章成果リスト第5章成果リスト ‐1 論文 - jst第5章成果リスト第5章...

第５章成果リスト


５‐１論文

[2003] 1. Small Maf compound mutants display CNS neuronal degeneration, aberrant transcription and Bach

protein mislocalization coincident with myoclonus and abnormal startle response. Katsuoka, F.,

Motohashi, H., Tamagawa, Y., Kure, S., Igarashi, K., Engel, J.D. and Yamamoto, M. Mol. Cell.

Biol. 23, 1163-1174 (2003)

2. Hemogenic and non-hemogenic endothelium can be distinguished by the activity of fetal liver kinase

(Flk)-1 promoter/enhancer during mouse embryogenesis. Hirai, H., Ogawa, M., Suzuki, N.,

Yamamoto, M., Breier, G., Mazda, O., Imanishi, J. and Nishikawa, S.I. Blood 101, 886-893 (2003)

3. Aberrant iron accumulation and oxidized status of erythroid-specific d-aminolevulinate synthase

(ALAS2)-deficient definitive erythroblasts. Harigae, H., Nakajima, O., Suwabe, N., Yokoyama, H.,

Furuyama, K., Sasaki, T., Kaku, M., Yamamoto, M. and Sassa, S. Blood 101, 1188-1193 (2003)

4. Functional analysis of basic transcription element binding protein (BTEB) by gene targeting

technology. Morita, M., Kobayashi, A., Yamashita, T., Shimanuki, T., Nakajima, O., Takahashi, S.,

Ikegami, S., Inokuchi, K., Yamashita, K., Yamamoto, M.. and Fujii-Kuriyama, Y. Mol. Cell. Biol.

23, 2489-2500 (2003)

5. Influence of nrf2 genotype on modulation by oltipraz of benzo[a]pyrene-DNA adducts and tumor

yield in mice. Ramos-Gomez, M., Dolan, P.M., Itoh, K., Yamamoto, M. and Kensler, T.W.

Carcinogenesis 24, 461-467 (2003)

6. Modulation of keap1 and nrf2 – dependent gene expression by cancer chemopreventive

dithiolethiones: IDENTIFICATION OF NOVEL GENE CLUSTERS. Kwak, M.K., Wakabayashi, N.,

Itoh, K., Motohashi, H., Yamamoto, M. and Kensler, T.W. J. Biol. Chem. 278, 8135-8145 (2003)

7. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to

electrophiles. Itoh, K., Wakabayashi, W., Katoh, Y., Ishii, T., O’Connor, T. and Yamamoto, M.

Genes Cells 8, 379-391 (2003; cover)

8. HLF (HIF-2a) is a key factor for pathological angiogenesis in proliferative retinopathy. Morita, M.,

Ohneda, O., Yamashita, T., Takahashi, S., Nakajima, O., Kawauchi, S., Ema, M., Shibahara, S.,

Udono, T., Tomita, K., Tamai, M., Sogawa, K., Yamamoto, M. and Fujii-Kuriyama, Y. EMBO J.

22, 1134-1146 (2003)

9. EPR imaging and analysis of reducing activity in oxidative stress-related Nrf2 transcription factor

deficient mice. Hirayama, A., Yoh, K., Nagase, S., Ueda, A., Itoh, K., Morito, N., Hirayama, K.,

Takahashi, S., Yamamoto, M. and Koyama, A. Free Rad. Biol. Med. 34, 1236-1242 (2003)

10. Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not

stimulation of GATA-2. Obara, N., Imagawa, S., Nakano, Y., Suzuki, N., Yamamoto, M. and


Nagasawa, T. Arch. Toxicol. 77, 267-273 (2003)

11. Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse. Noda, S.,

Harada, N., Hida, A., Fujii-Kuriyama, Y., Motohashi, H. and Yamamoto, M. Biochem. Biophys.

Res. Commun. 303, 105-111 (2003)

12. Distinct specificity of xenobiotic response in AhR-humanized model mouse. Moriguchi, T.,

Motohashi, H., Hosoya, T., Nakajima, O., Takahashi, S., Ohsako, S., Aoki, Y., Nishimura, T.,

Tohyama, C., Fujii-Kuriyama, Y., and Yamamoto, M. Proc. Natl. Acad. Sci. USA 100, 5652-5657

(2003)

13. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative

regulation of ARE-driven gene expression. McMahon, M., Itoh, K., Yamamoto, M. and Hayes,

J.D. J. Biol. Chem. 278, 21592-21600 (2003)

14. Regulation of YB-1 gene expression by GATA transcription factors. Yokoyama, H., Harigae, H.,

Takahashi, S-I., Takahashi, S., Furuyama, K., Kaku, M., Yamamoto, M. and Sasaki, T. Biochem.

Biophys. Res. Commun. 303, 140-145 (2003)

15. Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic

precursor cells in midgestation mouse embryos. Minegishi, N., Suzuki, N., Yokomizo, T.,

Xiaoqing, P., Fujimoto, T., Takahashi, S., Hara, T., Nishikawa, S-i. and Yamamoto, M. Blood

102, 896-905 (2003)

16. GATA-1 testis activation region is essential for Sertoli cell-specific expression of GATA-1 gene in

transgenic mouse. Wakabayashi, J., Yomogida, K., Nakajima, O., Yoh, K., Takahashi, S., Engel,

J.D., Ohneda, K. and Yamamoto, M. Genes Cells 8, 619-630 (2003; cover)

17. Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts. Aono, J.,

Yanagawa, T., Itoh, K., Li, B., Yoshida, H., Kumagai, Y., Yamamoto, M. and Ishii, T. Biochem.

Biophys. Res. Commun. 305, 271-277 (2003)

18. Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse

NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. Nioi, P.,

McMahon, M., Itoh, K., Yamamoto, M. and Hayes, J. Biochem. J. 374, 337-348 (2003)

19. A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral

exposure to arsenate in rabbits. Pi, J., Horikuchi, S., Sun, Y., Nikaido, M., Hayashi, T., Yamauchi,

H., Itoh, K., Yamamoto, M., Sun, G., Waalkes, M.P., Shimojo, N. and Kumagai, Y. Free Rad.

Biol. Med. 35, 102-113 (2003)

20. Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down’s

syndrome. Xu, G., Nagano, M., Kanezaki, R., Toki, T., Hayashi, Y., Taketani, T., Taki, T., Mitui,

T., Koike, K., Kato, K., Imaizumi, M., Sekine, I., Ikeda, Y., Hanada, R., Sako, M., Kudo, K.,

Kojima, S., Ohneda, O., Yamamoto, M. and Ito, E. Blood 102, 2960-2968 (2003)

21. Transgenic overexpression of GATA-3 in T-lymphocytes improves autoimmune glomerulonephritis


in mice with BXSB/MpJ-Yaa genetic background. Yoh, K., Shibuya, K., Morito, N., Nakano, T.,

Ishizaki, K., Shimohata, H., Nose, M., Izui, S., Shibuya, A., Koyama, A., Engel, J.D., Yamamoto,

M. and Takahashi, S. J. Am. Soc. Nephrol. 14, 2494-2502 (2003)

22. Identification and characterization of two types of erythroid progenitors that express GATA-1 at

distinct levels. Suzuki, N., Suwabe, N., Ohneda, O., Obara, N., Imagawa, S., Pan, X., Motohashi,

H. and Yamamoto, M. Blood 102, 3575-3583 (2003)

23. Self-association of Gata1 enhances transcriptional activity in vivo in zebrafish embryos.

Nishikawa, K., Kobayashi, M., Masumi, A., Lyons, S. E. Weinstein, B. M. Paul Liu, P. and

Yamamoto, M. Mol. Cell. Biol. 23, 8295-8305 (2003)

24. 186. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1b, TNF-a or L-NMMA.

Imagawa, S., Nakano, Y., Obara, N., Suzuki, N., Doi, T., Kodama, T., Nagasawa, T. and

Yamamoto, M. FASEB J. 17, 1742-1744 (2003)

25. Nrf2 regulates the sensitivity of death receptor signals through intra-cellular glutathione levels.

Morito, N., Yoh, K., Itoh, K., Hirayama, A., Koyama, A., Yamamoto, M. and Takahashi, S.

Oncogene 18, 9275-9281 (2003)

26. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Wakabayashi,

N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., Kotsuji, T.,

Otsuka, F., Roop, D.R., Harada, T., Engel, J.D. and Yamamoto, M. Nature Genetics 35, 238-245

(2003)

27. Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug

resistance-associated protein1 (Mrp1/Abcc1) in mouse embryo fibroblasts. Hayashi, A., Suzuki,

H., Itoh, K., Yamamoto, M. and Sugiyama, Y. Biochem. Biophys. Res. Commun. 310, 824-829

(2003)

28. Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3

subunit is regulated by the Nrf2 transcription factor through an antioxidant response element.

Jowsey, I.R., Jiang, Q., Itoh, K., Yamamoto, M. and Hayes, J.D. Mol. Pharmacol. 64,

1018-1028 (2003)

29. Hematological aspects of a novel 9-aminoanthracycline, amrubicin. Obara, N., Imagawa, S.,

Nakano, Y., Yamamoto, M, Noguchi, T., and Nagasawa, T. Cancer Sci. 94, 1104-1106 (2003)

30. Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling

pathway. Kwak, M.K., Wakabayashi, N., Greenlaw, J.L., Yamamoto, M. and Kensler, T.W.

Mol. Cell. Biol. 23, 8786-8794 (2003)

31. Autocrine steroid hormone action in megakaryocytes triggers proplatelet formation. Nagata, Y.,

Yoshikawa, J., Hashimoto, A., Yamamoto, M., Payne, A. H. and Todokoro, K. Genes Dev. 17,

2864-2869 (2003)

32. Transgenic rescue of GATA-1-deficient mice with GATA-1 lacking a FOG-1 association site


phenocopies patients with X-linked thrombocytopenia. Shimizu, R., Ohneda, K., Engel, J.D.,

Trainor, C.D. and Yamamoto, M. Blood 103, 2560-2567 (2003)

[2004] 33. Transcription factor Nrf2 regulates inflammation by mediating the effect of

15-deoxy-D12,14-prostaglandin J2. Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T.,

Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K. and Yamamoto, M. Mol. Cell. Biol. 24,

36-45 (2004)

34. Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic

mechanisms for the vertebrate head specification. Kimura-Yoshida, C., Kitajima, K., Oda-Ishii, I.,

Tian, E, Suzuki, M., Yamamoto, M., Suzuki, T., Kobayashi, M., Aizawa, S. and Matsuo, I.

