bionoticias 3ª semana de diciembre
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Revista de noticias sobre Biología, Biotecnología, Medioambiente, Neurociencias, etc. Elaborada por la Biblioteca de la Facultad de Biología de la Universidad de SalamancaTRANSCRIPT
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La domesticación del caballo tuvo su
precio genético
Hace 5.500 años que el ser humano
comenzó a utilizar a los caballos para
el transporte y el trabajo. Desde
entonces, estos animales han
experimentado cambios en su
genoma, que ahora un equipo
científico ha logrado descifrar. La
Los árboles tropicales no crecen más
a pesar del aumento de CO2
El aumento del CO2 en la atmósfera
registrado en los últimos 150 años no
ha provocado un mayor crecimiento
de los árboles tropicales, como se
pensaba. Una investigación ha
analizado los anillos de los troncos de
diversas especies arbóreas
Cerca del 50% del fósforo que se
emite a la atmósfera proviene de la
actividad humana
Un equipo internacional de
investigadores ha realizado el balance
más realista hecho hasta el momento
del fósforo atmosférico en el planeta.
Durante décadas se había pensado
que la actividad humana sólo
aportaba un 5% del fósforo que
Detienen en Tenerife a una persona
con 21 ejemplares de un ave única de
Canarias
La Guardia Civil ha incautado más de
una veintena de pinzones azules de
Tenerife que
un individuo pretendía trasladar de
forma ilegal desde el aeropuerto
Reina Sofía a Italia. El pinzón azul es
una especie presente únicamente en
Identifican las mejores plantas del
cardo utilizado en la elaboración de la
Torta del Casar
Cynara cardunculus es uno de los
agentes fundamentales en la
elaboración del queso Torta del Casar
DO. Una nueva técnica desarrollada
por la Universidad de
Extremadura permite, no solo
diferenciar el Cynara cardunculus del
¿En el umbral de la píldora definitiva
contra la obesidad?
Unos investigadores del Instituto de
Células Madre de la Universidad
Harvard en Cambridge,
Massachusetts, Estados Unidos, han
efectuado lo que describen como el
primer paso hacia una píldora capaz
de ejercer el mismo efecto que el
La tecnología de microondas impide
que la fruta con hueso se pudra
Una investigación española, liderada
por el centro de Investigación y
Tecnología Agroalimentarias (IRTA)
en Cataluña, demuestra que los
melocotones infectados con el hongo
Monilinia no se pudren si son
tratados con microondas. Tras tres
Un megaestudio genético dibuja el
árbol familiar de aves, reptiles y
dinosaurios
Después de cuatro años de trabajo, un
consorcio internacional de más de
200 científicos ha trazado el mapa
filogenético de las aves modernas. El
estudio resuelve incógnitas sobre las
diferencias en el canto, cuándo
perdieron los
Detectan altas acumulaciones de
insecticidas en peces de río
Un estudio, con participación
española, ha permitido detectar por
primera vez elevadas concentraciones
de insecticidas piretroides en el tejido
de diferentes especies de peces de
cuatro ríos españoles. Los efectos de
estos contaminantes
¿Tienen las mujeres más neuronas
olfativas que los hombres?
La capacidad para identificar olores
varía mucho de una persona a otra.
Más importante aún es el hecho de
que hombres y mujeres difieren
grandemente en cómo perciben los
olores, superando las mujeres a los
hombres en muchos tipos
Descubierto un nuevo tipo de célula
madre pluripotente para la medicina
regenerativa
Desde 2006 los científicos saben
cómo reprogramar células maduras
para convertirlas en cualquier célula
especializada del organismo, un logro
que ha revolucionado la medicina
Revelaciones sobre la historia
evolutiva de los mamíferos gracias a
un cráneo fósil de la era de los
dinosaurios
El sorprendente descubrimiento de un
cráneo fosilizado de una criatura con
una antigüedad de entre 66 y 70
millones de años, con cierto parecido
a la marmota de América, encontrado
en Madagascar, ha llevado a nuevos
Las crías de lince ibérico marcan los
huesos de conejo igual que sus
progenitores
Las marcas observadas en los restos
fósiles pueden ser de origen humano
o animal. Un experimento realizado
por el IPHES ha permitido demostrar
que las marcas halladas en huesos de
Pollos y pavos, los herederos aviares
actuales de los dinosaurios
En los últimos años, ha aumentado de
forma considerable la cantidad de
evidencias de que los pájaros
descienden de un tipo de dinosaurios.
