nosis, radiopharmacology, technetium breast neoplasm/cancerdiagnosis, gene expression, human therapy evaluation, neo-plasm/cancer chemotherapy, pharmacokinetics, tumor pro-gression bioimaging/biomedical imaging, biopsy, clinicalresearch, female, human subject, immunocytochemistry, lab-oratory mouse, positron emission tomography, scanning elec-tron microscopy, women’s health

Institution: Washington UniversityLindell And Skinker BlvdSt. Louis, MO 63130

Fiscal Year: 2002Department: RadiologyProject Start: 01-Sep-1999Project End: 30-Jun-2004ICD: National Cancer InstituteIRG: ZCA1

WASHINGTON UNIVERSITY MOLECULARIMAGING CENTER

Grant Number: 1P50CA094056-01PI Name: Piwnica-Worms, David R.

Abstract: Description (provided by applicant): WashingtonUniversity Medical School’s concept of an In Vivo Cellularand Molecular Imaging Center (ICMIC) envisions a processthat will permit the Center to become the focal point for thedevelopment of novel in vivo molecular imaging initiativeson campus. This involves further expanding and reinforcingcollaborations and enhancing the productivity of multidisci-plinary programs in basic cancer cell biology and molecularimaging research. The ultimate objective of the proposedP50 Program is to combine the institutional expertise ofWashington University in the basic sciences of molecularoncology, immunology, molecular genetics and signal trans-duction with our well-developed infrastructure in medicalimaging under the formal configuration of an ICMIC. Weare strategically positioned to focus the majority of our IC-MIC resources on the advancement of novel interactive andcollaborative oncologic molecular imaging projects. To meetthese goals, an organizational structure with three molecularimaging cores, four multidisciplinary ICMIC researchprojects, four developmental research projects, an educa-tional program and a training/career development programare proposed. The four projects, representing innovative andexciting new initiatives on campus are: 1) In Vivo Imagingof Gene Expression in Prostate Cancer, 2) Non-InvasiveMonitoring of T Cell-Mediated Tumor Ablation, 3) ImagingCancer Viruses with Tat Transducible Peptides, 4) ImagingMDRI P-glycoprotein Transport Activity In Vivo with Tc-94m-Sestamibi PET to Predict Response to Chemotherapy in

Extensive Stage Small Cell Lung Cancer. An organizationalstructure for an ICMIC has been established and all mile-stones achieved with our active P20 planning grant. The P50Center grant will now promote excellence in molecular im-aging in cancer research by providing a formal conduit forinterdisciplinary multi-modality collaborations.

Thesaurus Terms: human therapy evaluation, magnetic res-onance imaging, neoplasm/cancer chemotherapy, positronemission tomography, prognosis bioimaging/biomedical im-aging, clinical research, human subject

Institution: Washington UniversityLindell And Skinker BlvdSt. Louis, MO 63130

Fiscal Year: 2002Department: RadiologyProject Start: 31-May-2002Project End: 31-Mar-2007ICD: National Cancer InstituteIRG: ZCA1

BREAST CANCER TREND ANALYSISUSING STOCHASTIC SIMULATION

Grant Number: 5U01CA088248-03PI Name: Plevritis, Sylvia K.

Abstract: The goals of this NCI cooperative research pro-gram (CISNET) are to explain the US breast cancer inci-dence and mortality trends, and to predict changes in thetrends with new interventions. We will collaboratively withCISNET investigators toward developing validated com-puter-based simulation analyses that will attain these goals.In addition, we will contribute to CISNET novel researchideas and validated methods to quantify the impact of bio-logical factors on breast cancer trends. The specific aims ofthis research effort will be: (1) to develop a stochastic modelof the natural history of breast cancer that describes thegrowth rate of the primary tumor, the size of the primarytumor when it sheds its first metastatic cell, and the growthrate of metastases; (2) to simulate the progression of breastcancer in the US population using a natural history model ofbreast cancer; (3) to explain and predict US breast cancertrends with validated computer simulation tools that incorpo-rate a natural history model of the disease. Awareness ofbiological factors on the breast cancer trends may providenew insights for more effectively targeting future breast can-cer control programs.

