BSE: update on BSE: update on surveillancesurveillance

FDA TSE Advisory CommitteeFDA TSE Advisory CommitteeBethesda, MDBethesda, MD

October 31, 2005October 31, 2005

Lisa A. Ferguson, DVMLisa A. Ferguson, DVMSenior Staff VeterinarianSenior Staff Veterinarian

USDA, APHIS, Veterinary Services USDA, APHIS, Veterinary Services

Total BSE cases Total BSE cases worldwideworldwide

Cumulative total – greater than 189,000 Cumulative total – greater than 189,000 casescases

Greater than 96% in United KingdomGreater than 96% in United Kingdom Greater than 89% occurred in 1996 and Greater than 89% occurred in 1996 and

beforebefore

OIE website lists current reported OIE website lists current reported totals:totals:

www.oie.intwww.oie.int

EU monitoring - 2004EU monitoring - 2004

EU-15 now EU-25EU-15 now EU-25 Total of 11,049,822 bovine testsTotal of 11,049,822 bovine tests

1.5 million risk animals, 9.5 million 1.5 million risk animals, 9.5 million healthy slaughterhealthy slaughter

865 positive (699 in risk/suspect, 166 865 positive (699 in risk/suspect, 166 healthy sltr)healthy sltr)

Number of cases decreased by 37%Number of cases decreased by 37% Overall prevalence in tested animals Overall prevalence in tested animals

decreased by 38%decreased by 38%

EU monitoring - 2004EU monitoring - 2004 Reductions and increasing age of positive Reductions and increasing age of positive

cases indicate success of control cases indicate success of control measuresmeasures

Analysis by year of birth of positive Analysis by year of birth of positive animalsanimals Peak of exposure appears well defined in Peak of exposure appears well defined in

some Member Statessome Member States France, Ireland – 1995France, Ireland – 1995 Germany, Belgium, Italy, Netherlands – 1996Germany, Belgium, Italy, Netherlands – 1996

TSE monitoring in small ruminantsTSE monitoring in small ruminants 1 goat positive for BSE (slaughtered in 2002)1 goat positive for BSE (slaughtered in 2002)

US - Enhanced BSE US - Enhanced BSE SurveillanceSurveillance

GOAL: GOAL:

Obtain as many samples as Obtain as many samples as possible from the targeted possible from the targeted high-risk population in a high-risk population in a 12-18 month period12-18 month period

BSE Surveillance PlanBSE Surveillance Plan

Targeting population where disease is Targeting population where disease is most likely to be diagnosed – most most likely to be diagnosed – most efficientefficient

Assumption if we cannot find disease in Assumption if we cannot find disease in targeted – or most likely – population, targeted – or most likely – population, even more unlikely to be found in non-even more unlikely to be found in non-targeted populationtargeted population

Use data obtained to extrapolate Use data obtained to extrapolate information about broader cattle information about broader cattle populationpopulation

BSE – Targeted BSE – Targeted SurveillanceSurveillance

Non-ambulatory animals Dead stock Field CNS Cases and on-farm

suspects Veterinary Diagnostic Laboratory

data Public health laboratories Ante-mortem condemns at

slaughter

Surveillance: NVSL Bovine Brain Surveillance: NVSL Bovine Brain Submissions FY 93-04 Submissions FY 93-04

(through 5/31/04)(through 5/31/04)

018952309

0

446448702759

14951

19777

3090

16560

20277

6331

9392

17121

0

5000

10000

15000

20000

25000

2000 2001 2002 2003 2004

Dead

Downer

Total

Enhanced BSE Enhanced BSE SurveillanceSurveillance

Total – ELISA and IHC tests conducted Total – ELISA and IHC tests conducted since June 1, 2004 – through October 23, since June 1, 2004 – through October 23, 20052005

1 positive – June 2005, Texas, 12-year old 1 positive – June 2005, Texas, 12-year old Brahma-cross (Brahma-cross (Bos indicusBos indicus) cow) cow

512,698512,698(503,391 ELISA and 4,907 IHC)(503,391 ELISA and 4,907 IHC)

Enhanced BSE Enhanced BSE SurveillanceSurveillance

Evaluating for appropriate geographic Evaluating for appropriate geographic distribution; populations as expecteddistribution; populations as expected

Vast majority of samples from Vast majority of samples from deadstock, non-ambulatory animals – deadstock, non-ambulatory animals – as expectedas expected

Good representation from all collection Good representation from all collection sites, with majority from animal sites, with majority from animal disposal facilities as expecteddisposal facilities as expected

Detailed analysis at completionDetailed analysis at completion

www.aphis.usda.gov