cellular response to dna damage
DESCRIPTION
Cellular response to DNA damage. Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal of DNA damage Enzymatic photoreactivation - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Cellular response to DNA damage](https://reader035.vdocuments.net/reader035/viewer/2022062721/5681360a550346895d9d8144/html5/thumbnails/1.jpg)
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Cellular response to DNA damage
Reponse Mechanisms
Tolerance of DNA damage Replicative bypass of template damage
Translesion DNA synthesis
Reversal of DNA damage Enzymatic photoreactivation
Repair of O6-alkylguanine, O4-
alkyltimidine
Ligation of DNA strand breaks
Excision of DNA damage Base Excision Repair
Nucleotide Excision Repair
Mismatch Repair
Double strand breaks ligation Single strand annealing
Recombinational Repair
Non-Homologous End Joining
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La radiazione Solare può essere distinta in 3 componenti principali a seconda della lunghezza d’onda:ULTRAVIOLETTO (100-400 nanometri) 10%VISIBILE ( 400-750nm.) 45%INFRAROSSO (750-3000nm.) 45%
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UV-induced damage
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UV-responsive photolyases
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Direct reversal (de-alkylating proteins)
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Base Excision Repair
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Nucleotide Excision Repair
(E.coli)
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Nucleotide Excision Repair (Global Genome Repair -Humans)
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Nucleotide Excision Repair(Transcription Coupled -Humans)
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Common features of GGR & TCR
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