cardiology finals revision
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Cardiology Finals Revision. Andrew Degnan PALI Wednesday 12 th September 2012. Why Cardiology?. Why Cardiology?. 2005 Paper 1-Heart failure Paper 2-Unstable angina Resit 1-Aortic stenosis Resit 2-Infective endocarditis and pericarditis 2006 Paper 1-Heart failure - PowerPoint PPT PresentationTRANSCRIPT
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Cardiology Finals Revision
Andrew DegnanPALI
Wednesday 12th September 2012
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Why Cardiology?
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Why Cardiology?• 2005
– Paper 1-Heart failure– Paper 2-Unstable angina– Resit 1-Aortic stenosis– Resit 2-Infective endocarditis
and pericarditis• 2006
– Paper 1-Heart failure– Paper 2-Primary prevention
• 2007– Paper 1-Heart failure and
pericarditis– Paper 2-None
• 2010– Paper 1-None– Paper 2-Postural hypotension– Resit 1-Aortic stenosis– Resit 2-Infective endocarditis
• 2011– Mock-Heart failure– Paper 1-None– Paper 2-Infective endocarditis and heart
failure– Resit 1-Acute MI– Resit 2-Postural hypotension
• 2012– Paper 1-None– Paper 2-Unstable angina and postural
hypotension
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2012 Mock Paper
Unstable Angina
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MEQ 1.8• A 39 year old Asian man was admitted to the medical
admissions unit with pains in his chest and neck. He admitted to smoking 20 cigarettes per day and a blood cholesterol had been measured at 7.2mmol/L (reference range 3.5-5.0mmol/L). His average HR on admission was 90 bpm and his blood pressure was 170/100mmHg. An initial diagnosis of unstable angina was made.
(a) What are his risk factors for coronary artery disease? (2 marks)
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MEQ 1.8
• A 39 year old Asian man was admitted to the medical admissions unit with pains in his chest and neck. He admitted to smoking 20 cigarettes per day and a blood cholesterol had been measured at 7.2mmol/L (reference range 3.5-5.0mmol/L). His average HR on admission was 90 bpm and his blood pressure was 170/100mmHg. An initial diagnosis of unstable angina was made.
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Risk Factors for CVD
Unmodifiable Factors• Male• Increasing age• Asian decent• Post-menopause• Family History
Modifiable Risk Factors• Smoking• Hyperlipidaemia• Obesity (diet and exercise)• Diabetes• Hypertension• Stress
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(b) You decide to admit him to hospital. What drug therapy could he be
started on? List 4 potentially beneficial drugs (2 marks) and give a reason for prescribing each (2 marks).
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Immediate Treatment of NSTEMI and UA
• Anti-ischaemic therapy (decrease myocardial oxygen demand)– Nitrates (GTNIV), venodilation, decrease venous return– Beta-blockers, decrease sympathetic drive and so decrease
O2 demand• Anti-thrombotic therapy (prevent further development of
partially occluded thrombus)– Aspirin, prevents platelet aggregation and activation– Clopidogrel, alternative action on platelets. Can be used in
combitaion with or in place of aspirin– Heparin, usually LMWH, breaks down any clots
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• Results of blood tests revealed a Troponin T of 0.35ng/ml (normal=unrecordable), peak CK was 180iu/ml (reference range: 25-200iu/ml) on day 2
(c) List the 2 cardinal ECG features of an acute full thickness anterior
myocardial infarction and outline their electrophysiological cause (4 marks)
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The Easy Bit
http://en.wikipedia.org/wiki/File:12_Lead_EKG_ST_Elevation_tracing_color_coded.jpg
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The Hard Bit
Is it enough to answer with “It just does”?
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• ST Elevation– Changes in the action potentials produced by necrotic tissue– Abnormal firing of action potentials leads to early
repolarisation secondary to ischaemia, causing this abnormal wave
• Pathological Q Waves– Any initial downward movement of the QRS is a Q wave.– Pathological Q waves are Q waves developing after MI
which have a width of ≥ 1 small box and a depth > 25% of the total QRS height
– Develop from living tissue behind the infarct which is picked up by the ECG as a downward movement as impulses move away from the anterior leads
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Cardiac Enzymes
http://en.wikipedia.org/wiki/File:AMI_bloodtests_engl.png
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Discussion Points?