A través de numerosos estudios, se ha
determinado, entre otras muchas
coincidencias, que
Un megaestudio genético dibuja el
árbol familiar de aves, reptiles y
dinosaurios
Después de cuatro años de trabajo, un
consorcio internacional de más de
200 científicos ha trazado el mapa
filogenético de las aves modernas. El
estudio resuelve incógnitas sobre las
diferencias en el canto, cuándo
perdieron los
Determinan los factores de riesgo
asociados al chagas en mujeres
embarazadas
Investigadores de Japón, EE UU y El
Salvador han profundizado por
primera vez en los factores de riesgo
asociados a la enfermedad de Chagas
en mujeres embarazadas
salvadoreñas: la edad menor de 35
años y la anemia. Por ello,
Las áreas verdes y azules tienen
efectos beneficiosos en el desarrollo
del comportamiento infantil
Un nuevo estudio confirma que los
espacios naturales tienen un impacto
positivo en el comportamiento de los
niños. El trabajo se basó en una
muestra de 2.111 niños en edad
escolar, de 7 a 10 años, de 36
escuelas de Barcelona.
Un nuevo método muestra cómo se
propagan las oscilaciones alfa
cerebrales
Un estudio revela un nuevo
método para captar la actividad alfa
cerebral que combina el
electroencefalograma con
el modelado biofísico. Hasta ahora no
se había llegado a un consenso en
cuanto a la velocidad de propagación
de las ondas
Descubierto un nuevo tipo de célula
madre pluripotente para la medicina
regenerativa
Desde 2006 los científicos saben
cómo reprogramar células maduras
para convertirlas en cualquier célula
especializada del organismo, un logro
que ha revolucionado la medicina
personalizada. Ahora, al explorar los
Ha nacido Muba, el primer cordero
fruto de un trasplante de útero
Una oveja ha dado luz en Cáceres al
primer cordero nacido de un útero
trasplantado. Se llama Muba y se
encuentra en perfecto estado de salud.
Variantes de un producto natural,
candidatos a fármaco contra la
malaria
Investigadores del IRB Barcelona
identifican una familia de moléculas
eficaces y selectivas para combatir el
parásito Plasmodium, causante de la
El 90% de los comedores escolares
sirve menús para alumnos con
alergias
Un estudio elaborado por la Agencia
de Salud Pública de Barcelona ha
detectado que el 89% de los centros
escolares de la ciudad catalana sirven
ya menús especiales para alumnos
con alergias o intolerancias
alimentarias. Sin embargo,
El índice glucémico está relacionado
con la rigidez arterial
Un nuevo estudio muestra una clara
relación entre dos parámetros que
hasta ahora se habían vinculado con
enfermedades cardiovasculares por
separado: el índice glucémico, que
mide la glucosa tras la ingesta de
Identifican genes implicados en la
regeneración de tejido cardíaco del
pez cebra
El trabajo, en el que participa la
Universidad de Sevilla, ha permitido
identificar los genes expresados en la
espuesta a lesiones cardiovasculares
en un organismo modelo como es el
pez cebra. Los resultados, publicados
en BMC Genomics,
Las células senescentes juegan un
papel esencial en la curación de
heridas
Un estudio del Instituto Buck,
Estados Unidos, destaca la capacidad
para hacer frente a un efecto
secundario potencial de los fármacos.
Un biomarcador permite predecir la
respuesta a la terapia con interferón-
beta en esclerosis múltiple
La colaboración con otros centros
mejora la accesibilidad al tratamiento
y la calidad de vida.
Una guía para conocer todos los
secretos de la reprogramación celular
Estudios que desvelan nuevos
detalles sobre los eventos que hacen
posible la reprogramación celular
para alcanzar el estado de
pluripotencialidad.
