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CALIFORNIA TUMOR TISSUE REGISTRY California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350 (909) 824-4788 FAX: (909) 478-4188

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Page 1: CALIFORNIA TUMOR TISSUE REGISTRY - Uscap fileCALIFORNIA TUMOR TISSUE REGISTRY California Tumor Tissue Registry ... distal femur, involving the metaphysis and epiphysis and extending

CALIFORNIA TUMOR TISSUE REGISTRY

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350

(909) 824-4788 FAX: (909) 478-4188

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CONTRIBUTOR: Lorna Linda Pathology Group (drc) CASE NO.1 - JANUARY 1996 Lorna Linda, CA

TISSUE FROM: Para nasal sinuses ACCESSION #27763

CLINICAL ABSTRACT:

This 45-year-old female had a two year history of headaches, nasal blockage and visual problems in her left eye. Maxillary sinus drainage at the time oLinitial presentation failed to correct her problems. A cr scan later revealed a tumor in the cavernous sinus region. At surgery, the tumor filled both maxillary sinuses, with destruction of the lateral nasal walls and posterior nasal septum. It involved the base of the skull, extending to the pituitary fossa.

GROSS PATHOLOGY:

The tumor was resected in multiple fragments which totalled 100 grams.

CONTRIBUTOR: Lorna Linda Pathology Group (drc) CASE NO.2 - JANUARY 1996 Lorna Linda, CA

TISSUE FROM: Right chest wall ACCESSION #27624

CLINICAL ABSTRACT:

This 46-year-old Caucasian male had a 2-3 year history of a mass in the anterolatera] aspect of the right seventh rib. There was no associated pain and he had been told that it was a "benign problem." However, in recent months he had noticed the mass increasing in size. CT scan demonstrated the mass to involve the periosteum or ·perichondrium at about the tip of the 7th rib, and was suspicious for a soft tissue tumor. Physical examination revealed a non-tender, soft mass which did not appear to be attached to the underlying structures. A wide local excision of the right anterior chest wall tumor was performed.

GROSS PATHOLOGY:

The specimen was a 195 gram, 12.5 x 8.5 x 4.8 em portion of right anterior chest wall, which included portions of ribs .6, 7, and 8 and their costal cartilage. Arising from the costal cartilage adjacent to the costochondral junction of the 7th rib, near its junction with the 8th costal cartilage, was a 5.0 x 3.5 x 3.0 em cartilaginous tumor.

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CONTRIBUTOR: Loma Linda Pathology Group (drc) CASE NO.3 - JANUARY 1996 Lomu Linda, CA

TISSUE FROM: Right distal femur ACCESSION #27612

CLINICAL ABSTRACT:

This 13-year-old Hispanic female had a three month history of painful swelling in the distal femur. Following a biopsy, she underwent an above-the-knee amputation of her right leg.

GROSS PATHOLOGY:

A 13 em long, soft, granular, yellow-red, focally cystic and necrotic tumor was present in the distal femur, involving the metaphysis and epiphysis and extending into adjacent soft tissues.

CONTRffiUTOR: Drs. Enfield & Bassis San Frnncisco, CA

TISSUE FROM: Lert hemipelvis

CLINICAL ABSTRACT:

CASE NO.4 • JANUARY 1996

ACCESSION #27771

This 40 year old Hispanic male presented with a large mass on the left hip. After biopsy, an internal hemipelvectomy with wide local excision was performed. At surgery, the tumor was associated with the bony stalk of an apparently pre-existing exostosis which protruded from the outer table of the ilium.

GROSS PATHOLOGY:

A 12 x 10 x 7 em lobulated firm white tumor contained foci of hemorrhage, calcification and mucinous degeneration.

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CONTRIBUTOR: W. E. Carroll, M.D. CASE NO. S • JANUARY 1996 Santa Barbara, CA

TISSUE FROM: Base of skull ACCESSION #27145

CLINICAL ABSTRACT:

This 26 year old man developed facial pain with numbness and visual difficulties over a one month period. An MRI showed a mass arising from the floor of the middle fossa with erosion of adjacent tissues.

GROSS PATHOLOGY:

Multiple fragments of bone and soft tissue formed a 6 em aggregate.