Development 131, 57-71 (2004)

35. Evaluation of MafG interaction with Maf recognition element arrays by surface plasmon resonance

imaging technique. Kyo, M., Yamamoto, T., Motohashi, H., Kamiya, T., Kuroita, T., Tanaka, T.,

Kawakami, B. and Yamamoto, M. Genes Cells 9, 153-164 (2004)

36. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of

cytoprotective phase 2 genes. Kang, M.I., Kobayashi, A., Wakabayashi, N., Kim, S.G. and

Yamamoto, M. Proc. Natl. Acad. Sci. USA, 101, 2046-2051(2004)

37. Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages:

activation by oxidatively modified LDL and 4-hydroxynonenal. Ishii, T., Itoh, K., Ruiz, E., Leake,

D.S., Unoki, H., Yamamoto, M. and Mann, G.E. Circulation Res., 94, 609-616 (2004)

38. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of

cysteines of the Keap1 sensor modified by inducers. Wakabayashi N, Dinkova-Kostova AT,

Holtzclaw WD, Kang M-I, Kobayashi A, Yamamoto, M, Kensler TW, Talalay P. Proc Natl Acad

Sci U S A. 101, 2040-2045 (2004)

39. Interleukin-6 and tumor necrosis factor-alpha in patients with obstructive sleep apnea-hypopnea

syndrome. Imagawa, S., Yamaguchi, Y., Ogawa, K., Obara, N., Suzuki, N., Yamamoto, M. and

Nagasawa, T. Respiration 71, 24-29 (2004)

40. A constitutively active arylhydrocarbon receptor induces growth inhibition of Jurkat T cells through

changes in the expression of genes related to apoptosis and cell cycle arrest. Ito, T., Tsukumo, S.,

Suzuki, N., Motohashi, H., Yamamoto, M., Fujii-Kuriyama, Y., Mimura, J., Tien-Min, Lin.,

Richard, E.P., Tohyama, C. and Nohara, K. J. Biol. Chem. 279, 25204-25210 (2004)

41. Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the

Keap1-Nrf2 regulatory pathway. Motohashi, H., Katsuoka, F., Engel, J.D., and Yamamoto, M. Proc

Natl Acad Sci U S A. 101, 6379-6384 (2004)

42. In vivo and in vitro constant expression of GATA-4 in mouse postnatal Sertoli cells. Imai, T., Kawai,


Y., Tadokoro, Y., Yamamoto, M., Nishimune, Y. and Yomogida, K. Mol Cell Endocrinol. 214,

107-115 (2004)

43. Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr. Morito, N., Yoh, K.,

Hirayama, A., Itoh, K., Nose, M., Koyama, A., and Yamamoto, M. and Takahashi, S. Kidney Int.

65, 1703-1713 (2004)

44. Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Yoshida, S.,

Takakura, A., Ohbo, K., Abe, K., Wakabayashi, J., Yamamoto, M., Suda, T., and Nabeshima Y.

Dev Biol. 269, 447-458 (2004)

45. Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice. Goldring, C.E.P., Kitteringham,

N.R., Elsby, R., Randle, L.E., Clement, Y.N., Williams, D.P., McMahon, M., Hayes, J.D., Itoh, K.,

Yamamoto, M. and Park, B.K. Hepatology 39, 1267-1276 (2004)

46. Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox

sensitive Neh2 degron and the redox-insensitive Neh6 degron. McMahon, M., Thomas, N., Itoh,

K., Yamamoto, M. and Hayes, J.D. J. Biol. Chem. 279, 31556-31567 (2004)

47. The transcriptional program of antibody class switching involves the repressor Bach2. Muto, A.,

Tashiro, S., Nakajima, O., Hoshino, H., Takahashi, S., Sakoda, E., Ikebe, D., Yamamoto, M. and

Igarashi, K. Nature 429, 566-571 (2004) (Paper Selected for Advanced Online Publication;

E-pub May 21, 2004)

48. The transcription factor Nrf2 protects against pulmonary fibrosis. Cho, H-Y., Reddy, S.P.M.,

Yamamoto, M. and Kleeberger, S.R. FASEB J. 18, 1258-1260 (2004)

49. MafT, a new member of the small Maf protein family in zebrafish. Takagi, Y., Kobayashi, M., Li,

L., Suzuki, T., Nishikawa, K., and Yamamoto, M. Biochem. Biophys. Res. Commun. 320, 62-69

(2004)

50. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate

proteasomal degradation of Nrf2. Kobayashi, A., Kang, M.I., Ohkawa, H., Ohtuji, M., Zenke, Y.,

Chiba, T., Igarashi, K. and Yamamoto, M. Mol. Cell. Biol. 24, 7310-7319 (2004)

51. Identification of polymorphisms in the promoter region of human NRF2 gene. Yamamoto, T.,

Yoh, K., Kobayashi, K., Ishii, Y., Kure, S., Koyama, A., Sekizawa, K., Motohashi, H., and

Yamamoto, M. Biochem. Biophys. Res. Commun. 321, 72-79 (2004)

52. Do b-globin, GATA-1 or EpoR regulatory domains specifically mark erythroid progenitors in

transgenic reporter mice? Suzuki, N., Imagawa, S., Noguchi C. T. and Yamamoto, M. Blood

104, 2968-2969 (2004)

53. Multiple, distant Gata2 enhancers specify temporal and tissue-specific patterning in the developing

urogenital system. Khandekar, M. J., Suzuki, N., Lewton, J., Yamamoto, M. and Engel, J. D.

Mol. Cell. Biol. 24, 10263-10276 (2004)

54. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder


carcinogenesis. Iida, K., Itoh, K., Kumagai, Y., Oyasu, R., Hattori, K., Kawai, K., Shimazui, T.,

Akaza, H., and Yamamoto, M. Cancer Res. 64, 6124-6431 (2004)

55. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.

Rangasamy, T., Cho, C.Y., Thimmulappa, R.K., Zhen, L., Srisuma, S.S., Kensler, T.W.,

Yamamoto, M., Petrache, I., Tuder, R.M., and Biswal, S. J. Clin. Invest. 114, 1248-1259 (2004)

56. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1b, TNF-a or L-NMMA.

Imagawa, S., Nakano, Y., Obara, N., Suzuki, N., Doi, T., Kodama, T., Nagasawa, T., and

Yamamoto, M. Blood 104, 4300-4307 (2004)

57. Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1,

glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.

McWalter, G.K., Higgins, L.G., McLellan, L.I., Henderson, C.J., Song, L., Thornalley, P.J. Itoh, K.,

Yamamoto, M. and Hayes, J.D. J. Nutr. 134, 3499S-3506S (2004)

58. Leukemogenesis caused by incapacitated GATA-1 function. Shimizu, R., Kuroha, T., Ohneda, O.,

Pan, X., Ohneda, K., Takahashi, S., Philipsen, S., and Yamamoto, M. Mol. Cell. Biol. 24,

10814–10825 (2004)

[2005] 59. Gene expression profiling of NRF2-mediated protection against oxidative injury. Cho, H-Y.,

Reddy, S.P., DeBiase, A., Yamamoto, M. and Kleeberger, S.R Free Rad. Biol. Med. 38, 325–

343 (2005)

60. Molecular determinants of NOTCH4 transcription in vascular endothelium. Wu, J., Iwata, F.,

Grass, J.A., Elnitski, L., Ohneda, O., Yamamoto, M., and Bresnick, E.H. Mol. Cell. Biol. 25,

1458-1474 (2005)

61. Transgenic overexpression of GATA-1 mutant lacking N-finger domain causes hemolytic

syndrome in mouse erythroid cells. Nakano, M., Ohneda, K., Mukai, H.Y. Shimizu, R., Ohneda,

O., Ohmura, S., Suzuki, M., Tsukamoto, S., Yanagawa, T., Yoshida, H., Takakuwa, Y. and

Yamamoto, M. Genes Cells 10, 47-62 (2005)

62. Transgenic expression of Bach1 transcription factor results in megakaryocytic impairment. Toki,

T., Katsuoka, F., Kanezaki, R., Xu, G., Kurotaki, H., Sun, J., Kamio, T., Watanabe, S., Tandai, S.,

Terui, K., Yagihashi, S., Komatsu, N., Igarashi, K., Yamamoto, M. and Ito, E. Blood 105,

3100-3108 (2005)

63. Nrf2 transcriptionally activates the mafG gene through an antioxidant response element.

Katsuoka, F., Motohashi, M., Engel, J.D. and Yamamoto, M. J. Biol. Chem. 280, 4483-4490

(2005)

64. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated

degradation of the protein by proteasome. Katoh, Y., Iida, K., Kang, M-I., Kobayashi, A.,


Mizukami, M., Tong, K.I., McMahon, M., Hayes, J.D., Itoh, K. and Yamamoto, M. Arch.

