bipn100’humanphysiology1...
TRANSCRIPT
![Page 1: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/1.jpg)
1. Dr K’s office hours: In office Tuesdays 2:30 - 3:30 PM (In office: 3122A Pacific Hall) Group Fridays 11:00 AM - noon (Meeting room: 3501 Pacific Hall)
2. Dr K’s problem-solving session: Wed and Thurs 5-6 in 3500 Pacific Hall (same material).
3. Midterm exams: returned at around noon—have your ID in hand. 4. Grading errors?
1. Check the answer key on the web site (by mid-afternoon today). 2. Talk to the appropriate TA (see “# graded” below) by Wed, Nov. 11. 3. Turn in a written description of the error(s) to Dr. K, along with exam, by Fri. Nov. 13. ***Dr. K may regrade the whole ***
5. Pick up graded exams: If you signed the waiver, outside the elevator of the third floor of Pacific Hall. If you did not sign the waiver, from Dr. K after class or at office hours.
6. TA sections, office hours:
BIPN100 Human Physiology 1 Bill Kristan, Ph.D.
. Section IA # graded Office Hour . Fri 11:00-11:50am SEQUO 148…..Winjet Chou……....(3)…..Wed 3-3:50 pm……...HSS 1145B Fri 12:00-12:50pm SEQUO 147…...Saatchi Patell…….(7)…..Wed 1-1:40 pm……...Muir Woods Fri 1:00-1:50pm WLH 2115 ….. Justine Liang….….(4)…..Tues 10-10:50 am…..Hi Thai Fri 2:00-2:50pm WLH 2206 …….Hao Shi……………(2)…...Fri 3-3:50 pm………...HSS 1128A Mon 9:00-9:50am WLH 2115……. Tim Macaulay....….(8)…...Tues 12:30-1:20 pm…Mandeville Cart Mon 4:00-4:50pm WLH 2208……. Mallorie Nguyen….(6).....Thurs 2-2:50 pm…….Goody's Market Mon 5:00-5:50pm WLH 2208……..Donel Purcella……(5)..…Mon 3:30-4:20 pm…..Price Center East, SR 2 Mon 6:00-6:50pm WLH 2115……...Kyra Rashid………(1)…..Thurs 10-10:40 am…Revelle Com. Lounge
![Page 2: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/2.jpg)
Time course of twitches in fast (L.R.), slow (S.), and mixed (G.) muscles
L.R. = lateral rectus (eye muscle—pulls eye outward) G. = gastrocnemius (large calf muscle—extends ankle) S. = soleus (small calf extensor; parallel to gastocnemius)
![Page 3: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/3.jpg)
Synergistic and antagonistic muscles in the lower leg that control ankle movements
![Page 4: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/4.jpg)
Fatigue rates in slow twitch and fast twitch muscles
![Page 5: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/5.jpg)
![Page 6: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/6.jpg)
Fast vs. slow muscles
![Page 7: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/7.jpg)
![Page 8: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/8.jpg)
1. Skeletal muscle
Muscles are of 3 general sorts:
2. Smooth muscle
3. Cardiac muscle
![Page 9: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/9.jpg)
Smooth muscle
Skeletal (striated) muscle
![Page 10: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/10.jpg)
Contrac;on and relaxa;on rates in skeletal, cardiac, and smooth muscles
![Page 11: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/11.jpg)
Figure 12-11 Skeletal muscle contraction Figure 12-28 Smooth muscle contraction
(L-type)
(RyR)
Metabotropic receptor
G
IP3
Ligand (DHP)
![Page 12: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/12.jpg)
Figure 12-28 Smooth muscle contraction Figure 12-9 How Ca++ causes skeletal muscle contraction
![Page 13: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/13.jpg)
Figure 12-29 (Silverthorn 5th edition) Relaxation of smooth muscle
![Page 14: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/14.jpg)
Functional anatomy of smooth muscle
![Page 15: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/15.jpg)
Connec;ons between smooth muscle cells.
![Page 16: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/16.jpg)
Aka: unitary
Two types of smooth muscle
![Page 17: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/17.jpg)
Control systems of smooth muscles
![Page 18: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/18.jpg)
Relationships between membrane potential (Em) and force (F) in different types of smooth muscle
intestines
blood vessels blood vessels
intestines
![Page 19: BIPN100’HumanPhysiology1 ’’’’’’’’Bill!Kristan,!Ph.D.classes.biology.ucsd.edu/bipn100B.FA15/BIPN100.F15.lect... · 2015. 10. 29. · 1. Skeletal muscle Muscles are](https://reader036.vdocuments.net/reader036/viewer/2022071114/5feb211e7fb99a7f4f61d262/html5/thumbnails/19.jpg)
Strategy #1. As per the course outline: average of top 5 grades = 92
A (90% of 92) = 83-‐94 [36] B (75-‐89% of 92) = 69-‐82 [119] C (60-‐74% of 92) = 55-‐68 [92] D (50-‐59% of 92) = 46-‐54 [34] F (<50% of 92) = 30-‐45 [28]
305 students took midterm 1 High score = 94 Low score = 30
Grade distribu;on:
Strategy #2. Mean (67%) is the B-‐C cutoff, other cutoffs are + 1 standard devia;on (13%):
A = 80-‐94 [56] B = 67-‐79 [117] C = 54-‐66 [81] D = 40-‐53 [41] F = 30-‐39 [10]
Mean = 67 St. dev. = 13