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BLOOD COAGULATION AND

ANTICOAGULANT,

THROMBOLYTIC, AND

ANTIPLATELET DRUGS

Alfi Yasmina

Dea Arie Kurniawan

Antikoagulan, Antitrombotik, Trombolitik,

Hemostatik

Beberapa Istilah

• Hemostasis

• Koagulasi

• Trombosis

• Antikoagulan

• Antitrombotik

• Trombolitik

• Hemostatik

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• Indirect Trombin Inhibitor

– Heparin

– Warfarin

– Rivaroxaban

• Direct Trombin Inhibitor

– Bivalirudin, Hirudin, Lepirudin,

Argatroban

– Dabigatran, Ximelagatran

Antikoagulan

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• LMWH

– Bemiparin, dalteparin, enoxaparin,

reviparin, fondaparinux

• Monitoring pemeriksaan darah

• Indikasi: trombosis vena, emboli paru,

PJR, penyakit jantung iskemik

Antikoagulan

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Aspirin

Dipiridamol

Tiklopidin

Klopidogrel

Epoprostenol (PGI2)

Abciximab

Antitrombotik

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Fosfolipid membran

Asam arakidonat

Rangsang

Gangguan pada membran sel

Hidroperoksid

Leukotrien

Endoperoksid (PGG2/ PGH)

PGE2, PGF2, PGD2, PGI2 Tromboksan A2

Fosfolipase

SiklooksigenaseLipooksigenaseAspirin

• Indikasi: cegah trombosis pada

TIA/ stroke, infark miokard, bedah

kardiovaskuler, Raynaud’s phenomen

Antitrombotik

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• Streptokinase

• Urokinase

• Plasminogen activator

(u-PA, t-PA)

Trombolitik

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• Indikasi: infark, emboli paru, trombosis

vena/ arteri

• Mahal

Trombolitik

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• Transfusi

• Faktor VIII

• Kompleks faktor II, V, IX, X

• Fibrinogen

• Vitamin K

• Asam aminokaproat

• Asam traneksamat

• Karbazokrom

Hemostatik

Further Reading

• Katzung BG, Masters SB, Trevor AJ. Basic and

Clinical Pharmacology 11th Edition. McGraw-Hill,

2009.

• Goodman & Gilman’s Manual of Pharmacology and

Therapeutics. McGraw-Hill, 2008