biophysics division -1- biophysics division cellular/molecular imaging for bonghan system study...
TRANSCRIPT
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Biophysics DivisionBiophysics DivisionBiophysics DivisionBiophysics Division
Cellular/Molecular Imaging for Cellular/Molecular Imaging for Bonghan System StudyBonghan System Study
2006. 9. 27.2006. 9. 27.Kwang-Sup Soh Kwang-Sup Soh
Biomedical Physics Lab. for Korean MedicineBiomedical Physics Lab. for Korean MedicineSchool of Physics, Seoul National UniversitySchool of Physics, Seoul National University
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Biophysics DivisionBiophysics Division
ContentsContents
I. Introduction on Bonghan SystemI. Introduction on Bonghan System
II. Co-operative Research ProgressII. Co-operative Research Progress
(1)(1) Electron MicroscopeElectron Microscope
(2)(2) Atomic Force MicroscopeAtomic Force Microscope
(3)(3) NanoparticlesNanoparticles
Biophysics DivisionBiophysics Division
I. Bonghan SystemI. Bonghan System
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Biophysics DivisionBiophysics Division
Bonghan SystemBonghan System
Organ-Surface BH duct Organ-Surface BH duct (on the surface of organs)(on the surface of organs)
Superficial BH ductSuperficial BH duct(Acupuncture meridian)(Acupuncture meridian)
Superficial BH CorpuscleSuperficial BH Corpuscle(Acupoints)(Acupoints)
skin : superficial BH ductsskin : superficial BH ducts
network network surface of organs : OSBHDsurface of organs : OSBHD
inside vessels : intra-vascular inside vessels : intra-vascular BHD BHD
Intravascular BH Intravascular BH ductduct
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Biophysics DivisionBiophysics Division
Physiological SignificancePhysiological Significance
New Circulation System New Circulation System Hyaluronic acid, Amino acid, Mono nucleotide, Hyaluronic acid, Amino acid, Mono nucleotide, Hormone: Adrenalin/noradrenalinHormone: Adrenalin/noradrenalin
Bonghan Granules (Bonghan Granules (ФФ≈0.8~2.4≈0.8~2.4μμm) containing DNAm) containing DNA Adult stem cells: cell therapyAdult stem cells: cell therapy Natural “micro-cell”: gene therapyNatural “micro-cell”: gene therapy
Biophysics DivisionBiophysics Division
II. Research ProgressII. Research Progress
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Biophysics DivisionBiophysics Division
Future ProspectsFuture Prospects
AnatomyAnatomy
PhysiologyPhysiology
Electron MicroscopesElectron Microscopes
AFMAFM
NanobiotechnologyNanobiotechnology
Optical TweezerOptical Tweezer
2005 Sept, CKC Symposium 2005 Sept, CKC Symposium
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Biophysics DivisionBiophysics Division
Electron MicroscopesElectron Microscopes
Microscopy Research & Technology, 2006Microscopy Research & Technology, 2006
Electron Microscopic Study of Novel Threadlike Structures on the Surfaces of Mammalian Organs
Byung-Cheon Lee,1 Jung Sun Yoo,1 Vyacheslav Ogay,1 Ki Woo Kim, 2 Harald Dobberstein, 3 Kwang-Sup Soh, 1, † and Byung-Soo Chang 4, †
1Biomedical Physics Laboratory, FPRD, School of Physics and Astronomy, Seoul National University, Seoul, Korea
2National Instrumentation Center for Environmental Management, College of Agriculture and Life Sciences, Seoul National University, Seoul, Korea
3Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, UK
4Department of Cosmetology, Hanseo University, Seosan, Korea
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Biophysics DivisionBiophysics Division
Electron MicroscopesElectron Microscopes
Fig.1. Stereomicroscopic Images of novel threadlike structures
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Biophysics DivisionBiophysics Division
Electron MicroscopesElectron Microscopes
SEMSEM
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Biophysics DivisionBiophysics Division
Electron MicroscopesElectron Microscopes
TEMTEM
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Biophysics DivisionBiophysics Division
Electron MicroscopesElectron Microscopes
Cryo-SEMCryo-SEM FIB/SEMFIB/SEM((CavendishCavendish))
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Biophysics DivisionBiophysics Division
Atomic Force MicroscopeAtomic Force Microscope
Investigation of morphology and physical properties of Bonghan microcell using AFM and TEM
1Ku Youn Baik, 1Joonhyung Kwon, 1Byung –Cheon Lee, 2Harald Dobberstein, and 1Kwang-Sup Soh$
1Biomedical Physics Laboratory, Department of Physics, Seoul National University, Seoul, 151-747, Korea
2Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, UK
- 2006.7.2-7 Molecular Cell Biology GRC, NH, USA
Microcell-like granules in the Bonghan corpuscle on the surfaces of mammalian internal organs
1Ku Youn Baik, 1Vyacheslav Ogay, 2Harald Dobberstein, and 1Kwang-Sup Soh
1Biomedical Physics Laboratory, Department of Physics, Seoul National University, Seoul, 151-747, Korea2Cavendish Laboratory, University of Cambridge, Cambridge, CB3 0HE, UK
- 2006.8.27 WC2006 Conference, Seoul, Korea
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Biophysics DivisionBiophysics Division
Atomic Force MicroscopeAtomic Force Microscope
Bonghan microcell cycle (Bonghan Kim, 1965)
(1) All the morphological components of organism are ceaselessly reproduced.
(2) The self-reproduction of organism takes the form of Bonghan microcell-cell cycles.
(3) The self-reproduction of organism is performed by the acupuncture-meridian system.
Theory of Bonghan Microcell
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Biophysics DivisionBiophysics Division
A Topography, B Error, C Magnified of B, D line profile
1.4 um x 1um x 350nm sized oval Bonghan microcell. It shows clearly unique surface structure of layers and portions (B & C) whose size is from 0.2um to 0.6 um in diameter. The line profile analysis shows that the common patterns on the surface are steps of about 20nm height. This pattern is thought to be revealing the stereotype of its membrane structure.
AFM image of Bonghan microcellAFM image of Bonghan microcell
20nm
AA BB CC
DD
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Biophysics DivisionBiophysics Division
NanobiotechnologyNanobiotechnology
Flowing Channel of NanoparticlesFlowing Channel of Nanoparticles