cardiac tumors
TRANSCRIPT
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CARDIAC TUMORSCARDIAC TUMORS
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Primary Cardiac tumorsPrimary Cardiac tumors BenignBenign MalignantMalignant
Secondary Cardiac TumorsSecondary Cardiac Tumors BenignBenign MalignantMalignant
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GeneralGeneral
NeoplasiaNeoplasia of the heart or of the heart or pericardium pericardium : :
Secondary more common thanSecondary more common than PrimaryPrimary
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GeneralGeneral
Primary tumorsPrimary tumors• <3/10,000 autopsies<3/10,000 autopsies• Over ¾ are benignOver ¾ are benign
Secondary Secondary • 20-40 x more common20-40 x more common• Present in 20% of patients dying of malignancyPresent in 20% of patients dying of malignancy
Prevalence:
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OutlineOutline
GeneralGeneral Primary Cardiac tumorsPrimary Cardiac tumors
BenignBenign
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Primary Cardiac TumorsPrimary Cardiac Tumors
BenignBenign MyxomaMyxoma Papillary fibroelastomaPapillary fibroelastoma FibromaFibroma LipomaLipoma RhabdomyomasRhabdomyomas
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Benign Benign Primary Cardiac TumorsPrimary Cardiac Tumors
The most common primary cardiac tumor in The most common primary cardiac tumor in the Age > 35 the Age > 35
75% in the Lt. Atrium near fossa ovalis75% in the Lt. Atrium near fossa ovalis 15% Rt. Atrium15% Rt. Atrium 5-10% Lt. Ventricle5-10% Lt. Ventricle 5% multiple sites5% multiple sites
Myxomas
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Benign Primary Cardiac TumorsBenign Primary Cardiac Tumors
GrosslyGrossly• Typically pedunculatedTypically pedunculated• Gelatinous consistencyGelatinous consistency• FriableFriable
HistologicallyHistologically• Copious mucopolysaccharide stromaCopious mucopolysaccharide stroma• Scattered solitary or clustered polygonal cells.Scattered solitary or clustered polygonal cells.
Myxomas
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MICROSCOPYMICROSCOPY
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ManangementManangement
High propensity for embolizationHigh propensity for embolization Surgical results excellentSurgical results excellent
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BenignBenign Primary Cardiac TumorsPrimary Cardiac Tumors
Familial pattern of Myxomas with autosomal Familial pattern of Myxomas with autosomal dominant featuresdominant features
Age < 30Age < 30
Carney Complex
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Papillary FibroelastomaPapillary Fibroelastoma
The most common The most common valvularvalvular tumor, followed by tumor, followed by• SarcomaSarcoma• MelanomaMelanoma
Present in all age groups, but most commonly Present in all age groups, but most commonly in Age>60in Age>60
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Papillary FibroelastomaPapillary Fibroelastoma
Small tumors (<1cm) with homogeneous speckeled Small tumors (<1cm) with homogeneous speckeled patternpattern
Commonly pedunculated with multiple frondsCommonly pedunculated with multiple fronds Affect the Lt and Rt sides with same frequencyAffect the Lt and Rt sides with same frequency Attach to Attach to
• Atrial surface of AV valves, andAtrial surface of AV valves, and• Ventricular surface of semilunar valvesVentricular surface of semilunar valves
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Papillary FibroelastomaPapillary Fibroelastoma
Adults Adults Aortic valve Aortic valve Children Children Tricuspid valve Tricuspid valve Rarely on endocardial surfacesRarely on endocardial surfaces Symptomatic only in the aortic position (other than Symptomatic only in the aortic position (other than
embolic Sx)embolic Sx)• Ostial occlusion Ostial occlusion angina, sudden death angina, sudden death• Rarely valvular dysfunctionRarely valvular dysfunction
Source of embolization in up to 30% of patientsSource of embolization in up to 30% of patients
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FibromasFibromas
Encapsulated, solitary tumorsEncapsulated, solitary tumors Frequently in the septal myocardiumFrequently in the septal myocardium Often encroach on the conduction Often encroach on the conduction
system as they growsystem as they grow
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FibromasFibromas
With septal involvement V.Fib is often the With septal involvement V.Fib is often the first presentationfirst presentation
Indications for surgical resection:Indications for surgical resection:• Mechanical problems due to sizeMechanical problems due to size• Arrhythmogenic nidusArrhythmogenic nidus
Resection of septal fibromas is Resection of septal fibromas is not always not always possible possible
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LipomasLipomas
Affect both myocardium and pericardiumAffect both myocardium and pericardium Can reach several centimeters in sizeCan reach several centimeters in size
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Rhabdomyoma:Rhabdomyoma:
Most common tumor of the heart for Age < Most common tumor of the heart for Age < 30 yr30 yr
Almost exclusively in childrenAlmost exclusively in children Associated with tuberous sclerosisAssociated with tuberous sclerosis Regression of tumor in infancy has been Regression of tumor in infancy has been
reportedreported
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A large firm, white tumor mass was A large firm, white tumor mass was found filling the left ventricle. This is found filling the left ventricle. This is
a cardiac rhabdomyoma.a cardiac rhabdomyoma.
