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大阪大学大学院薬学研究科研究業績集 (2003)

青字論文は（薬学研究科内）分野間共同研究

高分子化学 (Biophysical Chemistry) Structure and binding mode of a ribosome recycling factor (RRF) from mesophilic bacterium Nakano H, Yoshida T, Uchiyama S, Kawachi M, Matsuo H, Kato T, Ohshima A, Yamaichi Y, Honda T, Kato H, Yamagata Y, Ohkubo T, Kobayashi Y J. Biol. Chem., 278, 3427-3436 (2003) Effect of intracellular pH on rotational speed of bacterial flagellar motors Minamino T, Imae Y, Oosawa F, Kobayashi Y, Oosawa K J. Bacteriol., 185, 1190-1194 (2003) Inhibitory specificity change of the ovomucoid third domain of the silver pheasant upon introduction of an engineered Cys14-Cys39 bond Hemmi H, Kumazaki T, Yamazaki T, Kojima S, Yoshida T, Kyogoku Y, Katsu M, Shinohara F, Yokosawa H, Miura K, Kobayashi Y Biochemistry, 42, 2524-2534 (2003) Characterization of collagen model peptides containing 4-fluoroproline; (4(S)-fluoroproline-Pro-Gly)10 forms a triple helix, but (4(R)-fluoroproline-Pro-Gly)10 dose not Doi M, Nishi Y, Uchiyama S, Nishiuchi Y, Nakazawa T, Ohkubo T, Kobayashi Y J. Am. Chem. Soc., 125, 9922-9923 (2003) Relationship between redox function and protein stability of cytochromes c Terui N, Tachiiri N, Matsuo H, Hasegawa J, Uchiyama S, Kobayashi Y, Igarashi Y, Sambongi Y, Yamamoto Y J. Am. Chem. Soc., 125, 13650-13651 (2003) Synthesis and thermal stability of new collagen model peptides containing 4-hydroxyproline and 4-fluoroproline Nishi Y, Doi M, Uchiyama S, Nishiuchi Y, Nakazawa T, Ohkubo T, Kobayashi Y Peptide Science 2003, 389-392 (2003) Stabilization of triple helical structure of collagen molecule Kobayashi Y, Nishi Y, Doi M, Uchiyama S, Nishiuchi Y, Ohkubo T, Nakazawa T Peptide Science 2003, 25-28 (2003) Analysis of thermodynamics of RRF Domain I from mesophilic and thermophilic

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bacteria Ohshima A, Uchiyama S, Yoshida T, Ohkubo T, Kobayashi Y Peptide Science 2003, 299-302 (2003) Structure of transcription factor Sp1 DNA binding domain Oka S, Shiraishi Y, Yoshida T, Ohkubo T, Sugiura Y, Kobayashi Y Peptide Science 2003, 315-318 (2003) Characteristic domain motion in the ribosome recycling factor revealed by 15N NMR relaxation experiments and molecular dynamics simulations Yoshida T, Oka S, Uchiyama S, Nakano H, Kawasaki T, Ohkubo T, Kobayashi Y Biochemistry, 42, 4101-4107 (2003) Interaction of T4 endonuclease V with DNA: importance of the flexible loop regions in protein-DNA interaction Ahn HC, Ohkubo T, Iwai S, Morikawa K, Lee BJ J. Biol. Chem., 278, 30985-30992 (2003) Structure determination and conformational change induced by tyrosine phosphorylation of the N-terminal domain of the α-chain of pig gastric H+/K+-ATPase Fujitani N, Kanagawa M, Aizawa T, Ohkubo T, Kaya S, Demura M, Kawano K, Nishimura S, Taniguchi K, Nitta K Biochem. Biophys. Res. Commun., 300, 223-229 (2003) Characterization of the unfolding process of lipocalin-type prostaglandin D synthase Inui T, Ohkubo T, Emi M, Irikura D, Hayaishi O, Urade Y J. Biol. Chem., 278, 2845-2852 (2003) 機能素子化学 (Medicinal and Organic Chemistry) 3-Cyano-2-(N-cyanoimino)thiazolidine (3-cyano-NCT): an efficient electrophilic cyanating agent for activated methylene compounds Maezaki N, Furusawa A, Uchida S, Tanaka T Heterocycles, 59, 161-167 (2003) Geometrically selective synthesis of functionalized β,β-disubstituted vinylic sulfoxides by Cu-catalyzed conjugate addition of organozinc reagents to 1-alkynyl sulfoxides Maezaki N, Sawamoto H, Yoshigami R, Suzuki T, Tanaka T

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Org. Lett., 5, 1345-1347 (2003) Pd-catalyzed sulfinylzincation of activated alkynes with 1-alkynyl sulfoxides as a sulfinyl source Maezaki N, Yagi S, Yoshigami R, Maeda J, Suzuki T, Ohsawa S, Tsukamoto K, Tanaka T J. Org. Chem., 68, 5550-5558 (2003) Synthesis of chiral vinylic sulfoxides by Pd-catalyzed asymmetric sulfinylzincation Maezaki N, Yagi S, Ohsawa S, Ohishi H, Tanaka T Tetrahedron, 59, 9895-9906 (2003) Systematic construction of a monotetrahydrofuran-ring library in annonaceous acetogenins by asymmetric alkynylation and stereodivergent tetrahydrofuran-ring formation Kojima N, Maezaki N, Tominaga H, Asai M, Yanai M, Tanaka T Chem. Eur. J., 9, 4980-4990 (2003) Systematic synthesis of bis-THF ring cores in annonaceous acetogenins Maezaki N, Kojima N, Tominaga H, Yanai M, Tanaka T Org. Lett., 5, 1411-1414 (2003) Total synthesis of the antitumor acetogenin mosin B: desymmetrization approach to the stereodivergent synthesis of threo/trans/erythro-type acetogenins Maezaki N, Kojima N, Sakamoto A, Tominaga H, Iwata C, Tanaka T, Monden M, Damdinsuren B, Nakamori S Chem. Eur. J., 9, 389-399 (2003) First total synthesis of (±)-Linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells Yamashita M, Ohta N, Shimizu T, Matsumoto K, Matsuura Y, Kawasaki I, Tanaka T Maezaki N, Ohta S J. Org. Chem., 68, 1216-1224 (2003) Bromoallenes as synthetic equivalents of allyl dications: synthesis of medium-sized nitrogen heterocycles through the cyclization of bromoallenes in the presence of a palladium(0) catalyst and an alcohol Ohno H, Hamaguchi H, Ohata M, Tanaka T Angew. Chem., Int. Ed., 42, 1749-1753 (2003) Palladium(0)-catalyzed tandem cyclization of allenenes

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Ohno H, Miyamura K, Takeoka Y, Tanaka T Angew. Chem., Int. Ed., 42, 2647-2650 (2003) Radical cyclization by ipso substitution of the methoxy group: considerable effect of HMPA on samarium-mediated cyclization Ohno H, Wakayama R, Maeda S, Iwasaki H, Okumura M, Iwata C, Mikamiyama H, Tanaka T J. Org. Chem., 68, 5909-5916 (2003) Samarium(II)-promoted radical spirocyclization onto an aromatic ring Ohno H, Okumura M, Maeda S, Iwasaki H, Wakayama R, Tanaka T J. Org. Chem., 68, 7722-7732 (2003) Novel synthesis of azocine, azepine, oxocine, and oxepine derivatives by palladium-catalyzed medium-ring formation from bromoallenes Ohno H, Hamaguchi H, Ohata M, Kosaka S, Tanaka T Heterocycles, 61, 65-68 (2003) Novel synthesis of 3-azabicyclo[3.1.0]hexanes by unusual palladium(0)-catalyzed cyclopropanation of allenenes Ohno H, Takeoka Y, Miyamura K, Kadoh Y, Tanaka T Org. Lett., 5, 4763-4766 (2003) 生体機能分子化学 (Bio-Functional Molecular Chemistry) Transplantation of hepatocytes cultured on hydroxyapatite into Nagase analbuminemia rats Higashiyama S, Noda M, Muraoka S, Hirose M, Ohgushi H, Kawase M, Yagi K J. Biosci. Bioeng., 96, 83-85 (2003) Mixed-ligand modification of polyamidoamine dendrimers to develop an effective scaffold for maintenance of hepatocyte spheroids Higashiyama S, Noda M, Kawase M, Yagi K J. Biomed. Mater. Res., 64A, 475-482 (2003) Effects of the counterion on dielectric spectroscopy of a montmorillonite suspension over the frequency range 105-1010 Hz Ishida T, Kawase M, Yagi K, Yamakawa J, Fukada K J. Colloid Interface Sci., 268, 121-126 (2003) Novel function of rare catechin, epigallocatechin-3-(3"-O-methyl) gallate, against

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cold injury in primary rat hepatocytes Kagaya N, Hara Y, Saijo R, Kamiyoshi A, Tagawa Y, Kawase M, Yagi K J. Biosci. Bioeng., 96, 559-563 (2003) Maximization of hydrogen production ability in high-density suspension of Rhodovulum sulfidophilum cells using intracellular poly(3-hydroxybutyrate) as sole substrate Maeda I, Miyasaka H, Umeda F, Kawase M, Yagi K Biotechnol. Bioeng., 81, 474-481 (2003) Comparative study of the N-terminal hydrophilic region in Streptomyces lividans and E. coli FtsY Maeda I, Hirose N, Yamashiro H, Ichibori A, Ohshima S, Fujimoto T, Kawase M, Yagi K Curr. Microbiol., 47, 22-25 (2003) Adenoviral transfection of hepatocytes with the thioredoxin gene confers protection against apoptosis and necrosis Tsutsui T, Koide H, Fukahori H, Isoda K, Higashiyama S, Maeda I, Tashiro F, Yamato E, Miyazaki J, Yodoi J, Kawase M, Yagi K Biochem. Biophys. Res. Commun., 307, 765-770 (2003) Mechanism of enhancement effect of dendrimer on transdermal drug permeation through polyhydroxyalkanoate matrix Wang Z, Itoh Y, Hosaka Y, Kobayashi I, Nakano Y, Maeda I, Umeda F, Yamakawa J, Nishimine M, Suenobu T, Fukuzumi S, Kawase M, Yagi K J. Biosci. Bioeng., 96, 537-540 (2003) Nobel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer Wang Z, Itoh Y, Hosaka Y, Kobayashi I, Nakano Y, Maeda I, Umeda F, Yamakawa J, Kawase M, Yagi K J. Biosci. Bioeng., 95, 541-543 (2003) バイオ人工肝臓の開発を目的とした肝細胞の機能制御 (Review) 八木清仁

生産と技術, 55, 49-51 (2003)

肝星細胞との共培養による肝細胞の機能維持 (Review) 東山真二, 川瀬雅也, 八木清仁

再生医療実用化に向けた生物工学研究, 74-75 (2003)

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複合リガンド修飾デンドリマーによる機能性培養基材の作製 (Review) 東山真二, 川瀬雅也, 八木清仁

再生医療実用化に向けた生物工学研究, 44-45 (2003) 分子生物学 (Biochemistry and Molecular Biology) Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity Kobayashi A, Hori S, Suita N, Maeda M Biochem. Biophys. Res. Commun., 309, 815-822 (2003)