Thesaurus Terms: breast neoplasm, mathematical model,model design/development, neoplasm/cancer epidemiology,

ABSTRACTS OF NIH GRANTS Academic Radiology, Vol 11, No 1, January 2004

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neoplastic growth, women’s health breast neoplasm/cancerdiagnosis, computer simulation, cooperative study, healthcare model, neoplasm/cancer diagnosis, tumor progressionclinical research, human data

Institution: Stanford UniversityStanford, CA 94305

Fiscal Year: 2002Department: RadiologyProject Start: 01-Sep-2000Project End: 31-Aug-2004ICD: National Cancer InstituteIRG: ZCA1

INTERDISCIPLINARY SMALL ANIMALIMAGING FOR ONCOLOGY

Grant Number: 5R24CA092871-02PI Name: Pomper, Martin G.

Abstract: The goal of this application is to expand our inter-disciplinary small animal imaging program to include com-plementary imaging capabilities that will increase our under-standing of cancer. MR-based functional and metabolic im-aging is the backbone of our current effort, which has beenformalized into the Johns Hopkins pre-ICMIC. We now in-tend to balance that effort with a program that incorporates astrong nuclear imaging component. We intend to obtain adedicated small animal PET device and undertake the devel-opment of a biplane x-ray/gamma scintigraphy system thatwill enable us to study a wider array of physiologic pro-cesses. We are also initiating a collaboration to enhance ouroptical imaging potential. We intend to focus on three broadareas relevant to the diagnosis and treatment of cancer: newtechnology development, including drug development, in-depth analysis of the tumor microenvironment, and quantifi-cation of gene expression, primarily in cells and tissues ex-pressing the malignant phenotype. We will pursue these aimsby coordinating efforts in 3 core resource facilities: (I) tech-nology development, (II) molecular biology and (III) chemis-try, all of which will support the central imaging core. Aquantitative subcore will also support the imaging core.Among the 12 base grants are one center grant (the pre-IC-MIC) and 3 program project grants, all of which addressimportant questions in cancer biology and/or therapy andwill be greatly enhanced by an imaging component. Thecombined expertise of Johns Hopkins University (JHU), theUniversity of Virginia and the NIH will create an SAIRPwith strong molecular imaging capabilities accessible to re-searchers in the Mid-Atlantic region.

Thesaurus Terms: Animalia, imaging/visualization/scanninginterdisciplinary collaboration, technology/technique develop-ment bioimaging/biomedical imaging

Institution: Johns Hopkins University3400 N Charles StBaltimore, MD 21218

Fiscal Year: 2002Department: RadiologyProject Start: 27-Aug-2001Project End: 31-Dec-2006ICD: National Cancer InstituteIRG: ZCA1

MULTIDISCIPLINARY RESEARCHTRAINING IN CANCER IMAGING

Grant Number: 5R25CA092043-02PI Name: Price, Ronald R.

Abstract: Description (provided by applicant): This applica-tion proposes to establish a unique training program in can-cer imaging research. The program is designed to train bothmedical post-doctoral candidates with extensive experiencein medical imaging, oncology or cancer biology, and basic-science post-doctoral candidates with extensive experience inimaging technology or cancer biology who desire to becomeindependent investigators. Trainees will utilize the wide vari-ety of imaging resources available through the Departmentsof Radiology at Vanderbilt University Medical Center andMeharry Medical College, The Vanderbilt In-Vive ImagingCenter and The Vanderbilt/Keck Free Electron Laser Facil-ity. Individual trainee research projects will be integratedwith ongoing projects in the cancer laboratories of theVanderbilt/Meharry Alliance with special emphasis on theprojects of The Vanderbilt-lngram Cancer Center and theConsortium for Mouse Models of Human Cancer. Eachtrainee will be assigned two or more mentors representingboth the imaging sciences and cancer biology disciplines.The specialized curriculum provided by this training programwill establish two new courses, a new cancer imaging semi-nar and a new cancer imaging Journal club. The curriculumis also supplemented through existing courses offered by thecooperating departments: Biomedical Engineering, ElectricalEngineering/Computer Sciences, Cell/Cancer Biology, Math-ematics, Physics, Biochemistry and Clinical Investigation.The program leadership will consist of three co-directorsreflecting the multidisciplinary nature of the training pro-gram. Ronald R. Price, Ph.D. will coordinate the specializedcurriculum components specific to training in the imagingsciences. Lynn Matrisian, Ph.D. will coordinate the curricu-lum components specific to training in the biological sci-ences. Charles DePriest, M.D. will direct minority recruit-ment and will coordinate training components specific to

Academic Radiology, Vol 11, No 1, January 2004 ABSTRACTS OF NIH GRANTS

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