calcified senile scleral plaques

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Correspondences 119 [5] Parmar H, Park P, Brahma B, Gandhi D. Imaging of idio- pathic spinal cord herniation. Radiographics 2008 Mar—Apr; 28(2):511—8. [6] Arts MP, Lycklama A, Nijeholt G, Wurzer JA. Surgical treatment of idiopathic transdural spinal cord herniation: a new tech- nique to untether the spinal cord. Acta Neurochir (Wien) 2006 Sep;148(9):1005—9. M. Mejdoubi Department of Neuroradiology, Purpan Hospital, place du Docteur-Baylac, 31059 Toulouse, France E. Schmidt Department of Neurosurgery, Purpan Hospital, Toulouse, France Corresponding author. E-mail address: [email protected] (M. Mejdoubi). Available online 12 August 2008 doi:10.1016/j.neurad.2008.06.006 Calcified senile scleral plaques Plaques sclérales séniles calcifiées To investigate the prevalence of calcified senile scleral plaques (CSSP), all cranial CT scans acquired at Braunsch- weig Teaching Hospitals between 1st and 16th November 2007 were retrospectively evaluated for the presence of CSSP (N = 300 patients; mean age 61.7 years, range: 10—93; 50.3% female; axial CT with 3 mm slices of the posterior fossa, including the orbits, 6 mm supratentorially). Indica- tions included focal neurological deficit (33.3%), headache (13.3%), head injury (11.7%), reduced vigilance (10.3%), psy- chiatric states (10.3%), vertigo (9.3%) and staging (9.3%). CSSP were identified in 18 patients (6%; mean age 80.6 years, range 51—93; 83.3% female). Prevalence increased from 2% in patients aged less than 70 years to 7.2% in those aged 70 to 79 years and to 22.6% in those aged more or equal to 80 years. The plaques most frequently involved the insertions of the medial rectus muscles (77.7%) and were symmetrical in 55.5%, appearing as ovoid hyperdensities (length 1—5 mm, width about 1 mm; bone window settings) (Fig. 1). The lateral recti were involved in 27.7% of cases (one patient had medial and lateral recti involvement) and no plaque was identified at the insertions of the superior and inferior recti. Scleral calcification has a differential diagnosis that includes major pathologies such as inflammation, lym- phoma and hypercalcemic states [1], but is not infrequently encountered in asymptomatic patients. In such cases, like dystrophic calcification elsewhere in the body, calcium salts are deposited in plaque-like areas of hyaline dege- neration, usually anterior to the insertions of the rectus muscles. While usually asymptomatic, plaque sequestration and expulsion with ulceration may occur [2,3]. No associa- tion with systemic conditions has been observed [4] and prevalence of between 3% and 6.2% has been recorded (ran- domly selected scans, ophthalmological indications [4—6]). CSSP were present in 6% of cases in our general patient popu- lation, which is similar to that in a previous report of an ophthalmological population (6.2%, N = 145 [5]). In contrast, Figure 1 CT appearances of calcified senile scleral plaques: bilateral occurrence in a typical location —– anterior to the inser- tion of the medial rectus muscle —– in a 72-year-old man. The plaques appear as small ovoid calcifications on bone window settings (A) and are slightly more rounded in soft-tissue win- dows (B). Aspect TDM de plaques sclérales séniles calcifiées : localisa- tion bilatérale typique —– antérieure à l’insertion du muscle droit médial—–chez un homme âgé de 72 ans. Les plaques apparaissent comme des calcifications ovoïdes de petite taille en fenêtres osseuses (A) et discrètement plus arrondies en fenêtres molles (B). a lower prevalence of 3% was recorded in one study (N = 100 [6]), although that population was considerably younger (mean age 35 years). We found that the prevalence of CSSP increases considerably with age, which compares favorably with previously published age distributions: Gordon et al. [5] reported a prevalence of 22.6% for patients more than 70 years and Moseley [4] recorded a prevalence of 4% for those aged 70 to 79 years old and 22% for patients more or equal to 80 years. As documented by Alorainy [7], we also found a higher prevalence in women, which may be partly explained by the higher mean age of the women in our cohort (65.8 years vs. 57.3 years for men). Due to scan- ning in a transverse plane in our study, an under-recognition of plaque presence in the superior and inferior recti may have occurred, although this is unlikely, given that Alorainy [7] found that only one of 109 plaques (0.9%) in their series was located at the insertion of the superior rectus —– with none at the insertion of the inferior rectus. In conclusion, around 6% of subjects undergoing cra- nial CT scanning for unrelated indications showed calcified senile scleral plaques, with a prevalence increasing with age. Radiologists should be aware of the appearance and location of this ‘‘don’t-touch’’ lesion to distinguish it from high-density foreign bodies and clinically relevant scleral calcifications. References [1] Shields J, Shieds C. CME Review: sclerochoroidal calcifications: the 2001 Harold Gifford lecture. Retina 2002;22:251—61.

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Page 1: Calcified senile scleral plaques

119

Figure 1 CT appearances of calcified senile scleral plaques:bilateral occurrence in a typical location —– anterior to the inser-tion of the medial rectus muscle —– in a 72-year-old man. Theplaques appear as small ovoid calcifications on bone windowsettings (A) and are slightly more rounded in soft-tissue win-dows (B).Aspect TDM de plaques sclérales séniles calcifiées : localisa-tion bilatérale typique —– antérieure à l’insertion du muscledroit médial —– chez un homme âgé de 72 ans. Les plaquesaef

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Correspondences

[5] Parmar H, Park P, Brahma B, Gandhi D. Imaging of idio-pathic spinal cord herniation. Radiographics 2008 Mar—Apr;28(2):511—8.

