BIOCHEMISTRYT&DJUNE2020PaperDiscussionDR. DEEPAKMARWAH

1.A15-dayoldneonatehasmultipleepisodesofsubtleseizures.Onexaminationblondhairandblueirisisnotedwhileparentshaveblackhairandbrowneyes.Whichdiseaseissuspected?a.Albinismb.Tyrosinemiac.PKUd.MSUD

2.CorrectaboutLipoprotein‘A’?a.Promotesatherosclerosisb.Reducesatherosclerosisc.Deliverscholesteroltoliverd.Deliverscholesterolfromperipheraltissuetoliver

3.Fishoilisgoodforpeoplewith?a.ElevatedLDLb.Elevatedtriglyceridesc.Dayblindnessd.Alloftheabove

4.Cardiolipinis_________?a.Phosphadityl-cholineb.Phosphatidyl-ethanolaminec.Diphosphadityl glycerold.Sphingomyelin

5.Whichofthefollowingisnotanenzyme?a.Racemaseb.Ribozymec.Peptidased.Mutase

6.Whichofthefollowingisacofactorforcytochromeoxidase?a.Zincb.Magnesiumc.Copperd.Molybdenum

7.Correctaboutgangliosidesis?a.Glycolipidswithsialicacidandfoundinnerveendingsb.Glycolipidswithsialicacidandfoundinwhitematterofbrainc.Glycophospholipids withlecithinandfoundinlungsd.Glycophospholipids withalcoholandfoundinadrenalgland

8.NAD+isacoenzymeforwhichofthefollowingenzyme?a.Transaminaseb.Transketolasec.Carboxylased.Dehydrogenase

9.WhichisnotacomponentofMichaelisMenton equation?a.Initialvelocityb.Maximumvelocityc.Substrateconcentrationd.Temperature

10.WhichofthefollowinghasleastcontentofPUFA?a.Saffloweroilb.Sunfloweroilc.Rapeseedoild.Coconutoil

11.Neuraminidaseenzymeisinhibitedby?a.Acyclovirb.Oseltamivirc.Methotrexated.Allopurinol

12.Trueaboutcompetitiveinhibition?a.KmremainsthesameandVmaxdecreaseb.KmremainsthesameandVmaxincreasesc.KmincreasesandVmaxisreducedd.KmincreasesandVmaxissame

13.Whichiscorrectaboutcervonic acid?a.Omega3fattyacidb.Omega6fattyacidc.Omega9fattyacidd.Alloftheabove

14.Whichofthefollowingisanimino acid?a.Arginineb.Histidinec.Leucined.Proline

15.Correctaboutergosterolis?a.PrecursorforvitaminDb.Precursorforcoproporphyrinc.PrecursorforHistamined.Precursorfortrans-fattyacids

16.WhichisCorrectaboutZwitter ion?a.Positivechargeb.Negativechargec.Doesnotmovetowardsanodeorcathoded.Showspositivemigrationtowardscathode

17.Nitricoxideisformedfrom?a.Aspartateb.Asparaginec.Alanined.Arginine

18.Whichiscorrectabout21st aminoacid?a.SelenocysteinecodedbyUGAstopcodonb.SelenocysteinecodedbyUAGstopcodonc.Pyrrolysine codedbyUAGstopcodond.Pyrrolysine codedbyUGAstopcodon

19.Correctaboutglycine?a.Largestaminoacidb.Opticallyactivec.Everysecondaminoacidincollagenisglycined.Itisbothexcitatoryandinhibitoryneurotransmitter

20.Correctaboutfunctionofglutathione?a.Bindingofcarbondioxidetohemoglobinb.Freeradicalscavengerc.Conformationalabilityincollagend.Synthesisofbetaine

21.Testforfolicaciddeficiency?a.Schillingtestb.FIGLUlevelsinurinec.ALAlevelsinurined.Dihydrofolatereductaseassay