Molecular tag team revealed to
control cell division
Scientists have explored the role of
three molecules in controlling the
process of cell division in a bid to
gain new insight into the transmission
of vital signals from a cell's exterior
to its interior. The researchers show
that the three protein
Nutrient availability can cause whole-
genome recoding
The availability of a trace nutrient
can cause genome-wide changes to
how organisms encode proteins,
report scientists. The use of the
nutrient -- which is produced by
bacteria and absorbed in the gut --
appears to boost the speed and
Reshaping the horse through
millennia: Sequencing reveals genes
selected by humans in domestication
Whole genome sequencing of modern
and ancient horses unveils the genes
that have been selected by humans in
the process of domestication through
the last 5,500 years, but also reveals
the cost of this domestication. An
international
Squid supplies blueprint for printable
thermoplastics
Squid, what is it good for? You can
eat it and you can make ink or dye
from it, and now a team of
researchers is using it to make a
thermoplastic that can be used in 3-D
printing.
Molecular 'hats' allow in vivo
activation of disguised signaling
peptides
When someone you know is wearing
an unfamiliar hat, you might not
recognize them. Researchers are
using just such a disguise to sneak
biomaterials containing peptide
signaling molecules into living
animals.
Cell biologists discover on-off switch
for key stem cell gene
A new study by cell and systems
biologists investigating stem cells in
mice shows, for the first time, a
relationship between the Sox2 gene
which is critical for early
Control knob for fat?
Researchers found a new function for
a long-studied gene: it appears to
regulate fat storage in C. elegans. A
version of the protein, which exists in
humans, also regulates protein
production in the cell, raising the
Oil-dwelling bacteria are social
creatures in Earth's deep biosphere
Oil reservoirs are scattered deep
inside the Earth like far-flung islands
in the ocean, so their inhabitants
might be expected to be very
different, but a new study shows
these underground microbes are
Mitochondrial research: New studies
build on 60 years of work
New research was built on a mission
to determine, bit by bit, how
mitochondria -- the power plants of
cells -- generate the energy required
to sustain life. What these researchers
Reasons for malaria's drug resistance
discovered
Scientists have discovered, in a
breakthrough study, exactly how the
malaria parasite is developing
resistance towards the most important
front-line drugs used to treat the
disease. Malaria is a mosquito-borne
3-D maps of folded genome: Catalog
of 10,000 loops reveals new form of
genetic regulation
In a triumph for cell biology,
researchers have assembled the first
high-resolution, 3-D maps of entire
folded genomes and found a
structural basis for gene regulation --
Sharing that crowded holiday flight
with countless hitchhiking dust mites
As if holiday travel isn't stressful
enough. Now researchers say we're
likely sharing that already
overcrowded airline cabin with
countless tiny creatures including
house dust mites.
Blocking receptor in brain's immune
cells counters Alzheimer's in mice
The mass die-off of nerve cells in the
brains of people with Alzheimer's
disease may largely occur because an
entirely different class of brain cells,
called microglia, begin to fall down
on the job, according to a new study.
The
New way to turn genes on
discovered: Technique allows rapid,
large-scale studies of gene function
Using a gene-editing system
originally developed to delete
specific genes, researchers have now
shown that they can reliably turn on
any gene of their choosing in living
cells. The findings are expected to
help researchers refine and
New drug proves effective against
antibiotic-resistant 'superbugs'
A new treatment is far more effective
than traditional antibiotics at
inhibiting the growth of drug-
resistant bacteria, including so-called
'superbugs' resistant to almost all
existing antibiotics, which plague
hospitals and nursing homes. The
Cells can use dynamic patterns to
pluck signals from noise
Scientists have discovered a general
principle for how cells could
accurately transmit chemical signals
Biologists map crocodilian genomes
Understanding the crocodilian
genome can help scientists better
understand birds. The DNA in
alligators, crocodiles and gharials is
about 93 percent identical across the
Human DNA shows traces of 40-
million-year battle for survival
between primate and pathogen
Examination of DNA from 21
primate species – from squirrel
monkeys to humans – exposes an
evolutionary war against infectious
bacteria over iron that circulates in
Ebola virus may replicate in an exotic
way
Researchers ran biochemical analysis
and computer simulations of a
livestock virus to discover a likely
and exotic mechanism to explain the
replication of related viruses such as
Ebola, measles and rabies. The
mechanism may be a
Is that Ginkgo biloba supplement
really what you think it is?
A new study has investigated the use
of DNA barcoding to test the
authenticity of Ginkgo biloba, an
herbal dietary supplement sold to
consumers that is purported to boost
cognitive capacity.