Further characterization of Chinese hamster carbonyl reductases (CHCRs) Terada T, Sugihara Y, Nakamura K, Mizobuchi H, Maeda M Chem. Biol. Interact., 143-144, 373-381 (2003) 転写制御機構の解析 3-5: DNA 結合因子の解析 小林綾子, 若尾りか（分担執筆）

生物薬科学実験講座 第８巻遺伝子, 廣川書店, 463-484(2003)

分子合成化学 (Synthetic Organic Chemistry) An efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water : effect of additive on radical reaction in water Nambu H, Anilkumar G, Matsugi M, Kita Y Tetrahedron, 59, 77-85 (2003) Kinetically controlled optical resolution of racemic norbornene aldehyde derivatives Fujioka H, Kotoku N, Fujita T, Inoguchi R, Murai K, Nagatomi Y, Sawama Y, Kita Y Chirality, 15, 60-67 (2003) Concise asymmetric synthesis of (–)-herbertenediol Kita Y, Futamura J, Ohba Y, Sawama Y, Ganesh JK, Fujioka H Tetrahedron Lett., 44, 411-413 (2003) The rearrangement of 2,3-epoxysulfonates and its application to natural products syntheses: formal synthesis of (–)-aphanorphine and total syntheses of (–)-α-herbertenol and (–)-herbertenediol Kita Y, Futamura J, Ohba Y, Sawama Y, Ganesh JK, Fujioka H J. Org. Chem., 68, 5917-5924 (2003)

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A simple determination method of the absolute configuration of 1-arylethanthiols by an intramolecular CH/π shielding effect in 1H-NMR of diastereomeric thiol esters Matsugi M, Hagimoto Y, Itoh K, Nojima M, Kita Y Chem. Pharm. Bull., 51, 460-462 (2003) Optical resolution of (±)-1-furo[2,3-c]pyridin-5-yl-ethanol using extraction technique: formal total synthesis of PNU-142721, HIV-1 reverse transcriptase inhibitor Matsugi M, Itoh K, Nojima M, Hagimoto Y, Kita Y Tetrahedron Lett., 44, 3355-3358 (2003) Effective nonenzymatic kinetic resolution of (±)-trans-2-arylcyclohexanols using 3β-acetoxyetienic acid, DCC, and DMAP Matsugi M, Hagimoto Y, Nojima M, Kita Y Org. Proc. Res. Dev., 7, 583-584 (2003) Facile and efficient oxidative transformation of primary alcohols to methyl esters in water using hypervalent iodine(III) reagents Tohma H, Maegawa T, Kita Y Synlett, 723-725 (2003) A novel and direct synthesis of alkylated 2,2′-bithiophene derivatives using a combination of hypervalent iodine(III) reagent and BF3·Et2O Tohma H, Iwata M, Maegawa T, Kiyono Y, Maruyama A, Kita Y Org. Biomol. Chem., 1, 1647-1649 (2003) The first total synthesis of discorhabdin A Tohma H, Harayama Y, Hashizume M, Iwata M, Kiyono Y, Egi M, Kita Y J. Am. Chem. Soc., 125, 11235-11240 (2003) A convenient synthesis of the Beraprost intermediate: a useful method for introducing a C3 unit at the benzyl position Higuchi K, Sawada K, Nambu H, Shogaki T, Kita Y Org. Lett., 5, 3703-3704 (2003) Facile and efficient oxidation of sulfides to sulfoxides in water using hypervalent iodine reagents Tohma H, Maegawa T, Kita Y Arkivoc, 6, 62-70 (2003) Synthesis of p-phenylthio-peri-hydroxy polyaromatic compounds by

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strong-base-induced [4+2] cycloaddition of 4-(phenylthio)homophthalic anhydrides with phenylsulfinyl-dienophiles Iio K, Okajima A, Takeda Y, Kawaguchi K, Whelan BA, Akai S, Kita Y Arkivoc, 8, 144-162 (2003) Oxidative coupling reaction of phenol ether derivatives using the activated hypervalent iodine(III) reagent Hamamoto H, Tohma H, Kita Y FIU Report, 6, 115-127 (2003) Synthetic applications (total synthesis and natural product synthesis) (Review) Tohma H, Kita Y Topics in Current Chemistry, 224: Hypervalent Iodine Chemistry - Modern Developments in Organic Synthesis (T. Wirth, Ed.), Springer, 209-248 (2003) 次世代型酵素触媒反応を志向する不斉合成反応の開発研究 (Review) 赤井周司 薬学雑誌 (学術振興賞受賞総説), 123, 919-931(2003) 電子求引性保護基(アシル基, スルホニル基)を持つエポキシアルコール類の酸

転位反応：不斉四級炭素および不斉スピロ中心の構築と天然物合成への応用

(Review) 藤岡弘道, 吉田裕, 北泰行 有機合成化学協会誌, 61, 133-143 (2003) アセタールの不斉アルキル化 (Review) 藤岡弘道 実験化学講座 19 巻:有機合成Ⅶ 第５版,日本化学会編, 210-230 (2003) 薬用資源解析学（三栄源エフ・エフ・アイ）寄附講座

(Medicinal Plant Resource Exploration) New anti-malarial peroxides with in vivo potency derived from spongean metabolites Murakami N, Kawanishi M, Mostaqul HM, Li J, Itagaki S, Horii T, Kobayashi M Bioorg. Med. Chem. Lett., 13, 4081-4084 (2003) New semisynthetic quassinoids with in vivo antimalarial activity Murakami N, Sugimoto M, Kawanishi M, Tamura S, Kim HS, Begum K, Wataya Y, Kobayashi M J. Med. Chem., 46, 638-641 (2003)

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細胞生物学 (Cell Biology)

Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli Hirakawa H, Nishino K, Hirata T, Yamaguchi A J. Bacteriol., 185, 1851-1856 (2003) Global analysis of genes regulated by EvgA of the two-component regulatory system in Escherichia coli Nishino K, Inazumi Y, Yamaguchi A J. Bacteriol., 185, 2667-2672 (2003) Cloning of rat ABCA7 and its preferential expression in platelets Sasaki M, Shoji A, Kubo Y, Nada S, Yamaguchi A Biochem. Biophys. Res. Commun., 304, 777-782 (2003) Membrane topology of ABC-type macrolide antibiotic exporter MacB in Escherichia coli Kobayashi N, Nishino K, Hirata T, Yamaguchi A FEBS Lett., 546, 241-246 (2003) Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to β-lactams Nishino K, Yamada J, Hirakawa H, Hirata T, Yamaguchi A Antimicrob. Agents Chemother., 47, 3030-3033 (2003) β-Lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A J. Antimicrob. Chemother., 52, 576-582 (2003) Mechanisms of drug/H+ antiport: complete cysteine-scanning mutagenesis and the protein engineering approach Tamura N, Konishi S, Yamaguchi A Curr. Opin. Chem. Biol., 7, 570-579 (2003) Multidrug-exporting secondary transporters Murakami S, Yamaguchi A Curr. Opin. Struct. Biol., 13, 443-452 (2003)

異物排出トランスポーターの結晶構造、ついに決まる (Review) 村上聡, 山口明人

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蛋白質・核酸・酵素, 48, 26-32 (2003)

多剤排出トランスポーターAcrB の結晶構造解析 (Review) 村上聡

生物工学, 81, 155-160 (2003)

大腸菌多剤排出トランスポーターAcrB のＸ線結晶構造解析 (Review) 村上聡, 中島良介, 山下栄樹, 山口明人

放射光, 16, 204-212 (2003)

大腸菌多剤排出トランスポーターAcrB の結晶構造解析 (Review) 村上聡, 中島良介, 山下栄樹, 山口明人

日本結晶学会誌, 45, 256-261 (2003)

薬剤排出蛋白質遺伝子資源の解析に関する研究 (黒屋奨学賞受賞論文)

(Review) 西野邦彦

日本細菌学雑誌, 58, 581-594 (2003) 生物有機化学 (Bioorganic Chemistry) Selective recognition of CG interruption by 2',4'-BNA having 1-isoquinolone as a nucleobase in a pyrimidine motif triplex formation Hari Y, Obika S, Sekiguchi M, Imanishi T Tetrahedron, 59, 5123-5128 (2003) Triplex formation with 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) having C3'-endo conformation at physiological pH Koizumi M, Morita K, Daigo M, Tsutsumi S, Abe K, Obika S, Imanishi T Nucleic Acids Res., 31, 3267-3273 (2003) Synthesis of a novel bridged nucleoside bearing a fused-azetidine ring, 3'-amino-3',4'-BNA monomer Obika S., Andoh J, Onoda M, Nakagawa O, Hiroto A, Sugimoto T, Imanishi T Tetrahedron Lett., 44, 5267-5270 (2003) Sequence specific DNA binding of Ets-1 transcription factor: molecular dynamics study on the ETS domain-DNA complexes Obika S, Reddy SY, Bruice TC J. Mol. Biol., 331, 345-359 (2003)

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Synthesis and properties of a novel bridged nucleic acid with a P3'→N5' phosphoramidate linkage, 5'-amino-2',4'-BNA Obika S, Nakagawa O, Hiroto A, Hari Y, Imanishi T Chem. Commun., 2202-2203 (2003) Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 2-pyridone base analogue: efficient and selective recognition of C:G interruption Torigoe H, Hari Y, Obika S, Imanishi T Nucleosides, Nucleotides & Nucleic Acids, 22, 1097-1099 (2003) Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 1-isoquinolone base analogue: efficient and selective recognition of C:G interruption Torigoe H, Hari Y, Obika S, Imanishi T Nucleosides, Nucleotides & Nucleic Acids, 22, 1571-1573 (2003) 2'-O,4'-C-Ethylene-bridged nucleic acid(ENA™) for effective antisense formation Morita K, Yamate K, Kurakata S, Watanabe K, Imanishi T, Koizumi M Nucleosides, Nucleotides & Nucleic Acids, 22, 1619-1621 (2003) Conformations and dynamics of Ets-1 ETS domain-DNA complexes Reddy SY, Obika S, Bruice TC Proc. Natl. Acad. Sci. USA, 100, 15475-15480 (2003) A novel nucleic acid analogue, 3'-amino-2'-deoxy-3',4'-BNA, with an N3'→P5' phosphoramidate linkage and an S-type conformation Nakagawa O, Hiroto A, Obika S, Imanishi T Nucleic Acids Res. Suppl., 3, 87-88 (2003) trans-3',4'-BNAs, novel nucleic acid analogues with an S-type conformation: synthesis and incorporation into oligonucleotides Sekiguchi M, Osaki T, Harada Y, Obika S, Imanishi T Nucleic Acids Res. Suppl., 3, 111-112 (2003) The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3 Gao P, Zhou XY, Yashiro-Ohtani Y, Yang YF, Sugimoto N, Ono S, Nakanishi T, Obika S, Imanishi T, Egawa T, Nagasawa T, Fujiwara H, Hamaoka T J. Leukoc. Biol., 73, 273-280 (2003) Synthesis and properties of 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) as

