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Brookhaven National Brookhaven National LaboratoryLaboratory

VenturesVenturesRobert L. McGrathRobert L. McGrathProvost & Executive Vice Provost & Executive Vice President President for Academic Affairsfor Academic AffairsVice President for Brookhaven Vice President for Brookhaven AffairsAffairsStony Brook UniversityStony Brook University

December 14, 2004

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Some history…Some history…1947 Brookhaven National Laboratory founded

by AUI.1957 Stony Brook (L.I. College) founded by SUNY

with 14 faculty,3 staff, 148 students.1997 U.S. Dept of Energy decides to re-compete

BNL M&O contract. RFP > university-corporate partnering.

1997 Brookhaven Science Associates (BSA) wins five year performance-based contract, complete with “off ramp” provisions.

1998 BSA era begins with J. Marburger president/director.

2000 “Off ramp” review is “excellent to outstanding, as are annual review grades.

2004 BNL receives L.I. Pine Barrens Award for Outstanding Contribution to L.I.’s Environment

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Brookhaven Science Brookhaven Science AssociatesAssociates

LLC partnership of Battelle Science and Technology International and the Research Foundation of SUNY on behalf of Stony Brook.

BSA Board membership 5+5+6 Core universities: Columbia, Cornell,

Harvard, MIT, Princeton, Yale. New model for M&O contractors? UT-

Battelle, others? Benefits to SBU,BNL, and DOE Hope for more benefits via SUNY and NYS

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National Science LabsNational Science Labs Argonne National Lab (U Chicago) Brookhaven National Lab (BSA) Lawrence Berkeley National Lab (U

California) Oak Ridge National Lab (Tennessee-Battelle) Pacific Northwest National Lab (Battelle) Ames Lab (Iowa State) Fermilab (URA) Princeton Plasma Physics Lab (Princeton) Stanford Linear Accelerator Center (Stanford) Thomas Jefferson National Accelerator Facility (SURA) Lawrence Livermore National Lab ( U California) Los Alamos National Lab ( U California)

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Some Major BNL-Stony Brook Some Major BNL-Stony Brook ConnectionsConnections

Joint appointments and major links…Arts &Sciences Engineering& App. Sci Health SciencesBiochemistry Applied Mathematics Anesthesiology Chemistry Biomedical Engineering MicrobiologyGeosciences Computer Science NeurologyEcology Materials Science PharmacologyNeurobiology PediatricsPhilosophyMarine Sciences PsychiatryPhysics RadiologyPsychology

Senior SB appointments… John Marburger, Director Peter Paul, Deputy Director for Science, Interim Director Helene Benveniste, Acting Assoc Director Life Sciences, Chair of Medicine James Glimm, Center for Data Intensive Computing

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NewNew BNL-Stony Brook BNL-Stony Brook ConnectionsConnections

Center for Data Intensive Computing. New Joint faculty appointments:

• Nanoscience, Materials Science, Structural Biology, Medicine (systems neuroscience)

BNL-SBU seed grant program. SBU leads in establishing satellite NIH

General Clinical Research Center at BNL. SBU-BNL win NSF Center for Environmental

Molecular Science. SBU-BNL work to secure major NSF support

for high energy physics program at BNL.

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PHENIX PHENIX Detector at Detector at RHICRHIC

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PHENIX PHENIX DetectorDetector

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Stony Brook at Stony Brook at PHENIXPHENIX•Six faculty with senior management roles•SBU staff/facilities for design construction•15 Ph.D students, 30 undergraduatesRing Imaging Cherenkov (RICH) Detector contains 2560 PMTs with light funnel. Arrays built by Stony Brook UG’s.

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PHENIX PHENIX Track Track ReconstructionReconstruction

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Chemistry

Geosciences

Materials Science

Physics

Marine Science

Environmental ScienceNational Synchrotron

Light Source

Stony Brook UniversityStony Brook UniversityBrookhaven National LabBrookhaven National Lab

Multidisciplinary collaborations provide new insights and greater access to technological capabilities

Temple U. - Chemistry

Penn State U.- Geochemistry

5 year funding: NSF $5.7M, DOE $2.3M

CEMS: Center for Environmental CEMS: Center for Environmental Molecular ScienceMolecular Science

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• Arsenic is actively taken up as As(V) by several types of hyper-accumulating plants

• As(V) is rapidly reduced to As(III), which is less toxic to the plant.