CONTRffiUTOR: Ron Mihata, M.D. CASE NO. 6 • JANUARY 1996 Riverside, CA

TISSUE FROM: Left orbit und skull ACCESSION #19493

CLINICAL ABSTRACT:

This 31 year old woman had a 3 month history of proptosis with an increasing sensation of pressure behind her left eye. A skull film showed a 3 em diameter dome-like zone of calcification projecting from the floor of the left frontal fossa in the region of the cribriform plate. At surgery, an extradural tumor was found beneath the left frontal lobe. The tumor extended into the left orbit and left frontal sinus.

GROSS PATHOLOGY:

Multiple fragments of pink-white rubbery tissue formed a 6 em aggregate.

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CONTRIBUTOR: Albert Hirst, M:D. CASE NO. 7 • JANUARY 1996 Lorna Linda, CA

TISSUE FROM: Distal right femur ACCESSION #2~540

CLINICAL ABSTRACT:

This 44 year old man complained of pain and swelling in the right knee for 5 months. Radiographs showed a lytic le;sion in the lateral eondyle and lateral epicondyle of the distal end of the right femur. The lesion was curetted.

GROSS PATHOLOGY:

Multiple fragments of gray-white bone and soft tissue formed a 6 gram aggregate.

CONTRIBUTOR: Arthur Koehler, M.D. CASE NO. 8 • JANUARY 1996 Pasadena, CA

TISSUE FROM: Right sphenoid bone ACCESSION #22113

CLINICAL ABSTRACT:

This 75 year old woman developed drooping of the left face and inability of ambulate. Diagnostic studies showed a lesion interpreted as a meningioma. This was excised.

GROSS PATHOLOGY:

Multiple fragments of bone and soft tissue formed a 4 em aggregate.

SPECIAL STAINS:

Vimentin 3+ Cytokeratin 1·2 +

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CONTRIBUTOR: Shinichi Hnmnshige, M.D. CASE NO. 9 - JANUARY 1996 Fullerton, CA

TISSUE FROM: Skull ACCESSION #20268

CLINICAL ABSTRACf:

This 64 year old male noted a painless mass near the apex of the skull which had grown slowly over a period of two years. It was excised.

GROSS PATHOLOGY:

A 12 em mass showed bony trabeculae separated by gray-tan mucoid appearing tissue. The underlying dura was involved by the process. ·

CONTRIBUTOR: Marvin Stein, M.D. CASE NO. 10 - JANUARY 1996 Sherman Onks, CA

TISSUE FROM: First thoracic vertebra ACCESSION #20236

CLINICAL ABSTRACf:

This 27 year old male developed spastic paraparesis. A radiograph showed a 7 em posterior mediastinal mass causing compression of the esophagus and displacement of the trachea. Tumor involved the transverse process and pedicle of the first thoracic vertebra.

GROSS PATHOLOGY:

An 8 em mass was brown-tan, friable and hemorrhagic.

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CALIFORNIA T UMOR TISSUE REGISTRY

SUGGESTED READING (Genernl Topics from Recent Literature):

Jonas U, Anton P. (Editors)· Renal Cell Carcinoma. World Journal of Urology, June 1995; L3(~): 137-200

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, California 92350

(909) 824-4788 FAJ<: (909)478-4188

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CASE NO. 1, ACCESSION NO. 27763 JANUARY 1996

INlAND <RIVERSIDE/SAN BERNARDINO) - Well-differentiated chondrosarcoma (7); Chordoma (1).

LONG BEACH - Cho.ndrosarcoma (10).

SAN DIEGO (Naval Medical Center) - Well-differentiated chondrosarcoma.(4); Chondroid chordoma (6).

SANTA BARBARA - C\londroma. •

SANTA ROSA - Chondrosarcoma (1); lAw grade chondrosarcoma (2).

BAY AREA - Chondroid chordoma (3)

PLEASANTON/FREMONT , Chondrosarcoma (6).

PENNSYLVANIA (Johnstown) - Chondrosarcoma.

NEW JERSEY (Summit) - Chondrosarcoma ( 4). _

MARYLAND (Bethesda Naval Med Ctrl - lAw grade chondrosarcoma (6), Chondroid chordoma (5).

NEW HAMPSHIRE (Catholic Med Ctrl - lAw grade chondrosarcoma (1); C~ondrosarcoma (1).