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2005 Paper 1
Left Ventricular Failure
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MEQ 1.2• A 78 year old man had a large anterior myocardial infarction
three years ago. Initially he made a good recovery, but has had to take a diuretic for ankle swelling since. In the last 2 months he has become short of breath on exertion. You suspect that he has developed left ventricular failure
(a) Give 2 additional symptoms that would support this diagnosis (2
marks)
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MEQ 1.2• A 78 year old man had a large anterior myocardial infarction
three years ago. Initially he made a good recovery, but has had to take a diuretic for ankle swelling since. In the last 2 months he has become short of breath on exertion. You suspect that he has developed left ventricular failure
(a) Give 2 additional symptoms that would support this diagnosis (2
marks)
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Left Heart Failure
• Exertional dyspnoea• Orthopnoea• Paraxysmal nocturnal
dyspnoea• Fatigue and weakness• Poor exercise tolerance• Cardiac wheeze• Nocturnal cough with frothy
pink sputum• Impaired urine output during
the day and nocturia at night• Impaired metal status• Cold peripheries
Right Heart Failure
• Peripheral oedema• Abdominal discomfort• Weight gain• Anorexia and nausea
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Left Heart Failure
• Exertional dyspnoea• Orthopnoea• Paraxysmal nocturnal
dyspnoea• Fatigue and weakness• Poor exercise tolerance• Cardiac wheeze• Nocturnal cough with frothy
pink sputum• Impaired urine output during
the day and nocturia at night• Impaired mental status• Cold peripheries
Right Heart Failure
• Peripheral oedema• Abdominal discomfort• Weight gain• Anorexia and nausea
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Left Heart Failure
• Cachexia• Cyanosis• Sweating• Tachopnoea
• Tachycardia• Pulses alternans• Bilateral basal crackles• Displaced apex beat• Extra heart sounds and
murmurs (depends on cause)
Right Heart Failure
• Cachexia• Oedema
• Increased JVP with positive hepatojugular reflex
• RV heave• Hepatomegaly• Ankle oedema• Sacral oedema• Ascities
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(b) You arrange for a chest X-ray. Give four features that would support
the diagnosis of left ventricular failure (4 marks)
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Adapted from http://www.e-radiography.net/technique/chest/chest_eval.htm
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Adapted from http://www.learningradiology.com/archives2007/COW%20267-Pulmonary%20edema-CHF/caseoftheweek267page.html
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Adapted from http://en.wikipedia.org/wiki/Kerley_lines
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Adapted from http://www.radiologysingapore.com/lectures/plain-films-with-diagnosis-6/
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(c) Give 2 neurohormonal mechanisms which may be
activated in heart failure (2 marks)
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4 Neurohormonal Mechanisms 1. Sympathetic Nervous System Activity
– Fall in CO detected by baroreceptors, sympathetic drive increases, ↑ HR and BP
2. RAAS– Decreasing renal perfusion activates RAAS which ↑ PVR (angiotensin II)
and blood volume (aldosterone) which both play a role in ↑ BP3. ADH
– Released in response to low BP and release of angiotensin II. ↑ blood volume and hence BP
4. Natriuretic Peptides– Both ANP and BNP. Both inhibit RAAS and so ↓ blood volume and BP.
Beneficial effect, but not released in sufficient enough quantities. BNP=prognostic marker
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These all have an effect on…?• Frank Starling Mechanism• Improved venous return improves LV contraction • Preload vs. afterload
And this combination leads to• Symptoms of LV HF• Hypertrophy
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(d) If starting this patient on an ACE inhibitor, what precautions would
you take? (3 marks)
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Side-effects
• First dose hypotension• Persistent cough• Hyperkalaemia• Renal impairment
• Headache• Dizziness• Fatigue• Nausea
Contra-indications and Cautions
• Hypersensitivity• Bilateral renal artery
stenosis• Pregnancy
• Impaired renal function• Aortic stenosis• Cardiac outflow obstruction• Hypovolaemia• Haemodialysis
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Other Precautions
• Check baseline BP (first dose hypotension) and Us+Es (hyperkalaemia, renal dysfunction)
• Start low, tritrate dose up• Continue to monitor Us+Es• Drug interactions
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Discussion Points?
