http://www.ukm.my/farmasi

Inspiring Future, Nurturing Posibilities

Advancing Pharmacy for Health

The National Universityof Malaysia

CENTRE FOR DRUG DELIVERY RESEARCH

Faculty of Pharmacy

ABOUT US

The focus of the Centre For Drug Delivery Research is utilising rational strategies in the study and development of contemporary and advanced drug delivery system or dosage form design. These

include acquiring knowledge of the physiochemical properties of traditional and biotechnological based drug moieties as well as understanding the mechanisms of cellular uptake and transport across biological membranes. The Centre’s particular strength include research and development in nanoparticulate delivery systems, advanced topical and transdermal dosage forms, and the use of polymers, both synthetic and natural, in designing better and improved delivery systems.

VISIONTo lead and innovate in drug delivery and novel targeting research with a strong emphasis on the rational approach to drug design

MISSION To foster interdisciplinary research within a positive collaborative environment in the areas of drug delivery and novel targeting utilising expertise in formulation science and advanced technology.

KEY RESEARCH AREAS:

TOPICAL AND TRANSDERMAL DELIVERY• The design and development of topical and transdermal formulations, ranging from

the conventional such as creams, ointments and gels to novel systems, including lyophilised hydrogels, particulate delivery systems and polymers.

SOLID DOSAGE FORMS• Tablet formulation including immediate-release, sustained-release and controlled-

release systems. In addition a number of formulation methods employ natural and synthetic materials in order to achieve desirable drug release profiles.

PROTEIN AND GENE DELIVERY• The development of nanoparticles and delivery systems based on biodegradable polymers, i.e.

chitosan and nata de coco to deliver proteins e.g. insulin and siRNA.

INJECTIONS, VACCINES AND STERILE PREPARATIONS• The formulation of palm oil based nanoemulsions for injections and parenteral nutrition

preparations. • Formulation of poultry vaccine using palm oil nanoemulsion as adjuvant.

TARGETED DRUG DELIVERY• Synthesising a series of co-polymers which are insoluble in the fluids of the upper GIT but which

are likely to be metabolised by bacterial enzymes or the low redox potential within the colon.

POLYMER SYNTHESIS AND APPLICATIONS FOR DRUG DELIVERY• Bacterial cellulose derived gel systems. • Novel co-polymer systems for drug delivery.

DR. HALIZA KATAS (Head)Associate ProfessorExpertise : pharmaceutics, drug delivery systems, gene delivery systems, biodegradable polymeric nanoparticles, proteins/ peptides, dna/sirna/dsirna, chitosan and derivatives, transdermal delivery, colonic deliverye-Mail : haliza.katas@ukm.edu.my

DR. NG SHIOW FERNAssociate ProfessorExpertise : Preformulation studies, physical and chemical characterizations of drug delivery systems, in vitro and in vivo testings of topical and transdermal formulations, films and freeze-dried polymeric systems for drug delivery, formulation of mucosal (wounds) drug delivery systemse-Mail : nsfern@ukm.edu.my

DR. FAZREN AZMILecturerExpertise : Vaccine & antibacterial agents development, peptide chemistry, lipid, nanoparticles, adjuvant, chemical conjugation, vaccine evaluation, antimicrobial testinge-Mail : fazren.azmi@ukm.edu.my

DR. MOHD CAIRUL IQBAL MOHD AMINProfessorExpertise : Novel drug delivery, dosage form design, hydrogel, pharmaceutical sciencese-Mail : mciamin@ukm.edu.my

DR. MOHD HANIF ZULFAKAR Senior LecturerExpertise : Topical dosage form design and delivery, oils and fatty acids in drug delivery e-Mail : hanifzulfakar@ukm.edu.my

RESEARCHERS

The Centre is proud to boast a number of researchers from various background and experience in the discipline of pharmaceutics and has achieved excellent rating

for research performance for many years in a row, exemplified by the reputation and stature of the researchers, the amount of research grants and the high number of quality publications produced consistently each year. Several ideas from the researchers have also been successfully patented and have high potential for commercialisation.

Contact UsCentre for Drug Delivery Research

Faculty of Pharmacy Universiti Kebangsaan Malaysia

Jalan Raja Muda Abdul Aziz50300 Kuala Lumpur, Malaysia

Tel : (+60)03-928977971Fax : (+60)03-26983271

Website: http://www.ukm.my/farmasi

RESEARCH FACILITIES

• Good Preparation Practice (GPP)-certified clean room complex.• Particle size analysis laboratory• Pharmaceutical manufacturing laboratory• Pharmaceutical research laboratory• Transdermal and parenteral research laboratory

SELECTED LABORATORY EQUIPMENT

• Malvern Zetasizer• Malvern Mastersizer• Permagear Franz Diffusion cells• Instron Universal Testing machine• Brookfield texture analyser• Microfluidizer• Rotary tablet machine• High pressure homogenizer