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effective antisense oligonucleotides Morita K, Takagi M, Hasegawa C, Kaneko M, Tsutsumi S, Sone J, Ishikawa T, Imanishi T, Koizumi M Bioorg. Med. Chem., 11, 2211-2226 (2003) Total synthesis of an antitumor antibiotic, fostriecin (CI-920) Miyashita K, Ikejiri M, Kawasaki H, Maemura S, Imanishi T J. Am. Chem. Soc., 125, 8238-8243 (2003) Artificial model for cystathionine β-synthase: construction of a catalytic cycle with a pyridoxal model compound having an ionophore function Miyashita K, Murafuji H, Iwaki H, Yoshioka E, Imanishi T Tetrahedron, 59, 4867-4872 (2003) Artificial model for cystathionine β-synthase: efficient β-replacement reaction with thiols employing a novel pyridoxal model compound having an imidazole function Miyashita K, Murafuji H, Iwaki H, Yoshioka E, Imanishi T Tetrahedron, 59, 4873-4879 (2003) Total synthesis of (±)-spiroxin C Miyashita K, Sakai T, Imanishi T Organic Lett., 5, 2683-2686 (2003) 細胞生理学 (Immunology) Role of γδT cells in the inflammatory response of experimental colitis mice Tsuchiya T, Fukuda S, Hamada H, Nakamura A, Kohama Y, Ishikawa H, Tsujikawa K, Yamamoto H J. Immunol., 171, 5507-5513 (2003) Isolation of proliferation factor of immature T-cell clone in concanavalin A-stimulated splenocyte culture supernatant Kohama Y, Shinoda S, Hagihara K, Hashimoto T, Yamaguchi A, Nakamura A, Tsuchiya T, Tsujikawa K, Yamamoto H Immunology, 109, 209-216 (2003) Overexpression of leucocyte common antigen (LAR) P-subunit in thyroid carcinomas Konishi N, Tsujikawa K, Yamamoto H, Ishida E, Nakamura M, Shimada K, Yane K, Yamashita H, Noguchi S Brit. J. Cancer, 88, 1223-1228 (2003)

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Dietary cadmium inhibits spontaneous hepatocarcinogenesis in C3H/HeN mice and hepatitis in A/J mice, but not in C57BL/6 mice Nishiyama S, Itoh N, Onosaka S, Okudaira M, Yamamoto H, Tanaka K Toxicol. Appl. Pharmacol., 186, 1-6 (2003) Induction of systemic immunity by expression of interleukin-23 in murine colon carcinoma cells Wang YQ, Ugai S, Shimozato O, Yu L, Kawamura K, Yamamoto H, Yamaguchi T, Saisho H, Tagawa M Int. J. Cancer, 105, 820-824 (2003) Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects Ugai S, Shimozato O, Yu L, Wang YQ, Kawamura K, Yamamoto H, Yamaguchi T, Saisho H, Sakiyama S, Tagawa M Cancer Gene Ther., 10, 771-778 (2003) Helicobacter pylori CagA containing ITAM-like sequences localized to lipid rafts negatively regulates VacA-induced signaling in vivo Asahi M, Tanaka Y, Izumi T, Ito Y, Naiki H, Kersulyte D, Tsujikawa K, Saito M, Sada K, Yanagi S, Fujikawa A, Noda M, Itokawa Y Helicobacter, 8, 1-14 (2003) 毒性学 (Toxicology) Protective effect of zinc against lipopolysaccharide/D-galactosamine-induced lethality Kimura T, Itoh N, Takehara M, Oguro I, Ishizaki J, Nakanishi T, Isobe M, Tanaka K J. Health Sci., 49, 40-44 (2003) Dietary cadmium inhibits spontaneous hepatocarcinogenesis in C3H/HeN mice and hepatitis in A/J mice, but not in C57BL/6 mice Nishiyama S, Itoh N, Onosaka S, Okudaira M, Yamamoto H, Tanaka K Toxicol. Appl. Pharmacol., 186, 1-6 (2003) Requirement of calcium and phosphate ions in expression of sodium-dependent vitamin C transporter 2 and osteopontin in MC3T3-E1 osteoblastic cells Wu X, Itoh N, Taniguchi T, Nakanishi T, Tanaka K Biochim. Biophys. Acta, 1641, 65-70 (2003) Zinc-induced sodium-dependent vitamin C transporter 2 expression: potent roles

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in osteoblast differentiation Wu X, Itoh N, Taniguchi T, Nakanishi T, Tatsu Y, Yumoto N, Tanaka K Arch. Biochem. Biophys., 420, 114-120 (2003) The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3 Gao P, Zhou XY, Yashiro-Ohtani Y, Yang YF, Sugimoto N, Ono S, Nakanishi T, Obika S, Imanishi T, Egawa T, Nagasawa T, Fujiwara H, Hamaoka T J. Leukoc. Biol., 73, 273-280 (2003) 骨芽細胞 sodium-dependent vitamin C transporter 2 の亜鉛による誘導 Wu X, 伊藤徳夫, 谷口隆, 中西剛, 田中慶一 Biomedical Research on Trace Elements, 14, 377-378 (2003) 神経薬理学 (Molecular Neuropharmacology) Roles of cathepsins in reperfusion –induced apoptosis in cultured astrocytes Takuma K, Kiriu M, Mori K, Lee E, Enomoto R, Baba A, Matsuda T Neurochem. Int., 42, 153-159 (2003) The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze Sakaue M, Ago Y, Sowa C, Koyama Y, Baba A, Matsuda T Eur. J. Pharmacol., 458, 141-144 (2003) Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries Takahashi K, Takahashi T, Suzuki T, Onishi M, Tanaka Y, Hamano-Takahashi A, Ota T, Kameo K, Matsuda T, Baba A Eur. J. Pharmacol., 458, 155-162 (2003) Endothelin-1 stimulates glial cell line-derived neurotrophic factor expression in cultured rat astrocytes Koyama Y, Tsujikawa K, Matsuda T, Baba A Biochem. Biophys. Res. Commun., 303, 1101-1105 (2003) Overexpression of PACAP in transgenic mouse pancreatic β-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes Yamamoto K, Hashimoto H, Tomimoto S, Shintani N, Miyazaki J, Tashiro F, Aihara H, Nammo T, Li M, Yamagata K, Miyagawa J, Matsuzawa Y, Kawabata Y, Fukuyama Y, Koga K, Mori W, Tanaka K, Matsuda T, Baba A

15

Diabetes, 52, 1155-1162 (2003) Protective effect of T-588 on toxic damage by serum deprivation and amyloid-β protein in cultured neurons Yamamuro A, Ago Y, Maeda S, Sakai Y, Baba A, Matsuda T J. Pharmacol. Sci., 92, 153-156 (2003) T-588, a cognitive enhancer, simulates in vivo phosphorylation of extracellular signal-regulated kinases in the hippocampus Yokoyama I, Sakai Y, Hatayama Y, Tsuji S, Koyama Y, Baba A, Matsuda T Cogn. Brain Res., 17, 522-525 (2003) Focal adhesion kinase is required for endothelin-induced cell cycle progression of cultured astrocytes Koyama Y, Yoshioka Y, Matsuda T, Baba A Glia, 43, 185-189 (2003) Intracerebroventricular administration of an endothelin ETB receptor agonist increases expressions of GDNF and BDNF in rat brain Koyama Y, Tsujikawa K, Matsuda T, Baba A Eur. J. Neurosci., 18, 887-894, (2003) The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice Sakaue M, Ago Y, Baba A, Matsuda T Psychopharmacology, 170, 73-79 (2003) Changes in light-induced phase shift of circadian rhythm in mice lacking PACAP Kawaguchi C, Tanaka K, Isojima Y, Shintani N, Hashimoto H, Baba A, Nagai K Biochem. Biophys. Res. Commun., 310, 169-175 (2003) Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type I receptor-mutant mice Matsuyama S, Matsumoto A, Hashimoto H, Shintani N, Baba A Neuroreport, 14, 2095-2098 (2003) Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced

proliferation and ERK activation in astrocytes Hashimoto H, Kunugi A, Arakawa N, Shintani N, Fujita T, Kasai A, Kawaguchi C, Morita Y, Hirose M, Sakai Y, Baba A Biochem. Biophys. Res. Commun., 311, 337-343 (2003)

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Functional roles of the neuropeptide PACAP in brain and pancreas Shintani N, Tomimoto S, Hashimoto H, Kawaguchi C, Baba A Life Sci., 74, 337-343 (2003) Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex Ago Y, Koyama Y, Baba A, Matsuda T Neuropharmacology, 45, 1050-1056 (2003) Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588 Yamamuro A, Ago Y, Takuma K, Maeda S, Sakai Y, Baba A, Matsuda T Neurochem. Res., 28, 1779-1783 (2003) Pituitary adenylate cyclase-activating polypeptide does not colocalize with vasoactive intestinal polypeptide in the hypothalamic magnocellular nuclei and posterior pituitary of cats and rats Vereczki V, Köves K, Tóth ZE, Baba A, Hashimoto H, Fógel K, Arimura A, Kausz M Endocrine, 22, 225-237 (2003) 遺伝子改変動物における精神運動興奮薬の感受性変化：PACAP 遺伝子欠損マウ

スにおける中枢神経作用薬の反応性 新谷紀人, 田中一裕, 橋本均, 馬場明道

日本薬理学雑誌,122 suppl., 1P-4P (2003) 遺伝子改変マウスを用いた神経ペプチド PACAP の in vivo 機能解析（Review） 橋本均, 新谷紀人 日本薬理学雑誌, 122, 427-435 (2003) 薬剤学（Biopharmaceutics） A novel PPARγ gene therapy to control inflammation associated with inflammatory bowel disease in a murine model Katayama K, Wada K, Nakajima A, Mizuguchi H, Hayakawa T, Nakagawa S, Kadowaki T, Nagai R, Kamisaki Y, Blumberg RS, Mayumi T Gastroenterology, 124, 1315-1324 (2003） Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride)co-polymer and its application for renal drug targeting Kamada H, Tsutsumi Y, Sato-Kamada K, Yamamoto Y, Yoshioka Y, Okamoto T, Nakagawa S, Nagata S, Mayumi T