Biochem. Biophys. 433, 342-350 (2005)

65. Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif

region of mouse Keap1. Padmanabhan, B., Scharlock, M., Tong, K.I., Nakamura, Y., Kang, M-I.,

Kobayashi, A., Matsumoto, T., Tanaka, A., Yamamoto, M. and Yokoyama, S. Acta

Crystallographica (Section F, Structural Biology and Crystallization Communications) 61,

153-155 (2005)

66. Essential role of synoviolin in embryogenesis. Yagishita, N., Ohneda, K., Amano, T., Yamasaki,

S., Sugiura, A., Tsuchimochi, K., Shin, H., Kawahara, K., Ohneda, O., Ohta, T., Tanaka, S.,

Yamamoto, M, Maruyama, I., Nishioka, K., Fukamizu, A. and Nakajima, T. J. Biol. Chem. 280,

7909-7916 (2005)

67. Constitutively active-aryl hydrocarbon receptor expressed specifically in T-lineage cells causes

thymus involution and suppresses immunization-induced increase in splenocytes. Nohara, K., Pan,

X., Tsukumo, S., Hida, A., Ito, T., Nagai, H., Inouye, K., Motohashi, H., Yamamoto, M.,

Fujii-Kuriyama, Y. and Tohyama, C. J. Immunol. 174, 2770-2777 (2005)

68. Pi-class glutathione S-transferase genes are regulated by Nrf2 through an evolutionarily conserved

regulatory element in zebrafish. Suzuki, T., Takagi, Y., Osanai, H., Li, L., Takeuchi, M., Katoh,

Y., Kobayashi, M. and Yamamoto, M. Biochem. J. 388, 65-73 (2005)

69. UVA irradiation induces Nrf2 activation in dermal fibroblasts: Protective role in UVA-induced

apoptosis. Hirota, A., Kawachi, Y., Itoh, K., Nakamura, Y., Xu, X., Banno, T., Takahashi, T.,

Yamamoto, M. and Ohtsuka, F. Invest. Dermatol. 124, 825-835 (2005)

70. The distal sequence element of the selenocysteine tRNA gene is a tissue dependent enhancer

essential for mouse embryogenesis. Kelly, V.P., Suzuki, T., Nakajima, O., Arai, T., Tamai, Y.,

Takahashi, S., Nishimura, S. and Yamamoto, M. Mol. Cell. Biol. 25, 3658-3669 (2005)

71. GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell

line through the inhibition of STAT3 activity. Ezoe, S., Matsumura, I., Gale, K., Satoh, Y.,

Ishikawa, J., Mizuki, M., Takahashi, S., Minegishi, N., Nakajima, K., Yamamoto, M., Enver, T.

and Kanakura, Y. J. Biol. Chem. 280, 13163-13170 (2005)

72. Role of 15-deoxyD12-14 Prostaglandin J2 and Nrf2 Pathways in Protection against Acute Lung Injury.

Mochizuki, M., Ishii, Y., Itoh, K., Iizuka, T., Morishima, Y., Kimura, T., Kiwamoto, T., Matsuno,

Y., Hegab, A. E., Nomura, A., Sakamoto, T., Uchida, K., Yamamoto, M. and Sekizawa, K. Am.

J. Res. Cri. Care Med. 171, 1260-1266 (2005)

73. Increased dose of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2

mice. Yanagida, M., Osato, M., Yamashita, N., Liqun, H., Jacob, B., Wu, F., Cao, X., Nakamura,

T., Yokomizo, T., Takahashi, S., Yamamoto, M., Shigesada, K. and Ito, Y. Oncogene 24,

4477-4485 (2005)


74. Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway. Minegishi, N.,

Suzuki, N., Kawatani, Y., Shimizu R., and Yamamoto, M. Genes Cells 10, 693-704 (2005)

75. Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of

erythroid progenitors. Pan, X., Ohneda, O., Ohneda, K., Lindeboom, F., Iwata, F., Shimizu, R.,

Nagano, M., Suwabe, N., Philipsen, S., Lim, K.C., Engel, J.D. and Yamamoto, M. J Biol Chem.

280, 22385-22394 (2005)

76. Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in

endothelial cells. Hosoya, T., Maruyama, A., Kang, M.I., Kawatani, Y., Shibata, T., Uchida, K.,

Warabi, E., Noguchi, N., Itoh, K. and Yamamoto, M. J Biol Chem. 280, 27244-27250 (2005)

77. Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin

lesions. Tauchi, M., Hida, A., Negishi, T., Katsuoka, F., Noda, S., Mimura, J., Hosoya, T., Yanaka,

A., Aburatani, H., Fujii-Kuriyama, Y., Motohashi, H. and Yamamoto, M. Mol Cell Biol. 25,

9360-9368 (2005)

78. GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2 Gene.

Kobayashi-Osaki, M, Ohneda, O., Suzuki, N., Minegishi, N., Yokomizo, T., Takahashi, S., Lim,

K.C., Engel, J.D. and Yamamoto, M. Mol. Cell. Biol. 25, 7005-7020 (2005)

79. Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response

Element-Dependent Genes. Katsuoka, F., Motohashi, H., Ishii, T., Aburatani, H., Engel, J.D. and

Yamamoto, M. Mol Cell Biol. 25, 8044-8051 (2005)

80. Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation

of ring sideroblasts and siderocytes. Nakajima, O., Okano, S., Harada, H., Kusaka, T., Gao, X.,

Hosoya, T., Suzuki, N., Takahashi, S., and Yamamoto, M. Genes Cells. 11, 685-700 (2005)

81. Real-time monitoring of stress erythropoiesis in vivo using Gata1- and beta-globin LCR-luciferase

transgenic mice. Suzuki, M., Ohneda, K., Hosoya-Ohmura, S., Tsukamoto, S., Ohneda, O.,

Philipsen, S., and Yamamoto, M. Blood. 108, 726-733 (2005)

82. Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.

Usami, H., Kusano, Y., Kumagai, T., Osada, S., Itoh, K., Kobayashi, A., Yamamoto, M. and

Uchida, K. J Biol Chem. 280, 25267-25276 (2005)

83. Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif

region of mouse Keap1. Padmanabhan, P., Scharlock, M., Tong, K.I., Nakamura, Y., Kang, M.I.,

Kobayashi, A., Matsumoto, T., Tanaka, A., Yamamoto, M., and Yokoyama, S. Acta Cryst.F61:

153-155 (2005)

84. Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II

type 1a receptor. Kato, H., Ishida, J., Imagawa, S., Saito, T., Suzuki, N., Matsuoka, T., Sugaya, T.,

Tanimoto, K., Yokoo, T., Ohneda, O., Sugiyama, F., Yagami, K.I., Fujita, T., Yamamoto, M.,

Nangaku, M. and Fukamizu, A. FASEB J. 19, 2023-2025 (2005)


85. Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective

role in UVA-induced apoptosis. Hirota, A., Kawachi, Y., Itoh, K., Nakamura, Y., Xu, X., Banno, T.,

Takahashi, T., Yamamoto, M. and Otsuka, F. J. Invest. Dermatol. 124, 825-832 (2005)

86. Role of 15-deoxy-D12,14 Prostaglandin J2 and Nrf2 pathways in protection against acute lung

injury Mochizuki, M., Ishii, Y., Itoh, K., Iizuka, T., Morishima, Y., Kimura, T., Kiwamoto, T.,

Matsuno, Y., Hegab, A.E., Nomura, A., Sakamoto, T., Uchida, K., Yamamoto, M., and Sekizawa,

K. Am J Respir Crit Care Med 171, 1260-1266 (2005)

87. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts:

protection against reactive oxygen and nitrogen species-induced cell injury. Zhu, H., Itoh, K.,

Yamamoto, M., Zweier, J.L. and Li, Y. FEBS Lett. 579, 3029-3036 (2005)

88. Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary

inflammation and emphysema. Ishii, Y., Itoh, K., Morishima, Y., Kimura, T., Kiwamoto, T.,

Iizuka, T., Hegab, A.E., Hosoya, T., Nomura, A., Sakamoto, T., Yamamoto, M., Sekizawa, K. J.

Immunol. 175, 6968-6975 (2005)

89. Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Iizuka, T., Ishii,

Y., Itoh, K., Kiwamoto, T., Kimura, T., Matsuno, Y., Morishima, Y., Hegab, A.E., Homma, S.,

Nomura, A., Sakamoto, T., Shimura, M., Yoshida, A., Yamamoto, M., and Sekizawa, K. Gene

Cells. 10, 1113-25. (2005)

90. Differential effects of GATA-1 on proliferation and differentiation of erythroid lineage cells. Zheng,

J, Kitajima, K., Sakai, E., Kimura, T., Minegishi, N., Yamamoto, M. and Nakano, T. Blood 107,

520-527 (2005)

91. Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balance. Negishi, T.,

Kato, Y., Ooneda, O., Mimura, J., Takada, T., Mochizuki, H., Yamamoto, M., Fujii-Kuriyama, Y.

and Furusako, S. J. Immunol. 175, 7348-7356 (2005)

92. GATA-1 is required for expression of Fc{varepsilon}RI on mast cells: analysis of mast cells

derived from GATA-1 knockdown mouse bone marrow. Nishiyama, C., Ito, T., Nishiyama, M.,

Masaki, S., Maeda, K., Nakano, N., Ng, W., Fukuyama, K., Yamamoto, M., Okumura, K. and

Ogawa, H. Int. Immunol. 17, 847-856 (2005)

93. Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in

BXH2 mice. Yanagida, M., Osato, M., Yamashita, N., Liqun, H., Jacob, B., Wu, F., Cao, X.,

Nakamura, T., Yokomizo, T., Takahashi, S., Yamamoto, M., Shigesada, K., and Ito, Y.

Oncogene 24, 4477-4485. (2005)

94. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice.

Rangasamy, T., Guo, J., Mitzner, W.A., Roman, J., Singh, A., Fryer, A.D., Yamamoto, M.,

Kensler, T.W., Tuder, R.M., Georas, S.N., and Biswal, S. J Exp Med. 202, 47-59 (2005)


[2006] 95. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against

acute drug toxicity. Okawa, H., Motohashi, H., Kobayashi, A., Aburatani, H., Kensler, T.W. and

Yamamoto, M. Biochem. Biophys. Res. Commun. 339, 79-88 (2006)

96. Tissue Prx I in the protection against Fe-NTA and the reduction of nitroxyl radicals. Uwayama, J.,

Hirayama, A., Yanagawa, T., Warabi, E., Sugimoto, R., Itoh, K., Yamamoto, M., Yoshida, H.,

Koyama, A., and Ishii, T. Biochem. Biophys. Res. Commun. 339, 226-231 (2006)

97. Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow

niche. Suzuki, N., Ohneda, O., Minegishi, N., Nishikawa, M., Ohta, T., Takahashi, S., Engel, J.D.,

and Yamamoto, M. Proc. Natl. Acad. Sci. USA. 103, 2202-2207 (2006)

98. Structural Basis for Defects of Keap1 Activity Provoked by its Point Mutations in Lung Cancer.

Padmanabhan, B., Tong, K.I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.I.,

Kobayashi, A., Yokoyama, S., and Yamamoto, M. Mol. Cell. 21, 689-700 (2006)

99. Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of

Keap1 Kobayashi, A., Kang, M.I., Watai, Y., Tong, K.I., Shibata, T., Uchida, K., and Yamamoto,

M. Mol Cell Biol. 26, 221-229 (2006)

100. A Crucial Role of Nrf2 in In Vivo Defense against Oxidative Damage by an Environmental

Pollutant, Pentachlorophenol. Umemura, T., Kuroiwa, Y., Kitamura, Y., Ishii, Y., Kanki, K.,

Kodama, Y., Itoh, K., Yamamoto, M., Nishikawa, A., and Hirose, M. Toxicol. Sci. 90, 111-119

(2006)

101. Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human. Morito, N.,

Yoh, K., Fujioka, Y., Nakano, T., Shimohata, H., Hashimoto, Y., Yamada, A., Maeda, A., Matsuno,

F., Hata, H., Suzuki, A., Imagawa, S., Mitsuya, H., Esumi, H., Koyama, A., Yamamoto, M., Mori,

N. and Takahashi, S. Cancer Res. 66, 812-819 (2006)

102. Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus

involution independently of the Fas/Fas ligand signaling pathway. Nagai, H., Kubo, M., Abe, R.,

Yamamoto, M, and Nohara, K. Int. Immunopharmacol. 6, 279-286 (2006)

103. Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in

hypoxia-induced pulmonary hypertension in mice. Satoh, K., Kagaya, Y., Nakano, M., Ito, Y., Ohta,

J., Tada, H., Karibe, A., Minegishi, N., Suzuki, N., Yamamoto, M., Ono, M., Watanabe, J., Shirato,

K., Ishii, N., Sugamura, K. and Shimokawa, H. Circulation. 113, 1442-1450 (2006)

104. Differential gene expression profiling between wild-type and ALAS2-null erythroblasts:

identification of novel heme-regulated genes. Fujiwara, T., Harigae, H., Takahashi, S., Furuyama,

K., Nakajima, O., Sun, J., Igarashi, K., Yamamoto, M., Sassa, S., Kaku, M., and Sasaki, T.

