Biophan Technologies, Inc.Company Overview

Michael Weiner, CEOPharma Finance 2005 Conference

June 23, 2005

Cautionary Statement

Certain statements included in this presentation may constitute forward-looking statements within the meaning of applicable securities laws. These statements reflect what Biophan anticipates, expects or believes may happen in the future. Biophan's actual results could differ materially from the outcome or circumstance expressed or implied by such forward looking statements as a result of a variety of factors including, but not limited to: Biophan's ability to develop its technologies; the approval of Biophan's patent applications; the successful implementation of Biophan's research and development programs; the ability of Biophan to demonstrate the effectiveness of its technology; the acceptance by the market of Biophan's technology and products incorporating such technology; the ability of Biophan to effectively negotiate and enter into contracts with medical device manufacturers for the licensing of Biophan's technology; competition; the ability of Biophan to raise capital to fund its operating and research and development activities until it generates revenues sufficient to do so; and the timing of projects and trends in future operating performance, as well as other factors expressed from time to time in Biophan's periodic filings with the Securities and Exchange Commission (the "SEC"). As a result, this presentation should be read in conjunction with Biophan's periodic filings with the SEC which are incorporated herein by reference.  The forward-looking statements contained herein are made only as of the date of this presentation, and Biophan undertakes no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances.

Biophan’s Mission

• Enable over $12 billion worth of medical devices shipping annually safe for use with MRI, and imageable. Many are not:– Guidewires, catheters, endoscopes, biopsy needles– Pacemakers, defibrillators, neurostimulators, drug

pumps (safety issues, also imaging issues), pain control devices

– Stents, embolism clips, aneurysm clips, artificial hips, knees, most other orthopedics

• Bring other innovations for competitive advantage to biomedical device and pharmaceutical companies.

Summary Financial Information

• Share Price (06.14.05): $2.72• 52-Week High: $3.50• 52 Week Low: $0.30• Shares Outstanding: 74 million• Float: 65 million• Market Cap: $203 million• Average Daily Volume: 1,026,650

Biophan’s Solutions

• MRI Safety: (many products contraindicated)– RF filter from Johns Hopkins (heating)

– Biophan multi-filar wire solution (heating)

– “Anti-Antenna” lead design (induced voltages)

• Image Compatibility

• Nanomagnetic particle thin film coatings (Nanoset, LLC and Alfred University)– Minimize image artifacts

– Makes catheters, guidewires, stents, and devices visible under MRI

Management• Stu MacDonald, VP R&D at J&J division, with a 400

person organization

• Jeff Helfer, VP Engineering – formerly Dir. Of Engineering at the same J&J division

• John Lanzafame, President, Nanolution Division – former President STS Biopolymers, acquired by Angiotech (ANPI)

• Robert Wood, VP Finance, Treasured and CFO, CPA in public and private firms

• And now Dr. Michael Friebe, and Dr. Andreas Melzer, two well known leaders in MRI technologies

Biophan-Europe• Acquired February, 2005, AMRIS (now Biophan

Europe) adds enormous additional capability to Biophan

• 2 Ph.D. level MRI experts, Friebe and Gregor• MD, surgeon and inventor, Andreas Melzer, MD• Access to latest MRI devices• Excellent connections in the MRI community• Exciting, patented solutions

Core Business• Offering our customers competitive advantage

– Through proprietary solutions that can gain marketshare for them

– FDA approval is pursued by the customer– Marketing and distribution of the final device is theirs

• We sell high margin components and develop annuities for our shareholders

Relationship With Boston Scientific

• Joint development agreement, originally entered into November, 2003

• Recently moved to second and third phase, and has expanded to multiple products

• One of the companies referred to in recent 10Q• Reached agreement on term sheet, working on

final contract phase

SE coronal image of 3 aluminum wires (1/32”). Wire (3) is uncoated.

1 2 3

Biophan’s thin-film

nanomagnetic particle

coating technology

provides a controllable,

“magnetic” signal

capable of creating an

image of the coated

device.

#3 is uncoated.

MRI Device Imaging

MR image artifacts occur when the magnetic field of the MRI scanner is “warped” or distorted by the presence of magnetizable material placed in the scanner (i.e. a medical device).

Thin-film nanomagnetic particle coatings can “nullify” or neutralize the magnetization of the medical device and as a result, minimize or eliminate the image artifact.

