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Corporate Presentation February 2020 Revive Therapeutics Ltd. | Office: 905-605-5535 | E-mail: [email protected] Cannabis and Psychedelic Life Sciences Company

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Page 1: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

Corporate PresentationFebruary 2020

Revive Therapeutics Ltd. | Office: 905-605-5535 | E-mail: [email protected]

Cannabis and Psychedelic

Life Sciences Company

Page 2: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

FORWARD LOOKING STATEMENTS

Certain statements contained in this presentation constitute forward-looking information within the meaning of securities laws. Forward-looking information may relate to our future outlook and anticipated events or results and may include statements regarding our future financial position, business strategy, budgets, litigation, projected costs, capital expenditures, financial results, taxes and plans and objectives. In some cases, forward-looking information can be identified by terms such as “may”, “will”, “should”, “expect”, “plan”, “anticipate”, “believe”, “intend”, “estimate”, “predict”, “potential”, “continue” or other similar expressions concerning matters that are not historical facts. These statements are based on certain factors and assumptions regarding, among other things, expected growth, results of operations, performance, and business prospects and opportunities. While we consider these assumptions to be reasonable based oninformation currently available to us, they may prove to be incorrect. Forward looking-information is also subject to certain factors, including risks and uncertainties that could cause actual results to differ materially from what we currently expect. These factors include, among other things, the availability of funds and resources to pursue development projects, the successful and timely completion of clinical studies, and the ability to take advantage of business opportunities, the granting of necessary approvals by regulatory authorities, and general economic, market and business conditions. For more exhaustive information on these risks and uncertainties you should refer to our most recently filed Annual Information Form which is available at www.sedar.com. Forward-looking information contained in this presentation is based on our current estimates, expectations and projections, which we believe are reasonable as of the current date. You should not place undue importance on forward-looking information and should not rely upon this information as of any other date. While we may elect to, we are under no obligation and do not undertake to update this information at any particular time.

Page 3: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

REVIVE THERAPEUTICS

§ Emerging cannabis and psychedelic life sciences company

§ Developing novel cannabis and psychedelic based therapies to treat liver, inflammatory, and rare diseases

§ Robust cannabis and psychedelic based product portfolio targeting multi-billion market opportunities

§ Significantly undervalued compared to its peers

§ Unique opportunity to invest in the next evolution of the cannabis and psychedelic market

Page 4: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

PHARMA CANNABIS MARKET OPPORTUNITY

Page 5: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

Cannabinoids may represent ~10% of $20

Billion specialty pharma market over next 5 years1

Targeting Inflammation and Rare Diseases

Novel Cannabinoid Delivery System

FDA Orphan Designations

CANNABINOID PHARMACEUTICAL STRATEGY

Page 6: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

CANNABINOID DELIVERY TECHNOLOGY

§ Delivering naturally extracted and synthetic cannabinoids with novel combination of composites via multiple delivery formats

• Tannin (plant-based) - antibacterial, antifungal, antioxidant & wound healing properties• Chitosan (shrimp-based) - blood-clotting & antimicrobial properties

§ Unique attributes of composites for potential synergistic and better therapeutic effect with cannabis• Releases (rapid, controlled, sustained), improved bioavailability, no first-pass metabolism

§ Allows for potential best-in-class products• Accelerate reduction of inflammation & healing rate, reduce & protect from infections

Page 7: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

PATENT PORTFOLIOSCIENCE AND IP DRIVEN CANNABIS-BASED PRODUCTS

4Exclusive licenses to patents

Cannabinoid Patents

Delivery System

Liver disease

Compelling Features

Improved bioavailability

Delivery options (oral, buccal, topical)

Rapid, Sustained, Controlled delivery

Improved safety, effectiveness, compliance

Page 8: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

PRODUCT PIPELINE

CANNABINOID PHARMACEUTICALS

Product Candidates Target Indications Addressable Market Size US Population Development

Status

Topical CBDDermatitis, Psoriasis, AcneWound Care

$25Bn$35Bn

+40mm12mm Preclinical

Oral/IV CBDLiver diseases: Autoimmune Hepatitis, Nonalcoholic steatohepatitis

$19.5Bn 30mm Preclinical

Page 9: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

LIVER DISEASE OPPORTUNITY§ Potential $19.5Bn market by 2022; affecting +30mm people in U.S.