• Upon plant death, As(V) is re-oxidized to As(III)• Effective for immobilization of As, but requires

harvesting of the plant for remediation of As-impacted soils

Expe

rimen

tsEx

perim

ents

pe

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Uptake and transformation of arsenic in plant-soil Uptake and transformation of arsenic in plant-soil systems: implications for toxicity, bioavailability, and systems: implications for toxicity, bioavailability, and

remediationremediationMarianna Kissell1,3, Richard J. Reeder1,3, and Mark Fuhrmann2,3

1Department of Geosciences, Stony Brook University2Dept. of Environmental Sciences, Brookhaven National Lab 3Center for Environmental Molecular Science

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Colloidal Transport of Nuclear Waste:X-ray Colloidal Transport of Nuclear Waste:X-ray Spectromicroscopy StudiesSpectromicroscopy Studies

Clusters 22, 5: pure hematiteClusters 3, 4: two different types of incorporation

of Lu in hematite

M. Lerotic, C. Jacobsen, and S. Wirick, CEMS/Stony Brook PhysicsT. Schäfer et al., Institute for Nuclear Waste Research, Karlsruhe, Germany

•Lutetium used as a stand-in for the radioisotope Americium•Binding to hematite colloids: can lead to thousandfold increase of transport rate in ground water near leaking nuclear waste repositories!

•Environmental scientists: brought a problem of great interest to DoE•Physicists at Stony Brook: developed soft x-ray microscope, and pattern recognition techniques for handling the complexity of 40,000 spectra (at each 40 nm pixel)

•Approach revealed previously unrecognized phase of Lu incorporation•Ultramicroscopy 100, 35 (2004)

Oxygen near-absorption-edge spectra show occupancy of different molecular orbitals

Image at one energy

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Soft x-ray Soft x-ray microscopymicroscopy

• Support: NIH, NSF, NASA• Physics postdocs, graduate

students: technical developments

• Collaborative science: international users in biology, environmental science, astrobiology…

Stony Brook soft x-ray scanning microscope

• Fresnel zone plate optics: focusing by diffraction

• Resolution: ~finest feature width (30 nm at present)

• Nanostructuring using electron beam lithography

• Present optics work: Stony Brook and Brookhaven at Bell Labs

• Future efforts: Stony Brook co-director of new nanofabrication lab to be built in Brookhaven’s Center for Functional Nanomaterials

These zones: 40 nm wide (~180 atoms across), 140 nm tall, in nickel

Fibroblast labeled for tubulin

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Soft X-Ray ImagingSoft X-Ray Imaging

NIL 8 fibroblast (wet, fixed): Oehler et al.

Human sperm (unfixed): Fleckenstein et al.

Fibroblast, immunogold labeling (tubulin): Ultramicroscopy 62, 191 (1996)

Fibroblast (frozen hydrated): Maser et al., J. Micros. 197, 68 (2000)

• Original development: Stony Brook, NSLS. Since 1990: Stony Brook at NSLS X1A

• Optics since 1991: Stony Brook, Bell Labs. Future optics: Stony Brook, BNL’s CFN

• Support: NIH, NSF, NASA

• Physics graduate students: technical developments

• Collaborative science: international users in biology, environmental science, astrobiology…

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HSC – BNL Interactions: GCRCHSC – BNL Interactions: GCRC

BNL MRI Program

BNL PETProgram

BNLClinical

ResearchCenter

BNL CRC = GCRC Satellite

NIH-NCRR-funded

SBU: M. Gelato, MD, PhD, Director, GCRC OperationsSBU: P. Glass, MD (Chair, GCRC Advisory Committee)BNL: H. Benveniste, MD, PhD (Associate Director GCRC)

GJ Wang, MDJ. Fowler

P. Coyle, MD (SUNY-SB)GJ Wang, MDH. Benveniste, MD

BNL Q/A Physician:A. Baumann, MD

GCRC RSA:T. Dedournas, RN

Neuro-Psychology

R. Goldstein, PhD

Compliance

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Smokers have 35-45% reduced MAO B in brain, heart, lungs, kidneys and spleen

Does reduced MAO B account for some of the medical effects of smoking and can MAO B inhibitors be used in smoking cessation?

N

11CH3

H H

N

11CH3

D D

Quantification of MAO B Activity in the Quantification of MAO B Activity in the Human BodyHuman Body

Fowler et al., 2003

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Brookhaven Center for Translational NeuroimagingBrookhaven Center for Translational Neuroimaging

ChemistryMedicinePhysicsNeuroscienceInstrumentation

Radiotracer Chemistry

ImagingPhysics

Preclinical &Clinical

Neuroscience

SynthesisAutoradiographyMechanismsKinetic Models

Awake AnimalPET/microPETMRI/microMRIOptical ImagingmicroCT

CRCAnimal ModelsMicrodialysisNeuroanatomyAnesthesiaBehavior

HealthyBrain

Mother Fetus

kMF

kFMkML kFL

Drug Mother Fetus

kMF

kFMkML kFL

Drug LSOslab

APDslab

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050100

Time

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Training the Next Generation of Training the Next Generation of Imaging ScientistsImaging Scientists

Graduate Students (13)* Undergraduates (6)Post-doctoral Fellows (9)Residents (3)*

Partnerships with SBU:

*In SBU DepartmentsChemistry

Biomedical EngineeringNeurobiology and Behavior Anesthesiology

PsychologyPharmacology

Neurology