biomedical engineering and biomedical informatics program

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Presented by Biomedical Engineering and Biomedical Informatics Program Barbara Beckerman Modeling and Simulation Group Computational Sciences and Engineering Division

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Biomedical Engineering and Biomedical Informatics Program. Barbara Beckerman Modeling and Simulation Group Computational Sciences and Engineering Division. Biomedical engineering and biomedical informatics research at ORNL. Biokinetic and biotransport modeling - PowerPoint PPT Presentation

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Page 1: Biomedical Engineering and Biomedical Informatics Program

Presented by

Biomedical Engineering and Biomedical Informatics Program

Barbara BeckermanModeling and Simulation Group

Computational Sciences and Engineering Division

Page 2: Biomedical Engineering and Biomedical Informatics Program

Beckerman_0611

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Biomedical engineering and biomedical informatics research at ORNL Biokinetic and biotransport modeling

Three-dimensional organ and tissue modeling using CT or other imagery (pulmonary, arterial, musculoskeletal)

Prediction of outcomes based on biomedical models

Knowledge discovery and intelligent agents for data mining and analysis

Integration of models at multiple temporal and spatial scales

Computer environments (data repositories, search tools, visualization, etc.) in support of biomedical and medical applications

Page 3: Biomedical Engineering and Biomedical Informatics Program

ORNL HotBox integrates all the DARPA Virtual Soldier windows

HotBox interfaceHotBox interface

Anatomical ontology:Foundational model

of anatomy

Anatomical ontology:Foundational model

of anatomy

Predicted locationof wound

SCIRun Net

Physiology display

Geometry window with thorax model

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Page 4: Biomedical Engineering and Biomedical Informatics Program

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*Funded by National Library of Medicine–NLM-N01-LM-0-1-3512 and LM-0018-01 (1998–2003); PI–Mitch Schnall, University of Pennsylvania; Co-PI/Technical Director–B. Beckerman, Oak Ridge

Biomedical applications for thenext-generation Internet (NIH/NLM)*

NationalDigital

MammographyArchive

NationalDigital

MammographyArchive

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Goal: Predict migration of smooth muscle cells from mediato intima due to inflammatory response after injury

Model for predictingvascular disease

Predictive multi-scale modeling

Spatial modelingof cell migration

Kinetic modelingof biochemicals

Result: A multi-scale hybrid continuous-discrete predictive model for tissue pathology

Atherosclerotic artery

MMP3

proMMP9

TIMP1 TIMP1proMMP9

MMP3MMP3proMMP9

TIMP1

TIMP1 TIMP1

TIMP3TIMP3

TIMP2

TIMP2 TIMP2

MMP9

MMP9

MMP9

MMP9

MMP9

MMP9 MMP9

MMP9

Collagen IV

Collagen IV

MMP3

Inhibited

Inhibited

Inhibited

Activation of MMP-9

Inhibition of MMP-9

MMP-9-inducedcollagenolysis

ACTIVE

Matrix metalloproteinases (MMPs)

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Dorsal view Ventral view

Metrics for tissue anatomy

Temporal measurement of lumenal diameter

Imaging of vascular wall perturbations after injury due to balloon angioplasty

Biological modeling and simulation environments (cellular, tissue, and multi-scale kinetics models)

Discrete event simulationsto predict resultsof vascular wall injury

Thoracic and neck vasculature seen in the microCAT scanner using the vascular

contrast agent Fenestra VC(Images courtesy of J. Wall,

University of Tennessee Medical Center)

Computational modelingfor vascular systems:Collaboration with the UT Medical Center Mammalian models Computational models

Page 7: Biomedical Engineering and Biomedical Informatics Program

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Orthopedics research at UTK/ORNL:Dynamic and kinematic models of motion for knees, hips, and spine

Cervical SpineDynamic ModelCervical SpineDynamic Model

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Computational modeling of pre- and post-operative lumbar spine system

In vivo imaging and analysis of lumbar spine system (Komistek, Mahfouz)

Finite-element mesh models of the spine (Nukala)

Constitutive modeling of intervertebral discs (Nukala)

Two vertebrae and a discTwo vertebrae and a disc

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Seizalert on PDA:2005 R&D 100 award*

Non-linear analysis approach predicts onset of epileptic seizure

Implemented in software on a PDA or wearable device to alert wearer to occurrence of seizure

Protected by five patents and two pending

Licensed to Hercules Development Corporation

*Hively, Protopopescu, Munro, Kruse (2005)

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Page 10: Biomedical Engineering and Biomedical Informatics Program

ORNL solves biomedical problems

Convert CT slice data to finite-element mesh

Abdominal aneurysms

Prediction of wounds

Data repositories

Parallel computations

Computational tools for toxicants

Agent technologies

Ontologies and informatics

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Page 11: Biomedical Engineering and Biomedical Informatics Program

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Contacts

Barbara BeckermanProgram Manager, Biomedical EngineeringComputational Sciences and Engineering Division(865) [email protected]

Brian WorleyDirector, Computational Sciences and Engineering Division(865) [email protected]

Richard WardSenior Research ScientistComputational Sciences and Engineering Division(865) [email protected]

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