Multi-slice MR images of RF ablation probe showing distortion

Oncology Imaging

Making Stents Imageable

• Seeing blockage of stents has required an invasive procedure

• Stents imageable under MRI would be competitively advantaged

• Biophan’s business is competitive advantage for our customers through technology innovation

• Nanoset has a coating solution• AMRIS, now Biophan-Europe, has a “retrofit”

solution• Both solutions are PATENTED! • Together we “cover the waterfront”

Implications

• Impact the $5+ billion stent market

• Help manufacturers make pacemakers, defibrillators, neurostimulators safe, and imageable – competitive advantage to our licensees

• Make guidewires, catheters, endoscopes, biopsy needles safe and image compatible

• Opens the field of interventional medicine under MRI (currently only X-Ray/Fluoroscopy)

Biothermal Battery

• Goal: To provide a long-lived electrical power system for implanted medical devices– Powered by body heat differential.

• Acquired 51% interest in TE-Bio, which holds an issued U.S. patent for the battery

• Batteries are a $500 million market, sell for $100 to $225 each in the pacemaker, defibrillator and drug pump markets

• Sold to same customers who need MRI safety

Agreement with NASA

• Announced on August 17th a deal with NASA Ames Research Center for Nanotechnology to jointly develop the biothermal battery– NASA wants technology for their long duration manned

MARS mission for biosensing and miniature therapeutic devices

– Biophan gets commercial rights to jointly developed and NASA developed technology

– Nanotechnology and materials science advances makes the biothermal battery possible

Substrate

Polymer Coating

Nanomagnetic layer

Con

trol

led

Mag

netic

Fie

ldDrug bound to NMP carrier

Con

trol

led

Mag

netic

Fie

ld A

Con

trol

led

Mag

netic

Fie

ld B

Particle type ADrug AParticle type BDrug B

Surface Elution on Demand

Reloading Drug Eluting Coatings

Substrate

Polymer Coating

Concentration G

radient

Controlled

Magnetic F

ield

Drug Molecules

Drug bound to NMP carrier

Nanomagnetic layer

Guided Drug Delivery

Solid tumor

Apply magnetic field to concentrate particles

Modulate field to release drug from particles

Inject NMPs IV,NMP will circulate through the blood stream

Other options for targeting:1 - Direct injection into tumor site2 - Coating NMP with antibodies to target tumor

Other Solution Offerings

• MRI Safe Drug Pump (non-magnetic)

• Nanomagnetic particles for contrast agents

– Also used for

•MRI compatibility

•Reduce device heating

•Enable DRUG DELIVERY CAPABILITIES!

NanoView™ MRI Contrast Agents

Nano-particulate technology has the potential to provide a new consumable

product capable of significantly enhancing MR detection sensitivity (i.e. lowest detectable concentration) and specificity (i.e. the ability to reliably

detect the desired substance).

PROTECTED, PROTECTED!

• Technologies covered by– 127 U.S. Patents

• 37 ISSUED• 90 pending or allowed

• 46 International Pending or Issued• Owned by Biophan or licensed exclusively to

Biophan for the medical market

Goals• Close major deal – underway, at contract phase• Close second deal – we have multiple prospects

in the U.S. Europe, and Asia• List on major exchange – requires $5 million

capital, we meet all other qualifications, we plan to file as soon as capital in hand

Revenue Potential for MRI Safety and Visibility

(by example, not a forecast)

Customer SalesIn Billion$ Year

3%(million$ yr)

5%(million$ yr)

1 30 50

2 60 100

3 90 150

4 120 200

5 150 250

12 360 600

Sensitivities• Deal Terms Improve with:

– Proof of principle – Issued patents (the more the better)– Multiple prospects– Cash in the bank– Capability– Capacity

Other Markets• Battery: $500 million • Contrast Agents: $800 million • Drug Pumps: $1 billion• Drug Delivery: $40 billionCautions: Penetration can take timeFDA approval and/or CE Mark could take timeBright side is, once deal is underway, patents and annuity

streams can last a long time

Biophan (OTC: BIPH)

We don’t make medical devices; We make them safe, and imageable, for MRI

And other competitive advantages for our customers

Four of our six technologies are based on nanotechnology

WWW.BIOPHAN.COM

Thank You!

More good things will unfold in 2005!

BIOmedPHArmaNano

Technologies