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Biosynthesis of peptide hormones DNA (gene) Hormone

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Page 1: Biosynthesis of peptide hormones DNA (gene) Hormone

Biosynthesis of peptide hormones

DNA (gene)

Hormone

Page 2: Biosynthesis of peptide hormones DNA (gene) Hormone

Protein secretory pathway

Page 3: Biosynthesis of peptide hormones DNA (gene) Hormone

rough endoplasmic reticulum

Protein secretory pathway

Page 4: Biosynthesis of peptide hormones DNA (gene) Hormone

Secretory pathway

rough ER

Page 5: Biosynthesis of peptide hormones DNA (gene) Hormone

Signal sequences & SRP

Page 6: Biosynthesis of peptide hormones DNA (gene) Hormone

Signal sequences & SRP

SRP (signal recognition

particle)

Page 7: Biosynthesis of peptide hormones DNA (gene) Hormone

Multiple hormone cleavage products

pro-opiomelanocortin polypeptide (POMC)

ACTH-lipotropin

-MSH -lipotropin-MSH

CLIP -endorphin

-MSH

MET-enk

Page 8: Biosynthesis of peptide hormones DNA (gene) Hormone

Steroid hormone synthesis

• tissues involved in steroid hormone synthesis:

testosterone

estradiol

Page 9: Biosynthesis of peptide hormones DNA (gene) Hormone

Steroid hormone synthesis

• synthesis occurs in

cholesterol

Page 10: Biosynthesis of peptide hormones DNA (gene) Hormone

Biosynthesis of steroids

cholesterol (C27)

Page 11: Biosynthesis of peptide hormones DNA (gene) Hormone

Gluco- and mineralo-corticoid synthesis

glucocorticoidglucocorticoid

mineralorticoidmineralorticoid

Page 12: Biosynthesis of peptide hormones DNA (gene) Hormone

Androgen & estrogen synthesis

androgenandrogen

estrogensestrogens

Page 13: Biosynthesis of peptide hormones DNA (gene) Hormone

Vitamin D synthesis

UV light

liver, kidney

Page 14: Biosynthesis of peptide hormones DNA (gene) Hormone

Thyroid hormone synthesis

• thyroid hormone synthesis

• forms of active thyroid hormone:

Page 15: Biosynthesis of peptide hormones DNA (gene) Hormone

Thyroid hormone biosynthesis

Page 16: Biosynthesis of peptide hormones DNA (gene) Hormone

Biosynthesis of eicosanoids

arachidonic acid

Page 17: Biosynthesis of peptide hormones DNA (gene) Hormone

Biosynthesis of eicosanoids

Page 18: Biosynthesis of peptide hormones DNA (gene) Hormone

Anti-inflammatory drugs & eisosanoids

thromboxane leukotriene

inflammation response

phospholipase A

arachidonic acid

fatty acids

Page 19: Biosynthesis of peptide hormones DNA (gene) Hormone

Hormone delivery

• endocrine:

• paracrine:

• autocrine:

• neuroendocrine:

Page 20: Biosynthesis of peptide hormones DNA (gene) Hormone

Plasma transport of hormones

Page 21: Biosynthesis of peptide hormones DNA (gene) Hormone

Hormone turnover

• typical half-life

• peptide hormones

• steroid & thyroid hormones


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