BIOS E-127– 10.12.06

Evolution of pathogens

(Grenfell et al., 2004)

(Kerr et al., 2006. Nature)

(Grenfell et al., 2004)

(Smith et al., 2004)

Monday (12/13):

***Avida presentations***Revised projects due 12/15

Graduate reviews due 12/17

Mutation Rate vs. Mutation #

• Can a large number of slow mutators adapt faster than a few fast mutators?

• Evolve Mut+ and Mut- in an environment that awards some tasks.

• Compete Mut+ and Mut- in a new environment awarding different tasks.

Conlusions

• Mutators have an advantage• Mutators’ advantage counteracted by

population size.• Can’t determine the balance point where

neither have an advantage- need more granularity and larger N.

Patrick SchlossUniversity of Michigan, Department of Microbiology and Immunology

“The only constant is change: temporal dynamics of host-associated microbiota”

Thursday, December 9th @ 6PM***Note Alternate Location: Haller Hall, Geological Museum 1st Floor (Rm 102)***24 Oxford St, Harvard University, Cambridge

Please join us for a wine and cheese reception at 5:30 pmHost: Curtis Huttenhower- MSI Seminar Schedule: http://www.msi.harvard.edu/thursdays.html- Directions to 24 Oxford St:  http://www.msi.harvard.edu/ov_dir.html