§ Focus on Autoimmune Hepatitis (AIH) and Nonalcoholic steatohepatitis (NASH)

§ AIH - rare disease (~ 76k patients in US) causing liver inflammation• Drawbacks of current therapies (steroids): Severe side effects in 13%,

relapse after drug withdrawal in 50%-86%*

§ NASH – fatty liver, most common liver disease (3-5% adults)• No approved therapeutic for NASH; Patients increased risk of cirrhosis,

expected to be leading cause of liver transplants

Source: World J Gastroenterol. 2010 Feb 28; 16(8): 934–947Global NASH Market July 2017 Acute Market Reports

Pharma deals in liver diseases:

§ Allergan/Tobira $1.7Bn acquisition§ Novartis/Conatus $650mm license§ Gilead/Nimbus $1.2Bn acquisition

Page 10: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

INFLAMMATORY SKIN DISEASE OPPORTUNITY§ Inflammatory skin diseases from immune system reactions

§ Unmet medical need requiring new treatment options • Current treatments are inadequate, have unwanted side effects

profiles, and expensive

§ Dermatitis (Eczema) Market Opportunity• ~ 31mm patients in the U.S. and ~ $4Bn market size

§ Psoriasis Market Opportunity• ~ 7.5mm patients in the U.S. and ~ $20Bn market size

§ Acne Market Opportunity• ~$4.9Bn market size in 2016 and potential of ~$7.3Bn by 2025

Psoriasis

Dermatitis

Pharma deals in skin diseases:

§ Purdue/Exicure $790mm license§ Astra/Valeant $445mm license§ Allergan/Vitae $639mm deal

Page 11: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

WOUND CARE OPPORTUNITY

§ Global wound care market estimated at USD $35Bn by 2022

§ Unmet medical need requiring new treatment options

§ Types of wounds include surgical scars, burns and diabetic foot and pressure ulcers

§ Diabetic Foot and and Pressure Ulcers Opportunity• USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015

• 387mm with diabetes globally and expected to increase to 592mm by 2035

• 25% of diabetics will acquire a nonhealing ulcer in their lifetime; ~3mm diabetic ulcers annually

Surgical Scar

Diabetic Foot Ulcer

Source:Wound Care Market. August 2017 MarketsandMarketsGlobal Diabetic Foot Ulcers & Pressure Ulcers Market. March 2017. Transparency Market Research

Page 12: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

PSYCHEDELIC OPPORTUNITY

§ Entered into LOI to acquire Psilocin Pharma Corp. (PPC)

§ PPC has novel methods of production of Psilocybin-based formulations

§ Developed six unique formulations for both natural and synthetically derived Psilocybin§ Capsules (PSY-0.1), Sublingual Spray (PSY-0.2), Gel Cap (PSY-0.3), Effervesce

Tablets (PSY-0.4/0.5), and Breath Strip (PSY-0.6).

§ Target markets§ Mental Health (Depression, PTSD & Anxiety) - 450mm population§ Eating Disorders (Anorexia, Bulimia & other classified EDs) – 70mm population§ Addiction (Alcohol, Drugs, Cigarettes) – 240mm population

Page 13: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

FOUNDER – PSILOCIN PHARMA

§ Derrick Welsh§ 14 years of Health Care experience, with the past 5 years in the Cannabis

industry

§ Worked with several high profile publicly-traded Cannabis companies like Xanthic Bio Pharma and Green Growth Brands

§ Developed several patent pending formulations such as water Soluble THC and CBD products such as beverages, water enhancers and effervescent tablets

§ Developed a catalog of formulations, extraction and purification technology for the compound Psilocybin (6 products with different dosages) and can be titrated to suit clinical trials or public consumption in markets where Psilocybin is legal

Page 14: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

Product highlights

• Often easier to swallow

• Protects sensitive ingredients

• Easily opened

• Reduced stomach irritation

• Unique ingredient combinations are possible

• Gelatin and vegetarian enclosure options

• Oil or fat-soluble nutrient delivery options

Micro Dosing involves taking roughly one-tenth of a psychedelic dose of the drug Psilocybin, an amount too little to trigger hallucinations but enough, its proponents say to deliver multiple health benefits.