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2011 Paper 2 (also 2005 Resit 1 and 2010 Paper 2)
Infective Endocarditis
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MEQ 2.6A 32 year old woman, who is a known alcoholic and abuser of intravenous drugs, presents to A+E complaining of gradual onset malaise, fever, weight loss and night sweats. She is pyrexial (38.5°). She has a pansystolic murmur which is thought to be a new finding and you suspect she has a diagnosis of infective endocarditis
(a) Name 4 additional clinical signs that may be found on examination in
this patient (2 marks)
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MEQ 2.6A 32 year old woman, who is a known alcoholic and abuser of intravenous drugs, presents to A+E complaining of gradual onset malaise, fever, weight loss and night sweats. She is pyrexial (38.5°). She has a pansystolic murmur which is thought to be a new finding and you suspect she has a diagnosis of infective endocarditis
(a) Name 4 additional clinical signs that may be found on examination in
this patient (2 marks)
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http://en.wikipedia.org/wiki/File:Acopaquia.jpg
http://en.wikipedia.org/wiki/File:Splinter_hemorrhage.jpg
http://en.wikipedia.org/wiki/File:Osler_Nodules_Hand.jpg
http://medicalpicturesinfo.com/janeway-lesion/
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Signs of Infective Endocarditis
• Hands– Splinter haemorrhages– Janeway lesions – Osler’s nodes– Clubbing
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Signs of Infective Endocarditis
• Hands– Splinter haemorrhages– Janeway lesions – Osler’s nodes– Clubbing
• Eyes– Roth Spots
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http://www.aao.org/theeyeshaveit/optic-fundus/roth-spot.cfm
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Signs of Infective Endocarditis• Hands
– Splinter haemorrhages– Janeway lesions – Osler’s nodes– Clubbing
• Eyes– Roth Spots
• Heart– New murmur– Signs of HF
• Others– Abscess– Splenomegaly– Petechia
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Agent Route
Strep. Viridans Dental procedures
Staph. aureus IVDU/Thoracotomy/Peripheral lines
Enterococci UTI
Candida Peripheral lines/catheters
Strep. Bovis Colorectal carcinoma
(b)Name the 2 most likely organisms likely to be implicated in infective endocarditis (2 marks)
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• Blood (microhaematuria)• Pathology
– Micro-emboli from vegetation on heart valve– Can block vessels in the glomerulus, causing
glomerularnephritis and ARF.– Micro-emboli cause other clinical signs
(c)Your FY2 asks you to dip the urine. What would you expect to find and what is the pathology behind this abnormality? (2 marks)
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(d) Name two investigations that are mandatory to confirm your diagnosis
(1 mark)
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• Blood Cultures– 3 sets– Different times– Different places
Major Criteria (x2)• Positive blood culture
– Typical organism in 2 separate cultures
– Persistently +’ve over time• Echo evidence of valvular
involvement• New valvular regurgitation
(murmur)
• Echo– Trans-oesophageal more
sensitive– >2mm for trans-thoracic
Minor Criteria (x5)• Risk factors • Fever• Vascular phenomenon• Immunological phenomenon• Positive blood cultures not
meeting requirement for major criteria
• Echo evidence not meeting requirement for major requirement
Dukes Criteria
1 Major + 3 Minor
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Environment favourable to Infection
• IVDU• Dental surgery• Thoracotomy• Catheterisation• Peripheral/central lines• Immunosuppression
Allow Implantations and Growth of Organism
• Prosthetic heart valve• Pre-existing valvular disease
– Rheumatic– Acquired– Congenital
(e)Other than IVDU, name 4 risk factors for this condition (2 marks)
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On further examination you can also hear the pansystolic murmur. This is loudest at the left sternal edge and you demonstrate the JVP is elevated with giant “v” waves. In addition she also has tender pulsatile hepatomegaly.
(f) What is the most likely cardiac lesion to be responsible for this, given
the above history and examination? (1 mark)
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On further examination you can also hear the pansystolic murmur. This is loudest at the left sternal edge and you demonstrate the JVP is elevated with giant “v” waves. In addition she also has tender pulsatile hepatomegaly.
(f) What is the most likely cardiac lesion to be responsible for this, given the
above history and examination? (1 mark)
Tricuspid Regurgitation
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Murmurs Systolic
• Loud• Radiate• Ejection Systolic
– Aortic Stenosis• Pansystolic
– Mitral Regurge
Diastolic• Quiet• Accentuated by
manoeuvres• Early-mid diastolic
– Aortic regurge• Late diastolic
– Mitral stenosis• Remember DARMS
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Discussion Points?
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Thank You!