[6] Arts MP, Lycklama A, Nijeholt G, Wurzer JA. Surgical treatmentof idiopathic transdural spinal cord herniation: a new tech-nique to untether the spinal cord. Acta Neurochir (Wien) 2006Sep;148(9):1005—9.

M. Mejdoubi ∗

Department of Neuroradiology, Purpan Hospital,place du Docteur-Baylac,

31059 Toulouse, FranceE. Schmidt

Department of Neurosurgery, Purpan Hospital,Toulouse, France

∗ Corresponding author.E-mail address: [email protected] (M. Mejdoubi).

Available online 12 August 2008

doi:10.1016/j.neurad.2008.06.006

Calcified senile scleral plaques

Plaques sclérales séniles calcifiées

To investigate the prevalence of calcified senile scleralplaques (CSSP), all cranial CT scans acquired at Braunsch-weig Teaching Hospitals between 1st and 16th November2007 were retrospectively evaluated for the presence ofCSSP (N = 300 patients; mean age 61.7 years, range: 10—93;50.3% female; axial CT with 3 mm slices of the posteriorfossa, including the orbits, 6 mm supratentorially). Indica-tions included focal neurological deficit (33.3%), headache(13.3%), head injury (11.7%), reduced vigilance (10.3%), psy-chiatric states (10.3%), vertigo (9.3%) and staging (9.3%).

CSSP were identified in 18 patients (6%; mean age 80.6years, range 51—93; 83.3% female). Prevalence increasedfrom 2% in patients aged less than 70 years to 7.2% in thoseaged 70 to 79 years and to 22.6% in those aged more orequal to 80 years. The plaques most frequently involved theinsertions of the medial rectus muscles (77.7%) and weresymmetrical in 55.5%, appearing as ovoid hyperdensities(length 1—5 mm, width about 1 mm; bone window settings)(Fig. 1). The lateral recti were involved in 27.7% of cases(one patient had medial and lateral recti involvement) andno plaque was identified at the insertions of the superiorand inferior recti.

Scleral calcification has a differential diagnosis thatincludes major pathologies such as inflammation, lym-phoma and hypercalcemic states [1], but is not infrequentlyencountered in asymptomatic patients. In such cases, likedystrophic calcification elsewhere in the body, calciumsalts are deposited in plaque-like areas of hyaline dege-neration, usually anterior to the insertions of the rectusmuscles. While usually asymptomatic, plaque sequestrationand expulsion with ulceration may occur [2,3]. No associa-tion with systemic conditions has been observed [4] and

prevalence of between 3% and 6.2% has been recorded (ran-domly selected scans, ophthalmological indications [4—6]).CSSP were present in 6% of cases in our general patient popu-lation, which is similar to that in a previous report of anophthalmological population (6.2%, N = 145 [5]). In contrast,

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pparaissent comme des calcifications ovoïdes de petite taillen fenêtres osseuses (A) et discrètement plus arrondies enenêtres molles (B).

lower prevalence of 3% was recorded in one study (N = 1006]), although that population was considerably youngermean age 35 years). We found that the prevalence of CSSPncreases considerably with age, which compares favorablyith previously published age distributions: Gordon et al.

5] reported a prevalence of 22.6% for patients more than0 years and Moseley [4] recorded a prevalence of 4% forhose aged 70 to 79 years old and 22% for patients morer equal to 80 years. As documented by Alorainy [7], welso found a higher prevalence in women, which may beartly explained by the higher mean age of the women inur cohort (65.8 years vs. 57.3 years for men). Due to scan-ing in a transverse plane in our study, an under-recognitionf plaque presence in the superior and inferior recti mayave occurred, although this is unlikely, given that Alorainy7] found that only one of 109 plaques (0.9%) in their seriesas located at the insertion of the superior rectus —– withone at the insertion of the inferior rectus.

In conclusion, around 6% of subjects undergoing cra-ial CT scanning for unrelated indications showed calcifiedenile scleral plaques, with a prevalence increasing withge. Radiologists should be aware of the appearance andocation of this ‘‘don’t-touch’’ lesion to distinguish it fromigh-density foreign bodies and clinically relevant scleralalcifications.

eferences

1] Shields J, Shieds C. CME Review: sclerochoroidal calcifications:the 2001 Harold Gifford lecture. Retina 2002;22:251—61.

Page 2: Calcified senile scleral plaques

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2] Manschot WA. Senile scleral plaques and senile scleromalacia.Br J Ophthalmol 1972;62:376—80.

3] Hillenkamp J, Sundmacher R, Sellmer R, Witschel H. Seques-trating senile scleral plaque initially mistaken for necroti-zing scleritis. Surgical treatment. Klin Monatsbl Augenheilkd2000;216:177—80.

4] Moseley I. Spots before the eyes: a prevalence and clini-coradiological study of senile scleral plaques. Clin Radiol2000;55:198—206.

5] Gordon RN, Slamovits TL, Rosenbaum PS, Bello J. Calcified

scleral plaques imaged on orbital computed tomography. Am JOphthalmol 1999;127:461—3.

6] Murray JL, Hayman LA, Tang RA, Schiffmann JS. Inciden-tal asymptomatic orbital calcifications. J Neuroophthalmol1995;15:203—8. d

Correspondences

7] Alorainy I. Senile scleral plaques: CT. Neuroradiology 2000;42:145—8.

J. Gossner ∗

J. LarsenInstitute for Roentgendiagnostics and Nuclear Medicine,

Braunschweig Teaching Hospitals, Salzdahlumer Straße 90,38126 Braunschweig, Germany

∗ Corresponding author.E-mail address: [email protected] (J. Gossner).

Available online 9 August 2008

oi:10.1016/j.neurad.2008.06.001