centre for drug design and discovery · 2010-01-08 · centre for drug design and discovery is the...
TRANSCRIPT
CENTRE FOR DRUG DESIGN AND DISCOVERY
is the investment fund
and technology transfer
platform for early phase
innovative drug discovery
and target validation!
MISSION CD3 STRATEGY
TargetIdentifi-cation
TargetValidation
AssayDevelop-ment
ScreeningHit identi-fication
Hit-to-Lead
LeadOptimiza-tion
Pre-clinicalstudies
Clinicalstudies
CD3 CLOSES THE GAP BETWEEN “ACADEMIC” BIOMEDICAL RESEARCH AND INDUSTRY
UNIVERSITIES – RESEARCH INSTITUTES – SMALL BIOTECHS
CD3
• new targets• new approaches and insights• biology expertise• biological assays (transfer)• support in hit-to-lead process• mechanism-of-action studies• in vivo POC
• assay optimisation and HTS• high quality compound libraries• in silico drug design & screening• pharma medicinal chemistry• preliminary ADME-Tox• in vivo POC• project coordination and follow-up• IP support • … everything missing to reach goals
PHARMA – BIOTECHINDUSTRY
• final lead optimisation• pre-clinical development• clinical development• project planning• production• commercialisation• marketing
1. “Screening projects”start = specific target or innovation
2. “Rational design projects”start = target with structural information
3. “Development or Hit-to-Lead projects”start = hit compounds
Exceptionally4. “Target identification or validation projects”start = non-drug like compound or non-validated target
FOUR TYPES OF PROJECTS WITH
DIFFERENT STARTING POINTS
SELECTION PROCESS
WITH INVESTMENT
COMMITTEE &
SCIENTIFIC ADVISORY
BOARD
www.lrd.kuleuven.be/CD3
Number
of
projectsCD3 team
SAB
IC
PARTNERS
CONTACT Centre for Drug Design and Discovery, CD3Minderbroedersstraat 12, B-3000 Leuven, BE
Tel +32-16-32 65 [email protected]
“Stimulating and optimizing the transformation of
innovative European academic
research results into small
molecule drugs”
“Supplement innovative
biomedical research witheverything lacking for
professional small molecule
drug discovery in order to
develop drug lead compoundswith in vivo POC”
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