22.Duringstarvationneuronswilluse?a.Homocysteineb.Valinec.Taurined.Glutamine

23.Homocysteineaccumulationleadstoacutecoronarysyndrome.Whichofthefollowingisresponsible?a.Deficiencyofthiamineb.Deficiencyofriboflavinc.Deficiencyofniacind.Deficiencyofcyanocobalamin

24.Serotoninisproducedby?a.Tryptophanb.Tyrosinec.Glycined.Histidine

25.UreabicyclelinksureatoTCAcyclethrough_____and______a.Ornithineandcitrullineb.Fumarateandaspartatec.Arginineandcitrullined.Arginineandfumarate

26.Obermeyertestisusedfordiagnosisof?a.Alkaptonuriab.PKUc.Hartnup diseased.Trimethylaminuria

27.SDS-PAGEisusedforseparationofproteins.Itisbasedonwhichofthefollowingproperties?a.Chargeb.Molecularweightc.pHd.alloftheabove

28.WhichofthefollowingisincorrectaboutChylomicrons?a.Maximumtriglyceridecontentb.Leastdensec.Highestelectrophoreticmobilityd.MajorapolipoproteinisApoB-48

29.Crumpledtissuepapercytoplasminmacrophagesisafeatureof?a.Fabry’sdiseaseb.Gaucher’diseasec.Taysach diseased.Krabbe disease

30.WhatisenzymedefectinFabry’sdisease?a.Alphagalactosidaseb.Betagalactosidasec.HexosaminidaseAd.HexosaminidaseB

31.Acidceramidasedeficiencyleadsto__________diseasea.Wolmanb.Farberc.Sandhoffd.Metachromaticleukodystrophy

32.Arcussenilis isduetoa.ExcessofLDLb.DeficiencyofLDLc.DeficiencyofLiduronidased.Excessofchondroitinsulfate

33.AtphysiologicalpHDNAmoleculesare?a.Positivelychargedb.Negativelychargedc.Neutrald.Amphipathic

34.Whatinvestigationwouldyouliketoperforminaboychildwithhistoryofrecurrentself-inflictedinjuries/mutilationandskinrashes?a.Tryptophanlevelsb.Uricacidc.Orotic acidlevelsinurined.Serumleadlevels

35.Hyperuricemiaisfoundin?a.Gaucherdiseaseb.FamilialChylomicronaemiac.Malignancyd.Orotic aciduria

36.WhichofthefollowingisaquantitativeDNA?a.ReverseTranscriptase-PCRb.Realtime- PCRc.Nested-PCRd.Multiplex-PCR

37.VitaminHis?a.Biotinb.Panthothenic acidc.Pyridoxald.Nicotinicacid

38.Erythrocytetransaminaseactivityisusedforassayof?a.B1deficiencyb.B3deficiencyc.B6deficiencyd.B9deficiency

39.Majormetabolicfuelofadiposetissue?a.Glucoseb.Ketonebodiesc.LDLd.HDL

40.EnzymedeficientinFarberdisease?a.α-galactosidaseb.β-galactosidasec.Ceramidased.Arylsulfastase A

41.Non-carbohydratesthatproducepositivebenedicttestare?a.Ascorbicacidb.Pantothenicacidc.BUNd.Triacylglycerol

42.Nolossofgeneticmaterialoccursin?a.Deletionb.Insertionc.Inversiond.substitution

43.Hay’stestisusedtodetect?a.Urinebilesaltsb.Urineketonesc.Urinesugard.Urineaminoacids

44.Smallestunitofgeneticexpressionwhichcodesforapolypeptidechain?a.Intronb.Exonc.Spliceosomed.Cistron

45.AWhichofthefollowingprocesswilloccurinbothcytoplasmandmitochondria?a.Betafattyacidoxidationb.Steroidsynthesisc.HMPshuntd.Gluconeogenesis

46.Whichofthefollowingisanamphibolicpathway?a.Krebscycleb.Ureacyclec.Heme synthesisd.Ketogenesis

47.Antimycininhibits?a.Cytochromeoxidaseb.Electrontransferfromcyt BtoCyt C1c.NADH- CoQ reductased.ADPphosphorylation

