Cardiovascular disease or cardiovascular diseases

refers to the class of diseases that involve the heart or blood vessels (arteries and veins). While the term technically refers to any disease that affects the cardiovascular system.

Most countries face high and increasing rates of cardiovascular disease. Each year, heart disease kills more peoples than cancer.

Types of cardiovascular diseases

Aneurysm Angina Atherosclerosis Cerebrovascular Accident (Stroke) Cerebrovascular disease Congestive Heart Failure Coronary Artery Disease

Aneurysm

An aneurysm (or aneurism) is a localized, blood-filled dilation (balloon-like bulge) of a blood vessel caused by disease or weakening of the vessel wall.

Aneurysms most commonly occur in arteries at the base of the brain and in the aorta (the main artery coming out of the heart, a so-called aortic aneurysm). As the size of an aneurysm increases, there is an increased risk of rupture, which can result in severe hemorrhage or other complications including sudden death.

Risks

Rupture and blood clotting are the risks involved with aneurysms. Rupture leads to drop in blood pressure, rapid heart rate, and lightheadedness. The risk of death is high except for rupture in the extremities.

Risk factors

Risk factors for an aneurysm are diabetes, obesity, hypertension, tobacco use, alcoholism, and copper deficiency.

Angina pectoris

commonly known as angina, is severe chest pain due to ischemia (a lack of blood and hence oxygen supply) of the heart muscle, generally due to obstruction or spasm of the coronary arteries (the heart's blood vessels). Coronary artery disease, the main cause of angina, is due to atherosclerosis of the cardiac arteries.

Symptoms

Most patients with angina complain of chest discomfort rather than actual pain: the discomfort is usually described as a pressure, heaviness, tightness, squeezing, burning, or choking sensation.

Angina is typically precipitated by exertion or emotional stress. It is exacerbated by having a full stomach and by cold temperatures. Pain may be accompanied by breathlessness, sweating and nausea in some cases. It usually lasts for about 3 to 5 minutes, and is relieved by rest or specific anti-angina medication. Chest pain lasting only a few seconds is normally not angina.

CauseMyocardial ischemia comes about when the myocardia (the heart muscles) receive insufficient blood and oxygen to function normally either because of increased oxygen demand by the myocardia or by decreased supply to the myocardia. This inadequate perfusion of blood and the resulting reduced delivery of oxygen and nutrients is directly correlated to blocked or narrowed blood vessels.

Risk FactorMajor risk factors for angina include cigarette smoking, diabetes, high cholesterol, high blood pressure, sedentary lifestyle and family history of premature heart disease.

A variant form of angina (Prinzmetal's angina) occurs in patients with normal coronary arteries or insignificant atherosclerosis. It is thought to be caused by spasms of the artery. It occurs more in younger women.

Subtypes

Stable angina

This refers to the more common understanding of angina related to myocardial ischemia. Typical presentations of stable angina is that of chest discomfort and associated symptoms precipitated by some activity (running, walking, etc) with minimal or non-existent symptoms at rest. Symptoms typically abate several minutes following cessation of precipitating activities and resume when activity resumes.

Unstable angina

Unstable angina (UA) is defined as angina pectoris that changes or worsens.

It has least one of three features:

1. it occurs at rest (or with minimal exertion), usually lasting >10 min

2. it is severe and of new onset (i.e., within the prior 4–6 weeks); and/or

3. it occurs with a crescendo pattern (i.e., distinctly more severe, prolonged, or frequent than previously).

Diagnosis

In angina patients who are momentarily not feeling any chest pain, an electrocardiogram (ECG) is typically normal, unless there have been other cardiac problems in the past. During periods of pain, depression or elevation of the ST segment may be observed.

Atherosclerosis

is a disease affecting arterial blood vessels. It is a chronic inflammatory response in the walls of arteries, in large part due to the accumulation of macrophage white blood cells and promoted by low density (especially small particle) lipoproteins (plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high density lipoproteins (HDL). It is commonly referred to as a "hardening" or "furring" of the arteries. It is caused by the formation of multiple plaques within the arteries.

Atherosclerosis eventually produces two main problems:

First, the atheromatous plaques eventually lead to plaque ruptures and clots inside the artery lumen over the ruptures.

The clots heal and usually shrink but leave behind stenosis (narrowing) of the artery, or worse, complete closure, and, therefore, an insufficient blood supply to the tissues and organ it feeds.

