biosensor using aptamer
DESCRIPTION
Biosensor using aptamer. C ontents. What is biosensor? What is aptamer ? How can we use aptamer ? How can we find aptamer ?. What is Biosensor?. Analytical device using biological element Sensing organic molecule’s state or concentration. Biomarker of Heart attacks. - PowerPoint PPT PresentationTRANSCRIPT
Biosensor us-ing aptamer
ContentsWhat is biosensor?What is aptamer?How can we use aptamer?How can we find aptamer?
What is Biosensor?• Analytical device
using biological element
• Sensing organic molecule’s state or concentration
Biomarker of Heart attacks
What is aptamer?
• Piece of single strand DNA or RNA
• High affinity for cer-tain molecule
• Used for bioreceptor of biosensor
• Small size easy production, modification
• High stability easy to handle, regeneration
• Economically efficient
• No immune rejection response
• Adjust to many toxic material or complex pro-
tein
How can we find aptamer?
vitro selection
SELEX(Systematic Evolution of Lig-ands by Exponential Enrichment)
Different kind of SELEX Cell SELEX
Capillary electrophoresis SELEX (CE SELEX)
Speigelmer
How can we use aptamer?Sensor
Diagnosis
Cure
DiscussionWhere can aptamer be used in
another way?
Reference 장승훈 , 정기준 , 압타머 (Aptamer) 개발의 최근 연구 동향 ,
한국과학기술원 생명화학공학과 Li Cai, Ze-Zhong Chen, Min-Yan Chen, Hong-Wu Tang*,
Dai-Wen Pang, MUC-1 aptamer-conjugated dye-doped silica nanoparticles for MCF-7 cells detection, 2013, Biomaterials
Thank you!!