Biochem. Biophys. Res. Commun. 340, 105-110 (2006)


105. Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site

molecular recognition model. Tong, K.I., Katoh, Y., Kusunoki, H., Itoh, K., Tanaka, T. and

Yamamoto, M. Mol. Cell. Biol. 26, 2887-2900 (2006)

106. GATA-4 incompletely substitutes for GATA-1 in promoting both primitive and definitive

erythropoiesis in vivo. Hosoya-Ohmura, S., Mochizuki, N., Suzuki, M., Ohneda, O., Ohneda, K.,

and Yamamoto, M. J. Biol. Chem. 281, 32820-32830 (2006)

107. Predictive base substitution rules that determine the binding and transcriptional specificity of Maf

recognition elements. Yamamoto, T., Kyo, M., Kamiya, T., Tanaka, T., Engel, J.D., Motohashi, H.

and Yamamoto, M. Genes Cells 11, 575-591 (2006)

108. MafG sumoylation is required for active transcriptional repression. Motohashi, H., Katsuoka, F.,

Miyoshi, C., Uchimura, Y., Saitoh, H., Francastel, C., Engel, J.D. and Yamamoto, M. Mol Cell

Biol. 26, 4652-4663 (2006)

109. BRG1 Interacts with Nrf2 to Selectively Mediate HO-1 Induction in Response to Oxidative Stress.

Zhang, J., Ohta, T., Maruyama, A., Hosoya, T., Nishikawa, K., Maher, J.M., Shibahara, S., Itoh, K.,

and Yamamoto, M. Mol. Cell. Biol. 26, 7942-7952 (2006)

110. 2-oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin

through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis. Matsumoto, K.,

Imagawa, S., Obara, N., Suzuki, N., Takahashi, S., Nagasawa, T., and Yamamoto, M. J. Cell.

Physiol. 209, 333-340 (2006)

111. Transgene insertion into the proximity of the c-myb gene disrupts erythroid-megakaryocytic lineage

bifurcation. Mukai, H.Y., Motohashi, H., Ohneda, O., Suzuki, N., Nagano, M. and Yamamoto,

M. Mol Cell Biol 26, 7953-7965 (2006)

112. Ebselen, a seleno-organic antioxidant, as an electrophile. Sakurai, T., Kanayama, M., Shibata, T.,

Itoh, K., Kobayashi, A., Yamamoto, M. and Uchida, K. Chem. Res. Toxicol. 9, 1196-1204

(2006)

113. MafB is essential for renal development and F4/80 expression in macrophages. Moriguchi, T.,

Hamada, M., Morito, N., Terunuma, T., Hasegawa, K., Zhang, C., Yokomizo, T., Esaki, R., Kuroda,

E., Yoh, K., Kudo, T., Nagata, M., Greaves, R.D., Engel, J.D., Yamamoto, M. and Takahashi, S.

Mol Cell Biol. 26, 5715-5727 (2006)

114. Unique and overlapping transcriptional roles of Arnt (Arylhydrocarbon receptor nuclear

translocator) and Arnt2 in xenobiotic and hypoxic responses. Sekine, H., Mimura, J., Yamamoto,

M. and Fujii-Kuriyama Y. J Biol Chem 281, 37507-37516 (2006)

115. Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2,

endoglin and CD34 in the mouse embryo. Ema, M., Yokomizo, T., Wakamatsu, A., Terunuma, T.,

Yamamoto, M. and Takahashi, S. Blood. 108, 4018-4024 (2006)


116. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of

Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Zhang, Y., Crouch, D.H.,

Yamamoto, M. and Hayes, J.D. Biochem J. 399, 373-385 (2006)

117. Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is

attenuated by alkenal/one oxidoreductase. Yu, X., Egner, P.A., Wakabayashi, J., Wakabayashi, N.,

Yamamoto, M. and Kensler, T.W. J. Biol. Chem. 281, 26245-26252 (2006)

118. Glutathione Peroxidase 2, the Major Cigarette Smoke-inducible Isoform of GPX in Lungs is

Regulated by Nrf2. Singh, A., Rangasamy, T., Thimmulappa, R.K., Lee, H., Osburn, W.O.,

Brigelius-Flohe, R., Kensler, T.W., Yamamoto, M., and Biswal, S. Am J Respir Cell Mol Biol. 35,

639-650 (2006)

119. Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a

"tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex. McMahon, M.,

Thomas, N., Itoh, K., Yamamoto, M. and Hayes, J.D. J Biol Chem. 281, 24756-24768 (2006)

120. Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress. Zhu, H,

Zhang, L., Itoh, K., Yamamoto, M., Ross, D., Trush, M.A., Zweier, J.L. and Li, Y. Free Radic

Biol Med. 41, 132-143 (2006)

121. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.

Thimmulappa, R.K., Lee, H., Rangasamy, T., Reddy, S.P., Yamamoto, M, Kensler, T.W. and

Biswal, S. J Clin Invest. 116, 984-995 (2006)

122. Characterization of GATA-1+ hemangioblastic cells in the mouse embryo. Yokomizo, T.,

Takahashi, S., Mochizuki, N., Kuroha, T., Ema, M., Wakamatsu, A., Shimizu, R., Ohneda, O.,

Osato, M., Okada, H., Komori, T., Ogawa, M., Nishikawa, S., Ito, Y. and Yamamoto, M. EMBO

J. 26, 184-196 (2006)

123. Wilms’ tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2

mRNA. Horiuchi, K., Umetani, M., Minami, T., Okayama, H., Takada, S., Yamamoto, M.,

Aburatani, H., Reid, P.C., Housman, D.E., Hamakubo, T., and Kodama, T. Proc Natl Acad Sci

USA 103, 17278-17283 (2006)

124. Nrf2-dependent protection from LPS induced inflammatory response and mortality by

CDDO-Imidazolide. Thimmulappa, R.K., Scollick, C., Traore, K., Yates, M., Trush, M.A., Liby,

K.T., Sporn, M.B., Yamamoto, M., Kensler, T.W. and Biswal, S. Biochem Biophys Res

Commun 351, 883-889 (2006)


[2007] 125. Shear stress stabilizes NF-E2 related factor 2 and induces antioxidant genes in endothelial cells:

Role of reactive oxygen/nitrogen species. Warabi, E., Takabe, W., Minami, T., Inoue, K., Itoh, K.,

Yamamoto, M., Ishii, T., Kodama, T. and Noguchi, N. Free Rad Biol Med 42, 260-269 (2007)

126. Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to

2-amino-3-methylimidazo [4,5-f] quinoline. Kitamura, Y., Umemura, T., Kanki, K., Kodama, Y.,

Kitamoto, S., Saito, K., Itoh, K., Yamamoto, M., Masegi, T., Nishikawa, A. and Hirose, M.

Cancer Sci. 98, 19-24 (2007)

127. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent

inducers of Nrf2-regulated genes. Yates, M.S., Tauchi, M., Katsuoka, F., Flanders, K.C., Liby,

K.T., Honda, T., Gribble, G.W., Johnson, D.A., Johnson, J.A., Burton, N.C., Guilarte, T.R.,

Yamamoto, M., Sporn, M.B. and Kensler, T.W. Mol Cancer Therapeutics, 6, 154-162 (2007)

128. Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. Zhang,

J., Hosoya, T., Maruyama, A., Nishikawa, K., Maher, J.M., Ohta, T., Motohashi, H., Fukamizu, A.,

Shibahara, S., Itoh, K. and Yamamoto, M. Biochem J. 404, 459-466 (2007)

129. Cell cycle-dependent oscillation of GATA2 expression in hematopoietic cells. Koga, S.,

Yamaguchi, N., Abe, T., Minegishi, M., Tsuchiya, S., Yamamoto, M. and Minegishi, N. Blood.

109, 4200-4208 (2007)

130. Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1

chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia. Asou, N., Yanagida, M., Huang, L.,

Yamamoto, M., Shigesada, K., Mitsuya, H., Ito, Y. and Osato, M. Blood. 109, 4023-4027 (2007)

131. GATA-1 self-association controls erythroid development in vivo. Shimizu, R., Trainor, C.D.,

Nishikawa, K., Kobayashi, M., Ohneda, K. and Yamamoto, M. J. Biol. Chem. 282, 15862-15871

(2007)

132. Inchinkoto, an Herbal Medicine, and Its Ingredients Dually Exerts Mrp2/MRP2-Mediated

Choleresis and Nrf2-Mediated Antioxidative Action in Rat Livers. Okada, K., Shoda, J., Kano,

M., Suzuki, S., Ohtake, N., Yamamoto, M., Takahashi, H., Utsunomiya, H., Oda, K., Sato, K.,

Watanabe, A., Ishii, T., Itoh, K., Yamamoto, M., Yokoi, T., Yoshizato, K., Sugiyama, Y. and

Suzuki, H. Am J Physiol Gastrointest Liver Physiol. 292, G1450-G1463 (2007)

133. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice

upon dextran sulfate treatment. Osburn, W.O., Karim, B., Dolan, P.M., Liu, G., Yamamoto, M.,

Huso, D.L. and Kensler, T.W. Int J Cancer. in press.