Human exposure to metal cadmium
may accelerate cellular aging
The metal cadmium has been the
focus of new study that finds that
higher human exposure can lead to
significantly shorter telomeres, bits of
DNA at the ends of chromosomes
that are associated with
cardiovascular disease, diabetes and
other
Sampling rivers for genes rather than
organisms
Effective environmental management
depends on a detailed knowledge of
the distribution of species. But
taxonomists are in short supply, and
some species can be difficult to
identify, even for experts. Scientists
are now pursuing a new
Breakthrough solves centuries-old
animal evolution mystery
Researchers have developed a
method for spying on the activity of
every gene within a cell at once. The
breakthrough allows them to
determine the order in which the
three layers of cells in animal
embryos evolved. Other applications
Analogues of a natural product are
drug candidates against malaria
Two analogues of borrelidin were
found to cure 100 percent of infected
mice and produce immunological
memory in these animals, a property
not previously observed in an
antimalarial drug. Growing resistance
to current treatment for
Yeast are first cells known to cure
themselves of prions
Yeast cells can sometimes reverse the
protein misfolding and clumping
associated with diseases such as
Alzheimer's, according to new
research. The finding contradicts the
idea that once prion proteins have
changed into the shape
Solid-state proteins maximize
intensity of fluorescent-protein-based
lasers
The same research team that
developed the first laser based on a
living cell has shown that use of
fluorescent proteins in a solid form
rather than in solution greatly
increases the intensity of light
produced, an accomplishment that
takes
Turning biological cells to stone
improves cancer, stem cell research
Near-perfect replications of human
and animal cells enables improved
study of certain cancers and stem
cells, as well as the creation of
complex durable objects without
machinery, scientists report. A new
technique to transmute living cells
Injectable 3-D vaccines could fight
cancer, infectious diseases
A non-surgical injection of
programmable biomaterial that
spontaneously assembles in vivo into
a 3-D structure could fight and even
help prevent cancer and also
infectious disease such as HIV,
scientists have demonstrated. Tiny
A pill for obesity? Stem cell scientists
convert white fat to brown fat
Researchers have taken what they are
describing as 'the first step toward a
pill that can replace the treadmill' for
the control of obesity -- though it, of
course, would not provide all the
additional benefits of exercise. The
researchers have
Virtual bodyswapping diminishes
people's negative biases about others
Researchers explain how they have
used the brain's ability to bring
together information from different
senses to make white people feel that
they were inhabiting black bodies and
adults feel like they had children's
bodies. The results
Therapeutic strategy may treat
childhood neurological disorder
A possible therapy to treat
neurofibromatosis type 1 or NF1, a
childhood neurological disease
characterized by learning deficits and
autism, has been discovered by
scientists. "Children with
neurofibromatosis have a high
incidence
Neuronal circuits filter out
distractions in brain
Scientists have hypothesized for
decades about how the brain filters
out distractions, but it has been
challenging to find evidence to
support the theories. Now,
researchers have identified a neural
circuit in the mouse brain that
controls
Neurons listen to glia cells
A new signal pathway in the brain
has been discovered that plays an
important role in learning and the
processing of sensory input. It was
already known that distinct glial cells
receive information from neurons.
However, it was unknown
Parkinson's patients identify balance,
anxiety among top 10 research
priorities
Patients with Parkinson's, medics and
carers have identified the top ten
priorities for research into the
management of the condition. People
with personal experience of the
condition worked together to identify
crucial gaps in the
Show us how you play and it may tell
us who you are
The way in which toys are handled
and combined with one another
during object play can tell use a lot
about the cognitive underpinnings of
the actors. An international team of
scientists studied parrot species, as
well as crow species,
Signaling mechanism could be target
for survival, growth of tumor cells in
brain cancer
Neurology researchers have identified
an important cell signaling
mechanism that plays an important
role in brain cancer and may provide
a new therapeutic target. The
researchers found that this
mechanism -- a type of signaling
termed
Baby cells learn to communicate
using the lsd1 gene
Infant cells have to go through a
developmental process that involves
specific genes before they can take
part in the group interactions that
underlie normal cellular development
Research into aggression reveals new
insights
A new study is underway to learn
more about aggression. "This is a
really ambitious project, but I am
hopeful that by looking at the areas of
the brain and genes linked to
Immune cells in brain respond to fat
in diet, causing mice to eat
Immune cells perform a previously
unsuspected role in the brain that may
contribute to obesity, according to a
new study. When researchers fed
mice a diet high in saturated milk
Patient awakes from post-traumatic
minimally conscious state after
administration of depressant drug
A patient who had suffered a
traumatic brain injury unexpectedly
recovered full consciousness after the
administration of midazolam, a mild
depressant drug of the GABA A
Are you genetically predisposed to
antisocial behaviour?
