cell communication - mt. sac 4/biology 4 extra cre… · extra- cellular fluid signaling molecule...

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Page 1: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Cell Communication

Page 2: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Direct

Contact

Page 3: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Local

Signaling

Paracrine Signaling

Synaptic

Page 4: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Distant Signaling

Hormonal

Page 5: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Signal Transduction Pathway

Reception

Transduction

Response

Page 6: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Stages of Intracellular Signaling

Reception

G-Protein-Coupled

receptors

Page 7: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Stages of Intracellular Signaling

Reception

Receptor Tyrosine

Kinases

Page 8: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Stages of Intracellular Signaling

Reception

Ligand-Gated Ion

Channels

Page 9: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Stages of Intracellular Signaling

Reception

Intracellular Receptors

Page 10: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Stages of Intracellular Signaling

TransductionProtein

Phosphorylation

Cascade

Page 11: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Stages of Intracellular Signaling

TransductionSmall Molecules

as Second

Messengers

Page 12: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Stages of Intracellular Signaling

TransductionCalcium Ions

and Inositol

Trisphophate

(IP3)

Page 13: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Cellular Response

Amplification

Page 14: Cell Communication - Mt. SAC 4/Biology 4 Extra Cre… · EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein DAG Phospholipase C (second essenger) G protein-coupled

Cellular Response

Specificity

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