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MalignantMalignant Primary Cardiac Tumors Primary Cardiac Tumors
AngiosarcomasAngiosarcomas
RhabdomyosarcomasRhabdomyosarcomas
MesotheliomasMesotheliomas
LymphomaLymphoma
Intrapericardial PheochromocytomasIntrapericardial Pheochromocytomas
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AngiosarcomasAngiosarcomas
Most common primary malignancy of the heartMost common primary malignancy of the heart Malignant cells that form vascular channelsMalignant cells that form vascular channels Most commonly affect theMost commonly affect the
• Rt. Heart Rt. Heart Rt. AtriumRt. Atrium
• PericardiumPericardium Hemorrhagic effusionHemorrhagic effusion ThrombusThrombus
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AngiosarcomasAngiosarcomas
Diffuse, irregularly shapedDiffuse, irregularly shaped Mean survival one yearMean survival one year Successful Rx with Chemo and XRT followed Successful Rx with Chemo and XRT followed
by transplant reportedby transplant reported
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RhabdomyosarcomasRhabdomyosarcomas
Most commonly seen in adultsMost commonly seen in adults No chamber selectivityNo chamber selectivity No pericardial involvementNo pericardial involvement Multiple sites of cardiac involvement is commonMultiple sites of cardiac involvement is common Poor prognosisPoor prognosis Limited success with resection and adjuvant Rx.Limited success with resection and adjuvant Rx.
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MesotheliomasMesotheliomas
Diffuse pericardial tumorDiffuse pericardial tumor Involve both parietal and visceral pericardiumInvolve both parietal and visceral pericardium Superficially invade the myocardiumSuperficially invade the myocardium Rarely invade the cardiac chambersRarely invade the cardiac chambers
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MesotheliomasMesotheliomas
Sx of pericarditis or tamponadeSx of pericarditis or tamponade Poor prognosisPoor prognosis XTR or chemo only offer temporary XTR or chemo only offer temporary
improvementimprovement
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LymphomaLymphoma
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MalignantMalignant Secondary Cardiac Secondary Cardiac TumorsTumors
Solid Tumors involving the heart:Solid Tumors involving the heart: LungLung BreastBreast Soft tissue sarcomasSoft tissue sarcomas Renal carcinomaRenal carcinoma MelanomaMelanoma
Leukemia and Lymphomas also common Leukemia and Lymphomas also common culpritsculprits
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MalignantMalignant Secondary Cardiac Secondary Cardiac TumorsTumors
IVC tumors in GeneralIVC tumors in General Renal carcinomaRenal carcinoma
• 80% 5 year survival for surgical resection of 80% 5 year survival for surgical resection of tumors migrating up the IVCtumors migrating up the IVC
HepatomaHepatoma Ovarian CAOvarian CA
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Q U I Z TIMEQ U I Z TIME
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How about this one? How about this one?
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Any Guesses??Any Guesses??
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Any Guesses??Any Guesses??
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Guesses?Guesses?
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What is this?What is this?