134. Impairment of erythroid and megakaryocytic differentiation by a Leukemia-Associated and

t(9;9)-derived fusion gene product, SET/TAF-Ibeta-CAN/Nup214. Saito, S., Nouno, K., Shimizu,

R., Yamamoto, M. and Nagata, K. J Cell Physiol. in press.


135. Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Wang, J., Fields, J.,

Zhao, C., Langer, J., Thimmulappa, R.K., Kensler, T.W., Yamamoto, M., Biswal, S. and Dore, S.

Free Radic Biol Med. 43, 408-414 (2007)

136. Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis. Iida, K.,

Itoh, K., Maher, J.M., Kumagai, Y., Oyasu, R., Mori, Y., Shimazui, T., Akaza, H., and Yamamoto,

M. Carcinogenesis. in press.

137. Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt

delta mice. Aoki, Y., Hashimoto, A.H., Amanuma, K., Matsumoto, M., Hiyoshi, K., Takano, H.,

Masumura K, Itoh K, Nohmi T, Yamamoto, M. Cancer Res. 67, 5643-5648 (2007)

138. Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury.

Shah, Z.A., Li, R.C., Thimmulappa, R.K., Kensler, T.W., Yamamoto, M., Biswal, S. and Dore, S.

Neuroscience 147, 53-59 (2007)

139. Does K-11706 Enhance Performance and Why? Imagawa, S., Matsumoto, K., Horie, M., Ohkoshi,

N., Nagasawa, T., Doi, T., Suzuki, N., amd Yamamoto, M. Int J Sports Med. 28, 928-933 (2007)

140. Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.

Tanabe, O., McPhee, D., Kobayashi, S., Shen, Y., Brandt, W., Jiang, X., Campbell, A.D., Chen,

Y.T., Chang, C., Yamamoto, M., Tanimoto, K. and Engel, J.D. EMBO J. 26, 2295-2306 (2007)

141. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants.

Reddy, N.M., Kleeberger, S.R., Cho, H.Y., Yamamoto, M. Kensler, T.W., Biswal, S. and Reddy,

S.P. Am J Respir Cell Mol Biol. 37, 3-8 (2007)

142. A Gata2 intronic enhancer confers its pan-endothelia-specific regulation. Khandekar, M., Brandt,

W., Zhou, Y., Dagenais, S., Glover, T.W., Suzuki, N., Shimizu, R., Yamamoto, M., Lim, K.C. and

Engel, J.D. Development. 134, 1703-1712 (2007)

143. Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute

lung injury. Marzec, J.M., Christie, J.D., Reddy, S.P., Jedlicka, A.E., Vuong, H., Lanken, P.N.,

Aplenc, R., Yamamoto, T., Yamamoto, M., Cho, H.Y. and Kleeberger, S.R. FASEB J. 21,

2237-2246 (2007)

144. Dynamic regulation of Gata factor levels is more important than their identity. Ferreira, R., Wai,

A., Shimizu, R., Gillemans, N., Rottier, R., Lindern, M., Ohneda, K., Grosveld, F., Yamamoto, M.

and Philipsen, S. Blood. 109, 5481-5490 (2007)

145. Regulation of GATA1 gene expression. Kobayashi, M. and Yamamoto, M. J Biochem (Tokyo).

142, 1-10 (2007)

146. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the

nuclear factor-E2-related factor-2 transcriptional pathway. Maher, J.M., Dieter, M.Z., Aleksunes,

L.M., Slitt, A.L., Guo, G., Tanaka, Y., Scheffer, G.L., Chan, J.Y., Manautou, J.E., Chen, Y., Dalton,

T.P., Yamamoto, M. and Klaassen, C.D. Hepatology. 46, 1597-1610 (2007)


147. Different electrostatic potentials define ETGE and DLG motifs as a hinge and latch in the oxidative

stress response. Tong, K.I., Padmanabhan, B., Kobayashi, A., Shang, C., Hirotsu, H., Yokoyama, S.

and Yamamoto, M. Mol. Cell. Biol. 27, 7511-7521 (2007)

148. Molecular basis distinguishing the DNA binding profile of NRF2-MAF heterodimer from that of

MAF homodimer.. Kimura, M., Yamamoto, T., Zhang, J., Itoh, K., Kyo, M., Kamiya, T., Aburatani,

H., Katsuoka, F., Kurokawa, H., Tanaka, T., Motohashi, H. and Yamamoto, M. J Biol Chem. in

press

149. Subcellular localization and cytoplasmic complex status of endogenous Keap1. Watai, Y.,

Kobayashi, A., Nagase, H., Mizukami, M., McEvoy, J., Singer, J.D., Itoh, K., and Yamamoto M.

Genes Cells. 12, 1163-1178 (2007)

150. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo

through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.

Satoh, T., Kosaka, K., Itoh, K., Kobayashi, A., Yamamoto, M., Shimojo, Y., Kitajima, C., Cui, J.,

Kamins, J., Okamoto, S., Izumi, M., Shirasawa, T. and Lipton, SA. J. Neurochem. in press.

151. Loss of p62/SQSTM1 Suppresses Cytoplasmic Inclusion Body Formation and Liver Injury in

Autophagy-Deficient Mouse. Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T.,

Mizushima, N., Iwata, J., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S., Natsume, T.,

Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue,

Z., Uchiyama, Y., Kominami, E. and Tanaka, K. Cell in press.

152. Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.. Sawa,

T., Zaki, M.H., Okamoto, T., Akuta, T., Tokutomi, Y., Kim-Mitsuyama, S., Ihara, H. Kobayashi, A.,

Yamamoto, M., Fujii, S., Arimoto, H. and Akaike, T. Nature Chem. Biol. 3, 727-735 (2007)

153. Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity. Toyama, T., Sumi, D.,

Shinkai, Y., Yasutake, A., Taguchi, K., Tong, K.I., Yamamoto, M., and Kumagai, Y. Biochem

Biophys Res Commun. 363, 645-650 (2007)

154. In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding

protein-1c expression. Takeuchi, Y., Yahagi, N., Nakagawa, Y., Matsuzaka, T., Shimizu, R.,

Sekiya, M., Iizuka, Y., Ohashi, K., Gotoda, T., Yamamoto, M., Nagai, R., Kadowaki, T., Yamada,

N., Osuga, J.I. and Shimano, H. Biochem Biophys Res Commun. 363, 329-335 (2007)

155. Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling

human CAKUT. Hoshino, T., Shimizu, R., Ohmori, S., Nagano, M., Pan, X., Ohneda, O.,

Khandekar, M., Yamamoto, M., Lim, K.C., and Engel, J.D. Gene Cells in press

156. Toxicological effects of polycyclic aromatic hydrocarbon quinones contaminated in diesel exhaust

particles. Kumagai, Y., and Taguchi, K. Asian Journal of Atmospheric Environment. in press

157. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the

hydroquinone associated with oxidative stress. Taguchi, K., Fujii, S., Yamano, S., Cho, A.K.,


Kamisuki, S., Nakai, Y., Sugawara, F., Froines, J.R., and Kumagai, Y. Free Rad. Biol. Med. 43,

789-799 (2007)

158. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Tanabe, O., Shen, Y., Liu,

Q., Campbell, A.D., Kuroha, T., Yamamoto, M. and Engel, J.D. Genes Dev. 21, 2832-2844

(2007)

159. Dysfunction of Nrf2 decreases KBrO(3)-induced oxidative DNA damage in Ogg1-null mice.

Jałoszyński, P., Murata, S., Shinkai, Y., Takahashi, S., Kumagai, Y., Nishimura, S. and Yamamoto

M. Biochem Biophys Res Commun. in press

160. Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor

GATA-2. Okitsu, Y., Takahashi, S., Minegishi, N., Kameoka, J., Kaku, M., Yamamoto, M.,

Sasaki, T. and Harigae, H. Biochem Biophys Res Commun. 364, 383-387 (2007)

161. Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4,

and HDAC5. Oshima, M., Mimura, J., Yamamoto, M. and Fujii-Kuriyama, Y. Biochem

Biophys Res Commun. 364, 276-282 (2007)

162. A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection

Against Ischemia. Nangaku, M., Izuhara, Y., Takizawa, S., Yamashita, T., Fujii-Kuriyama, Y.,

Ohneda, O., Yamamoto, M., van Ypersele de Strihou, C., Hirayama, N. and Miyata, T.

Arterioscler Thromb Vasc Biol. in press

163. Genetic and Pharmacologic Evidence Links Oxidative Stressto Ventilator-Induced Lung Injury in

Mice. Papaiahgari, S., Yerrapureddy, A., Reddy, S.R., Reddy, N.M., Dodd-O, J.M., Crow, M.T.,

Grigoryev, D.N., Barnes, K., Tuder, R.M., Yamamoto, M., Kensler, T.W., Biswal, S., Mitzner, W.,

Hassoun, P.M. and Reddy, S.P. Am J Respir Crit Care Med. in press

164. Genetic dissection of the Nrf2-dependent redox signaling regulated transcriptional programs of cell

proliferation and cytoprotection. Reddy, N.M., Kleeberger, S.R., Yamamoto, M., Kensler, T.W.,

Scollick, C., Biswal, S. and Reddy, S.P. Physiol Genomics. in press

165. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Shin, S.,

Wakabayashi, N., Misra, V., Biswal, S., Lee, G.H., and Agoston, E.S., Yamamoto, M., and Kensler,

T.W. Mol Cell Biol. 27, 7188-7197 (2007)

166. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor

it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Zhang, Y., Lucocq,

J.M., Yamamoto, M. and Hayes, J.D. Biochem J. 408, 161-172 (2007)

167. Deletion of selenocysteine tRNA gene in macrophage and liver results in compensatory gene

induction of cytoprotective enzymes by Nrf2. Suzuki, T., Kelly, V.P., Motohashi, H., Nakajima, O.,

Takahashi, S., Nishimura, S., and Yamamoto M. J Biol Chem. in press

168. Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2.

Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein.