Second, if the compensating artery enlargement process is excessive, then a net aneurysm results.

Causes

Atherosclerosis develops from low-density lipoprotein molecules (LDL) becoming oxidized (ldl-ox) by free radicals, particularly oxygen free radicals (ROS). When oxidized LDL comes in contact with an artery wall, a series of reactions occurs to repair the damage to the artery wall caused by oxidized LDL. The LDL molecule is globular shaped with a hollow core for carrying cholesterol throughout the body.

The body's immune system responds to the damage to the artery wall caused by oxidized LDL by sending specialized white blood cells (macrophages and T-lymphocytes) to absorb the oxidized-LDL. Unfortunately, these white blood cells are not able to process the oxidized-LDL, and ultimately grow then rupture, depositing a greater amount of oxidized cholesterol into the artery wall. This triggers more white blood cells, continuing the cycle.

Eventually, the artery becomes inflamed. The cholesterol plaque causes the muscle cells to enlarge and form a hard cover over the affected area. This hard cover is what causes a narrowing of the artery, reduces the blood flow and increases blood pressure.

Risk Factors

Diabetes or Impaired glucose tolerance (IGT) Dyslipoproteinemia (unhealthy patterns of serum proteins carrying fats & cholesterol)

High serum concentration of low-density lipoprotein Low serum concentration of functioning high density lipoproteinTobacco smokingHigh blood pressure

Elevated serum C-reactive protein concentration

Advanced age Male sex Having close relatives who have had some complication of atherosclerosis (eg. coronary heart disease or stroke) Genetic abnormalities e.g. familial hypercholesterolemia

Heart failure (HF)

is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest

Common causes of heart failure include myocardial infarction and other forms of ischemic heart disease, hypertension, valvular heart disease and cardiomyopathy. Heart failure can cause a large variety of symptoms such as shortness of breath (typically worse when lying flat), coughing, ankle swelling and reduced exercise capacity. Heart failure is often undiagnosed due to a lack of a universally agreed definition and challenges in definitive diagnosis. Treatment commonly consist of lifestyle measures (such as decreased salt intake) and medications, and sometimes devices or even surgery.

Heart failure is a common, costly, disabling and deadly condition. In developing countries, around 2% of adults suffer from heart failure, but in those over the age of 65, this increases to 6—10%. Mostly due to costs of hospitalisation, it is associated with a high health expenditure; costs have been estimated to amount to 2% of the total budget of the National Health Service in the United Kingdom, and more than $35 billion in the United States.

Heart failure is a global term for the physiological state in which cardiac output is insufficient for the body's needs.

This may occur when the cardiac output is low (often termed "congestive heart failure").

There are several terms which are closely related to heart failure, and may be the cause of heart failure, but should not be confused with it:

Cardiac arrest, and asystole both refer to situations in which there is no cardiac output at all. Without urgent treatment, these result in sudden death.

Heart attack refers to a blockage in a coronary (heart) artery resulting in heart muscle damage.

Cardiomyopathy refers specifically to problems within the heart muscle, and these problems usually result in heart failure.

Ischemic cardiomyopathy implies that the cause of muscle damage is coronary artery disease. Dilated cardiomyopathy implies that the muscle damage has resulted in enlargement of the heart.

Hypertrophic cardiomyopathy involves enlargement and thickening of the heart muscle.

Causes:

A 19 year study of 13000 healthy adults in the United States found the following causes ranked by Population Attributable Risk score:

Ischaemic Heart Disease 62% Cigarette Smoking 16% Hypertension (high blood pressure)10% Obesity 8% Diabetes 3% Valvular Heart Disease 2% (much higher in older populations)

An Italian registry of over 6200 patients with heart failure showed the following underlying causes:

Ischaemic Heart Disease 40% Dilated Cardiomyopathy 32% Valvular Heart Disease 12% Hypertension 11% Other 5%

Rarer causes of heart failure include:

Viral Myocarditis (an infection of the heart muscle) Infiltrations of the muscle such as amyloidosis HIV cardiomyopathy (caused by Human Immunodeficiency Virus) Connective Tissue Diseases such as Systemic lupus erythematosus Abuse of drugs such as alcohol Pharmaceutical drugs such as chemotherapeutic agents. Arrhythmias

Obstructive Sleep Apnea a condition of sleep disordered breathing overlaps with obesity, hypertension and diabetes and is regarded as an independent cause of heart failure.