MASSACHUSETIS !Berkshire Med Ctr) - Well-differentiated chondrosarcoma (8).

CONNECTICUT CUniv of CTHealth Ctrl - Chondrosarcoma (well-differentiated) (5); Chondromyxoid fibroma (1).

TEXAS TECH <El Paso) - Conventional intramedullary osteosarcoma.

WASHINGTON <Duwamish Valley) - lAw grade chOi'tdrosarcoma (2).

AUSTRAllA (Svdney) - Chondrosarcoma, grade 1 - 2 (of 4).

DIAGNOSIS:

C:IIONDROSARCOMA, GRADE I, PAR<I.NASAL SINUSES T22000/M92203

REFERENCES:

Pu YS, Perzin KH. Non'Epithclial Tumors of the Nasal Cavity, Paranasal Sinusci and Nasopharynx. A Clinicopathologic Study III Cartilaginous Tumors (Chondroma, Chondrosarcoma). Cancer 19(34): 453-463.

Sato K, Milcaga H, Horikoshi T. Chondrosarcoma of the Jaws and Facial Skeleton. A Review of the Japanese Literature: J · Oral Surg 1977; 35: 892-897.

Batsakis JG, Ditto WR. Chondrosarcoma of the Maxilla. Arch Otolaryngoll962; 75: .55-61.

C'lTR, Jaouary 1996 ••Minutes'' ~go2

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CASE NO. l, ACCESSION NO. 27624 JANUARY 1996

INLAND CRJVERS!PEISAN BERNARDINO) - Well-<liCferentiated chondrosarcoma (S); Periosteal chondroma (3).

LONG BEACH - Cbondrosarcorm~ (10).

SAN OTEGO (Naval Medical Center) - Well-difl'erentiated chondrosarcoma (10). ~

SANTA BARBARA - Low-grade chondrosarcoma.

SANl' A ROSA - Atypical osteochondroma (3).

BAY AREA - Chondrosarcoma, low grade (3).

PLEASANIQN/FREMONT - Osteochondroma (6).

PENNSYLVANJA <Johnstown) - Chondrosarcoma.

NEW JERSey (Summit) - Periosteal chondroma (3); Pcnosteallow-grade chondrosarcoma (1).

MARYLAND <Bethesda Naval Med Ctrl - Chondroma (6); Low grade chondromcoma (5).

NEW HAMfSH!RE (Catholic Med Ctrl - Chondroma with malignant changes {1); Chondroma with malignant transformation (1).

MASSACHUSEtTS C&rkshire Med Or) - Well-<lifferentiated chondrosarcoma possibly arising in osteochondroma (8).

CONNECQCliT Nniv o[ CT Health Ctrl - Chondrosarcoma (5); Periosteal chondroma (3}.

TEXAS TECH lEI Paso) - Juxtacortical chondrosarcoma, grade I.

WASHINGTON CDuwamish Vallcv) - Enchondroma (1); Periosteal enchondroma (1).

AUSTRALIA (Sydney) - Periosteal chondroma.

DIAGNOSIS:

CHONDROSARCOMA, GRADE I, CHEST WALL TYZ130/M9Zl03

CONSULTATION: K. Krishnan Unni, B.S., M.B., Mayo Clinic, Rochester, Minnesota: Chondrosarcoma, grade I.

FOLLOW-UP: One year later, a CT scan showed a mass at the 6th and 7th ribs. Radiographic interpretation was tumor

recurrence vs. post surgical scarring.

REFERENCES:

Faber LP, Somers 1, Templeton A C. Olest Wall Tumors. Current Prob in Surg 1995; 32(8):661-756. Barren NR. PrimarY Tumours or Rib. Br 1 Surg 1955; 43: 113-132. Ron 10, Amir O,lnbar MJ, and Chaitchik S. Oear Cell Chondrosarcoma of Rib Following Repetitive Low-lmpad Trauma.

Am JOin Oncol1995; 18(1): 87-89. Bun M, Fulton M. WC$Soer-Ounlap S, Karpel> M, et at PrimarY Oony and Cartilaginous Sarcomas of Chest Well. Results or

Therapy. Ann Thone Surg 1992; 54{2): 226-232. Dirix LY, Van-Oasterom AT. O.Ondrosan::oma and Other Rare 9ooc Sa<eamas. Curr Opin Oncoll991; 3(4): 694-699.