Higgins, L.G., Cavin, C., Itoh, K., Yamamoto, M. and Hayes, J.D. Toxicol Appl Pharmacol. in

press

７‐２招待講演、学会発表

1. Leukemia in GATA-1 knockdown mouse. Masayuki Yamamoto. USA-JAPAN Cancer Seminar.

“Hematopoiesis, Hematopoietic Malignancies and Novel Therapeutic Approaches”. Maui Prince

Hotel, Hawaii, February 12-14. 2003

2. A constitutively active aryl hydrocarbon receptor mutant induces growth inhibition by cell cycle

arrest and apoptosis in Jurkat T cells. Tomohiko Ito, Shinichi Tsukumo, Masayuki Yamamoto,

Hozumi Motohashi, Norio Suzuki, Yoshiaki Fujii-Kuriyama, Chiharu Tohyama and Keiko Nohara.

Society of Toxicology Annual Meeting, Salt Lake City, March 2003

3. Thymocyte alterations in CD2-driven constitutively active arylhydrocarbon receptor (AhR)

transgenic mice. Keiko Nohara, Tomohiko Ito, Shinichi Tsukumo, Masayuki Yamamoto, Hozumi

Motohashi, Azumi Hida, Yoshiaki Fujii-Kuriyama, K. Inouye, H. Nagai and Chiharu Tohyama.

Society of Toxicology Annual Meeting, Salt Lake City, March 2003

4. Nrf2 and its protein-protein interactions regulate drug-dependent gene induction. Masayuki

Yamamoto. Experimental Biology-ASPET 2003, Division for Drug Metabolism Symposium.

“Structural Domains and Motifs: Functional Implications for Drug-sensing Transcription Factors”.

San Diego Convention Center, San Diego, April 14, 2003

5. Transcription factor regulation of cellular defense mechanisms against electrophiles and reactive

oxygen species. Masayuki Yamamoto. The Charles E. Dohme Memorial Symposium for

“Protection against Cancer: Genes and Chemistry”. Vernon B. Mountcastle Auditorium, John’s

Hopkins University, Baltimore, April 22, 2003

6. GATA-2 function in HSC and progenitor. Masayuki Yamamoto. Gordon Research Conference

on Red Cells. Il Ciocco, Barga, Italy, May 25-30, 2003

7. Nrf2-Keap1 Regulation of cellular defense mechanisms against electrophiles and reactive oxygen

species. Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003, Tsukuba Convention Center,

June 5-7, 2003 (Abstract in Proceedings p. 12)

8. Principles of chemoprevention. John D. Hayes, Mike McMahon, C. Bonnesen, L. I. McLellan, C.

Roland Wolf, Ken Itoh and Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003, Tsukuba

Convention Center, June 5-7, 2003 (Abstract in Proceedings p. 14)

9. The role of Nrf2 in susceptibility to pulmonary oxidant injury. Steven R. Kleeberger, Sekher

Reddy, Thomas W. Kensler, Masayuki Yamamoto and Hye-Youn Cho. JBS Bio-Frontier

Symposium 2003, Tsukuba Convention Center, June 5-7, 2003 (Abstract in Proceedings p. 15)


10. The Role and Mechanism of Nrf2/Keap1 System in the Downstream of Cyclopentenone

Prostaglandins. Ken Itoh, Mie Mochizuki, Yukio Ishii, Tania O’Connor, Tetsuro Ishii, Kiyohisa

Sekizawa, Koji Uchida and Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003, Tsukuba


11. Small Maf proteins are functional partner molecules of Nrf2 in keratinocytes. Hozumi Motohashi,

Fumiki Katsuoka, James Douglas Engel and Masayuki Yamamoto. JBS Bio-frontier symposium

2003, Tsukuba Convention Center, June 5-7, 2003 (Abstract in Proceedings p. 18)

12. Revealing new interactions between the small Maf proteins and the developmental pathway in

which they act. James Douglas Engel, Carolyn Jahn, Fumiki Katsuoka, Hozumi Motohashi and

Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003, Tsukuba Convention Center, June 5-7,

2003 (Abstract in Proceedings p. 23)

13. Functional analysis of large Maf transcription factor MafB in vivo. Satoru Takahashi, Takashi

Moriguchi, Michito Hamada, Chuan Zhang, Naoki Morito and Masayuki Yamamoto. JBS

Bio-Frontier Symposium 2003, Tsukuba Convention Center, June 5-7, 2003 (Abstract in

Proceedings p. 25)

14. Small Maf compound mutants display central nervous system neuronal degeneration, aberrant

transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle

response. Fumiki Katsuoka, Hozumi Motohashi, Yuna Tamagawa, Shigeo Kure, Kazuhiko

Igarashi, James Douglas Engel and Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003,

Tsukuba Convention Center, June 5-7, 2003 (Abstract in Proceedings p. 33)

15. Knockdown of tRNASeC gene expression variously influences the activity of oxidative stress

protective selenoprotein enzymes. Vincent P. Kelly, Susumu Nishimura, Osamu Nakajima and

Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003, Tsukuba Convention Center, June 5-7,

2003 (Abstract in Proceedings p. 35)

16. Two cysteines of the redox sensor Keap1 are crucial for the repression of Nrf2 transcriptional

activity through a complex with actin filaments. Moon-Il Kang, Nobunao Wakabayashi, Akira

Kobayashi, Ken Itoh and Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003, Tsukuba


17. Keap1 mediates Nrf2 accumulation in response to electrophiles. Yasutake Kato, Ken Itoh,

Katsuyuki Iida and Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003, Tsukuba


18. Characterisation of the mouse glutathione S-transferase Alpha 3 gene: Identification of an

antioxidant response element in the gene promoter which mediates Nrf2-dependent gene expression.

Jowsey, I.R., Jiang, Q., Itoh, K., Yamamoto, M. and Hayes, J.D. JBS Bio-Frontier Symposium

2003, Tsukuba Convention Center, June 5-7, 2003 (Abstract in Proceedings p. 38)

19. Electrophile response element-mediated induction of the cysteine/glutamate exchange transporter


gene expression. Hiromi Sasaki, Hideyo Sato, Kazumi Kuriyama-Matsumura, Kanako Sato,

Kanako Maebara, Hongyu Wang, Michiko Tanba, Ken Itoh, Masayuki Yamamoto and Shiro

Bannai. JBS Bio-Frontier Symposium 2003, Tsukuba Convention Center, June 5-7, 2003

(Abstract in Proceedings p. 42)

20. Transcriptional regulation of zebrafish GSTP gene. Takafumi Suzuki, Yaeko Takagi, Hiroshi

Osanai, Makoto Kobayashi and Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003,


21. Nrf2 regulates the sensitivity of death receptor signals through intra-cellular glutathione levels.

Naoki Morito, Keigyou Yoh, Ken Itoh, Masayuki Yamamoto and Satoru Takahashi. JBS


Proceedings p. 45)

22. Susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine induced urinary bladder carcinogenesis is

increased and chemoprotective efficiency of oltipraz is lost in nrf2-deficient mice. Katsuyuki Iida,

Ken Itoh, Hideyuki Akaza and Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003,


23. Nrf2 controls expression of CD36 by oxidatively modified LDL and 4-hydroxynonenal in murine

peritoneal macrophages. Tetsuro Ishii, Ken Itoh, Emilio Ruiz, David S. Leake, Masayuki

Yamamoto and Giovanni E. Mann. JBS Bio-Frontier Symposium 2003, Tsukuba Convention

Center, June 5-7, 2003 (Abstract in Proceedings p. 47)

24. Activation of Nrf2 and accumulation of ubiquitin-conjugated A170 stress protein in cultured murine

osteoblasts by arsenic. Junko Aono, Toru Yanagawa, Ken Itoh, Hiroshi Yoshida, Yoshito

Kumagai, Masayuki Yamamoto and Tetsuro Ishii. JBS Bio-Frontier Symposium 2003, Tsukuba


25. Disruption of nrf2 gene causes tooth decolorization: iron transport disorder in nrf2 knockout

enamel organ. Toru Yanagawa, Ken Itoh, Akira Yamaguchi, Yasuaki Shibata, Satoru Takahashi,

Tetsuro Ishii, Hiroshi Yoshida and Masayuki Yamamoto. JBS Bio-Frontier Symposium 2003,


26. Transgenic overexpression of MafK suppresses T cell proliferation and function in vivo. Yoh K,

Sugawara T, Motohashi H, Takahama Y, Koyama A, Yamamoto M, Takahashi S. JBS


Proceedings p. 50)

27. Increased susceptibility of Nrf2 knockout mice to diesel exhaust -- accelerated DNA adduct

formation in the lung and mutagenicity. Yasunobu Aoki, Hiromi Sato, Noriko Nishimura, Akiko

Hashimoto, Satoru Takahashi, Ken Itoh, Takehiko Nohmi, and Masayuki Yamamoto. JBS


Proceedings p. 51)


28. EPR imaging of reducing activity in Nrf2 transcriptional factor deficient mice. Aki Hirayama,

Keigyo Yoh, Sohji Nagase, Atsushi Ueda, Ken Itoh, Naoki Morito, Kouichi Hirayama, Satoru

Takahashi, Masayuki Yamamoto and Akio Koyama. JBS Bio-Frontier Symposium 2003,


29. Erythropoietin expression is required for neovascularization in the retinopathy of prematurity and

is regulated by HLF/Hif-2a. Masayuki Yamamoto, Osamu Ohneda, Toshiharu Yamashita, Norio

Suzuki, Shigehiko Imagawa, Yoshiaki Fujii-Kuriyama. 6th International Leubeck Conference on

the Pathophysiology and Pharmacology of Erythropoietin and other Hematopoietic Growth Factors,

Leubeck,, Germany, June 26-29, 2003 (Abstract in Ann. Hematol. 82, S112)

30. Chemical induction of dimerizer of EPO receptor cytosolic domain regulates erythropoiesis in vivo.

Norio Suzuki, Harumi Y. Mukai, Osamu Ohneda, Shigehiko Imagawa, Toshiro Nagasawa,

Masayuki Yamamoto. 6th International Leubeck Conference on the Pathophysiology and

Pharmacology of Erythropoietin and other Hematopoietic Growth Factors, Leubeck,, Germany,

June 26-29, 2003 (Abstract in Ann. Hematol. 82, S114)

31. K-7174 (A GATA-Specific inhibitor) rescues anemia of chronic disease. Shigehiko Imagawa,

Yoko Nakano, Naoshi Obara, Norio Suzuki, T. Doi, Toshiro Nagasawa, Masayuki Yamamoto.

6th International Leubeck Conference on the Pathophysiology and Pharmacology of Erythropoietin

and other Hematopoietic Growth Factors, Leubeck,, Germany, June 26-29, 2003 (Abstract in Ann.

