Metformin

Decreasing gluconeogenesis & increasing peripheral utilization of glucose. Only if there is residual

pancreatic function

Adult and Child over 10 years 500 mg with breakfast > one week > 500 mg with breakfast & dinner > one week > 500 mg with 3 meals 1500

Glibenclamide Initially 5 rng daily with or immediately after break-fast, dose adjusted according to response ; max. 15 mg daily 10

Gliclazide(MR) Initially 30 mg daily with breakfast, adjusted according to response every 4 weeks ; max. 120 mg daily 60

Glipizide Initially 2.5—5 mg daily shortly before breakfast or lunch, adjusted according to response; max. 20 mg daily.Up to 15 mg (Sigle dose), higher doses divided. 10

Glimerpride Initially 1 mg daily, adjusted according to response at 1-2 week intervals; max. 4 mg daily taken shortly before or with first main meal 3

Repaglinide > 18 years, initially 500 micrograms within 30 minutes before main meals ; up to 4 mg may be given as a single dose, max. 16 mg daily 3

Natiglinide > 18 years, initially 60 mg 3 times daily within 30 minutes before main meals, up to max. 180 mg 3 times daily 180

AcarboseInhibits intestinal glucosidase , delays the digestion & absorption of starch &

sucrose

> 18 years, initially 50 mg daily increased to 50 mg 3 times daily, max. 200 mg 3 times daily Tablets should be chewed with first mouthful of food or swallowed whole with a little liquid immediately before food

150

PioglitazoneReduce peripheral insulin resistance,

leading to a reduction of blood-glucose concentration

> 18 years, initially 15-30 mg once daily increased to 45 mg once daily according to response 30

SitagliptinInhibits dipeptidylpeptidase-4 so increases insulin secreation and

lowers glucagon secretion> 18 years, 100 mg once daily 100

Mode of Action & Dose of Oral Anti-Diabetic Drugs ( Accordinf to the British National Formulary BNF March 2010)

Active Principle Mode of Action

Augmentig Insulin secreation. During long term adminestration they have

extrapanceatic action

Stimulate insulin release. Both drugs have a rapid onset of action and short

duration of activity

Avr. Dose mgDose Details