million gigabytes…9,000 desktop hard drives.
Or about 360,000 DVDs...a stack 2 miles high.
Wexner Institute (1987)
+ 60,000 SF Additional Fit-Out (1997)
+ 30,000 SF
Research Building III (2012)
+ 237,000 SFResearch Building II (2003)
+ 158,000 SF
NCH RESEARCH INSTITUTE FACILITY PLANNING In the past decade, Nationwide Children’s has doubled the number of its investigators.
NCH RESEARCH INSTITUTE: MASTER PLAN
III
II
IIV
V
NCH RESEARCH BUILDING III
Size
225,000 SF Completion Date
2012 Construction Cost
$90,000,000Components
Wet/dry labs
cGMP
Vivarium
Offices, seminar & conference rooms
Café
Drivers
Highly collaborative
Flexibility & efficiency
NCH RESEARCH BUILDING III: FROM HOSPITAL CHASSIS TO RESEARCH CAMPUS
NCH RESEARCH BUILDING III With Research Building III, Nationwide Children’s Hospital fully integrated computational research with traditional wet laboratories.
Lab
SupportOffice
NCH RESEARCH BUILDING III
NCH RESEARCH BUILDING III The design of the collaborative spaces connects the labs on different floors.
Two-story spaces adjacent to labs link departments, driving interdisciplinary research.
Labs are co-located with offices and collaboration spaces and are separated by full-height, glass partitions. Researchers can maintain a visual connection between areas.
NCH RESEARCH INSTITUTE SPACE: WET AND DRY
Dry Faculty Offices
0% RB I (1986) 6% RB II (2004)
41% RB III (2012)
27% TOTAL
Dry Faculty
37% Last 5 years
35% TOTAL
Not enough dry space!
SPACE PLANNING DRIVERS
Speed of change
Proximity Bench Bedside
Scientists: Unique people, unique needs
Hospital environment
DRIVERS OF THE MISSION
Different Endeavors/Metrics/Timelines Healthcare vs. Research
Different Cultures MD vs. PhD
MD Scientists Clinical vs. research time
IT Patient protection vs. academic freedom
Money Revenue vs. expense
Strategic PlanningHospital-driven vs. research-driven
THE BEST OUTCOMES ARISE FROM A COMPREHENSIVE, INTEGRATED DELIVERY SYSTEM
Quality, Safety & Service
Education
Optimal Performance
Wellness & Population Health
Partnerships
Preeminent Clinical & Research Programs
Comprehensive, Integrated Delivery System Best Outcomes
TRANSLATIONAL RESEARCH STRATEGIC PLANNING: A SIMPLIFIED VIEW
What are your critical health/research issues?
How many faculty can you afford ($ + space)?
What % wet vs. dry?
Make it flexible!
WHAT CAN WE LEARN FROM TECH INDUSTRY WORK ENVIRONMENTS THAT DELIVER INNOVATION?
Image: Bob Mical/Flickr
Amazon Headquarters Samsung America Headquarters
Tech workplaces = best practices for research-intensive work
Google Bay View CampusTencent Corporate Headquarters
Tech is rapidly moving into the biomedical research space—and it’s way beyond “biotech.”
The most desirable skill is the ability to analyze and make sense of metadata.
TODAY’S SCIENCE WORKPLACE
Transparent
Collaborative
Somewhat flexible
Daylit
TODAY’S COMPUTATION WORKPLACE Transparent / Collaborative / Flexible / Daylit
Image: Jasper Sanidad
FIVE CHARACTERISTICS OF THE NEXT GENERATION, DATA-DRIVEN TRANSLATIONAL RESEARCH BUILDING
IT IS CONNECTED AT THE CORE
Despite technology, physical connectivity is still critical to translational science
IT HAS A HIGHLY FLEXIBLE CHASSIS
NEIGHBORHOOD 3
NEIGHBORHOOD 2
NEIGHBORHOOD 1
Lab Benches
Lab Support
Office
Collaborative Space
Technicians’ Desks
Conference
IT IS ULTRA FLEXIBLE
One Big Flexible “Plug and Play” Volume: Facebook’s new corporate HQ has more in common with the Salk Institute than it has differences. Image: Jasper Sanidad
IT IS MODULAR
Over 90% of the elements in a typical biomedical research lab are individually prefabricated—in the near future, this will extend to componentized systems.
IT FUNCTIONS LIKE A DYNAMIC STUDIO
The computational research life cycle—conceptualizing virtually, testing physically and feeding back data virtually—will find new efficacy in loft-like lab studio spaces.
COMPUTATIONAL PLANNING: TOOLS & TECHNIQUES
STRATEGIC PLANNING: THEMES
Increasingly, there is wide range of research types being undertaken— from traditional biomedical research to computation and engineering.
The type of research and the need set of researchers is changing more rapidly now and therefore environments must change more frequently.
Computational research requires less space.
As strategic plans evolve more quickly, space impacts needs to assessed more dynamically and fluidly.
TRANSLATING PLANNING TO SPACE
Strategic Plan Space Needs Space Availability Layouts & Testing
Here’s how we normally translate a strategic plan to space…
TRANSLATING PLANNING TO SPACE
Here’s how we normally translate a strategic plan to space…
Strategic Plan Space Needs Space Availability Layouts & Testing
How do we speed up the translation of strategic planning to space planning?
How can we more easily and quickly evaluate the spatial impact of strategic planning?
TRANSLATING PLANNING TO SPACE
DEMO: COMPUTATIONAL PLANNING TOOL NBBJ’s proprietary computational tool for lab module planning helps clients optimize layouts.
Computation and large dataset analysis are challenging the nature and processes of translational research.
The increase in computation has a significant impact on how organizations plan AND program for translational research activities.
The link between strategic planning, programming and design is much more dynamic and requires faster feedback to drive value creation.
Dynamic design computation tools can allow for rapid development of planning scenarios.
KEY TAKEAWAYS
FOR MORE INFORMATION:
Andy Snyder, AIA, LEED APPrincipal, NBBJ Science & Education Practice Leader
About NBBJNBBJ creates innovative places and experiences for organizations worldwide and designs environments, communities, and buildings that enhance people’s lives. Founded in 1943, NBBJ is an industry leader in healthcare and corporate facilities and has a strong presence in the commercial, civic, science, education, and sports markets. The firm has won numerous awards and has been recognized as one of the world’s “Top Ten Most Innovative Architecture Firms” by Fast Company magazine. NBBJ has more than 750 employees in 10 offices worldwide, including Beijing, Boston, Columbus, London, Los Angeles, New York, Pune, San Francisco, Seattle and Shanghai. Clients include Amazon, the Bill & Melinda Gates Foundation, Boeing, Cambridge University, Cleveland Clinic, GlaxoSmithKline, Google, Massachusetts General Hospital, Microsoft, Reebok, Salk Institute, Samsung, Stanford University, Starbucks, Telenor, Tencent, and the Wellcome Trust.
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