CTTR.. January 1996 ••Miautu"

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CASE NO. 3, ACCESSION NO. 2761Z

INlAND lRIVEBSIPEJSAN BE.R."'ARDINO> - Osteosarcoma (8).

LONG BEACH - Osteogenic sarcoma (10).

SAN DIEGO <Naval MediC11I Center) - Osteosarcoma (10).

SANTA BARBARA - Angiosarcoma. •

SANTA ROSA - Osteosarcoma (3).

BAY AREA - ? well -differentiated osteosarcoma (need x-ray) (3).

PLEASANTQN/FREMONT - Osteosarcoma (6).

PENNSYL V ANJA (Johnstown) - Osteosarcoma.

JANUARY 1996

NEW JERSEY (Summjt) - Osteogenicsaicoma (3); Osteolytic osteogenic sarcoma (1).

MARYLAND CBcthesda Naval Med Ctr) - Osteosarcoll}a (probably post chemotherapy) (ll).

NEW HAMPSHIRE (Catholic Med Ctr) - Osteosarcoma (1); Osteogenic sarcoma (1).

MASSACHUSETTS ( Berkshire Med Ctr) - Osteosarcoma (8).

CONNECTICUT CUniv of CT Health Ctr) - Osteosarcoma (8).

TEXAS TECH <EI Paso) - Osteosarcoma (probably telaogieetatic).

WASHINGTON <Duwamisb Valley) - Osteosarcoma_(!); Osteosarcoma (osteoblastic-type) (t).

AUSTRALIA (Sydney) - Osteosarcoma, osteoblastic, bigb grade .

.DIAGNOSIS:

OSTEOBlASTIC OSTEOSARCO!\<lA, FEMUR T11710IM91803

REFERENCES:

Dahlin DC, Unni KK. O.teooat<Xl<Da ofBooe and liS lmpo.unr RecoSI'izable Varieties. Am J Surg Pathoii9TI; 1: 61-72. Enneking WF, Kaaan A. "Skip" Metascases in O.lCOSareomo. cancer 1975; 36: 2192·2205. Dahlin DC. Unni KK. Bone Tumors. General Asp<d$ and Dara on 8,542 Cases, 4th ed.Springfield, Charles C Thom,. 1986;

357-365. ~i G, Picci P, Ferrari S, Ruggieri P, et al. Primary Chemolherapy and Delayed Surgery for Non-Merasraric O.teosarcoma of

the Extremities. Resulrs in 164 ParieniS TrC3ted wilh High Doses of Methotrexate Followed by Cisplarinum and Doxorubicin. cancer 1993; 72(11): 3227-3238.

CITR. Juuary 1996 ''Mioutcs" paac4

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~i\SE NO. 4, ACCESSION NO. 2777-1 JANUARY 1996

INlAND IRJVERSIDF/SAN BERNARDINO) • Well-differentiated ·cbondrosarcoma (6); Cartilaginous neoplasm of uncertain malignant potential (2).

LONG BEACH • Cho.ndrosareoma (10).

SAN DIEGO (Naval Medical Center) · WeU-differentiated chondrosarcoma {10).

SANTA BARBARA • Chondrosarcom~t

SANTA ROSA • Chondrosarcoma (2); Low grade chondrosarcoma (1 ) .

BAY AREA • Chondrosarcoma (3).

PLEASANTON/FREMONT • Chondrosarcoma {6).

PENNSYL V AN1A (Johnstown) - Chondrosarcoma.

NEW JERSEY (Summit) • Ctiondrosarcoma, low grade (4).

MARYLAND !Bethesda Naval Med Ctr) • Low grade chondrosarcoma (?arising in osteochondroma)(ll).

NEW HAMPSHIRE (Catholic Mcd Ctr) • Chondrosarcoma (2).

MASSACHUSE'ITS !Berkshire Mcd Ctr) - WeU-differentiated chondrosarcoma (8).

CONNECTICUT CUniv.of cr Health Ctr) • Chondrosarcoma (8).

TEXAS TECH CEI Paso) • Chondr()sarcoma, grade I.

WASHINGTON (Duwamish Valley) • Low grade chondrosarcoma (2).

AUSTRALIA (Sydney) • Chondrosarcoma, low grade(? secondary to osteochondroma).

