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  • Case study II: Nanotech Roadmap in Japan

    Gaku Ichihara, M.D.,Ph.D.Tokyo University of Science

    Technical Workshop for the Asia-Pacific Region on Nanotechnology and Manufactured Nanomaterials: Safety

    Issues 10&11 September 2012 Bangkok, Thailand1

  • From Wikipedia

    The concepts that seeded nanotechnology were first discussed in 1959 by renowned physicist Richard Feynmanin his talk There's Plenty of Room at the Bottom, in which he described the possibility of synthesis via direct manipulation of atoms.

    The term "nano-technology" was first used by Norio Taniguchi in 1974, though it was not widely known.

    History of Nanotechnology

    2

    Prof. Norio Taniguichi(1912 1999)Tokyo University of Science

    https://en.wikipedia.org/wiki/Richard_Feynmanhttps://en.wikipedia.org/wiki/There's_Plenty_of_Room_at_the_Bottomhttps://en.wikipedia.org/wiki/Norio_Taniguchi

  • (May 27, 1912 November 15, 1999) was a professor of Tokyo University of Science.

    He coined the term nano-technology in 1974to describe semiconductor processes such as thin film deposition and ion beam milling exhibiting characteristic control on the order of a nanometer: "Nano-technology' mainly consists of the processing of separation, consolidation, and deformation of materials by one atom or one molecule."

    Prof. Norio Taniguchi

    3

    https://en.wikipedia.org/wiki/Tokyo_University_of_Sciencehttps://en.wikipedia.org/wiki/Nanotechnology

  • 4

  • 5

  • Science and

    Technology Basic Law

    FY1995 FY1996-2000 FY2001-2005 FY2006-2010

    1st S&TBasic Plan

    2nd S&TBasic Plan

    3rd S&TBasic Plan

    Formulation of a New Research System

    Featuresof the Policy

    Japan, the Innovator

    17.6 Trillion Yen(Results)

    21.1 Trillion Yen(Results)

    25 Trillion Yen(Etimated)

    4 Prioritized Promotion FieldsLife ScienceInformation & CommunicationEnvironmentNanotechnology & Materials

    * Council for Science and Technology Policy

    Strategic Promotion for Innovation

    FY2011-2015

    4th S&TBasic Plan

    CSTP* started25 Trillion Yen(Planned)

    Science and Technology Plans of Japan

    6

  • 4th Science and Technology Basic Plan

    Recovery and rebirth from the disaster

    Green innovation

    Life innovation

    Nanotech & Materials R&D as key technologies

  • Structural materials for safer social infrastructureUltra-high-strength bolts

    Weathering steels(atmospheric corrosion resistant)

    Welding technologies & materials

    Double-walled welding wireAr-MIG welding

    Inner (Inconel)

    Outer hoop(Steel)

    0.6m

    m

    1.2m

    m

    Materials R&D forRecovery and Rebirth from the Disaster

  • Energy saving white LED illumination

    Diamond LED Atom transistor

    SiAlON phosphors

    Materials R&D forGreen Innovation

    Energy saving devices for high-level information society

  • heating

    Collagen Structures: high biocompatibility

    Materials R&D forLife Innovation

    Scaffolds for Regenerative Medicine

    Shape Memory Materials with Biodegradability

  • Hybrid / Electric Vehicle

    Magnet withoutrare earth element (Dy)

    Ferrite magnet

    EFTEM Nd mapNeodymium magnet

    Materials R&D forCritical Materials Issues

  • 12

  • Nanotechnology Platform: Member Institutes

    13

  • 15

    Core Members of TIA-nano

    AIST NIMSUniversity ofTsukuba KEK

    KeidanrenJapan Business Federation)

  • University of Tsukuba

    AIST

    AIST

    NIMS

    NIMS

    AIST

    NIMS

    AIST NIMS KEKUniversity of Tsukuba

    KEK

    Location of members at Tsukuba-city

    16

  • IntellectualProperty

    WG

    Net w

    orking School WG

    Under O

    ne Roof W

    G

    Nano-E

    lectronics WG

    Power E

    lectronics WG

    Carbon

    Nanotube

    Nano-

    Material Safety W

    G

    Nano-G

    reen WG

    N-M

    EM

    S WG

    Organization of TIA-nanoExecutive BoardChairman:Teruo Kishi

    Steering BoardChairman:

    Michiharu NakamuraUniversity of Tsukuba

    NIMS,AIST,KEK,Industry

    AdviserProf. Nishi: Stanford Univ

    Prof.Hirayama: NY state UnivSecretariat

    Secretary-General:Hiroshi Iwata

    University of TsukubaNIMS,AIST,

    KEK,Keidanren

    InspectorProf. Takayanagi: Tokyo

    University of Science

    ObserverCabinet Office

    MEXTMETI

    Innovation CoordinatorAIST(Dr.Akimune)