Both positive and negative
experiences influence how genetic
variants affect the brain and thereby
behavior, according to a new study.
“Evidence is accumulating to show
that the effects of variants of many
genes that are common in the
New way to diagnose brain damage
from concussions, strokes, and
dementia
New optical diagnostic technology
promises new ways to identify and
monitor brain damage resulting from
traumatic injury, stroke or vascular
dementia—in real time and without
invasive procedures.
Progesterone offers no significant
benefit in traumatic brain injury
clinical trial
Treatment of acute traumatic brain
injury with the hormone progesterone
provides no significant benefit to
patients when compared with
placebo, a phase III clinical trial has
concluded.
Novel fMRI technique identifies
HIV-associated cognitive decline
before symptoms occur
A five-minute functional MRI test
can pick up neuronal dysfunction in
HIV-positive individuals who don't
yet exhibit cognitive decline, say
neuroscientists and clinicians. The
issue of neural dysfunction in the
HIV-positive population is
Myelin linked to speedy recovery of
human visual system after tumor
removal
An interdisciplinary team of
neuroscientists and neurosurgeons
has used a new imaging technique to
show how the human brain heals
itself in just a few weeks following
surgical removal of a brain tumor.
The team found that recovery of
Cognitive training can improve brain
performance of students in poverty
The cognitive effects of poverty can
be mitigated during middle school
with a targeted intervention,
according to researchers who, for the
first time, examined the efficacy of
cognitive training in a large and
diverse group of 7th and 8th
Obese children's brains more
responsive to sugar
The brains of obese children literally
light up differently when tasting
sugar, a new study has found. This
elevated sense of "food reward" --
which involves being motivated by
food and deriving a good feeling
from it -- could mean some
Parkinson's disease: Study focuses on
regulation of dopamine levels
A mechanism regulating dopamine
levels in the brain has been revealed
by a study on a mouse model of late
onset Parkinson's disease. Using gene
expression profiling, a method to
measure the activity of thousands of
genes, researchers
Important gene interaction defined
that drives aggressive brain cancer
Targeted therapies are a growing and
groundbreaking field in cancer care in
which drugs or other substances are
designed to interfere with genes or
molecules that control the growth and
Discovery of novel drug target may
lead to better treatment for
schizophrenia
A novel drug target that could lead to
the development of better
antipsychotic medications has been
discovered by researchers. Current
treatment for patients with
Saving old information can boost
memory for new information
The simple act of saving something,
such as a file on a computer, may
improve our memory for the
information we encounter next,
according to new research. The
research suggests that the act of
Fructose and glucose: Brain reward
circuits respond differently to two
kinds of sugar
New information suggests the brain
responds differently to different
sugars, and that one type could be
connected with overeating. Brain
responses to fructose, a simple sugar
Hepatitis C ruled out as cause of
mental impairment in HIV patients
Advances in treatment for human
immunodeficiency virus (HIV) have
made it possible for people with HIV
to survive much longer. As they age,
however, many experience impaired
Roller coaster rides trigger stroke in
young boy
Riding a couple roller coasters at an
amusement park appears to have
triggered an unusual stroke in a 4-
year-old boy, according to a report.
Distraction, if consistent, does not
hinder learning
A new study challenges the idea that
distraction is necessarily a problem
for learning. Researchers found that if
attention was as divided during recall
of a motor task as it was during
learning the task, people performed
as if there were
One in six Ontario adults say they've
had a traumatic brain injury in their
lifetime
Nearly 17 percent of adults surveyed
in Ontario said they have suffered a
traumatic brain injury that left them
unconscious for five minutes or
required them to be hospitalized
Early identification of modifiable risk
factors for cognitive decline
Researchers now believe it's possible
that risk factors for cognitive decline
may show up long before diseases
such as Alzheimer's develop. In a
new study, scientists found that clues
such as high blood pressure are often
present in mid-
Blocking receptor in brain's immune
cells counters Alzheimer's in mice
The mass die-off of nerve cells in the
brains of people with Alzheimer's
disease may largely occur because an
entirely different class of brain cells,
called microglia, begin to fall down
on the job, according to a new study.