DIAGNOSIS:

CHONDROSARCOMA, GRAD.E I, HIP TY1500/M92203

REFERENCES:

Pritchard TJ,Lunke RJ, Taylor WI', Dahlin DC, Medley BE. Chondrosarcoma. A Clinicopathologic and Stlltistical Analysis. Cancer 1980; 45: 149·157.

Gitelis S, Bertoni F, Pizzi P, Campanacei M. Chondrosarcoma of Bone. The Experience at the lnstituto Orthopedico Rizz.oli. J Bone Joint Surg 1981; 63a: 1248-1257.

Young Ct. Sim FH, Unni KK. McLeod RA Chondr<l$arcoma of Bone in Children. Cancer 1990; 66: 1641-1648.

~January 1996 .. Minute$' Jl"geS

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CASE NO. 5, ACCESSION NO. 27145 JANUARY 1996

INLAND CRIVERSIDE./SAN BERNARDINO} - Poorly ditTerentiated chondrosarcoma (6); Mesenchymal chondrosarcoma (1); Chondroblastic osleosarcoma (1).

LONG BEACH - Mesenchymal chondrosarcoma (8); High grade chondrosarcoma (2);

SAN DIEGO (Naval Medical Center) - Chondroblastic o.\tcosarcoma (4); Moderately di(fe~ntiated chondrosarcoma ( 4); Mesenchymal chondrosarcoma (2).

SANTA BARBARA - High-grade chondrosarcoma .

SANIA ROSA - Chondrosarcoma (2); High gtade chondrosarcoma (1).

BAY AREA - Dediffen:ntiated chondrosarcoma (3)

PLEASANTONifREMONT - Chondrosarcoma (3); Mesenchymal chondrosarcoma (3).

PENNSYLVANIA (Johnstown} - ltl Chondroblastoma; 112 Cbondromyxoid fibroma.

NEW JERSEY (Summit) - Mesenchymal chondrosarcoma (4).

MARYLAND !Bethesda Naval Med Ctr) - Mesenchymal chondrosarcoma (5); Chondroblastic osteosarcoma (5); Chondroblasloma (1).

NEW HAMPSHIRE CC~tholic Med Ctr) - Chondrosarcoma {1); Dedifferentiated chondrosarcoma (1).

MASSACHUSETTS <Berkshire Med Ctr} - Mesenchymal chondrosarcoma (8).

CONNECTICUT <Univ of Cf Health Ctr) • Osteosarcoma (ohondrosarcomatous) (8).

TEXAS TECH CE! Paso} - Osteosarcoma •

WASHINGTON <Duwamish Vallev) - Higb grade chondrosarcoma (I); High grade chondrosarcoma (mesenchymal chondrosarcoma) (1).

AUSTRALIA (Sydney) - Mesenchymal chondrosarcoma (4); Chondroblastoma (2).

DIAGNOSIS:

SARC OMA Wn'B CHONDROBLASTIC AND OSTEOBLASTIC DIFFERENTIATION ("CHONDROBLASTIC OSTEOSARCOMA"), DASE OF SKULL 1lf045~1803/M88003

FOLLOW-UP: Patient expired one year later of tumor.

REFERENCES'

Kurt AM, Unni KK, McLeod RA, Pritchard DJ. Low-Grade Jntraossoous Osteosarcoma. cancer 1990; 65: 1418-1428. Unni K(edited} Bone Tum=. Contemporary Issues in Surgical Pathology. Surg Pathol1988, Churchill-LivingstOn. Price OIG, Truscott DE. Osteogenic Sarcoma- An Anal}'$ is or Survival and it.s Relationship to Histologic Grading and

Struerure. J Bone Surg (llr) 1961; 43: 30().313. ROO$ FGM. Osteogenic Sarcoma. Br J Radial1996; 37: 2.59-276.

C1TR. Juu.uy 1996 .. Minutes" pagc6

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CASE NO. 6, ACCESSION NO. 19493 JANUARY 1996

INLAND CRJVERS!DEISAN BERNARDINO> - Fibrous dysplasia (7); Aggressive osteoblastoma (1).

LONG BEACH • Fibrous dysplasia (10).

SAN DIEGO (Naval Medical Center) • Ossifying fibroma (8); Fibrous dysplasia (1); Fibromatosis (1).

