Prin%ng: Your  printer  might  not  print  the  same  way  our  printers  do,  so  make  sure  to  try  a  couple  of  test  prints.  If  things  aren’t  aligning  quite  right,  experiment  with  the  Scale  to  Fit  Paper  seCng.  It’s  located  in  the  Print  dialog  –  just  click  Full  Page  Slides  to  get  to  it.

And  did  you  no%ce  we  made  fold  marks  for  you?  They  are  really  light,  but  if  you  don’t  like  them  showing  on  your  brochure,  click  View,  Slide  Master,  and  delete  them  before  you  print.

Customizing  the  Content: The  placeholders  in  this  brochure  are  formaNed  for  you.  If  you  want  to  add  or  remove  bullet  points  from  text,  just  click  the  Bullets  buNon  on  the  Home  tab.

If  you  need  more  placeholders  for  %tles,  sub%tles  or  body  text,  just  make  a  copy  of  what  you  need  and  drag  it  into  place.  PowerPoint’s  Smart  Guides  will  help  you  align  it  with  everything  else.

Want  to  use  your  own  pictures  instead  of  ours?  No  problem!  Just  click  a  picture,  press  the  Delete  key,  then  click  the  icon  to  add  your  picture.

If  you  replace  a  photo  with  your  own  and  it’s  not  a  flawless  fit  for  the  space,  you  can  crop  it  to  fit  in  almost  no  %me.  Just  select  the  picture  and  then,  on  the  Picture  tools  Format  tab,  in  the  Size  group,  click  Crop.

Core  Infrastructure  and  Systems  Biology  

Advanced  Biomedical  Computing  Center    

Information  Systems  Program    

Frederick  National  Laboratory    for  Cancer  Research  

http://ncifrederick.cancer.gov/isp/abcc  

uma.mudunuri@fnlcr.nih.gov  301-846-6774

http://biodbnet.abcc.ncifcrf.gov  

bioDBnet   ABCC  

ISP,  FNLCR  

•  Convert across biological identifiers – 200 biological identifiers across 50 databases including EntrezGene, UniProt, RefSeq, Ensembl, DrugBank, OMIM, HMDB, Affy, dbSNP…

•  Functional annotations – GO annotations, KEGG, Reactome, Biocarta

•  Conversions across species – mouse affy probe id to human pathways

•  1000’s of users across the world

•  Integrated into EBI’s BioServices

Mudunuri et. al., Bioinformatics 2009 (PMID: 19129209)

bioDBnet  

proteomics

genomics

metabolomics methylation

protein disease drug

interaction

microarray probes

functional annotation

protein feature

taxon

pathway gene

orthologs

variation

transcriptomics

Data  Mining  •  Mine  from  multiple  formats  •  Species  agnostic  conversions  •  Biological  data  warehouse  •  Variant  Impact  Analysis  •  Species  agnostic  conversions  •  Large  scale  data  integration  •  SQL  and  NoSQL  •  Literature  Mining    

Systems  Biology  •  Disease  agnostic  queries  •  Clinical  and  genomic  integration  •  Multi-­‐omics  data  integration  •  Analysis  on  longitudinal  data  •  Secure  role  based  access  •  Data  sharing  across  collaborators  

 

Prin%ng: Your  printer  might  not  print  the  same  way  our  printers  do,  so  make  sure  to  try  a  couple  of  test  prints.  If  things  aren’t  aligning  quite  right,  experiment  with  the  Scale  to  Fit  Paper  seCng.  It’s  located  in  the  Print  dialog  –  just  click  Full  Page  Slides  to  get  to  it.

And  did  you  no%ce  we  made  fold  marks  for  you?  They  are  really  light,  but  if  you  don’t  like  them  showing  on  your  brochure,  click  View,  Slide  Master,  and  delete  them  before  you  print.

Customizing  the  Content: The  placeholders  in  this  brochure  are  formaNed  for  you.  If  you  want  to  add  or  remove  bullet  points  from  text,  just  click  the  Bullets  buNon  on  the  Home  tab.

If  you  need  more  placeholders  for  %tles,  sub%tles  or  body  text,  just  make  a  copy  of  what  you  need  and  drag  it  into  place.  PowerPoint’s  Smart  Guides  will  help  you  align  it  with  everything  else.

Want  to  use  your  own  pictures  instead  of  ours?  No  problem!  Just  click  a  picture,  press  the  Delete  key,  then  click  the  icon  to  add  your  picture.

If  you  replace  a  photo  with  your  own  and  it’s  not  a  flawless  fit  for  the  space,  you  can  crop  it  to  fit  in  almost  no  %me.  Just  select  the  picture  and  then,  on  the  Picture  tools  Format  tab,  in  the  Size  group,  click  Crop.

Systems Biology

Omics Analysis

Protein Features

Bioquery Medline

AVIA  •  Impact assessment

•  Clustering and Functional Annotations

•  Genomic and Protein positions as input

•  Visualize tissue expression levels, pathways, 3D structures, Circos plots

•  Prioritize and Summarize Variants and Genes

http://avia.abcc.ncifcrf.gov  

Vuong et. al., Bioinformatics 2014 (PMID: 24215028)

•  Role based secure data access

•  Data type aware browsing

•  Disease agnostic

•  Integration of omics data

•  Clinical and genomic data integration

•  Longitudinal analysis

•  Dynamic pathway and functional analysis

•  Applicable for multi-omics data sets

•  Query based on protein names or amino acid positions

•  All protein features from UniProt

•  Visualization using BioJS

•  Customizable user defined features

•  Clinical and genomic data integration

•  Query using gene symbols

•  Dynamic filtering options on known drug/disease/pathway associations

•  Visualize co-author networks