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TRANSCRIPT
Cell Signaling Technology
© 2003–2018 Cell Signaling Technology, Inc.
www.cellsignal.com
Direct Stimulatory Modification
Direct Inhibitory Modification
Multistep Stimulatory Modification
Multistep Inhibitory Modification
Tentative Stimulatory Modification
Tentative Inhibitory Modification
Transcriptional Inhibitory Modification
Pathway Diagram Key
Angiogenesis
VHL
Cul2Rbx1TCEB2
TCEB1
PHDs
elF4E1 4E-BP1
Erk1/2
Erk1/2
MNK
MEK1/2 Ras
S6K
mTOR
Akt PI3K
CBP/p300
HIF1α
HIF1α
HIF1β
HIF1β
HIF1α
PI3K Src
NOSAkt
FAK PLCλ
Erk1/2
Smad2/3p38 MAPK
HIF1α
HIF1α
Matrix RemodelingPAI-1
MMPCox2
OH
OH
OH
Normoxia
Nucleus
VEGFR2
VEGF
Tie2FGFR IGFR
EGFR
PDGFR-β
PDGF-BB
ROBO
SLIT
Notch
E3 Ligase Complex
Degradation
• Growth Factors• Cytokines• ECM Proteases
ExtracellularMatrix
Endothelial Cell
Pericyte
Normoxia
NormoxiaHypoxia
Angiogenesis
Blood Vessel
VascularGuidance
Cell Fate
VascularPermeability
Survival Migration ProliferationPericyteProliferation
Target GenesHRE
Basement Membrane
Cytoplasm
Pro-Angiogenic Cell
Extracellular S
pace
rev. 08/24/18rev. 08/24/18