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Nat. Biotechnol., 21, 399-404 (2003） Site-specific PEGylation of a lysine-deficient TNF-α with full bioactivity Yamamoto Y, Tsutsumi Y, Yoshioka Y, Nishibata T, Kobayashi K, Okamoto T, Mukai Y, Shimizu T, Nakagawa S, Nagata S, Mayumi T Nat. Biotechnol., 21, 546-552 (2003） Antitumor effect by interleukin-11 receptor α-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector Gao JQ, Tsuda Y, Katayama K, Nakayama T, Hatanaka Y, Tani Y, Mizuguchi H, Hayakawa T, Yoshie O, Tsutsumi Y, Mayumi T, Nakagawa S Cancer Research , 63, 4420-4425 (2003） An investigation of adverse effects caused by the injection of high-dose TNFα-expressing adenovirus vector into established murine melanoma Okada Y, Okada N, Mizuguchi H, Hayakawa T, Mayumi T, Mizuno N Gene Therapy, 10, 700-705 (2003） Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice Okada N, Masunaga Y, Okada Y, Mizuguchi H, Iiyama S, Mori N, Sasaki A, Nakagawa S, Mayumi T, Hayakawa T, Fujita T, Yamamoto A Gene Therapy, 10, 1891-1902 (2003） A novel T7 system utilizing mRNA coding for T7 RNA polymerase Nakano R, Nakagawa T, Imazu S, Katayama K, Mizuguchi H, Hayakawa T, Tsutsumi Y, Nakagawa S, Mayumi T Biochem. Biophys. Res. Commun., 301, 974-978 (2003） A novel cytomedical vehicle capable of protecting cells against complement Yoshioka Y, Suzuki R, Oka H, Okada N, Okamoto T, Yoshioka T, Mukai Y, Shibata H, Tsutsumi Y, Nakagawa S, Miyazaki J, Mayumi T Biochem. Biophys. Res. Commun., 305, 353-358 (2003） Incorporation of adult organ-derived endothelial cells into tumor blood vessel Koizumi K, Tsutsumi Y, Kamada H, Yoshioka Y, Watanabe M, Yamamoto Y, Okamoto T, Mukai Y, Nakagawa S, Tani Y, Mayumi T Biochem. Biophys. Res. Commun., 306, 219-224 (2003） Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems

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Xu ZL, Mizuguchi H, Mayumi T, Hayakawa T Gene, 309, 145-151 (2003） Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors Xu ZL, Mizuguchi H, Mayumi T, Hayakawa T Biochim. Biophys. Acta, 1621, 266-271 (2003） Anti-angiogenic effects of dimethyl sulfoxide on endothelial cells Koizumi K, Tsutsumi Y, Yoshioka Y, Watanabe M, Okamoto T, Mukai Y, Nakagawa S, Mayumi T Biol. Pharm. Bull., 26, 1295-1298 (2003） Combination effects of complement regulatory proteins and anti-complement polymer Yoshioka Y, Suzuki R, Okamoto T, Okada N, Mukai Y, Shibata H, Tsutsumi Y, Dohi N, Okada N, Nakagawa S, Mayumi T Biochim. Biophys. Acta, 1624, 54-59 (2003） Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions Mizuguchi H, Xu ZL, Sakurai F, Mayumi T, Hayakawa T Hum. Gene Ther., 14,1265-1277 (2003） Development of novel technology of DDS for gene therapy（Review） Nakagawa S, Mayumi T Drug Metabol. Pharmacokin., 18, 223-229 (2003）

ファージ表面提示法を駆使した機能性人工蛋白質の創出と DDS への展開

(Review) 堤康央, 真弓忠範 Drug Delivery System, 18, 536-544 (2003)

プロテオーム創薬と DDS (Review) 真弓忠範 Drug Delivery System, 18, 497 (2003) 医薬価値に優れた機能性人工タンパク質の網羅的かつ迅速同定システムとプロ

テオーム創薬への展開 (Review) 堤康央, 吉岡靖雄，真弓忠範 細胞工学, 22, 873-881 (2003)

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機能化高分子キャリアの開発とプロテオーム創薬への展開 (Review) 堤康央, 鎌田春彦，真弓忠範 Bio ベンチャー, 3, 56-57 (2003）

高分子化医薬（PEG 化製剤）(Review) 堤康央, 真弓忠範 血液・免疫・腫瘍, 8, 56-62 (2003） プロテオーム創薬にかなう機能性人工蛋白質の迅速創出とその PEGylation への

展開 (Review) 堤康央, 真弓忠範 蛋白質・核酸・酵素, 48, 1519-1526 (2003） アデノウィルスベクターを用いた PPARγの遺伝子治療：PPARγ遺伝子の導入に

よる炎症性腸疾患の治療 (Review) 中島淳，形山和史，真弓忠範 日薬理誌, 122, 309-316 (2003） DDS とナノ粒子 -特集によせて- (Review) 真弓忠範 生物工学会誌, 81, 177 (2003）

細胞内薬物動態制御を目指した機能性ナノ粒子の細胞質内導入 (Review) 中川晋作, 真弓忠範 生物工学会誌, 81, 189-192 (2003） 細胞性製剤による DDS (Review) 中川晋作, 真弓忠範 ドラッグデリバリーシステム DDS 技術の新たな展開とその活用法(遺伝子医学

別冊)、メディカルドゥ,38-43 (2003) 天然物化学 (Natural Product Chemistry) Stereostructure of komodoquinone A, a neuritogenic anthracycline, from marine Streptomyces sp. KS3 Itoh T, Kinoshita M, Wei H, Kobayashi M Chem. Pharm. Bull., 51, 1402-1404 (2003) Binding site(s) on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A Mitsuo M, Noguchi T, Nakajima Y, Aoki S, Ren XQ, Sumizawa T, Haraguchi M,

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Kobayashi M, Baba M, Nagata Y, Akiyama S, Furukawa T Oncology Research, 14, 39-48 (2003) New anti-malarial peroxides with in vivo potency derived from spongean metabolites Murakami N, Kawanishi M, Mostaqul HM, Li J, Itagaki S, Horii T, Kobayashi M Bioorg. Med. Chem. Lett., 13, 4081-4084 (2003) Malformation of immature starfish oocytes by theonellapeptolide Ie, a tridecapeptide lactone from a marine sponge Petrosia species, through disturbance of cortical F-actin distribution Ohta E, Okada H, Ohta S, Kobayashi M, Kitagawa I, Horiike S, Takahashi T, Hosoya H, Yamamoto K, Ikegami S Biosci. Biotechnol. Biochem., 67, 1908-1915 (2003) Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp. KS3 Itoh T, Kinoshita M, Aoki S, Kobayashi M J. Nat. Prod., 66, 1373-1377 (2003) Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells Mukai M, Che XF, Furukawa T, Sumizawa T, Aoki S, Ren XQ, Haraguchi M, Sugimoto Y, Kobayashi M, Takamatsu H, Akiyama S Cancer Science, 94, 557-563 (2003) Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP1 Ren XQ, Furukawa T, Aoki S, Sumizawa T, Haraguchi M, Che XF, Kobayashi M, Akiyama S British Journal of Pharmacology, 138, 1553-1561 (2003) In situ photoaffinity labeling of the target protein for lembehyne A, a neuronal differentiation inducer Aoki S, Matsui K, Takata T, Kobayashi M FEBS Letters, 544, 223-227 (2003) Pyridoacridine alkaloids inducing neuronal differentiation in a neuroblastoma cell line, from marine sponge Biemna fortis Aoki S, Wei H, Matsui K, Rachmat R, Kobayashi M Bioorg. Med. Chem., 11, 1969-1973(2003)

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New semisynthetic quassinoids with in vivo antimalarial activity Murakami N, Sugimoto M, Kawanishi M, Tamura S, Kim HS, Begum K, Wataya Y, Kobayashi M J. Med. Chem., 46, 638-641 (2003) 海綿由来の生物活性物質と微生物共生 (Review) 小林資正

日本農芸化学会誌, 77, 143-145 (2003)

海洋生物からのがん多剤耐性克服物質の探索 (Review) 青木俊二, 小林資正

生産と技術, 55, 43-45 (2003) 有用海洋生物成分の探索 (Review) 小林資正 海洋天然物／錯体／コンビナトリアル／全合成（日本化学会編）, 丸善, 3-9 (2003)

複合薬物動態学 (Medicinal Pharmacology) The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze Sakaue M, Ago Y, Sowa C, Koyama Y, Baba A, Matsuda T Eur. J. Pharmacol., 458, 141-144 (2003) Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries Takahashi K, Takahashi T, Suzuki T, Onishi M, Tanaka Y, Hamano-Takahashi A, Ota T, Kameo K, Matsuda T, Baba A Eur. J. Pharmacol., 458, 155-162 (2003) Roles of cathepsins in reperfusion-induced apoptosis in cultured astrocytes Takuma K, Kiriu M, Mori K, Lee E, Enomoto R, Baba A, Matsuda T Neurochem. Int., 42, 153-159 (2003) Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of GDNF and BDNF in rat brain Koyama Y, Tsujikawa K, Matsuda T, Baba A Eur. J. Neurosci., 18, 887-894 (2003) Focal adhesion kinase is required for endothelin-induced cell cycle progression of

22

cultured astrocytes Koyama Y, Yoshioka Y, Matsuda T, Baba A Glia, 43, 185-189 (2003) Endothelin-1 stimulates glial cell line-derived neurotrophic factor expression in cultured rat astrocytes Koyama Y, Tsujikawa K, Matsuda T, Baba A Biochem. Boiphys. Res. Commun., 303, 1101-1105 (2003) Overexpression of PACAP in transgenic mouse pancreatic β-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes Yamamoto K, Hashimoto H, Tomimoto S, Shintani N, Miyazaki J, Tashiro F, Aihara H, Nammo T, Li M, Yamagata K, Miyagawa J, Matsuzawa Y, Kawabata Y, Fukuyama Y, Koga K, Mori W, Tanaka K, Matsuda T, Baba A Diabetes, 52, 1155-1162 (2003) The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice Sakaue M, Ago Y, Baba A, Matsuda T Psychopharmacology, 170, 73-79 (2003) Protective effect of T-588 on toxic damage by serum deprivation and amyloid-β protein in cultured neurons Yamamuro A, Ago Y, Maeda S, Sakai Y, Baba A, Matsuda T J. Pharmacol. Sci., 92, 153-156 (2003) Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588 Yamamuro A, Ago Y, Takuma K, Maeda S, Sakai Y, Baba A, Matsuda T Neurochem. Res., 28, 1779-1783 (2003) T-588, a cognitive enhancer, stimulates in vivo phosphorylation of extracellular signal-regulated kinases in the hippocampus Yokoyama I, Sakai Y, Hatayama Y, Tsuji S, Koyama Y, Baba A, Matsuda T Cognitive Brain Res., 17, 522-525 (2003) Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex Ago Y, Koyama Y, Baba A, Matsuda T Neuropharmacology, 45, 1050-1056 (2003) 長期隔離飼育マウス脳の無拘束マイクロダイアリシス法

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吾郷由希夫, 松田敏夫

日薬理誌, 122, 135-140 (2003) GDNF によるパーキンソン病の治療 (Review) 小阪田正和, 松田敏夫

日薬理誌, 122, 556 ( 2003)

臨床薬効解析学 (Clinical Evaluation of Medicines and Therapeutics) Physiologically based pharmacokinetic model of venlafaxine considering CYP2D6 polymorphisms Ohmoto M, Watanabe Y, Ohno M, Fukuda T, Azuma J, Akazawa K Trans. Jpn. Soc. Med. Biol. Eng., 41, 440-448 (2003) Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers Otani M, Fukuda T, Naohara M, Maune H, Senda C, Yamamoto I, Azuma J Eur. J. Clin. Pharmacol., 59, 395-399 (2003) Taurine transporter in cultured neonatal cardiomyocytes: a response to cardiac hypertrophy Itoh T, Takahashi K, Yamauchi Y, Takahashi K, Ueyama S, Schaffer SW, Azuma J Adv. Exp. Med. Biol., 526, 33-40 (2003) Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients Yamamoto I, Fujitsu J, Nohnen S, Igarashi T, Motomura T, Inaba M, Tsubakimori S, Azuma J Diabetes Res. Clin. Pract., 59, 219-224 (2003) No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3 Hanatani T, Fukuda T, Onishi S, Funae Y, Azuma J Eur. J. Clin. Pharmacol., 59, 233-235 (2003) MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation Maeda M, Yamamoto I, Fukuda M, Nishida M, Fujitsu J, Nonen S, Igarashi T, Motomura T, Inaba M, Fujio Y, Azuma J Diabetes Care, 26, 547-548 (2003) Diabetic retinopathy possibly results from poor blood sugar control associated with MTHFR gene polymorphism in type 2 diabetic patients: response to Yoshioka et al.