Brain scans link frontal abnormalities
to suicidal behaviors in adolescents,
young adults
Scientists are closer to understanding
how suicidal thoughts and behaviors
are generated. According to a study,
reduced integrity of white matter in
key frontal brain systems that control
emotion, motivation and memory was
observed in a of
Sleep disturbance linked to amyloid
in brain areas affected by Alzheimer's
disease
Disturbed sleep could be an early
target in preventing cognitive deficits
later in life according to a study.
Amyloid, a protein which is elevated
in the brains of Alzheimer's Disease
patients, was found in higher
concentrations in the brains of
Prenatal exposure to common
household chemicals linked with
substantial drop in child IQ
Children exposed during pregnancy
to elevated levels of two common
chemicals found in the home -- di-n-
butyl phthalate and di-isobutyl
phthalate -- had an IQ score, on
average, more than six points lower
than children exposed at lower
Smoothing the path to an independent
life: Virtual reality based training
systems boost cognitive functions
Virtual reality is a powerful tool to
simulate real-life environments and
situations. Scientists are exploring the
medium as a way to help people with
Revolutionary new procedure for
epilepsy diagnosis unlocked by
research
Pioneering new research could
revolutionize global diagnostic
procedures for one of the most
common forms of epilepsy, scientists
Multiple, short learning sessions
strengthen memory formation in
fragile X syndrome
A learning technique that maximizes
the brain's ability to make and store
memories may help overcome
cognitive issues seen in fragile X
syndrome, a leading form of
intellectual disability, according to
neurobiologists.
Early results indicate potential for
focused ultrasound to treat OCD
The potential of focused ultrasound to
treat certain patients with obsessive-
compulsive disorder (OCD) has been
supported by new research. "There is
a need for non-invasive treatment
options for patients with OCD that
cannot be
Retina changes its 'language' with
changing brightness
The intricate nature of visual
responses has become more clear,
thanks to new research. The findings
may help to improve digital cameras
as well as visual prosthetics.
Robotic surgery technique to treat
previously inoperable head and neck
cancer tumors
In a groundbreaking new study,
researchers have for the first time
advanced a surgical technique
performed with the help of a robot to
successfully access a previously-
Brain inflammation a hallmark of
autism, large-scale analysis shows
While many different combinations
of genetic traits can cause autism,
brains affected by autism share a
pattern of ramped-up immune
responses, an analysis of data from
autopsied human brains reveals. The
study included data from 72
Even in our digital age, early parental
writing support is key to children's
literacy
Children of the Information Age are
inundated with written words
streaming across smartphone, tablet,
and laptop screens. A new study says
that preschoolers should be
encouraged to write at a young age --
even before they make their first
Possible genetic link found in
treatment-related cognitive issues in
children with leukemia
Common variations in four genes
related to brain inflammation or cells'
response to damage from oxidation
may contribute to the problems with
memory, learning and other cognitive
functions seen in children treated for
acute lymphoblastic
.
Brain tumor: Key found for
suppression of growth in
medulloblastomas
A key factor that can suppress
medulloblastoma, the most frequent
child brain tumor, has been identified
by researchers. Medulloblastoma is
the most common brain tumor in
children, and its treatment remains
inefficient. The work opens
Paying attention makes touch-sensing
brain cells fire rapidly and in sync
Whether we’re paying attention to
something we see can be discerned
by monitoring the firings of specific
groups of brain cells. Now, new work
shows that the same holds true for the
sense of touch. The study brings
researchers
First gene associated with familial
glioma identified
A gene associated with familial
glioma -- brain tumors that appear in
two or more members of the same
family -- has been identified by an
international consortium of
researchers, providing new support
that certain people may be
Two studies unveil seizure prediction
models in critically ill children
In a pair of studies, researchers
describe innovative models for
predicting seizure occurrence in
critically ill children.
Epilepsy, driving regulations
explored in three studies
People with epilepsy often struggle
with limited independence due to
state and federal driving restrictions.
New studies nalyze potential factors
that impair driving in people with
epilepsy and in people who
experience "seizure-like" non
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c/Donantes de Sangre s/n 37007 Salamanca
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