48.Phenylalaninepromotesgrowthof?a.Bacillussubtilisb.BacillusStearothermophilusc.Bacilluscereusd.Bacilluscoagulans

49.Orotic acidurialeadsto?a.Kidneyfailureb.Anaemiac.Musclecrampsd.Aminoaciduria

50.Mostcommondefectingalactosemiais?a.Galactose1uridyl transferaseb.Galactokinasec.Phosphoglucomutased.UDPGalactose4epimerase

51.WhichGlycogenstoragedisorderleadstocardiomyopathy?a.Coridiseaseb.Andersondiseasec.Mcardle syndromed.Pompe disease

52.Besttestfordetectionofinbornerrorsofmetabolismis?a.Chorionicvillussamplingb.P.U.B.Sc.Tandemmassspectrophotometryd.GelElectrophoresis

53.WhichofthefollowingisXLR?a.NiemanPickb.TaySachsc.Krabbe diseased.Fabrydisease

54.Mostcommonlysosomalstoragedisorderisduetodefectonwhichchromosome?a.Chromosome1b.Chromosome11c.Chromosome13d.Chromosome14

55.Whichofthefollowingtransfershepatictriglyceridestoperipheraltissues?a.Chylomicronsb.VLDLc.LDLd.HDL

56.Excessof________leadstoacutepancreatitis?a.Chylomicronsb.LDLc.HDLd.Alloftheabove

57.Whichofthefollowingisanindexofcholestasis?a.LipoproteinAb.ApolipoproteinBc.ApoEd.LipoproteinX

58.Whichofthefollowingvitamindeficiencycanleadtodementia?a.VitaminB6b.VitaminB12c.Biotind.Riboflavin

59.Cardiomyopathyisduetodeficiencyof:a.Zincb.cIronc.Seleniumd.Boron

60.Enzymedefectinessentialfructosuria?a.Fructokinaseb.Fructose1phosphatec.AldolaseBd.Fructose1,6Diphosphatase

61.EnzymeresponsibleforunwindingofDNAis?a.Helicaseb.Primasec.DNApolymerased.Transcriptase

62.Pseudo-uridineisfoundin?a.mRNAb.rRNAc.tRNAd.SnRNA

63.MitochondrialDNAis?a.Closedcircularb.Nickedcircularc.Lineard.Opencircular

64.Afterdigestionbyrestrictionendonucleases,DNAStrandscanbejoinedagainby?a.DNApolymeraseb.DNALigasec.DNATopoisomerased.DNAGyrase

65.Karyotypingunderlightmicroscopyisdoneby?a.R-Bandingb.Q-Bandingc.G-Bandingd.C-Banding

66.NotinvolvedinCori’scycle?a.Bloodb.Brainc.Liverd.Muscle

67.Enzymecommontoglycogenesisandglycogenolysisisa.Phosphoglucomutaseb.Glycogensynthetasec.Phosphorylased.Phosphofructokinase

68.Correctmatchingaboutthecycleandtheratelimitingstep?a.Porphyrinsynthesis:L-iduronidaseb.TCAcycle:Isosorbidedehydrogenasec.Fattyacidoxidation:AcetylCoAcarboxylased.Fattyacidsynthesis:Carnitineacyltransferase

69.Cofactorinsuccinatedehydrogenase?a.Manganeseb.Molybdenumc.Copperd.Iron

70.LongestRNAis?a.t-RNAb.r- RNAc.m-RNAd.alloftheabove

71.WhichofthefollowingissmallinterferingRNA?a.Si-RNAb.sno-RNAc.sn-RNAd.SRP-RNA

72.RespiratoryquotientofCarbohydratesis?a.0.66b.0.71c.0.8d.1.0

73.Translationoccursin?a.Nucleusb.Cytoplasmc.Nucleolusd.Mitochondria

74.MostrapidwaytosynthesiseATPis?a.Phosphocreatineb.Coricyclec.Krebscycled.Fatty-acid-oxidation