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Maeda M, Yamamoto I, Fukuda M, Nishida M, Fujitsu J, Nonen S, Igarashi T, Motomura T, Inaba M, Fujio Y, Azuma J Diabetes Care, 26, 1948 (2003) Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages Maeda M, Yamamoto I, Fujio Y, Azuma J Biochem. Biophys. Acta, 1623, 41-46 (2003) Cellular characterization of taurine transporter in cultured cardiac myocytes and nonmyocytes Takatani T, Takahashi K, Itoh T, Takahashi K, Hirata M, Yamamoto Y, Ohmoto M, Schaffer SW, Azuma J Adv. Exp. Med. Biol., 526, 25-31 (2003) Taurine transporter in primary cultured neonatal rat heart cells: a comparison between cardiac myocytes and nonmyocytes Takahashi K, Azuma M, Yamada T, Ohyabu Y, Takahashi K, Schaffer SW, Azuma J Biochem. Pharmacol., 65, 1181-1187 (2003) Taurine renders the cell resistant to ischemia-induced injury in cultured neonatal rat cardiomyocytes Takahashi K, Ohyabu Y, Takahashi K, Solodushko V, Takatani T, Itoh T, Schaffer SW, Azuma J J. Cardiovasc. Pharmacol., 41,726-733 (2003) In vitro inhibitory effects of Kampo medicines on metabolic reactions catalyzed by human liver microsomes Takahashi K, Uejima E, Morisaki T, Takahashi K, Kurokawa N, Azuma J J. Clinical Pharmacy Therapeu., 28, 319-327 (2003) Modulation of taurine on CYP3A4 induction by rifampicin in a HepG2 cell line Takahashi K, Matsuda H, Kinoshita K, Matsunaga N, Sumita A, Matsuda T, Takahashi K, Azuma J Adv. Exp. Med. Biol., 526, 237-244 (2003) Why is taurine cytoprotective? Schaffer SW, Azuma J, Takahashi K, Mozaffari M Adv. Exp. Med. Biol., 526, 307-321 (2003)

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医薬情報解析学 (Pharmaceutical Information Science) A new multiple comparison method using resampling technique for medical, pharmaceutical, and chemical data Takagi T, Okamoto K, Yokogawa Y, Yokota M, Kurokawa K, Yasunaga T Journal of Computer Aided Chemistry, 4, 27-34 (2003) Bacterial activity and community composition in stream water and biofilm from an urban river determined by fluorescent in situ hybridization and DGGE analysis Araya R, Tani K, Takagi T, Yamaguchi N, Nasu M FEMS Microbiology Ecology, 43, 111-119 (2003). Cyclization of aryl acyl radicals generated from S-(4-cyano)phenyl thiolesters by a nickel complex catalyzed electroreduction Ozaki S, Adachi M, Sekiya S, Kamikawa R J. Org. Chem., 68, 4586-4589 (2003) ノンパラメトリック回帰による構造活性相関解析～「ポスト IT」の時代の「計

量薬学」～

高木達也

SAR News, 4, 4-7 (2003) 新規化学物質と、新興・再興感染症に関する情報

高木達也

CICSJ Bull., 21, 76-79 (2003)

分子生理病態学 (Molecular Pathophysiology) Estimation of haplotype frequencies, linkage-disequilibrium measures, and combination of haplotype copies in each pool by use of pooled DNA data Ito T, Chiku S, Inoue E, Tomita M, Morisaki T, Morisaki H, Kamatani N Am. J. Hum. Genet., 72, 384-398 (2003) Coordinate induction of AMP deaminase in human atrium with mitochondrial DNA deletion Tomikura Y, Hisatome I, Tsuboi M, Yamawaki M, Shimoyama M, Yamamoto Y, Sasaki N, Ogino K, Igawa O, Shigemasa C, Ishiguro S, Ohgi S, Nanba E, Shiota G, Morisaki H, Morisaki T, Kitakaze M Biochem. Biophys. Res. Commun., 302, 372-376 (2003) Chamber-specific differentiation of Nkx2.5-positive cardiac precursor cells from

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murine embryonic stem cells Hidaka K, Lee JK, Kim HS, Ihm CH, Iio A, Ogawa M, Nishikawa S, Kodama I, Morisaki T FASEB J., 17, 740-742 (2003) Direct cell-cell interaction of cardiomyocytes is key for bone marrow stromal cells to go into cardiac lineage in vitro Fukuhara S, Tomita S, Yamashiro S, Morisaki T, Yutani C, Kitamura S, Nakatani T J. Thorac. Cardiovasc. Surg., 125, 1470-1479 (2003) Expression of ErbB receptors in ES cell-derived cardiomyocytes Kim HS, Hidaka K, Morisaki T Biochem. Biophys. Res. Commun., 309, 241-246 (2003) NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y, Takemura G, Horie M, Miyamoto Y, Morisaki T, Kuratomi S, Noma A, Fujiwara H, Yoshimasa Y, Kinoshita H, Kawakami R, Kishimoto I, Nakanishi M, Usami S, Saito Y, Harada M, Nakao K EMBO J., 22, 6310-6321 (2003) Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia Chade AR, Best PJ, Rodriguez-Porcel M, Herrmann J, Zhu X, Sawamura T, Napoli C, Lerman A, Lerman LO Kidney Int., 64, 962-969 (2003) Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis Chade AR, Rodriguez-Porcel M, Grande JP, Zhu X, Sica V, Napoli C, Sawamura T, Textor SC, Lerman A, Lerman LO Arterioscler. Thromb. Vasc. Biol., 23, 1295-1301 (2003) The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells Cominacini L, Fratta Pasini A, Garbin U, Pastorino A, Rigoni A, Nava C, Davoli A, Lo Cascio V, Sawamura T J. Am. Coll. Cardiol., 41, 499-507 (2003) Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by

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reducing its oxidative inactivation Cominacini L, Fratta Pasini A, Garbin U, Nava C, Davoli A, Criscuoli M, Crea A, Sawamura T, Lo Cascio V J. Am. Coll. Cardiol., 42, 1838-1844 (2003) Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation Honjo M, Nakamura K, Yamashiro K, Kiryu J, Tanihara H, McEvoy LM, Honda Y, Butcher EC, Masaki T, Sawamura T Proc. Natl. Acad. Sci. U S A, 100, 1274-1279 (2003) Oxidized LDL through LOX-1 modulates LDL-receptor expression in human coronary artery endothelial cells Hu B, Li D, Sawamura T, Mehta JL Biochem. Biophys. Res. Commun., 307, 1008-1012 (2003) LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury Kataoka K, Hasegawa K, Sawamura T, Fujita M, Yanazume T, Iwai-Kanai E, Kawamura T, Hirai T, Kita T, Nohara R Biochem. Biophys. Res. Commun., 300, 656-660 (2003) Modulation of endothelial Ca2+-activated K+ channels by oxidized LDL and its contribution to endothelial proliferation Kuhlmann CR, Schafer M, Li F, Sawamura T, Tillmanns H, Waldecker B, Wiecha J Cardiovasc. Res., 60, 626-634 (2003) LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells Li D, Liu L, Chen H, Sawamura T, Ranganathan S, Mehta JL Circulation, 107, 612-617 (2003) LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells Li D, Liu L, Chen H, Sawamura T, Mehta JL Arterioscler. Thromb. Vasc. Biol., 23, 816-821 (2003) Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction Li D, Williams V, Liu L, Chen H, Sawamura T, Romeo F, Mehta JL J. Am. Coll. Cardiol., 41, 1048-1055 (2003)

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Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium Li L, Sawamura T, Renier G Diabetes, 52, 1843-1850 (2003) Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature Rodriguez-Porcel M, Lerman A, Herrmann J, Schwartz RS, Sawamura T, Condorelli M, Napoli C, Lerman LO Cardiovasc. Res., 58, 213-221 (2003) Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function Rodriguez-Porcel M, Lerman LO, Herrmann J, Sawamura T, Napoli C, Lerman A Arterioscler. Thromb. Vasc. Biol., 23, 885-891 (2003) Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction Tatsuguchi M, Furutani M, Hinagata J, Tanaka T, Furutani Y, Imamura S, Kawana M, Masaki T, Kasanuki H, Sawamura T, Matsuoka R Biochem. Biophys. Res. Commun., 303, 247-250 (2003) Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia Wilson SH, Chade AR, Feldstein A, Sawamura T, Napoli C, Lerman A, Lerman LO Nephrol. Dial. Transplant., 18, 703-709 (2003) プリン代謝異常症の実験モデル (Review) 森崎隆幸 日本臨牀, 61（増刊号１）, 482-486 (2003) ES 細胞由来心筋細胞 (Review) 森崎隆幸, 日高京子

最新医学, 58, 633-640 (2003) 心不全と再生医療－心筋細胞再生の試み (Review) 日高京子, 森崎隆幸

内科, 91, 491-494 (2003) ゲノム医学における倫理的側面 (Review) 森崎隆幸 現代医療, 35, 1694-1699 (2003)

29

胚性幹細胞を用いた心筋再生 (Review) 森崎隆幸 医学のあゆみ, 207, 909-913 (2003)

発生制御学 (Developmental Regulation） Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations Tanaka H, Miyagawa Y, Tsujimura A, Matsumiya K, Okuyama A, Nishimune Y Mol. Hum. Reprod., 9, 69-73 (2003) Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein Kitamura K, Miyagawa Y, Iguchi N, Nishimura H, Tanaka H, Nishimune Y Mol. Hum. Reprod., 9, 237-243 (2003) A novel protein phosphatase 2C family member (PP2Cζ) is able to associate with ubiquitin conjugating enzyme 91 Kashiwaba M, Katsura K, Ohnishi M, Sasaki M, Tanaka H, Nishimune Y, Kobayashi T, Tamura S FEBS Lett., 538, 197-202 (2003) Differential expression of succinyl CoA transferase (SCOT) genes in somatic and germline cells of the mouse testis Tanaka H, Iguchi N, Miyagawa Y, Koga M, Kohroki J, Nishimune Y Int. J. Androl., 26, 52-56 (2003) The role of the c-kit receptor in the regenerative differentiation of rat Leydig cells Tsuchida J, Dohmae K, Kitamura Y, Nishimune Y Int. J. Androl., 26, 121-125 (2003) Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells Iguchi N, Tanaka H, Yomogida K, Nishimune Y Int. J. Androl., 26, 354-365 (2003) Functional analysis of the p53 gene in apoptosis induced by heat stress or loss of stem cell factor signaling in mouse male germ cells Ohta H, Aizawa S, Nishimune Y Biol. Reprod., 68, 2249-2254 (2003)