SANTA BARBARA - Meningioma. •

SANTA ROSA • Fibrous dysplasia (3).

BAY AREA - Meningioma (2); Ossifying fibroma (1).

PLEASANTQNIFREMONT • Fibrous dysplasia (6).

PENNSYL V AN1A (Johnstown) • Fibre-osseous tumor, non-ossifying fibroma.

NEW JERSEY <Summit) - Fibrous dysplasia (4).

MARYLAND <Bethesda Naval Med Ctr) • Fibrous dyspfasia (11).

NEW HAMPSHfRE(Catbolic Med Ctr) • Spindle cell malignancy vs fibrous dysplasia (1); Fibrous dysplasia (1).

MASSACHl.ISETIS <Berkshire Med Ctr) - Fibroblastic osteosarcoma (8).

CONNEcnCUT (l.Jrtiv of cr Health Ctr) - Fibrous dysplasia (8).

TEXAS TECH lEI Paso) • Fibrous dysplasia.

WASJ:flNGTON IDuwamish Valley) • Fibrous dysplasia (2).

AUSJRAUA (Sydney) • Fibrous dysplasia.

DIAGNOSIS:

FIDROUS D YSPLASIA, LEFT ORBIT AND SKULL TY0480n'10101JM74910

REFERENCES:

Parle Y-1<, Uoni KK. McLeod RA and Pritchord OJ. OstcoObrous Dysplasia. Unique Lesion, Fibrous Dysplasia Variant, or Reactive·Prooess Associated with Other Lesions? Hum Patboll993; 24: 1339-1347.

Harris WH, Dudley HR. Jr, Barry RJ. The Natural History of Fibrous Dysplasia. J Bone Joint Surg (AM) 1962;44: 207-2.33. Brige JA, Dembinski A, DeBoer J, et al. Clonal Olromooomal Abnormalities in Ostco6brous Dysplasia. Implications for

Histogenesis and Its Relation>hip with Adamantinoma. cancer 1994; 73: 1746-1752. Fechner RE, Mills SE. Tumor1 oftbc Bone and JoiniS. Alla.s of Tumor Pathology, Third Series, Fascicle 8, Washington D.C.

Anned Forces Institute of Pathology 1992; 147-151. Voyrek TM, Ro JY, Edeiken J, and Ayala AG. Fibrous Dysplasia and Cementa-Ossifying Fibroma. A Histologic Spectrum.

Am J Surg Patho ll995; 19: 775-781.

CTTR. lla1WJ 1996 " MJDuJes" Pli• 7

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CASE NO. 7, ACCESSION NO. 25540

INLAND OU\'ERSIDEISAN BERNARDINO) - Giant cdl tumor of bone (8).

LONG BEACH - Giant cell tumor (10).

SAN DIEGO (Naval Medical Center) - Giant cell rumor of bone (10).

SANTA BARBARA - Malignant giant o:Ji tumor.

SANTA ROSA - Giant cell tumor (3).

BAY ARFA - Giant ceD tumor of bone (3).

PLEASANTON/FREMONT - Giant cell tumor (osteoclastoma) (6).

PENNSYLVANIA (Johnstown) - Giant cell rumor.

NEW JERSEY (Sununjt) - Giant cell tumor (4).

MARYLAND CBetbcJI<Ia NavAl Med Ctrl - Giant cell1umor (11).

NEW HAMPSHIRE <Carbolic Med Ctr) - Giant cell tumor (2).

MASSACHUSETTS <Berkshire Med Ctr) - Giant cell tumor, grade D/IU.

CONNEGnC!JT CUnjv of CT Health Qr) - Giant cell rumor, low grade (8).

TEXAS TECH CEI Paso) - Giant cell rumor.

WASffiNGTON CDuwamisb Vallev) - Giant cell tumor (2).

AUSTRALIA (Sydney) - Ostcoclastoma (GCI of bone).

DIAGNOSIS:

GIANT CELL TUMOR OF BONE, DISTAL RJGBT FEMUR Tll710/M69210

REfERENCES:

JANUARY 1996

Campanacci M. Baldini N, Boriani S,Sudanese A. Giant Celt TUmor of Bone. J Bone Joint Surg 19S7; 69a: 106-114. MtDonald OJ. Sim FH, Mcleod RA, Dahlin DC. Giant Celt TUm<>r of Bone. J Bone Joint Surg 1986; 68a: 235-242. Roctc MG, Pritchard OJ, Unni KX. Metastases From Histologically Benign Giant Cell Tumor or Booe. J Bone Joint Surg

1984; 66a: 269·274.

