biomimetic molecules and their application to aesthetic medicine
DESCRIPTION
Lecture on Biomimetic Molecules and their application to Cosmetic Medicine given by Dr. Patrick Treacy on behalf of Dermagenica in London in 2012. Nature provides inspiration for designing materials and systems, which derive their functions from highly organized structures. The ordered organization of hierarchical structures in organisms begins via the molecular recognition of inorganics by proteins that control interactions and followed by the highly efficient self-assembly across scales.Following the molecular biological principle, proteins could also be used in controlling materials formation in practical engineering via self-assembled, hybrid, functional materials structures. In molecular biomimetics, material-specific peptides could be the key in the molecular engineering of biology-inspired materials.TRANSCRIPT
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History of Biomimetic Mesotherapy
• 1952 - Dr Michel Pistor - the beginning of a discipline called mesotherapy
• 1999 - NanopeptidesThe Nobel Prize in Physiology or Medicine 1999 was awarded to Günter Blobel "for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell".
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History of Biomimetic Mesotherapy
• Since 2002 - Dermaheal the world leader of research and marketing of Biomimetic Peptides and Growth Factors & a global supplier of biomimetic peptides and growth factors to the cosmetic industry with well established relationships with La Prairie,
Revlon, Dermalogica and Sasa.
• 2005 - 2009 - Dermaheal Introduces biomimetic mesotherapy
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Biomimetic peptides
• SynthShort chains of amino-acids responsible for the proliferation and differentiation of cells
• etic Growth factors
• They are responsible for cellular processes including wound healing
• Stimulate production of elastin
& collagen
• The latest trend in cosmetology
• A synthetic ingredient
• Repeatable technology
• No irritation or cancerogenic effects
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Platform TechnologyThe importance of cytokines and growth factors in the regulation of gene expression and cellular metabolism is well established in a field of skin biology.
Summarized functions of growth factors andmimicking peptides.• Removing damaged skin cells.• Stimulating skin and hair follicle proliferation.• Repairing and preventing wrinkle formation and minimizing
scar formation.• Soothing effect on acne and pimples.• Reducing and removing cellulites.• Acting as anti-microb agents.• Preventing hair loss.• Vitalizing skin and hair cells.
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Skin absorption of Nano-capsulation
Intercellular interval of skin is 70-180nmMolecules are tiny enough to deeply penetrateTransport cosmetic components into dermal skin tissue
Characteristics of Nano-capsulation
• Multi-layered• Therapeutic components in each globe layer• Continuous release effect
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CG-Boostrin / Oligopeptide-72
• Anti-wrinkle, skin firming.• Reduces and prevents lines and wrinkles by
actively generating new skin cells• Enhances skin tone that brimms with vitality
and energy
Cell Proliferation with Fibroblast Cells
Morphological Change of Fibroblast Cells
Anti-aging
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CG-EDP3/ Oligopeptide-24
• Anti-wrinkle, skin lifting, skin firming.• Reduces and prevents lines and wrinkles by actively generating new
skin cells. • Enhances skin tone that brimming with vitality and energy. • Minimize scars on skin by forming new skin cell. • Up-regulation of cell growth and migration, cell survival, extracellular
matrix expression
Anti-aging
Cell Proliferation with Fibroblast Cells
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CG-EDP3/ Oligopeptide-24
Morphological Change of Fibroblast Cells
Anti-aging
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CG-IDP2/ Decapeptide-4
• Anti-wrinkle, skin lifting, hair growth.• Strengthens skin elasticity by inducing the synthesis of collagen and
elastin.• Involves in normal skin growth, healing and wound repair.• Reduces and prevents lines and wrinkles by actively generating new
skin cells.
Anti-aging
Cell Proliferation with Keratinocyte and Fibroblast Cells
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CG-IDP2/ Decapeptide-4Anti-aging
Morphological Change of Keratinocyte and Fibroblast Cells
Skin Histology Study of CG-IDP2
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CG-IDP5/ Oligopeptide-20• Anti-wrinkle, skin lifting, hair growth.• Strengthens skin elasticity by inducing the synthesis of collagen and
elastin.• Involves in normal skin growth, healing and wound repair.• Reduces and prevents lines and wrinkles by actively generating new
skin cells.