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Novel actin-like proteins T-ACTIN 1 and T-ACTIN 2 are differentially expressed in the cytoplasm and nucleus of mouse haploid germ cells Tanaka H, Iguchi N, Egydio de Carvalho C, Tadokoro Y, Yomogida K, Nishimune Y Biol. Reprod., 69, 475-482 (2003) Dramatic expansion of germinal stem cells by ectopically expressed human glial cell line-derived neurotrophic factor in mouse Sertoli cells Yomogida K, Yagura Y, Tadokoro Y, Nishimune Y Biol. Reprod., 69, 1303-1307 (2003) Characterization of histone H2A.X expression in testis and specific labeling of germ cells at the commitment stage of meiosis with histone H2A.X promoter-enhanced green fluorescent protein transgene Tadokoro Y, Yomogida K, Yagura Y, Yamada S, Okabe M, Nishimune Y Biol. Reprod., 69, 1325-1329 (2003) Proliferation and differentiation of spermatogonial stem cells in W/Wv mutant mouse testis Ohta H, Tohda A, Nishimune Y Biol. Reprod., 69, 1815-1821 (2003) Genomic structure and promoter activity of the testis haploid germ cell-specific intronless genes, Tact1 and Tact2 Hisano M, Yamada S, Tanaka H, Nishimune Y, Nozaki M Mol. Reprod. Dev., 65, 148-156 (2003) Involvement of death receptor Fas in germ cell degeneration in gonads of Kit-deficient Wv/Wv mutant mice Sakata S, Sakamaki K, Watanabe K, Nakamura N, Toyokuni S, Nishimune Y, Mori C, Yonehara S Cell Death Differ., 10, 676-686 (2003) Methylation of CpG dinucleotides in the open reading frame of a testicular germ cell-specific intronless gene, Tact1/Actl7b, represses its expression in somatic cells Hisano M, Ohta H, Nishimune Y, Nozaki M Nucleic Acids Res., 31, 4797-4804 (2003) Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction Kitamura K, Tanaka H, Nishimune Y J. Biol. Chem., 278, 44417-44423 (2003)

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Transcriptional regulation of the cytosolic chaperonin θ subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and Net in the absence of serum response factor Yamazaki Y, Kubota H, Nozaki M, Nagata K J. Biol. Chem., 278, 30642-30651 (2003) In vitro and in vivo gene delivery by recombinant baculoviruses Tani H, Limn CK, Yap CC, Onishi M, Nozaki M, Nishimune Y, Okahashi N, Kitagawa Y, Watanabe R, Mochizuki R, Moriishi K, Matsuura Y J. Virol., 77, 9799-9808 (2003)

薬用資源学 (Medicinal Resources)

Secu'amamine A, a novel indolizidine alkaloid from Securinega suffruticosa var. amamiensis Ohsaki A, Ishiyama H, Yoneda K, Kobayashi J Tetrahedron Lett., 44, 3097-3099 (2003)

香と香材の保存の科学（５）：文化財としての木香の科学調査

米田該典

香料, 219, 33-37 (2003)

緒方洪庵の薬箱にみる呼吸器薬

米田該典

呼吸器学百年史，日本呼吸器学会, 242-243 (2003)

生薬とは

米田該典

入門漢方医学，日本東洋医学会, 146-148 (2003)

カラーアトラス 有毒きのこ

津田盛也，横山和正，米田該典(主監訳, 共訳）

広川書店，(2003)

大阪の薬は交流の所産 (Review) 米田該典

大阪府薬雑誌, 54, 16-18 (2003)

「大阪とくすり」を訪ねて(1)～(10) (Review) 米田該典 大阪府薬雑誌，54(3), 15-17～54(12), 16-17 (2003)

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茶人と香(1)～(12) (Review)

米田該典

淡交、57(1),100-103～57(12), 92 -95 (2003)

臨床薬物学 (Clinical Pharmaceuticals) Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis Miyatsuka T, Kaneto H, Kajimoto Y, Hirota S, Arakawa Y, Fujitani Y, Umayahara Y, Watada H, Yamasaki Y, Magnuson MA, Miyazaki J, Hori M Biochem. Biophys. Res. Commun., 310, 1017-1025 (2003) In vitro inhibitory effects of Kampo medicines on metabolic reactions catalyzed by human liver microsomes Takahashi K, Uejima E, Morisaki T, Takahashi K, Kurokawa N, Azuma J J. Clin. Pharmacy Therapeu., 28, 319-327 (2003) ウコン (Curcuma) 属生薬のヒト肝 CYP 代謝活性への阻害効果 西田裕子, 高橋京子, 上島悦子, 小松かつ子, 佐々木陽平, 荒川行生, 山本克己, 竹上学, 片岡和三郎, 黒川信夫, 東純一 臨床薬理 (Jpn. J. Clin. Pharmacol. Ther.), 34, 107S-108S (2003) がんの痛みと対策・最新の実践技術（１）：がんの痛みのアセスメント－薬剤師

からみたがんの痛みのアセスメント (Review) 上島悦子 がん看護, 8, 26-31 (2003) がんの痛みと対策・最新の実践技術（２）：がんの痛みの緩和ケア－薬剤師から

みたがんの痛みの緩和ケア (Review) 上島悦子 がん看護, 8, 109-114 (2003) がんの痛みと対策・最新の実践技術（３）：がん疼痛をめぐる最近の話題－レス

キューの必要性と服薬指導 (Review) 上島悦子 がん看護, 8, 201-204 (2003) 新薬展望 2003 (Ⅲ): 最近の新薬を治療にどう活かすか: 外用抗菌薬／点眼抗

菌薬 (Review) 岡本禎晃, 上島悦子 医薬ジャーナル, 39(S-1), 623-627 (2003)

33

各科共通エッセンシャルシート＜1＞ 疼痛管理－Ⅰ (Review) 岡本禎晃, 上島悦子, 黒川信夫 医薬ジャーナル, 39, 178-191 (2003) 各科共通エッセンシャルシート＜2＞ 疼痛管理－Ⅱ：鎮痛補助薬１ (Review) 岡本禎晃, 上島悦子, 出開美樹, 村井扶, 黒川信夫 医薬ジャーナル, 39, 1091-1096 (2003) 各科共通エッセンシャルシート＜3＞ 疼痛管理－Ⅲ：鎮痛補助薬２ (Review) 岡本禎晃, 上島悦子, 黒川信夫 医薬ジャーナル, 39, 1574-1584 (2003) 各科共通エッセンシャルシート＜4＞ 疼痛管理－Ⅳ：オピオイド (Review) 岡本禎晃, 上島悦子, 黒川信夫 医薬ジャーナル, 39, 2109-2124 (2003) 各科共通エッセンシャルシート＜5＞ 抗血小板剤・抗凝固剤 (Review) 竹上学, 上島悦子, 黒川信夫 医薬ジャーナル, 39, 2594-2609 (2003) 各科共通エッセンシャルシート＜6＞ 造血因子製剤 (Review) 上島悦子, 黒川信夫 医薬ジャーナル, 39, 3036-3050 (2003) 具体的な医療事故防止方策Ⅲ：システム指向の事故防止方策１：注射オーダー

警告 (Review) 小西清信 クリニカルリスクマネジメントナーシングプラクティス（中島和江,八田かずよ,

武田裕編）, 文光堂, 60-63 (2003) 具体的な医療事故防止方策Ⅲ：システム指向の事故防止方策２：ディスポーザ

ブル製品の利用 (Review) 八田かずよ, 中島和江, 小西清信

クリニカルリスクマネジメントナーシングプラクティス（中島和江,八田かずよ,

武田裕編）, 文光堂, 64-67 (2003)

具体的な医療事故防止方策Ⅳ：専門家による支援１：手術部への薬剤師の配置

(Review) 上島悦子 クリニカルリスクマネジメントナーシングプラクティス（中島和江,八田かずよ,

武田裕編）, 文光堂, 114-115 (2003)

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がん終末期ケアにおける薬剤師の役割Ｂ：病棟薬剤師の働きの実際 (Review) 上島悦子

がん終末期・難治性神経筋疾患進行期の症状コントロール － ターミナルケア

にたずさわる人たちへ（増訂版）（後明郁男,平塚良子,佐藤健太郎,神野進編）, 南山堂, 184-193 (2003)

薬物療法３：降圧薬の副作用 (Review) 上島悦子 やさしい高血圧の自己管理（改訂３版）（荻原俊男監修, 大阪大学大学院加齢医

学講座高血圧研究室編）, 医薬ジャーナル社, 32-33 (2003)

クローン病の治療３：薬物療法 (Review) 上島悦子

やさしいクローン病の自己管理（松澤佑次監修, 伊藤裕章編集）, 医薬ジャー

ナル社, 23-28 (2003)

細胞構造学 (Cellular Physiology) Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase Shimizu Y, Iwai S, Hanaoka F, Sugasawa K EMBO J., 22, 164-173 (2003) The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II Watanabe T, Hayashi K, Tanaka A, Furumoto T, Hanaoka F, Ohkuma Y Mol. Cell. Biol., 23, 2914-2926 (2003) 129-derived strains of mice are deficient in DNA polymerase ι and have normal immunoglobulin hypermutation McDonald JP, Frank EG, Plosky BS, Rogozin IB, Masutani C, Hanaoka F, Woodgate R, Gearhart PJ J. Exp. Med., 198, 635-643 (2003) Thymine-rich single-stranded DNA activates Mcm4/6/7 helicase on Y-fork and bubble-like substrates You Z, Ishimi Y, Mizuno T, Sugasawa K, Hanaoka F, Masai H EMBO J., 22, 6148-6160 (2003) Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis

35

Ito N, Nureki O, Shirouzu M, Yokoyama S, Hanaoka F Genes Cells, 8, 913-923 (2003) 生化学的アプローチ (Review) 花岡文雄 ゲノムの修復と組換え－原子レベルから疾患まで－（花岡文雄, 武田俊一, 柴田武

彦編）シュプリンガー・フェアラーク東京, 109-122 (2003)

遺伝子機能解析学 (Experimental Genome Research) Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes Azukizawa H, Kosaka H, Sano S, Heath WR, Takahashi I, Gao XH, Sumikawa Y, Okabe M, Yoshikawa K, Itami S Eur. J. Immunol., 33, 1879-1888 (2003) Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm Inoue N, Ikawa M, Nakanishi T, Matsumoto M, Nomura M, Seya T, Okabe M Mol. Cell. Biol., 23, 2614-2622 (2003) Alteration of gene expression by chromosome loss in the postnatal mouse brain Kaushal D, Contos JJ, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J J. Neurosci., 23, 5599-5606 (2003) Mouse germ cell-less as an essential component for nuclear integrity Kimura T, Ito C, Watanabe S, Takahashi T, Ikawa M, Yomogida K, Fujita Y, Ikeuchi M, Asada N, Matsumiya K, Okuyama A, Okabe M, Toshimori K, Nakano T Mol. Cell. Biol., 23, 1304-1315 (2003) Full reconstitution of hematopoietic system by murine umbilical cord blood Migishima F, Oikawa A, Kondo S, Ema H, Morita Y, Nakauchi H, Yokoyama M, Song SY, Nishijima M, Okabe M, Shinohara N Transplantation, 75, 1820-1826 (2003) Development of efficient strategies for the production of genetically modified pigs Nagashima H, Fujimura T, Takahagi Y, Kurome M, Wako N, Ochiai T, Esaki R, Kano K, Saito S, Okabe M, Murakami H Theriogenology, 59, 95-106 (2003)