Hematol. 82, S116)

32. GATA-2 and hematopoietic stem cells. Norio Suzuki, Osamu Ohneda, Naoko Minegishi, Maki

Osaki, Masumi Nagano, Ritsuko Shimizu, James Douglas Engel and Masayuki Yamamoto. The

3rd International Conference on GATA Transcription Factors in Health and Disease, IRCM,

Montréal, Canada, July 16-18, 2003 (Abstract p. 33)

33. Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic

precursor cells in midgestation mouse embryos. Naoko Minegishi, Norio Suzuki, Tomomasa

Yokomizo, Xiaoqing Pan, Tetsuhiro Fujimoto, Satoru Takahashi, Takahiko Hara, Shin-ichi

Nishikawa and Masayuki Yamamoto. The 3rd International Symposium on GATA Transcription

Factors in Health and Disease, IRCM, Montréal, Canada, July 16-18, 2003 (Abstract p. 44)

34. Leukemogenesis caused by incapacitated GATA-1 function. Ritsuko Shimizu, Osamu Ohneda,

Takashi Kuroha, Satoru Takahashi, Sjaak Philipsen, James Douglas Engel and Masayuki

Yamamoto. The 3rd International Symposium on GATA Transcription Factors in Health and

Disease, IRCM, Montréal, Canada, July 16-18, 2003 (Abstract p. 62)

35. Transgenic rescue of Runx1-deficient mice reveals the heterogeneity of the definitive hematopoietic

pathway. Satoru Takahashi, Tomomasa Yokomizo, Naomi Mochizuki, Takashi Kuroha, Ritsuko

Shimizu, Osamu Ohneda, Motomi Osato, Hitoshi Okada, Minetaro Ogawa, Shin-ichi Nishikawa,

Yoshiaki, Ito and Masayuki Yamamoto. The 3rd International Symposium on GATA


Transcription Factors in Health and Disease, IRCM, Montréal, Canada, July 16-18, 2003 (Abstract

p. 65)

36. Ectopic expression of GATA-4 transgene in erythroid lineage failed to rescue GATA-1 knockdown

mouse from embryonic lethality. Kinuko Ohneda, Naomi Mochizuki, Sakie Ohmura, Satoru

Takahashi, Osamu Ohneda, Masayuki Yamamoto. The 3rd International Symposium on GATA

Transcription Factors in Health and Disease, IRCM, Montréal, Canada, July 16-18, 2003 (Abstract

p. 67)

37. Transcription factor regulation of cellular defense mechanisms against electrophiles and reactive

oxygen species. Masayuki Yamamoto. The Second International Symposium on Redox Life

Science. Niseko Higashiyama Prince Hotel, Hokkaido August 20-22, 2003

38. Two domains of Nrf2 cooperatively bind CREB binding protein and synergistically activate

transcription. Mechanism of eukaryotic transcription. Ken Itoh, Yasutake Katoh, Eisaku Yoshida,

Makoto Miyagishi, Akiyoshi Fukamizu and Masayuki Yamamoto. Cold Spring Harbor

Laboratory, August 27-31, 2003

39. The role and mechanism of Nrf2-Keap1 system in the downstream of cyclopentenone

prostaglandins. Ken Itoh, Mie Mochizuki, Yukio Ishii, Kiyohisa Sekizawa, Koji Uchida and

Masayuki Yamamoto. The International Meeting of the Society for Free Radical Research-Asia.

Cultural Center of Seoul National University, November 6-8, 2003

40. Role of Nrf2-Keap1 pathway in detoxification of reactive electrophiles. Ken Itoh, Nobunao

Wakabayashi, Tetsuro Ishii, Masayuki Yamamoto. International Joint Meeting on Food Factors and

Free Radicals in Health & Disease. Kyoto Park Hotel, December 4-7, 2003

41. A novel GATA-specific inhibitor (GSI) rescues anemia of chronic disease by oral administration.

Shigehiko Imagawa, Yoko Nakano, Naoshi Obara, Norio Suzuki, Toshiro Nagasawa and Masayuki

Yamamoto. The American Society of Hematology 45th Annual Meeting, San Diego, California,

December 7, 2003

42. Transcription factor regulation of drug metabolizing and antioxidant enzymes and cancer

chemoprevention. Masayuki Yamamoto. The 8th Korea-Japan Cancer Research Workshop

“Molecular Mechanisms of Tumor Suppression”, Okinawa Miyako Hotel, December 19-20, 2003

(Abstract pp. 24-25)

43. Role and mechanism of Nrf2/Keap1 system in macrophages in the downstream of cyclopentenone

prostaglandins. Ken Itoh, Mie Mochizuki, Yukio Ishii, Tetsuro Ishii, Kiyohisa Sekizawa, Koji

Uchida and Masayuki Yamamoto. 13th International Symposium on Molecular Cell Biology of

Macrophage 2004. Senri Life Science Center, Osaka, July 1-2, 2004

44. Nrf2-Keap1: Regulation of cellular defense mechanisms against electrophiles and reactive oxygen

species. Masayuki Yamamoto. 15th international Symposium on Microsomes and Drug

Oxidations: Chemical Biology in the Postgenomic Era. July 4-9, 2004 (Abstract p. 131)


45. Self-association of GATA1 enhances transcriptional activity. Keizo Nishikawa, Makoto

Kobayashi, Masayuki Yamamoto. 6th International Conference on Zebrafish Development &

Genetics, Madison, July 29 - August 2, 2004.

46. Fine Regulation of GATA-1 and GATA-2 Gene Expression In Vivo. Masayuki Yamamoto. The

14th Conference on Hemoglobin Switching. Rosario Resort, Orcas Island, Washington, USA.

September 10-14, 2004

47. Regulatory Mechanisms of the Keap1-Nrf2 Oxidative Stress Sensor System. Masayuki Yamamoto.

The 41st Nobel Symposium on Oxygen Biology, Nobel Forum, Karolinska Institute, Stockholm,

November 11-13, 2004

48. Nrf2-Keap1 Regulation of cellular defense mechanisms against electrophiles and reactive oxygen

species. Masayuki Yamamoto. The 2nd International Symposium on DNA Metabolism and

Chromatin Dynamics in Cellular Responses, Hiroshima University, Hiroshima. December 16-17,

2004

49. Control of GATA factors. Masayuki Yamamoto. Gordon Conference on Red Cells. Tilton School,

Tilton NH, June 12-17, 2005

50. Nrf2-Keap1 pathway and cancer chemoprevention. Masayuki Yamamoto. Invited Special Lectures

in 10th Japanese-German Workshop on Molecular and Cellular Aspects of Carcinogenesis. Essen

Germany, 29 September-1 October, 2005

51. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen

species. Masayuki Yamamoto Advances in Enzyme Regulation Meeting, University of Bologna,

Italy, October 3-4, 2005

52. Players Regulating and Supporting Cytoprotective Function of Nrf2. Hozumi Motohashi,

Takafumi Suzuki, Hiromi Okawa, Kit Tong, Fumiki Katsuoka, Akira Kobayashi, and Masayuki

Yamamoto. 1st Asian and Pacific International Society for the Study of Xenobiotics 2005

53. Regulation and essential role of the erythropoietin gene in the liver. Norio Suzuki, Naoshi Obara,

Ki-Bom Kim, Xiaoqing Pan, Ko-ichi Jishage, Shigehiko Imagawa, Masayuki Yamamoto 7th

International Luebeck Conference on the Pathophysiology and Pharmacology of Erythropoietin and

other Hemopoietic Growth Factors. Luebeck, Germany, September 6-9. 2005

54. GATA factors constitutively repress the erythropoietin gene expression in the epithelial cells.

Naoshi Obara, Norio Suzuki, Ki-Bom Kim, Shigehiko Imagawa, Toshiro Nagasawa and Masayuki

Yamamoto 7th International Luebeck Conference on the Pathophysiology and Pharmacology of

Erythropoietin and other Hemopoietic Growth Factors. Luebeck, Germany, September 6-9 2005

55. Gene expression regulation and domain function of hematopoietic GATA factors. Masayuki

Yamamoto Virchow-Lectures in Molecular Medicine (früheres Virchow-Colloquium) des

Biomedizinischen Forschungszentrums der Charité. Forschungshaus Campus Virchow-Klinikum

Hörsaal der Pathologie, Berlin. April 4, 2006


56. Introductory lecture: Molecular mechanisms of Nrf2-Keap1 response against oxidative and

electrophilic stresses. Masayuki Yamamoto 57th Mosbacher Kolloquium 2006 on "Redox

Signaling: Mechanisms and Biological Impact" (Scientific Organization: Stefanie Dimmeler &

Helmut Sies) April 6 – 8, 2006, Mosbach, Baden, Germany (Abstract p 6)

57. Regulation by Nrf2-Keap1 System of Cellular Defense Mechanisms against Electrophiles and

Carcinogenesis Masayuki Yamamoto , Takafumi Suzuki, Kit Y. Tong and Akira Kobayashi CNIO

Cancer Conference on "Inflammation and Cancer", CNIO, Madrid, May 22-24, 2006

58. Regulation by Nrf2-Keap1 System of Cellular Defense against Electrophiles and Oxidative Stress.

Masayuki Yamamoto Trinity College Seminar, Trinity College, Dublin, Ireland. May 25, 2006

59. Molecular Mechanisms of Nrf2-Keap1 Response against Oxidative and Electrophilic Stresses.

“Redox: Redox Sensor Mechanisms against Electrophiles” (organized by Koji Uchida and Tom

Kensler). Masayuki Yamamoto, Kit I. Tong, Akira Kobayashi, Takafumi Suzuki, Tae Yamamoto,

Hozumi Motohashi, Ken Itoh. The 20th IUBMB Congress and 11th FAOBMB Congress, Kyoto,

Japan. June 18-23, 2006

60. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism.

Masayuki Yamamoto Scientific Colloquium at PHILIP MORRIS Research Laboratories, Koln,

Germany. September 13, 2006

61. Regulation of Mouse Gata1 Gene Expression in Erythroid Progenitors. Masayuki Yamamoto,

Mikiko Suzuki, Norio Suzuki, and Ritsuko Shimizu. The 15th Hemoglobin Switching Conference at

St John's College, Oxford, September 15-18, 2006


Masayuki Yamamoto. Wolfson Lecture Theatre, Biomedical Research Centre. September 18, 2006

63. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. .

