T R A N S F U S I O N T E C H N O L O G Y

COM.TEC®THE MULTI-PROCEDURAL APHERESIS PLATFORM

Br_ComTec_04.07_GB.indd 1Br_ComTec_04.07_GB.indd 1 25.04.2007 11:57:53 Uhr25.04.2007 11:57:53 Uhr

COM.TEC®

The multi-procedural apheresis platform

Donation as well as therapeutic procedures

Continuous flow technology

Component collection outside of the centrifuge

Optional single-needle mode for selected protocols

Ultimate donor/patient safety

Apheresis sets with pre-donation capability

Easy (drawer like) installation of the separation chamber

Automatic or manual process management for all protocols

Equipped as standard with printer

Apheresismaster – the optional data management

Br_ComTec_04.07_GB.indd 2Br_ComTec_04.07_GB.indd 2 25.04.2007 11:57:58 Uhr25.04.2007 11:57:58 Uhr

The “Apheresismaster” provides a bi-directional

radio transmission capability of cell separators with

a server PC. As an option, the server PC can be

linked to the lab and the central data base.

The total monitoring of the production process with

central documentation provides completely new

perspectives. Apheresismaster documents all proce-

dures available on COM.TEC®.

CENTRALIZED MONITORING DOCUMENTATION

• For supervising the production process.

• All relevant separation data are immediately

available when alarms occur.

• Create your individual separation records match-

ing your requirements. The complete records can

be transmitted and printed on any PC.

ApheresismasterThe intelligent system

COM.TEC® 1 COM.TEC® 3

COM.TEC® 2 COM.TEC® 4

CentralDatabase

ServerPC

Br_ComTec_04.07_GB.indd 5Br_ComTec_04.07_GB.indd 5 25.04.2007 11:57:29 Uhr25.04.2007 11:57:29 Uhr

PLATELET COLLECTION

• Leuko-depleted platelet units without filtration

• Platelet collection in dual- or single-needle mode available

• Plasma recirculation for optimal flow conditions

• Donor-tailored separation parameters, for example “best flow”

• Protocol also recommended for therapeutic platelet depletion

THERAPEUTIC PROTOCOLS

By the plasma recircula-

tion the hematocrit in

the separation chamber

is adjusted to 37% and

almost constant flow con-

ditions are maintained.

This also prevents mod-

ulations of the interface,

and high level platelet

quality is achieved.

The RBC barrier ensures

the leuko-depleted flow

of platelets into the sec-

ond separation step.

Therapeutic plasma exchange

• Plasma exchange efficacy 87% on average

• Single-needle mode available

RBC exchange

• Implemented RBC replacement calculator

• Accurate achievement of desired post Hct

• Very efficient HbS depletion

RBC depletion

• Accurate achievement of desired post Hct

• Short procedure times

Plasma treatment on adsorber columns

• Flexible use of different adsorber columns

Therapeutic depletion of platelets

Platelet collection bag Whole blood inlet

Recircu-lation pump

Whole blood pump

Plasma pump

Drip chamber

Return fl ow

Cell pump

Seperation chamber

Br_ComTec_04.07_GB.indd 3Br_ComTec_04.07_GB.indd 3 25.04.2007 11:58:04 Uhr25.04.2007 11:58:04 Uhr

STEM CELL COLLECTION

• Variable protocol selection due to different donor/patient conditions

• Protocol selection dependent on targets

• Lymphocyte collection for consecutive photochemotherapy and donor lymphocyte infusions (DLI)

• CD34 + prediction

AutoMNC procedure for automated collection:

The spillover sensor detects the passing cell fraction and triggers

the spillover clamp from “return” to “collection”.

Correlation of predicted vs. collected CD34+ yield

[x106 Cells].

10000

1000

100

10

CD

34+

(in

teri

m y

ield

) [1

0e6]

CD34+ (predicted) [10e6]

10 100 1000 10000

Speaman’s correlation coefficient: r1 = 0.936 (p < 0.0001): r2 = 0.913 (p < 0.0001)

� MNC� RV-PBSC

Spillover Clamp

Drip Chamber

Spillover Detector

Collection Bag

Br_ComTec_04.07_GB.indd 4Br_ComTec_04.07_GB.indd 4 25.04.2007 11:58:23 Uhr25.04.2007 11:58:23 Uhr

Fresenius HemoCare GmbH A company of the Fresenius Kabi group

Pfingstweide 5361169 Friedberg · Germany Phone: +49-61 72-6 08 8499Fax: +49-61 72-6 08 8498

www.fresenius-kabi.com

Your local sales organization:

B 201 GB 04/2007 (Pure:Comm) © Copyright 2007, Fresenius HemoCare GmbH

Programs and disposables COM.TEC®

Programs Platelet Disposables

PLT 5d Platelet apheresis, 5-day storage C5L(simultaneous plasma harvest possible)

PLT 5d Platelet apheresis, Triple-concentrates, 5 day storage C5LT(simultaneous plasma harvest possible)

PLT 5d-SN Single needle platelet apheresis, 5 day storage S5L(simultaneous plasma harvest possible)

Programs Stem cell Disposables

PBSC-Lym Peripheral blood stem cell collection, C4Ylymphocyte collection or depletion

RV-PBSC Peripheral blood stem cell collection, RVYreduced collection volume

MNC Peripheral blood stem cell collection, P1Ymononuclear cell collection or depletion

autoMNC Automatic collection of peripheral blood stem cells, P1YAstem cells mononuclear cell collection

autoMNC Automated collection of lymphocytes in dual needle P1YAlymphocytes mode for consecutive photochemotherapy or DLI*

Granulo Granulocyte collection P1Y

BMSC Bone marrow stem cell processing P1Y + BMSC

Programs Therapy Disposables

Deplet Depletion of platelets or white blood cells C4L

RBC Therapeutic red cell exchange or depletion PL1; US: RBC

TPE Therapeutic plasma exchange PL1; US: TPE

Adsorb Therapeutic plasma treatment e. g. immunoadsorption P1R

*DLI (donor lymphocyte infusion)

Br_ComTec_04.07_GB.indd 6Br_ComTec_04.07_GB.indd 6 25.04.2007 11:57:40 Uhr25.04.2007 11:57:40 Uhr