36

Difference of osteopontin gene regulation between bone and kidney Sakuma T, Higashibata Y, Kawahata H, Yamada S, Okabe M, Kitamura Y, Nomura S J. Orthop. Sci., 8, 361-366 (2003) Characterization of histone H2A.X expression in testis and specific labeling of germ cells at the commitment stage of meiosis with histone H2A.X promoter-enhanced green fluorescent protein transgene Tadokoro Y, Yomogida K, Yagura Y, Yamada S, Okabe M, Nishimune Y Biol. Reprod., 69, 1325-1329 (2003) Evidence of the monoclonal composition of human endometrial epithelial glands and mosaic pattern of clonal distribution in luminal epithelium Tanaka M, Kyo S, Kanaya T, Yatabe N, Nakamura M, Maida Y, Okabe M, Inoue M Am. J. Pathol., 163, 295-301 (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S Science, 301, 640-643 (2003) レンチウイルスベクターによるトランスジェニック動物作製法 (Review) 伊川正人 実験医学, 21, 509-514 (2003) マウス：dsRNAをインジェクションする方法 (Review) 蓮輪英毅, 岡部勝 RNAi実験プロトコール(実験医学別冊), 138-145 (2003) マウス：pol III プロモーターを使ったトランスジーンによる方法 (Review) 蓮輪英毅, 岡部勝 RNAi実験プロトコール(実験医学別冊), 146-158 (2003) マウス個体におけるRNAi (Review) 蓮輪英毅, 岡部勝 遺伝子医学, 7, 59-64 (2003) RNAiノックダウンマウスの作製 (Review) 蓮輪英毅, 岡部勝 Medical Science Digest, 29, 28-31 (2003) GFPマウスを用いたイメージング (Review)

37

伊川正人, 磯谷綾子, 岡部勝 Bioベンチャー, 3, 86-88 (2003) 遺伝情報解析学 (Environmental Science and Microbiology) Detection of bacteria carrying the stx2 gene by in situ loop-mediated isothermal amplification Maruyama F, Kenzaka T, Yamaguchi N, Tani K, Nasu M Appl. Environ. Microbiol., 69, 5023-5028 (2003) Development of multicolour digital image analysis system to enumerate actively respiring bacteria in natural river water Ogawa M, Tani K, Yamaguchi N, Nasu M J. Appl. Microbiol., 95,120-128 (2003) Development of an adhesive sheet for direct counting of bacteria on solid surfaces Yamaguchi N, Ishidoshiro A, Yoshida Y, Saika T, Senda S, Nasu M J. Microbiol. Methods, 53, 405-410 (2003) Rapid detection of respiring Escherichia coli O157:H7 in apple juice, milk and ground beef by flow cytometry Yamaguchi N, Sasada M, Yamanaka M, Nasu M Cytometry, 54A, 27-35 (2003) Bacterial activity and community composition in stream water and biofilm from an urban river determined by fluorescent in situ hybridization and DGGE analysis Araya R, Tani K, Takagi T, Yamaguchi N, Nasu M FEMS Microbiol. Ecol., 43, 111-119 (2003) Change in the bacterial community of natural river biofilm during biodegradation of aniline-derived compounds determined by denaturing gradient gel electrophoresis Araya R, Yamaguchi N, Tani K, Nasu M J. Health Science, 49, 379-385 (2003)

環境中の微生物を培養することなく追跡する (Review) 山口進康，那須正夫

日本農芸化学会誌, 77, 1233-1236 (2003)

培養操作に依存しない遺伝子伝播研究 (Review) 谷佳津治，那須正夫

生物工学, 81, 438-440 (2003)

細菌を迅速，高精度に検出する (Review) 那須正夫

38

生産と技術, 55, 61-65 (2003)

医薬品製造用水の微生物管理 (Review) 川井眞好，那須正夫

月刊海洋, 号外 33, 170-178 (2003)

培養操作に依存しない微生物群集構造解析 (Review) 山口進康，那須正夫

月刊海洋, 号外 33, 29-40 (2003)

遺伝子を指標とした水環境中の微生物モニタリング (Review) 山口進康, 那須正夫

月刊海洋, 号外 35, 46-53 (2003)

環境中の細菌を迅速に検出する－その現状と応用－(Review) 見坂武彦, 那須正夫

ファルマシア,39, 137-141 (2003)

新しい微生物検出法とその醸造学分野への応用 (Review) 山口進康, 那須正夫

日本醸造協会誌,98, 534-543 (2003)

蛋白情報解析学 (Protein Molecular Engineering) Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T Blood, 101, 4748-4756 (2003) PREP1, MEIS1 homolog protein, regulates PF4 gene expression Okada Y, Matsuura E, Nagai R, Sato T, Watanabe A, Morita I, Doi T Biochem. Biophys. Res. Commun., 305, 155-159 (2003) Role of class A scavenger receptor in the atherosclerosis and multiple pattern recognition Kodama T, Doi T Atherosclerosis Supplements, 4, 192 (2003) PPARδ agonist ameliorates obesity and insulin resistance through coordinate regulation of fatty acid metabolism in skeletal muscle Tanaka T, Iwasaki S, Asaba H, Hamura H, Watanabe M, Tachibana K, Watanabe Y,

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Uchiyama Y, Sumi K, Magoori K, Ioka RX, Doi T, Naito M, Auwerx J, Hamakubo T, Sakai J, Kodama T Atherosclerosis Supplements, 4, 217 (2003) Analysis of peroxisome proliferator-activated receptors (PPARs) target genes in the HepG2 cells overexpressing each PPAR isoform in the tetracycline (Tet)-regulated system Tachibana K, Tanaka T, Tagami M, Kobayashi Y, Katayama T, Ishimoto K, Yamasaki D, Ueda C, Sumitomo M, Kodama T, Doi T Atherosclerosis Supplements, 4, 218 (2003) Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T, Sakai J Proc. Natl. Acad. Sci. USA, 100, 15924-15929 (2003) 微生物動態学 (Environmental Biochemistry) Validity test for a yeast two-hybrid assay to screen for estrogenic activity, and its application to insecticides and disinfectants for veterinary use Eguchi K, Ozawa M, Endoh YS, Nishikawa J, Nishihara T, Goto K, Yoshimura H Bull. Environ. Contam. Toxicol., 70, 226-232 (2003) Estrogenic and thyroid hormone activity of a series of hydroxy-polychlorinated biphenyls Shiraishi F, Okumura T, Nomachi M, Serizawa S, Nishikawa J, Edmonds JS, Shiraishi H, Morita M Chemosphere, 52, 33-42 (2003) Detection of thyroid hormone receptor-binding activities of chemicals using a yeast two-hybrid assay Kitagawa Y, Takatori S, Oda H, Nishikawa J, Nishihara T, Nakazawa H, Hori S J. Health Sci., 49, 99-104 (2003) Estrogenicity of metabolites of benzophenone derivatives examined by a yeast two-hybrid assay Takatori S, Kitagawa Y, Oda H, Miwa G, Nishikawa J, Nishihara T, Nakazawa H, Hori S J. Health Sci., 49, 91-98 (2003)

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Crucial role of TCL/TC10βL, a subfamily of Rho GTPase, in adipocyte differentiation Nishizuka M, Arimoto E, Tsuchiya T, Nishihara T, Imagawa M J. Biol. Chem., 278, 15279-15284 (2003) Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex Sutton A, Shia WJ, Band D, Kaufman PD, Osada S, Workman JL, Sternglanz R J. Biol. Chem., 278, 16887-16892 (2003) Basis of a high-throughput method for nuclear receptor ligands Kanayama T, Mamiya S, Nishihara T, Nishikawa J J. Biochem., 133, 791-797 (2003) Estrogenic activities of UV stabilizers used in food contact plastics and benzophenone derivatives tested by the yeast two-hybrid assay Kawamura Y, Ogawa Y, Nishimura T, Kikuchi Y, Nishikawa J, Nishihara T, Tanamoto K J. Health Sci., 49, 205-212 (2003) Methoxychlor induces CYP2C11 to convert itself into hormonally active metabolites Mikamo E, Harada S, Nishikawa J, Nishihara T J. Health Sci., 49, 229-232 (2003) Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor Mikamo E, Harada S, Nishikawa J, Nishihara T Toxicol. Appl. Pharmacol., 193, 66-72 (2003) 内分泌攪乱物質の核内受容体ファミリーを介する作用発現

西川淳一, 間宮聡, 金山知彦, 西原力 環境バイオテクノロジー学会誌, 3, 37-42 (2003) 毒性を見つける 3-3 : QSAR の利用 西原力, 松尾昌秊 環境リスクマネジメントハンドブック，中西準子他（編集者），朝倉書店，111-119 (2003) 健康と栄養

芹生幸子，西原力，西原照代 新ウェルネス栄養学，西原力（編者），大阪大学出版会, 1-6 (2003)

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栄養素の体内運命

伊藤順子，西原力 新ウェルネス栄養学，西原力（編者），大阪大学出版会，61-74 (2003) 食品の安全と食物アレルギー

西原力 新ウェルネス栄養学，西原力（編者），大阪大学出版会，141-145 (2003) 酵母レポータージーン試験

西原力 環境ホルモンの最新動向と測定・試験・機器開発，井口泰泉（監修），シーエム

シー出版，232-236 (2003) Discovery of anti-infective drugs using genome-based technologies (Review) Nakayama H, Nishihara T Biocont. Sci., 8, 43-54 (2003) Using simulation models to assess the ecological risk of pesticides to aquatic organisms (Review) Tsuzuki M, Inoue A, Takimoto Y, Nishihara T J. Health Sci., 49, 249-259 (2003) サイレンシングを制御するヒストンアセチル化酵素とクロマチン形成因子(Minireview) 長田茂宏 生化学, 75, 297-301 (2003)

微生物制御学 (Environmental Biotechnology) Bioactivities of nostocine A produced by a freshwater cyanobacterium Nostoc spongiaeforme TISTR 8169 Hirata K, Yoshitomi S, Dwi S, Iwabe O, Mahakhant A, Polchai J, Miyamoto K J. Biosci. Bioeng., 95, 512-517 (2003) Enhanced accumulation of Cd2+ by a Mesorhizobium sp. transformed with a gene from Arabidopsis thaliana coding for phytochelatin synthase Sriprang R, Hayashi M, Ono H, Takagi M, Hirata K, Murooka Y Appl. Environ. Microbiol., 69, 1791-1796 (2003) Regulation of phytochelatin synthesis by zinc and cadmium in marine green alga, Dunaliella tertiolecta