C1TR. laouary JQ96 "MiouiCC"' page8

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CASE NO. 8, ACCESSION NO. 22113 JANUARY 1996

INlAND <RIYERSIDEJSAN BERNARDINO) • Metastatic renal cell carcinoma (8).

LONG BEACH • Metastatic renal cell carcinoma (7); Paraganglioma (3).

SAN DIEGO (Naval Medical Center) - Para~nglioma (6); Cbordoma (3); Renal Cell Carcinoma, metastatic (1).

SANTA BARBARA - Carotid body tumor.

SANIA ROSA • Paraganglioma (3).

BAY AREA • Paraganglioma (3).

PLEASAN'f()NfFRE.'•!ONT • Clear cell chondrosarcoma (2); Chordoid meningioma (2); Met.utatic carcinoma (1); Don't know (1 ).

PENNSYLVANIA (Johnstown) - Metastatic renal cell carcinoma.

NEW JERSEX (Summit) - Panganglioma (3); RIO metastatic carcinoma (renal cell origin) (1).

MARYLAND CBethesda Naval Med Ctr) • Metastatic renal cell carcinoma (11).

NBW HAMPSHIRE (CathoUc Med Ctr) • Epithelioid meningioma vs metastatic clear cell adenocarcinoma (I); Metastatic clear cell ade~ocarcinoma vs meningioma (I).

MASSACHUSETIS <Berkshire Med Ctr) - Meningioma (2); Oligodendroglioma (1); Metastatic carcinoma (3); Paraganglioma (2).

CONNECJ1CUTfUnivofCT Health Ctr) - Paraganglioma (4); Metastatic renal cell carcinoma (3).

TEXAS TECH CEI Paso) • Meningioma.

WASHINGTON CDuwamish Valley) - Metastatic clear cell tumor (1); Meningioma with clear cell features (1).

AUSTRALIA (Sydney) - Metastatic renal cell carcinoma.

DIAGNOSIS: CONSISTENT WITH METASTATIC RENAL CELL CARCINOMA, RIGHT SPHENOID BONE Tl01.51JM831l3

FOLLOW-UP: The patient expired two years later due to unatural causes".

CONSUL TA TTON: Dr. Boleslaw H. Liwnicz, M.D., Ph.D. neuropathologist, LLUMC: Favor metasl<ltic renal cell carcinoma, but cannot totally exclude clear cell meningioma.

REEERENCFS: Mostofi FK, King 10, Jr. Pathology and Spread Renal Cell Carcinoma In Renal Neoplasia. Ed Boston. J.D. King, Jr. (Ed)

Boston, Unle Brown 1967; 41-86. Targooski PV, Frank W, Stuhldreher 0, Guinan PD. Value of Tumor Size in Predicting Survival·fl®l Renal Cell Carcinoma

Amoog Tumors, Nodes and MeltStases Stage l and Stage 2 P>tients. JUral (U.S.), Nov 1994; IS2(S Pt 1): 1389·1392. Fyfe G, Fisher Rl, RO$Cnberg SA, S:wol M, et al. Results of Treatment of25; Patients with MeltStatic Renal Cell Carcinoma

Who Received High-Dose Recombinantlntcrleukin·2 Therapy. 1 Clio Oneal (U.S.), Mar 1995, 13(3): 688-696. Kierney PC, van Hecrden JA, Segura lW and Weaver AL Surgeon's Role in the Management of Solitary Renal Cell

Carcinoma Mctasla$es Occurring Subsequent to lnithal Curarivc Nephrectomy. An Institutional Review. Ann Surg Oncol (U.S.), Jul1994; 1{4): 345-3$2.

Tongaookar HB, Kulkarni JN and Kamat MR. Solitary Meta<tases liom Ranal Cell Carcinoma. A Review.J ofSurg Oneal 1992; 49: 45-48.