Treatment Potential:

• Cancer with Depression, Anxiety, PTSD

PSILOCYBIN CAPSULES (PSY-0.1)

Page 15: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

Product Highlights:

• Faster onset and longer duration of action

• Provides ease of administration to patients who refuse to

swallow a tablet

• There is no requirement of drug disintegration

• Elimination of first pass metabolism, good mouth feels property

• Low dosage provides high efficacy as hepatic first pass

metabolism is avoided and also reduces the risk of side effects

Treatment Potential:

• Sudden onset Panic attacks

PSILOCYBIN SUBLINGUAL SPRAY (PSY-0.2)

Page 16: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

Product Highlights

• Often easier to swallow

• Protects sensitive ingredients

• Easily opened

• Reduced stomach irritation

• Unique ingredient combinations are possible

• Gelatin and vegetarian enclosure options

• Oil or fat-soluble nutrient delivery options

Treatment Potential:

• Obesity, Bulimia Nervosa, Anorexia Nervosa

PSILOCYBIN GEL CAP (PSY-0.3)

Page 17: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

Product Highlights

• Increased uptake of Psilocin

• Rapid metabolization via sublingual absorption

path way

• Easily dosed and titrated

• Easily packaged and produced

• Gentile on the gastrointestinal track

• Marketing advantages

Treatment Potential:

• Drug Addiction

PSILOCYBIN EFFERVESCENT TABLETS (PSY-0.4/0.5)

Page 18: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

Product Highlights

• Rapidly releases an expansive list of

pharmaceuticals, emulsified psilocybin

• Permits API’s to enter the blood stream through a

fast dose pathway without being degraded or

modified by first pass metabolism in the liver

• Sublingual and transmucosal transport of active

molecules result

Treatment Potential:

• Micro Dose Products

Micro Dosing involves taking roughly one-tenth of a psychedelic dose of the drug Psilocybin, an amount too little to trigger hallucinations but enough, its proponents say to deliver multiple health benefits.

PSILOCYBIN ORAL FAST DISSOLVING STRIP (PSY-0.6)

Page 19: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

STRATEGIC RELATIONSHIPS

Supply and collaboration of truffles

LOI Acquisition Psychedelic pharma

Research collaboration for liver diseases

License of cannabidiol for treatment of Autoimmune

Hepatitis

Licensed Dealer ofmedical cannabis

(R&D, Testing)

License of cannabinoid delivery technology

Medical cannabis research & development supply and

collaboration

Page 20: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

VALUE DRIVING MILESTONES IN 2020Q1-2020 Complete acquisition of Psilocin Pharma Corp.

Q2-2020 Submit IND for Phase 1/2a clinical study for CBD in the treatment of Autoimmune Hepatitis

Q2-2020 Initiate Phase 1/2a clinical study for CBD in the treatment of Autoimmune Hepatitis

Q2-2020 Pre-IND meeting with FDA for Psilocybin in treatment of mental illness (indication undisclosed)

Q2/3-2020 Initiate Phase 1/2a clinical study for Psilocybin in treatment of mental illness (indication undisclosed)

Q3-2020 Initiate marketing and sales of Psilocybin products in Brazil

Q3-2020 Complete pre-IND meeting with the FDA for CBD in the prevention of IRI resulting from solid organ transplantation

Q4-2020 Submit IND for Phase 1/2a clinical study for CBD in the prevention of IRI resulting from solid organ transplantation

Q4-2020 Initiate Phase 1/2a clinical study for CBD in the prevention of IRI resulting from solid organ transplantation

Q4-2020 Complete Phase 1/2a clinical study for CBD in the treatment of Autoimmune Hepatitis

Page 21: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

SIGNIFICANTLY UNDERVALUED

$90 MillionMarket Cap

$105 MillionMarket Cap

$60 MillionMarket Cap

$5 MillionMarket Cap

Potential$30 - $100 Million

Market Cap

10x – 20x return

Page 22: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

TEAM

Management

§ Michael FrankChairman and CEO

§ Carmelo MarrelliChief Financial Officer

Board of Directors§ Michael Frank

Chairman and CEO

§ William JacksonDirector

§ Joshua HermanDirector

§ Christian ScovennaDirector

§ Andrew LindzonDirector

Page 23: CannabisandPsychedelic Life SciencesCompany · §AIH -rare disease (~ 76k patients in US) causing liver inflammation ... •USD$4.9Bn by the end of 2024 from US$2.8Bn in 2015 •387mm

STOCK INFORMATION

Ticker Symbols RVV (CSE)

Share Price CAD $0.075 (February 14, 2020)

52 week High/Low CAD $0.10 / $0.025

Capital Structure 72,411,282 common shares (90,466,657 fully-diluted)

Market Cap CAD ~ $5,00,000