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Tsuji N, Hirayanagi N, Iwabe O, Namba T, Tagawa M, Miyamoto S, Miyasaka H, Takagi M, Hirata K, Miyamoto K Phytochem., 62, 453-459 (2003) Removal of hazardous phenols by microalgae under photoautotrophic conditions Hirooka T, Akiyama Y, Tsuji N, Nakamura T, Nagase H, Hirata K, Miyamoto K J. Biosci. Bioeng., 95, 200-203 (2003) Photosynthesis-dependent removal of 2,4-dichlorophenol by Chlorella fusca var. vacuolata Tsuji N, Hirooka T, Nagase H, Hirata K, Miyamoto K Biotechnol. Lett., 25, 241-244 (2003) Induction of tolerance to oxidative stress in the green alga, Chlamydomonas reinhardtii, by abscisic acid Yoshida K, Igarashi E, Mukai M, Hirata K, Miyamoto K Plant Cell Envrion., 26, 451-457 (2003)

微細藻類の機能開発と環境保全への応用 (Review) 宮本和久, 平田收正

ファルマシア, 39, 871-875 (2003) 内分泌かく乱化学物質の生物分解と環境浄化への応用 — 光独立栄養微生物の

利用— (Review) 廣岡孝志, 永瀬裕康

J. Environ. Biotechnol., 3, 23-32 (2003)

環境病因病態学 (Clinical and Experimental Pathophysiology ) Role of h1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells Morioka T, Koyama H, Yamamura H, Tanaka S, Fukumoto S, Emoto M, Mizuguchi H, Hayakawa T, Kojima I, Takahashi K, Nishizawa Y Diabetes, 52, 760-766 (2003) Aberrant methylation and silencing of the calponin gene in human sarcoma cells Yamamura H, Yoshikawa H, Takahashi K Anticancer Research, 23, 107-114 (2003) Increased locomotor activity, increased food and water intake and decreased PVN neurons in h1 calponin gene-deficient mice

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Bannai M, Yoshimoto R, Mitsui-Saito M, Hori M, Nishihara M, Takahashi K, Yamamura H, Taniguchi S, Katsuki M, Ozaki H, Karaki H Journal of Veterinary Medicine and Science, 65, 153-155 (2003) Immature tumor angiogenesis in high-grade and high-stage renal cell carcinoma Kinouchi T, Mano M, Matsuoka I, Kodama S, Aoki T, Okamoto M, Yamamura H, Usami M, Takahashi K Urology, 62, 765-770 (2003) A single-center, open-label, randomized, parallel-group study assessing the differences between an angiotensin II receptor antagonist and an angiotensin-converting enzyme inhibitor in hypertensive patients with congestive heart failure: the research for efficacy of angiotensin II receptor antagonist in hypertensive patients with congestive heart failure study Totsuka N, Awata N, Takahashi K, Yamamura H, Nakamura J, Tsuchikane E, Kobayashi Y, Nishibe A, Terai K Current Therapeutic Research Clinical and Experimental, 64, 81-94 (2003) Studies and perspectives of calponin in smooth muscle regulation and cancer gene therapy Takahashi K, Yamamura H Advances in Biophysics, 37, 91-111 (2003) Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy Tsuchikane E, Takeda Y, Kobayashi T, Yachiku K, Nasu K, Kobayashi Y, Matsumoto H, Awata N Circulation Journal, 67, 763-767 (2003) Effect of plaque debulking before stent implantation on in-stent neointimal proliferation: a serial 3-dimensional intravascular ultrasound study Takeda Y, Tsuchikane E, Kobayashi T, Terai K, Kobayashi Y, Nakagawa T, Sakurai M, Awata N, Kobayashi T American Heart Journal, 146, 175-182 (2003) A prospective, multianter randomized double-blind, well-controlled parallel group comparative efficacy and safety study of zomitriptan or cafergot on migraine Nishizawa Y, Nishizawa Y, Kinki migraine study group, Fushiki S Jap. J. Headach., 30, 72-77 (2003) Familial acromegaly: further evidence from the genetic study of a three-generation family: review of the literature

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Nishizawa Y, Nishizawa Y, Fushiki S, Nosaka S, Amenomori Y, Goto GH, Tanigaki Y, Amakata Y, Yoshioka F Asian J. Clin. Gent., 1, (2003) Monozygotic twins with discordant sexual phenotypes due to different ratios of mosaicism of 47, X, idic(Y), idic(Y)/46, X, idic(Y)/45, X Nishizawa Y, Nishizawa Y, Matsuhisa Y, Goto GH, Tanigaki Y, Yoshioka F, Nosaka S, Amenomori Y, Amakata Y, Nagano F, Yamada M, Yasuda R, Kawata Y, Hirata Y, Fushiki S Asian J. Clin. Gent., 2, (2003) Health hazards and biological effects of welding fumes on thyroid function in welders compared with non-welding healthy-subjects who showed no statistical significance in geographic characteristics Nishizawa Y, Nishizawa Y, Goto GH, Tanigaki Y, Nosaka S, Yoshioka F, Amenomori Y, Azuchi K, Amakata Y, Nagano F, Yamada M, Yasuda R, Kawata Y, Hirata Y, Fushiki S, Hiro to Kyuyo no Kagaku, 18, 83-93 (2003) アナフィラキシーショック死回避法の蘇生学的検討 我々のアナフィラキシー

ショック死対策から検討した回避方法

西澤芳男, 西澤恭子, 吉岡二三, 野坂修一, 天方義邦, 伏木信次 蘇生, 22, 111-118 (2003) 漢方薬の内科疾患急性疼痛改善効果：麦門冬湯と塩酸ホミノベンとの高齢者急

性気道炎症疾患起因咳嗽に対する前向き多施設無作為比較検討試験

西澤芳男, 西澤恭子, 吉岡二三, 天方義邦, 野坂修一, 谷垣由美子, 永野富美代, 山田まゆみ, 安田理絵, 平田弥生, 雨森保憲, 後藤グレイシィ広恵, 伏木信次 痛みと漢方, 13, 12-19 (2003) 神秘湯 (Shen-bi-tang:SBT) 吸入療法と sodium cromoglycate 吸入療法とのア

スピリン喘息への多施設無作為効果比較検討

西澤芳男, 西澤恭子, 吉岡二三, 山田まゆみ, 安田理絵, 平田弥生, 川田陽子, 永野富美代, 雨森保憲, 野坂修一, 天方義邦, 後藤グレイシィ広恵, 谷垣由美子, 伏木信次 耳鼻咽喉科展望, 46, 3-14 (2003) 漢方薬、麦門冬湯とブロムヘキシンの二次性シェーグレン症候群に対する唾液

分泌増加作用の多施設、無作為比較検討試験

西澤芳男, 西澤恭子, 吉岡二三, 後藤グレイシィ広恵, 天方義邦, 野坂修一, 雨森保憲, 伏木信次 第 47 回日本唾液腺学会, 65-70 (2003)

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全身臓器に嚢胞様変化を来し Clostridium perfringens 敗血症が推定された１剖検

例

安原裕美子, 塚本吉胤, 春日井務, 西澤恭子, 石黒信吾 診断病理, 20, 340-343 (2003) 病原微生物学 (Bacterial Infections) Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V cholerae Makino K, Oshima K, Kurokawa K, Yokoyama K, Uda T, Tagomori K, Iijima Y, Najima M, Nakano M, Yamashita A, Kubota Y, Kimura S, Yasunaga T, Honda T, Shinagawa H, Hattori M, Iida T Lancet, 361, 743-749 (2003) Vibrio vulnificus induces macrophage apoptosis in vitro and in vivo Kashimoto T, Ueno S, Hanajima M, Hayashi H, Akeda Y, Miyoshi S, Hongo T, Honda T, Susa N Infect. Immun., 71, 533-535 (2003) Survey of Vibrio cholerae O1 and its survival over the winter in marine water of Port of Osaka Miyagi K, Nakano T, Yagi T, Hanafusa M, Imura S, Honda T, Nakano Y, Sano K, Epidemiol. Infect., 131, 613-619 (2003) Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation Kawane K, Fukuyama H, Yoshida H, Nagase H, Ohsawa Y, Uchiyama Y, Okada K, Iida T, Nagata S Nature Immunology, 4, 138-144 (2003) The urease gene cluster of Vibrio parahaemolyticus does not influence the expression of the thermostable direct hemolysin (TDH) gene or the TDH-related hemolysin gene Nakaguchi Y, Okuda J, Iida T, Nishibuchi M Microbiol. Immunol., 47, 233-239 (2003) Effect of environmental conditions on proteins secreted by enterohemorrhagic Escherichia coli O26:H11 Yoh M, Bi Z, Matsuyama J, Nagayama K, Honda T Microbiol. Immunol., 47, 1-6 (2003)

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Structure and binding mode of a ribosome recycling factor (RRF) from mesophilic bacterium Nakano H, Yoshida T, Uchiyama S, Kawachi M, Matsuo H, Kato T, Ohshima A, Yamaichi Y, Honda T, Kato H, Yamagata Y, Ohkubo T, Kobayashi Y Journal of Biological Chemistry, 278, 3427-3436 (2003) Shiga toxin- and enterotoxin-producing Escherichia coli isolated from subjects with bloody and nonbloody diarrhea in Bangkok, Thailand Leelaporn A, Phengmak M, Eampoklap B, Manatsathit S, Tritilanunt S, Siritantikorn S, Nagayama K, Iida T, Niyasom C, Komolpit P Diagnostic Microbiology and Infectious Disease, 46, 173-180 (2003)

腸管出血性大腸菌 O157 抗原、べロトキシン

河野原吾, 本田武司

臨床検査, 47,163-168 (2003)

Providencia alcalifaciens による食中毒

本田武司

Medical Corner, 112, 9-11 (2003)

病原性大腸菌 O157：大腸菌 O157LPS 抗体

坂本雅子, 本田武司

綜合臨牀, 52, 143-146 (2003)

新たな食中毒原因菌-Providencia alcalifaciens 宇田隆行, 本田武司

臨床検査, 47, 513-517 (2003)

大腸菌ベロ毒素の構造と標的細胞に対する作用

余明順, 本田武司

診断と治療, 91, 1223-1230 (2003)

抗生物質・抗菌薬療法の実際/A.感染症からみた抗生物質・抗菌薬の選択と使用

の実際 腸管感染症, 食中毒 服部景子, 本田武司

Medical Practice, 20, 312-317 (2003)

腸管感染原因菌、特にビブリオ属菌と病原性大腸菌の病原因子の解析とその応用

的研究

本田武司

日本細菌学雑誌, 58, 491-503 (2003)

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細菌の病原性と遺伝子伝播

飯田哲也

生物工学, 81, 431-433 (2003)

環境・生活習慣と感染症 食品に由来した感染症―食中毒の現状とその予防―

岡田和久, 本田武司

成人病と生活習慣病, 33, 1055-1059 (2003)

腸炎ビブリオのゲノム解析

飯田哲也

日本食品微生物学会雑誌, 20, 170-175 (2003)

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