breast cancer hormone therapy
TRANSCRIPT
Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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Estrogen Effect
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Beneficial effects
Breast
Programs milk production
Liver and heart
Controls cholesterol
Uterus
Prepares for fetus
Bone
Preserves strength
Harmful effects
Breast
Increases cancer risk
Uterus
Increases cancer risk
Estrogen Effect
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Art
wo
rk b
y J
ean
ne
Ke
lly. ©
201
0.
Beneficial effects
Breast
Programs milk production
Liver and heart
Controls cholesterol
Uterus
Prepares for fetus
Bone
Preserves strength
Harmful effects
Breast
Increases cancer risk
Uterus
Increases cancer risk
Beneficialeffects
Harmfuleffects
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Hypothalamus(下視丘)
Gonadotropins (促性腺激素)-FSH (濾泡刺激素)-LH (黃體生成素)
Ovary(卵巢)
Estrogens (雌激素) Progesterone (黃體激素)
Prolactin
Growth Hormone
Pituitary gland
Adrenal gland(腎上腺)
Progesterone(黃體激素)
Androgens (雄性素)Estrogens(雌激素)
Corticosteroids(皮質固醇)
Premenopausal
Adrenocorticotropichormone (ACTH:促腎上腺皮質素)
Estrogen production
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Hypothalamus(下視丘)
Gonadotropins (促性腺激素)-FSH (濾泡刺激素)-LH (黃體生成素)
Ovary(卵巢)
Estrogens (雌激素) Progesterone (黃體激素)
Prolactin
Growth Hormone
Pituitary gland
Adrenal gland(腎上腺)
Progesterone(黃體激素)
Androgens (雄性素)Estrogens(雌激素)
Corticosteroids(皮質固醇)
Premenopausal
Adrenocorticotropichormone (ACTH:促腎上腺皮質素)
Estrogen production
Estrogen-Induced Proliferation andSpontaneous New Mutations
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Art
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y J
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lly. ©
201
0.
Estrogen stimulation
Normal breast cell
Mistake in DNA duplication
Increased proliferation
Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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• 補充女性荷爾蒙
• 減少停經症候群發生Postmenopausal
• 使用抗荷爾蒙藥物
• 減少乳癌復發
Early Stage Breast Cancer
• 使用抗荷爾蒙藥物
• 延緩乳癌疾病的惡化
Metastatic Breast Cancer
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Estrogen receptor antagonist 抗雌性激素
• 與雌性激素競爭受體,以阻斷雌性激素作用
• Tamoxifen
Aromatase Inhibitor 芳香環轉化酵素抑制劑
• 阻斷雌性激素的生成
• Anastrozole, Letrozole, Exemestane
GnRH agonist 類性腺激素釋放素
• 促黃體激素釋放荷爾蒙致效劑(LH-RH致效劑)
• Goserelin (Zoladex)
Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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Cancer and Estrogen
Breast Cancer Treatment
Hormone therapy
Premenopausal treatment
Postmenopausal treatment
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