Anti-aging
Morphological Change of Keratinocyte and Fibroblast Cells
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CG-IDP5/ Oligopeptide-20
Anti-aging
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CG-Demelarin/ Oligopeptide-58
• Skin Lightening & Brightening• Sun Protection• Even Skin Tone• Photo-aging Prevention• Aged Spot Treatment
Anti-pigmentation
Morphological Change
Inhibition of Melanin Synthesis after CG-Demelarin Treatment
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CG-TGP2/ Oligopeptide-34
• Skin Lightening & Brightening• Sun Protection• Even Skin Tone• Photo-aging Prevention• Aged Spot Treatment• Skin Trouble Care
Anti-pigmentation
Melanin Synthesis ComparisonWith Various Skin LighteningIngredients
Morphological ChangeOf Melanocyte Cell Line
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CG-Glamerin/ Oligopeptide-50
• Skin Lightening & Brightening• Sun Protection• Even Skin Tone• Photo-aging Prevention• Aged Spot Treatment
Anti-pigmentation
Morphological Change of Melanocyte Cell Line
Melanocytes are First!!To show signs of damage in the aging process
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CG-Prohairin-β4/ Octapeptide-2
• Hair growth.• Increases cell growth and migration.• Promotes hair growth by activating the stem
cells of hair follicle.
Hair-Growth
Structure of Prohairin- β4Cell Proliferation withKeratinocyte - Fibroblast cell nine
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CG-Prohairin-β4/ Octapeptide-2Hair-Growth
Cell Morphology Analysis after Prohairin-β4 Treatment
Cell Survival Test
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CG-Promkine/ Decapeptide-20
• Promotes hair growth by increasing proliferation of hair cells.
• Stimulates hair growth through NFkB signaling
Hair-Growth
Morphological Change of fibroblast cell and Keratinocyte cell
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CG-Lipoxyn/ Tripeptide-21
• Lipolysis• Helps restraining of accumulated lipid and
promotes lipolysis
Lipolysis
Inhibition of Lipid Accumulation by CG-Lipoxyn
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CG-Lipoxyn/ Tripeptide-21Lipolysis
Lipolysis Mechanism
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Biomimetic Mesotherapy
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Dermaheal HSR
Hyaluronic Acid Skin Rejuvenating Mesotherapy Solution• Anti-ageing product• Skin rejuvenating, regenerating and
moisturising effect• Intended especially for mature, very dry or
dehydrated skin
58 ACTIVE INGREDIENTS:• 1% of Hyaluronic Acid, 13 Vitamins• 24 Amino Acids, 5 Minerals,• 4 Coenzymes, 4 Nucleic Acids,• 2 Reducing Agents,• 5 Biomimetic Peptides
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Dermaheal HSR: 5 Biomimetic PeptidesAcetyl Decapeptide-3Reduces and prevents lines and wrinkles by actively generating new skin cells
Decapeptide-4Strengthens skin elasticity by inducing the synthesis of collagen and elastin
Oligopeptide-24Minimizes scars on skin by forming new skin cells
Tripeptide-6Hydrates dry skin and maintain its optimum moisture balance
Copper Tripeptide-1Helps blood circulation in the skin andrevitalises by generating new skin cells
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Dermaheal SR
Skin Rejuvenating Mesotherapy Solution for face, neck, hands and strechmarks
• Anti-ageing product• Skin rejuvenating & regenerating effect• Recommended for dull, dry, or combination
skin also with acne problems
57 ACTIVE INGREDIENTS:13 Vitamins, 24 Amino Acids,5 Minerals, 4 Coenzymes,4 Nucleic Acids, 2 Reducing Agents,5 Biomimetic Peptides
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Acetyl Decapeptide-3Reduces and prevents lines and wrinkles by actively generating new skin cells
Decapeptide-4Strengthens skin elasticity by inducing the synthesis of collagen and elastin
Oligopeptide-24Minimizes scars on skin by forming new skin cells
Tripeptide-6Hydrates dry skin and maintain its optimum moisture balance
Copper Tripeptide-1Helps blood circulation in the skin andrevitalises by generating new skin cells
Dermaheal SR: 5 Biomimetic Peptides
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Hair Regain Mesotherapy Solution
• Regenerative product• Prevents hair loss and alopecia in both men
and women• Promotes hair regrowth• Provides scalp care
58 ACTIVE INGREDIENTS:13 Vitamins, 24 Amino Acids,5 Minerals, 4 Coenzymes,4 Nucleic Acids, 2 Reducing Agents,4 Biomimetic Peptides
Dermaheal HL
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Dermaheal HLDecapeptide-4Strengthens hair while stimulating hair follicles to produce strong hair shaft
Acetyl Decapeptide-3Revitalises hair follicles by newly regenerating hair cells
