building magnetic nanostructures from magnetic fluids
TRANSCRIPT
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
Building magnetic nanostructures from magnetic fluids
Paulo C. [email protected]
Professor of PhysicsUniversity of Brasília - Brazil
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
Outline
The magnetic nanoparticle synthesisNanoparticle surface coatingSuperparamagnetismComplex nanoparticulated magnetic systemsEx situ versus in situ template loading & applicationsClosing remarks
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
1nm < d < 20nmmetallic ions Fe3+,
Co2+, Ni2+, …cubic ferrite nanoparticle
hydrophobic hydrophilic
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
<18% v.v.
shell
ionic
surfacted
biocompatible
Magnetic fluid
mm
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
Key Words
① Superparamagnetism❶ Magnetic manipulation
② Surface Aspects❷ Hydrophobicity × Hydrophilicity
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
m
KV mH
)( 2HVFo
∇=rr
µχ
Superparamagnetism)(@ etemperaturblockingTT B>
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
TM 42, 3596 (2006)
JNN 6, 2413 (2006)
JMMM 272, 2402 (2004)
INPI-001639
Fe2+ concentration
PI-0300855-0
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
Ex situ versus in situtemplate loading &
applications
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
In situ Species diffusion
Fe2+
Fe2+
NaOH ( )C
Fe(OH)2
mesoporoustemplate
oxidation
nanocomposite
cycling ( )N
(200 µm )
Fe2+ concentration
Styrene-Divinylbenzene
NL 1, 105 (2001)
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
0 10 20 30 40 50 600
5
10
15
20
25
30 N=1 N=2 N=3 N=4 N=5 N=6
M (m
g/g)
C (mmol/L)
∆M = (∂M/∂C)∆C + (∂M/∂N)∆N
M(C,N) = A[1-exp(-αC)][1-exp(-βN)]
CM 15, 2485 (2003)
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
Ex situ Nanoparticle diffusionVermiculiteMg3(Al,Si)4O10(OH)2.4H2O is an expanding clay
material with:① Mg2+ cation in the interlayer region to balance the
layer charge;② Mg2+ cation strongly hydrated separating adjacent
layers producing a shrinking and swelling clay;③ Mg2+ cation that can be exchanged with other
cation when water gets into the interlayer;④ Asbestos free availability.
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
Saccharomyces
JMMM 272, 2400 (2004)
JNN 7, 1069 (2007)
Erythrocytes
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HumanMelanoma
Cells
Control cell
Citrate-maghemite
DMSA-maghemite
Laurate-maghemite
n
n
n
JNN (in press)
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
Magnetoliposome
FS
FS
FS
FS
Liposome
LTC-liposome
Lipidic structure
PEG-Derivative
FS
FS
FSMagnetoliposome
JAP 97, 10Q906 (2005)
SKIN CANCER
THERAPY (PDT+MHT)
HRAN - Brasilia
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
UFU
UFRJ
USP, UNIFESP
UFG
UnB, EMBRAPA
HRAN, DNATech
FINATEC
FKBiotec
UFMS
Brazilian Nanobiomagnetism Network
Network Team
40 Professors (7 Full & 33 Associate + Assistant)
160 Students (Pos-Docs, Graduate & Undergraduate)
IPPTIPPT--PAS Warsaw 13.02.2008PAS Warsaw 13.02.2008
Brazilian NanobiomagnetismNetwork Achievements
1945-1998
1999-2008
1945-2008