Masayuki Yamamoto. International Symposium on the Redox-Sensitive Transcription Factors as

Potential Therapeutic Targets, Seoul National University Cultural Center. October 21, 2006

64. Regulatory Mediations of Gatal Gene Expression Using BAC Transgenic System. Masayuki

Yamamoto. AACR-JCA Joint Conference In the Forefront of Basic and Translational Cancer

Research. Hilton Waikoloa Village in Waikoloa, Hawaii. January 21-25, 2007

65. Erythropoietin gene regulation. Masayuki Yamamoto. AMGEN Co., January 30, 2007


Masayuki Yamamoto. UCSD Seminar in CMG auditorium, January 31, 2007

67. ALAS-E and sideroblastic anemia. Masayuki Yamamoto. The 2007 International BioIron

Society Scientific Program, Kyoto, April 2, 2007

68. Functional analyses of GATA-2 with knockdown and conditional knockout mice. Masayuki

Yamamoto. EMBO WORKSHOP ON The Role and Control of GATA Factors in Tissue

Development and Disease (Organizers: Roger Patient (Chairperson), Doug Engel, Mona Nemer,


Masayuki Yamamoto, Sjaak Philipsen, Robert Schulz), Capri, Italy, April 14-17, 2007

69. Genetic Analysis of Mouse GATA-related Leukemia and Leukemic Stem Cells. Masayuki Yamamoto.

Gordon Research Conference on Red Cells, Centre Paul Langevin in Aussois, France, May 20-25,

2007


Masayuki Yamamoto. The 3rd DECODE for Biological Responses International Meeting.

Tokyo, August 4, 2007


Masayuki Yamamoto. The 3rd DECODE for Biological Responses International Meeting, Odaiba,

Tokyo, August 4, 2007


Masayuki Yamamoto. National University of Singapore – Tohoku University/Centre of

Excellence Joint Symposium “Basic and Clinical Research on Signal Transduction Diseases”.

Centre for Life Sciences, National University of Singapore, September 5, 2007


Masayuki Yamamoto. NIEHS Seminar, Research Triangle Park, October 30, 2007


Masayuki Yamamoto. Adjunct Professor Lecture at Johns Hopkins University Blumberg School of

Public Health, Baltimore, October 31, 2007


Masayuki Yamamoto. Distinguished Professor’s Seminar at University of Arizona, Tucson,

November 2, 2007

７‐３総説、書籍等

1. 転写因子研究における in vivoイメージングの有用性大根田絹子、鈴木未来子、山本雅之

BIO ベンチャー2003年 11・12月号

2. 二次性貧血に対する新規治療薬の開発. 今川重彦、中野陽子、小原直、鈴木教郎、土肥

武、児玉龍彦、長澤俊郎、山本雅之医学のあゆみ 204; 903-904 (2003)

3. 環境応答系転写因子の分子機構の解明山下年晴、山本雅之化学工業 54 卷 641-645 頁

2003年８月号

4. 血色素の分子進化鈴木教郎、山本雅之日本医事新報 (2003)

5. 新規エリスロポエチン発現促進剤（K-7174）：腎性貧血への試み今川重彦，中野陽子，小

原直，鈴木教郎，土肥武，児玉龍彦，長澤俊郎，山本雅之医学のあゆみ 204, 291-292

(2003)


6. 遺伝子発現とクロマチン西川恵三、山本雅之 Molecular Medicine 41巻増刊号，

7. 組織特異的遺伝子発現小原直、鈴木教郎、山本雅之キーワードで理解するシリー

ズ「転写イラストマップ」（羊土社）p.139-149 (2003)

8. プロテインチップ法京基樹、本橋ほづみ、山本雅之実験医学別冊「プロテオー

ム解析マニュアル」p.203-213 (2003)

9. Nrf2-Keap1 defines a physiologically important stress response mechanism. Motohashi, H. and

Yamamoto, M. Trends Mol. Med. 10, 549-557 (2004, invited review)

10. 親電子性物質応答における Keap1/Nrf2 システムの活性化機構伊東健、山本雅之生化

学 76. 339-348 (2004)

11. GATA 転写因子からみる赤血球の分化・発生長野真澄，山本雅之実験医学 22(3);

361-366 (2004)

12. GATA-1 変異と白血病-転写因子の質的異常と量的異常長野真澄, 清水律子, 山本雅之

医学のあゆみ , 211(2) : 159-162 (2004)

13. GATA-1ノックダウンマウス清水律子、山本雅之 Mebio 2004年 8月号：58-62

14. モデル生物が切り開く造血発生研究の新展開大根田絹子、山本雅之蛋白質核酸酵素

50(6), 633-637 (2004)

15. 新規 GATA 阻害薬の経口投与による慢性貧血治療の試み中野陽子, 今川重彦, 小原直,

鈴木教郎, 長澤俊郎、山本雅之医学のあゆみ, 208(3) : 177-178 (2004)

16. 2-oxoglutarateによる vascular endothelial growth factorおよび erythropoetin産生抑制今川重

彦, 松本健, 小原直 , 鈴木教郎, 長澤俊郎 , 山本雅之医学のあゆみ , 211(4): 347-348

(2004)

17. 2-oxoglutarateによる hypoxia inducible factor-1結合活性および蛋白抑制松本健, 今川重彦,

小原直, 鈴木教郎, 長澤俊郎, 山本雅之医学のあゆみ, 211(7) : 785-786 (2004)

18. 第３章酸化ストレス応答「転写制御」山本多恵，山本雅之「酸化ストレスマーカー」

(2004)

19. 「Keap1-Nrf2 システムによる抗酸化酵素群の統一的発現制御機構」細谷朋方，山本雅之

分子呼吸器病 8，147-150 (2004)

20. 「転写因子と血液疾患」峯岸直子，山本雅之臨床検査 48, 473-481 (2004)

21. 環境問題に立ち向かう遺伝子の適応戦略山本雅之未来材料 , 5(11) 58-59 (2004)

22. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and

detoxifying enzymes. Kobayashi, A., Ohta, T. and Yamamoto, M. Methods Enzymology 378,

273-286. (2004, invited review)

23. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of antioxidant genes. Itoh, K.

and Yamamoto, M. Free Radical Biol. Med. 36, 1208-1213 (2004, invited review)

24. Gene expression regulation and domain function of hematopoietic GATA factors. Shimizu, R.

and Yamamoto, M. Seminars in Cell & Developmental Biology 16, 129-136, (2005)


25. GATA1 function, a paradigm for transcription factors in hematopoiesis. Ferreira, R., Ohneda, K.,

Yamamoto, M. and Philipsen, S. Mol. Cell. Biol. 25, 1215-1217 (2005)

26. 2-oxoglutarate による血管形成抑制松本健, 今川重彦, 小原直, 鈴木教郎, 長澤俊郎, 山

本雅之医学のあゆみ , 215(2): 158-159, (2005)

27. 産生細胞と発現制御鈴木教郎、山本雅之単行本『エリスロポエチンのすべて』（中外

医薬社）(2005)

28. 血液疾患に対する発生工学的アプローチー転写因子GATA-1の機能破綻と血液疾患山本

雅之，清水律子別冊・医学の歩み血液疾患 Ver.3, 187-190. (2005)

29. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen

species. Kobayashi, M. and Yamamoto, M. Adv. Enzyme Reg. 46, 113-140 (2005)

30. Molecular mechanisms activating Nrf2-Keap1 pathway in regulation of antioxidant genes.

Kobayashi, M. and Yamamoto, M. Antioxidants Redox Signaling 7, 384-395 (2005, invited

review)

31. Keap1-Nrf2システムが担う生体防御機構勝岡史城，山本雅之細胞工学（秀潤社） 25:

153-156 (2005)

32. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

Tong, K.I., Kobayashi, A., Katsuoka, F. and Yamamoto, M. Biol. Chem. 387, 1311–1320 (2006)

33. In vitro differentiation of mouse ES cells into haematopoietic cells. Ohneda O, and Yamamoto M.

OUP Practical Approach on Embryonic Stem Cells 169-188 (2006)

34. ヘモグロビンの構造と機能向井陽美，山本雅之「三輪血液病学」（第３版）（文光堂）

第１部基礎，II 赤血球，B 赤血球の生化学と機能，3 pp 171-182 (2006)

35. Keap1-Nrf2システムによるレドックスシグナル応答メカニズム鈴木隆史、山本雅之実

験医学(羊土社) 24, 1737-1743 (2006)

36. Nrf2-Keap1系が制御する生体の環境応答大川裕美，山本雅之ファルマシア 42, 685-589

(2006)

37. 転写因子・転写制御キーワードブック伊東健，小林牧，小林麻己人，三村純正，本橋

ほづみ，山本雅之転写因子・転写制御キーワードブック」（田村隆明・山本雅之編，

羊土社（2006）

38. ユビキチンリガーゼアダプターと酸化ストレスセンサー—Nrf2-Keap1系と Cul3による酸化

ストレス応答機構小林聡, Kit I Tong「ユビキチンープロテアソーム系とオートファジー

作動機構と病態生理」（2006）

39. Regulation of GATA1 gene expression. Kobayashi M, Yamamoto M. J Biochem (Tokyo). 142,

1-10 (2007)

40. Carcinogenesis and transcriptional regulation through Maf recognition elements. Motohashi, H.

and Yamamoto, M. Cancer Sci. 98, 135-139 (2007)

41. GATA因子スイッチングと GATA-1関連白血病清水律子、山本雅之日本生化学学会誌


79（10）

42. GATA-1の機能異常と白血病-Leukemogenesis related to GATA-1 mutation- 安部加奈子、清水

律子、山本雅之日本産婦人科・新生児血液学会会誌（2007）

43. Use of Gene Manipulated Mice in the Study of Erythropoietin Gene Expression. Suzuki N, Obara N,

Yamamoto M. Methods Enzymol. 435, 157-77. (2007)

44. 酸化ストレス防御のための生体内センサー田口恵子、山本雅之日本農芸化学会『化学と

生物』, Dec;45(12) 2007

７‐４受賞関係

1. Scientific Research Front Aword 2004 (Thomson Scientific Co.) Ken Itoh, Masayuki

Yamamoto （2004年 10月）

2. 日本生化学会奨励賞伊東健（2004年 1１月）

3. 第１８回つくば賞「環境適応・応答の分子機構の解明」山本雅之（2007年 7月）

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