C"nll. Januuy 1996 "Mlollles'' page9

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CASE NO. 9, ACCESSION NO. 20268 JANUARY 1996

INlAND ®VERSIDE/SAN BERNARDINO) • lntraosseous meningioma (6); Epithelioid hemangioma (2).

LONG BEACH • Meningiom~ (10).

SAN DIEGO <Naval Medjcal Center) • Meningioma (10).

SANIA BARBARA • Meningioma. •

SANTA ROSA • Meningioma (3).

BAY AREA • Meningioma (3).

PLEASANTQN/FREMONT - Mesenchymal chondrosarcoma (1); Meningioma {3); Don't know (2).

PENNSYLVANIA (Jobu.town) - Ill chordoma; 112 Metastatic prostate carcinoma, R/0.

NEW JERSEX (Summit) • Meningioma involving bone (4).

MARYLAND CBethe.<o<la Naval Med Ctr) • Meningio111a (6); Epithelioid hemangioendothelioma (5).

NEW HAMPSHIRE (Carbolic Mcd C!r) • Aggressive malignant meningioma {2).

MA§SACHYSEIJS <Berkshire Med Ctrl - Meni ngioma (8).

CONNECIJCVf (Univ Of CT Health Ctrl - Meningioma (8).

JEXAS TECH (EJ Paso) • Mcni.ngiomo .

WASHINGTON CDuwamjsh Valley) • Meningioma in bone (2).

AUSTRALIA (Sydncv) • Vascular meningioma.

DIAGNOSIS;

INVASIVE M:ENINGIOMA, SKULL T10101/M9S300

CONSULTAT ION: Boleslaw Liwnic~ M.D., Ph.D., neuropathologist, LLUMC: Invasive meningioma

REfERENCES:

Younis G, Sawaya R. lntraaaoial Osteolytic Malignant Meningiomas Appearing as EJ<tra-Cranial Son-TISSue Masses Neurosurgery 1992; 30: 932-935.

Burger PC, Scheithauer BW. Atlas of Tumor Pathology. Tumors o[ the Central Nervous System. Third Series, Fascicle 10, Washingron O.C, Armed Forces Institute of Pathology 1993; 259·286.

pogo 10

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CASE NO. 10, ACCESSION NO. 20236

INlAND OYyERSIDEISAN BER.~ARDINO) • Aneurysmal bone cyst (8).

LONG BEACH - Aneurysmal bone cyst (10).

JANUARY 1996

SAN DIEGO <Naval Medical Center) - Aneurysmal bone cyst (6); Osteosarcoma (3); Giant cell rumor arising from aneurysmal bone cyst (1). ..

SANTA BARBARA - Giant cell rumor.

SANTA ROSA • Aneurysmal bone cyst (3).

BAY AREA • Aneurysmal bone cyst arising within giant cell tumor (3).

PLEASANTON/FREMONT • Aneurysmal bone cyst (6).

PENNSYLVANIA Qobnstown) • Aneurysmal bone cyst.

NEW JERSEY (Summit) • Aneurysmal bone cyst (4).

MARYLANQ <Bethesda Naval Med Ctrl - Aneurysmal bone cyst (11).

NEW HAMPSHIRE ICatbolic Med Ctrl • Giant cell rumor (I); Osteocartilaginous fibroma, probably ? bone cyst (giant cell tumor)(!). .

MASSACHUSETTS !Berkshire Med Ctr) • Aneurysmal bone cyst (S); Telangiectatic osteosarcoma (3).

CONNECTICUT CUniv of CT Health Ctr) • Giant cell tumor with osteosarcomatous differentiation (3); Osteosarcoma, fibrobistiocytic type (3).

TEXAS TECH CEI Paso) • Osteosarcoma with prominent giant cells.

WASHJNQTON <Puwamish Valley) - Aneurysmal bone cyst (2).

AUSTRALIA (Sydney) - Aneurysmal bone cyst (solid and cystic).

DIAGNOSIS;

GIANT CELL TUMOR OF BONE, VERTEBRA T l0510/M69210

CONSULTATION: Lent C. Johnson, M.D., Chief, Orthopedic Pathology Division, AF!P: Recunent Giant Cell Tumor.

FOLLOW-UP: One year later there was cecurrent vertebral rumor.

REFERENCES:

(S<:e References with Case #7)

CTI'R.Janua.ry l996'.Mfnutcs" P•a•ll