rence of late relapses, raises the question of whether the malignant clone is ever truly eradicated in CML.

To date, the combined results available from PCR analysis suggests that it is possible to lose the malignant clone in the bone marrow after BMT, although the time taken to achieve this is variable and csn be many years. Examination of the peripheral blood is likely to be less sensitive than analysis of the bone marrow and may be- come negative soonen. A proportion of patients remain positive on PCR analysis several years after BMT and the long term outlook of these patients is uncertain at present. ~ospective trials are needed to determine whether relapse rates correlate with PCR status. The percentage of patients which remains positive after T- cell depleted BMT is higher than after non T-depleted BMT and probably reflects their higher relapse rate.

GJ Morgan (1) Institute of Cancer Research

London SW3 6JB, UK

The neu~~p~e c~~~~~n (CCK). Anatomy and biochemistry, receptors, pharmacology and pbysiofo- gy. J Hughes, G Dockray, G Woodruff. BlBs Horwood Ltd, Chichester, 1989.

“It now seems probable that CCK acts simultaneously as a gut hormone concerned with the regulation of small intestinal digestion and as a central neuropeptide” is the conclusion reached by the editors of this book in their introduction. The book provides a wide view of the fun- damental research that is rapidly advancing the knowl- edge of c~lecysto~nin, one of the most abundant brain neu~p~tides. It is written by a panel of ~temational ~v~tiga~~, who met in C~b~dge in late 1988, be- tween them con~but~g 36 chapters to the work. The first section deals with the distribution and ontology of CCK and its receptors, then follows the synthesis of CCK and descriptions of novel ligands for CCK recep- tors. The last section describes the action of CCK at the cellular level. Many biochemical and physiological techniques have been used in the study of the neuropep- tides; this book illustrates many of these approaches. CCK is of great interest to both academics and the phar- maceutical industry. This book is a source of informa- tion that will be of value to specialist neurochemists and neu~pha~acologists as wefl as to biomedical scientists. It not only traces recent progress in the study of CCK, but also can p~vide many hints and clues to stimulate other ~vestigators working on the action and control of neuropeptides.

MokuIar and ceWar action of abused drngs

The molecular and cellular actions of 3 classes of abused drugs, opiates, pschostimulants, and ethanol, are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are com- pared to those observed after long term exposure. A neu- robiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.

GFKoob (2) rnslimte of Cripps Clink La Jolla, CA32037, USA

(1) Luncer (1989) i, 928 (2) Science (1988) 242,715

Adalnt in the Asian Pacific region. DT Kelly. Springer- verlag, Be&& i990.

This hook deals with the symposium heId in Jakarta on calcium antagonist therapy which was sponsored by Bayer AC on the calcium antagonist drug nifedipine. This drug is used extensively in the Asian Pacific area for the treatment of hypertension, a common disease in this region, aud also for ischaemic heart disease. The book details both basic pharmacology and research stu- dies in the Asian Pacific region in the field of hyper- tension and ischaemic heart disease and, as such, is of considerable interest to c~iolog~ts in the region.

Cellular vnriation and adapt&ion in cancer. Biological basis and therapeutic consequences. M Woodruff Oxford University Press, UK, 1990

In recent years our understandmg of cancer biology has increased dramatically. There have also been major ad- vances in the treatment of some forms of cancer, but not of others. Many failures are due to the earIy dis- semination of cancer, and this realization prompted the introduction of adjuvant chemotherapy. Although this form of treatment has proved to be of value in some categories of patient, the early high hopes have not heen ful~1~. The author a~ibut~ this largely to the heter- ogeneity of cancer cells and their cap~i~ to diversify. It is difficult for clinicians to ~ders~d the revolution that is taking place in biology, and difficult for biolo- gists to appreciate how cancer is perceived by clinici- ans. Each group needs a user-friendly interface with the other’s field, and this book, addressed to both clinicians and biologists, attempts to meet these needs.