Oligopeptide-41Stimulates hair cell proliferation and migration
Copper Tripeptide-1Helps blood circulation in the scalp,revitalises hair follicles
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Dermaheal SB
Skin Brightening
Intended for hyperpigmentation, melasma, age spots, freckles
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Dermaheal SB
Oligopeptide-34 + Oligopeptide-50
• reduce the melanin synthesis by blocking the transfer of melanin to keratinocytes
• prevent pigmentation, • moisturize the skin• anti-inflammatory properties
Pentapeptide-13
Brightens and lightens the skin
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tCELLULITE
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Dermaheal LL
• A unique product that combines fat-burningcapabilities together with the regenerationand improvement of skin elasticity
• It is both effective in fighting cellulite and local
fat deposits
• Excellent results in slimming the body & restoring taut facial contours by breaking down adipose tissue
• By increasing collagen and elastin production it strengthens the skin, making it more supple and elastic
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Dermaheal LL
L-CarnitineResponsible for transport of fat cells into the mitochondria, where they decompose, detoxifying action.
Hydrogenated LecithinBreakdown & excretion of triglycerides.
Decapeptide 4Helps to burn & break down adipose tissue.Responsible for smoothing the skin.
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Treatment protocol: Stage 1 - Mesoroller
Skin Rejuvenation Treatment Regulate Function Of
1. Keranocytes2. Melanocytes3. Fibroblasts
Roller & Mesotherapy
Results always look natural
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Treatment protocol: Stage 1 - Mezoroller
Dermaheal SR Dermaheal HSR Dermaheal SB Dermaheal HL Dermaheal LL
5ml x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set 5ml x 10 vials / Set
Mesotherapy1 session per week1 vial for 1 session
Mesotherapy1 session per week1 vial for 1 session
Mesotherapy1 session per week1 vial for 1 session
Mesotherapy1~2 sessions per
week1 vial for 1 session
Mesotherapy1 session per week
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CG-aFGF/ sh-Polypeptide-11Growth Factors
Tertiary structure of aFGF
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CG-TGF-β3/ sh-Polypeptide-5Growth Factors
Tertiary structure of TGF-β3
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CG-EGF/ sh-Oligopeptide-1Growth Factors
Tertiary structure of EGF
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CG-IGF-2/ sh-Polypeptide-31Growth Factors
Tertiary structure of IGF-2
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CG-TGF-β1Growth Factors
Tertiary structure of TGF-β1
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CG-Thymosin-β4/ sh-Oligopeptide-4Growth Factors
Tertiary structure of Thymosin-β4
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CG-TRX/ sh-Polypeptide-2Growth Factors
Tertiary structure of TRX
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CG-bFGF/ sh-Polypeptide-1Growth Factors
Tertiary structure of bFGF
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CG-IGF-1/ sh-Oligopeptide-2Growth Factors
Tertiary structure of IGF-1
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CG-KGF/ sh-Polypeptide-3Growth Factors
Tertiary structure of KGF
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CG-VEGF/ sh-Polypeptide-9Growth Factors
Tertiary structure of VEGF
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Mesotherapy Treatment Plan• Exfoliation
• Mesotherapy
• Massage
• Pure Vitamin E Caps / Face-mask
• UVB Cream
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Mesoroller Micro needlingCollagen Induction TherapyDermaroller
The reduction of local fat deposits/Cellulite
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Chin
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Back
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Abdomen
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Butterfly Wings Region
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Love Handles / Hips
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Knees
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Dermaheal LL
Mesotherapy for cellulite
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Before After
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Before After
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Before After
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Thank you for your attention!
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