Myocardial infarction (MI or AMI for acute myocardial infarction)

commonly known as a heart attack, occurs when the blood supply to part of the heart is interrupted. This is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque, which is an unstable collection of lipids (like cholesterol) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and oxygen shortage, if left untreated for a sufficient period, can cause damage and/or death (infarction) of heart muscle tissue (myocardium).

Classical symptoms of acute myocardial infarction include sudden chest pain, shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety. Approximately one quarter of all myocardial infarctions are silent, without chest pain or other symptoms. A heart attack is a medical emergency, and people experiencing chest pain are advised to alert their emergency medical services, because prompt treatment is beneficial.

Myocardial infarction is a common presentation of ischemic heart disease. The WHO estimated that in 2002, 12.6 percent of deaths worldwide were from ischemic heart disease. Ischemic heart disease is the leading cause of death in developed countries.

Heart attacks are the leading cause of death for both men and women all over the world. Important risk factors are previous cardiovascular disease (such as angina, a previous heart attack or stroke), older age (especially men over 40 and women over 50), tobacco smoking, high blood levels of certain lipids (triglycerides, low-density lipoprotein or "bad cholesterol") and low high density lipoprotein (HDL, "good cholesterol"), diabetes, high blood pressure, obesity, chronic kidney disease, heart failure, excessive alcohol consumption, the abuse of certain drugs (such as cocaine), and chronic high stress levels.

Immediate treatment for suspected acute myocardial infarction includes oxygen, aspirin, and sublingual glyceryl trinitrate (colloquially referred to as nitroglycerin and abbreviated as NTG or GTN). Pain relief is also often given, classically morphine sulfate.

Stroke

A stroke is the rapidly developing loss of brain functions due to a disturbance in the blood vessels supplying blood to the brain. This can be due to ischemia (lack of blood supply) caused by thrombosis or embolism or due to a hemorrhage. As a result, the affected area of the brain is unable to function, leading to inability to move one or more limbs on one side of the body, inability to understand or formulate speech or inability to see one side of the visual field.

CT scan showing an intracerebral hemorrhage.

Hemorrhagic stroke

A stroke is a medical emergency and can cause permanent neurological damage, complications and death. It is the leading cause of adult disability in the United States and Europe. In the UK, it is the second most common cause of death, the first being heart attacks and third being cancer.

It is the number two cause of death worldwide and may soon become the leading cause of death worldwide.

Risk factors for stroke include advanced age, hypertension (high blood pressure), previous stroke or transient ischemic attack (TIA), diabetes, high cholesterol, cigarette smoking and atrial fibrillation. High blood pressure is the most important modifiable risk factor of stroke.

Cardiac hypertrophy is a thickening of the heart muscle (myocardium) which results in a decrease in size of the chamber of the heart, including the left and right ventricles. A common cause of cardiac hypertrophy is high blood pressure (hypertension) and heart valve stenosis.

Atrial fibrillation (AF or afib) is a cardiac arrhythmia (abnormal heart rhythm) that involves the two upper chambers (atria) of the heart. It can often be identified by taking a pulse and observing that the heartbeats don't occur at regular intervals, but a conclusive indication of AF is the absence of P waves on an electrocardiogram (ECG).

AF is the most common arrhythmia; risk increases with age, with 8% of people over 80 having AF. In AF, the normal electrical impulses that are generated by the sinoatrial node are overwhelmed by disorganized electrical impulses that originate in the atria and pulmonary veins, leading to conduction of irregular impulses to the ventricles that generate the heartbeat. The result is an irregular heartbeat which may occur in episodes lasting from minutes to weeks, or it could occur all the time for years.

Atrial fibrillation is often asymptomatic, and is not in itself generally life-threatening, but may result in palpitations, fainting, chest pain, or congestive heart failure. Patients with AF usually have a significantly increased risk of stroke (up to 7 times that of the general population).

Conduction

Sinus rhythm

Atrial fibrillation

In atrial fibrillation, the regular impulses produced by the sinus node to provide rhythmic contraction of the heart are overwhelmed by the rapid randomly generated electrical discharges produced by larger areas of atrial tissue, often localized to the pulmonary veins.