biologyaging2019-uw-final.pptx - read-only...+hduwexuq common and costly associated with reduced...

Aging: decreased salivachanges in taste perceptionfewer taste receptors

Gastrointestinal Aging (Heitkemper), NW GWEC Spring 2019 1

Common and costly

Associated with reduced quality of life

Barrier against refluxClinical problem:Reflux

ObesityDiet

Hiatal herniaRisk for Barrett’s

esophagusScreening –

American College of Gastroenterology guidelines


FD-men

Inci

de

nce

rat

e p

er

1000

pe

rso

n-y

r

02

4

6

8

10

12

14

16

20-29 30-39 40-49 50-59 60-69 70-79

F D-women

Age groups

IBS-men

IBS-women

Rodriguez et al. SJG 2000; 35:306-11FD = Functional DyspepsiaIBS = Irritable Bowel Syndrome


H.pylori

H.pylori –

Clostridium difficile colitis;


Brain-Gut-Microbiome Axis


C. difficile

‘The continued imprudent use of prolonged postoperative systemic antibiotics for presumed preventive purposes, particularly among the elderly and patients who have nasogastric tubes or other enteric tubes, appears to be a recipe for preventable infections with C difficile

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IBS-likesymptoms

n = 22Acute infectiousgastroenteritis

n = 75 No persistentsymptoms

n = 53

IBSat 6 months

n = 20

Predicted by psychological features

Gwee KA, et al. Lancet 1996

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biologyaging2019-uw-final.pptx - read-only...+hduwexuq common and costly associated with reduced...

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