    NIMS(Dr.Watanabe)U.Tsukuba(Dr.Niwa)

    KEK(Dr.Ikeda)

    IndustryB

    oard

    Director-G

    eneralB

    oard

    Research

    Director

    Board

    temporary

    17

  • Integrative data center and research frame for nano-material safety

    Integrated R&D frame from SiC wafer, device to power system

    R&D framework for green innovation driven by nanotechnology

    Backend device New materialAdvanced lithographyEUVL

    6 Core Research Domains

    Nano CMOSSilicon-photonicsCarbon-electronicsSpintronics

    Nanoelectronics Power Electronics

    N-MEMS Nano-Green

    Carbon Nanotubes Nano-Material Safety

    High-value-added niche MEMS and mass production integrated N-MEMS

    R&D framework of CNT mass production and CNT composites for wide applications

    3 Core Infra-

    structure

    Nanodevice Research Foundry

    Nanotech Open User Facilities

    Networking School of Nanotechnology

    Promoting verification of integrated CMOS devicesPromoting industrialization of advanced SiC power devicesPromoting commercialization of new technology for N-MEMS devices based on needs and seeds

    Open user research facilities in AIST and NIMS (nanocharacterization,

    nanoprocessing,etc.)

    Function of next generation human resource development through All-Japan university

    confederation headed by the University of Tsukuba

    Core Research Domains Core Infrastructures

    18

  • 19

  • The Japan Agency for Medical Research and Development (AMED) engages in research and development in the field of medicine, establishing and maintaining an environment for this R&D, and providing funding,

    in order to promote integrated medical R&D from basic research to practical applications,

    to smoothly achieve application of outcomes, and to achieve comprehensive and effective

    establishment / maintenance of an environment for medical R&D.

    What is AMED?

    20

  • Providing a one-stop service for research expenses, AMED consolidates budgets for research expenses, which had previously been allocated from different sources -- the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labour and Welfare, and the Ministry of Economy, Trade and Industry.

    In addition to making possible an integrated approach to providing research funding and establishing / maintaining research environments, the unification of points of contact and procedures for research expenses can be expected to reduce the administrative burden on institutions and researchers receiving allocations for research expenses.

    Role of AMED

    21

  • AMED aims to achieve the world's highest level of medical care / service

    and to form a society in which people live long, healthy lives by promoting integrated research and development, from basic research to practical application,

    and by establishing and maintaining an environment therefor, and linking this to various forms of growth in medical R&D.

    Aim of AMED

    22

  • Department of Research PromotionDivision of Drug ResearchDivision of Regenerative Medicine ResearchDivision of Cancer ResearchDivision of Neurological, Psychiatric and Brain ResearchDivision of Rare / Intractable Disease ResearchDivision of Infectious Disease ResearchDivision of Emerging Research

    Department of Industrial-Academic CollaborationDivision of Medical Device ResearchDivision of Industrial-Academic Collaboration

    Departments of AMED

    23

  • Department of International AffairsDivision of International Collaboration

    Department of Research InfrastructureDivision of Research Infrastructure

    Department of Clinical Research and TrialsDivision of Clinical Research and TrialsOffice of Regulatory Science and Clinical Research Support

    Department of Innovative Drug Discovery and Development

    Departments of AMED

    24

  • List o Programs

    Strategic Research Program for Brain Sciences (SRPBS) / Brain Mapping by Integrated Neurotechonologies for Disease Studies (Brain/MINDS)

    Comprehensive Research on Aging and Health

    Science Research Grants for Dementia R&D

    Health and Labour Sciences Research Grants for Comprehensive Research on Persons with Disabilities

    Division of Neurological, Psychiatric and Brain Research in AMED

    25

  • females: 86.61 yearsmales: 80.21 years

    Average Life Span

    26

  • Estimated prevalence of cognitive disorders (dementia) is 15% (N=4,260,000) of Japanese of 65 years old and over.

    Estimated prevalence of Mild cognitive impairment (MCI) is 13%(N=3,800,000) of Japanese of 65 years old and over.

    In total, 28% of Japanese of 65years old and over suffer from cognitive disorders or MCI.

    Alzheimer Disease and other cognitive disorders

    27

  • Cognitive disorders increase

    280

    500

    1000

    1500

    2000

    2500

    3000

    3500

    1990 1995 2000 2005 2010 2015 2020 20