biomedical science 2nd year immunology course introduction
TRANSCRIPT
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Immunology
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Immunology
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Immunology
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Inflammation and pathogenesis of type 1 diabetes: Discuss the current knowledge of
the contribution of cellular and molecular components of the immune system to the
pathology of type 1 diabetes
- What is Type1 diabetes?
- What are the molecular and cellular components of the immune system involved in the
initiation and development of Type 1 diabetes?
Review
Object of the exercise
- Test your capacity to process and synthesise large amounts
of information
- Test your critical thinking
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- You need to start searching and reading information for your essay
Inflammation and pathogenesis of type 1 diabetes: Discuss the current knowledge of
the contribution of cellular and molecular components of the immune system to the
pathology of type 1 diabetes
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1. Search and read the available information
Inflammation and pathogenesis of type 1 diabetes: Discuss the current knowledge of
the contribution of cellular and molecular components of the immune system to the
pathology of type 1 diabetes
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Bibliographic/Literature databasesSearching for the information
Some bibliographic databases of relevance for Life Sciences and Biomedicine
http://www.cell.com/
http://www.nature.com/siteindex/index.html
http://www.sciencemag.org/
http://www.biomedcentral.com/browse/journals/http://www.sciencedirect.com
http://www.ncbi.nlm.nih.gov/
(the database of databases: pubmed for bibliography)
http://apps.isiknowledge.com (also to find journals IF)
Highest impact scientific journals
To search for the latest high impact scientific work in Biomedical Sciences
Bibliographic databases
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How to handle largeamounts of information?
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2. Process and summarise read information
Inflammation and pathogenesis of type 1 diabetes: Discuss the current knowledge of
the contribution of cellular and molecular components of the immune system to the
pathology of type 1 diabetes
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2. Process and summarise read information
-Use BULLET LISTS: most relevant points that I will addressin my essay (review)
a) Bullet list with the information you have read in each source
(E.g. In each review article)
Example: Structure of review by Naidoo et al.s bullets points and sections
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2. Process and summarise read information
-Use BULLET LISTS: most relevant points that I will addressin my essay (review)
a) Bullet list with the information you have read in each source
(E.g. In each review article)
Example: Structure of review by Naidoo et al.s bullets points and sections:
- HGP
- Architecture and function of the human genome
- Development of the genome-wide association studies (GWAS) approach to complex diseases
and traits
- High-throughput sequencing technologies and their impact on genomic studies
- Personalised genomic medicine
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2. Process and summarise read information
-Use BULLET LISTS: most relevant points that I will addressin my essay (review)
a) Bullet list with the information you have read in each source
(E.g. In each review article)
b) Bullet list with the points I will be addressing in my essay
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- You need to start searching and reading information for your essay
- I will give you more directions about how to write your essay in week 4.
Inflammation and pathogenesis of type 1 diabetes: Discuss the current knowledge of
the contribution of cellular and molecular components of the immune system to the
pathology of type 1 diabetes
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QUESTIONS?
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Immunology
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Introduction to Immunology
Basic concepts
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Definition by Oxford Dictionary
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The organs, cellsand processesof the body that provide
resistance to infection, toxinsand cancer:
- Organsinclude the thymus, bone marrow, and lymphnodes.
- Cells: Leukocytes (circulating and tissue resident)
- Soluble factors:
- Antibodies
- Complement- Proteins (cytokines and chemokines) and lipid
intermediates: signalling proteins.
Immune System
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Cells of the blood: Haematopoiesis
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The organs, cellsand processesof the body that provide
resistance to infection, toxinsand cancer:
- Organsinclude the thymus, bone marrow, and lymphnodes.
- Cells: Leukocytes (circulating and tissue resident)
- Soluble factors:
- Antibodies
- Complement- Proteins (cytokines and chemokines) and lipid
intermediates: signalling proteins.
Immune System
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Antibodies
Globular proteins produced by B-cells that recognise and bind antigens
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Immunology: Basic concepts
Antigen: Any substance that can specifically bind to an antibody
or T cell receptor
- Examples: proteins, LPS, DNA, lipids
Immunogen: Antigen able to induce an immune response
Epitope (Antigenic determinant): Specific site in an Ag, which is
recognised by the immune system (site of antibody binding)
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The organs, cellsand processesof the body that provide
resistance to infection, toxinsand cancer:
- Organsinclude the thymus, bone marrow, and lymphnodes.
- Cells: Leukocytes (circulating and tissue resident)
- Soluble factors:
- Antibodies
- Complement- Proteins (cytokines and chemokines) and lipid
intermediates: signalling proteins.
Immune System
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P t i ( t ki d h ki ) d li id
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Proteins (cytokines and chemokines) and lipid
intermediates: signalling proteins
Function: Cell communication and signalling:
-Activation and modulation of the immune response
(proinflammatory vs regulatory signalling)
- Chemotaxis: Leukocyte trafficking
C t ki t k
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Cytokine networks
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QUESTIONS?