cerebrovascular accident. classification complete stroke complete stroke t.i.a t.i.a r.i.n.d r.i.n.d...
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CEREBROVASCULAR CEREBROVASCULAR ACCIDENTACCIDENT
CLASSIFICATIONCLASSIFICATION
Complete strokeComplete stroke T.I.AT.I.A R.I.N.DR.I.N.D Stroke in evolutionStroke in evolution
Acute neurological injury which occursAcute neurological injury which occurs as a as a result of ;result of ;
1—Embolism1—Embolism 2---Thrombosis2---Thrombosis 3---Haemorrhage3---Haemorrhage 4---Demyelation4---Demyelation 5---SOL { Space occupying lesion}5---SOL { Space occupying lesion}
RISK FACTORSRISK FACTORS
Age—advanced ageAge—advanced age Sex—males more than femalesSex—males more than females HypertensionHypertension DMDM HyperlipidemiaHyperlipidemia SmokingSmoking Excess alcohol consumptionExcess alcohol consumption PolycythemiaPolycythemia
O.C. pillsO.C. pills VasculitisVasculitis ThrombophilliaThrombophillia Anticardiolipin antibodyAnticardiolipin antibody HomocysteinureaHomocysteinurea
MANAGEMENTMANAGEMENT
HISTORYHISTORY
May be helpfulMay be helpfulHeadache + vomiting ---favour the Dx of IC hge Headache + vomiting ---favour the Dx of IC hge
or SAH or SAH
Abrupt onset of impaired cerebral function Abrupt onset of impaired cerebral function without focal symptoms suggest SAHwithout focal symptoms suggest SAH
EXAMINATIONEXAMINATION BPBP BreathingBreathing Fever----meningitisFever----meningitis subdural haematomasubdural haematoma brain abcessbrain abcess infective endocarditisinfective endocarditis Neck---for bruitsNeck---for bruits Pulses----in neck and armsPulses----in neck and arms
CVS---valvular heart disease ,AFCVS---valvular heart disease ,AF Skin---signs of cholesterol Skin---signs of cholesterol
embolism+IEembolism+IE FundusFundus
INVESTIGATIONSINVESTIGATIONS
CBC , ESRCBC , ESR U+E, RBSU+E, RBS LFT, PT, PTTLFT, PT, PTT CT scan brain or MRICT scan brain or MRI Doppler U.S of carotidsDoppler U.S of carotids EchoEcho Hypercoagguable screenHypercoagguable screen Screen for connective tissue diseaseScreen for connective tissue disease Toxicology screenToxicology screen
D/DD/D--Migraine--Migraine--Head trauma--Head trauma--Brain tumour--Brain tumour--Systemic infections--Systemic infections--Toxic metabolic disturbance--Toxic metabolic disturbance hypoglycemiahypoglycemia acute renal+ hepatic failureacute renal+ hepatic failure drug intoxicationdrug intoxicationTodd,s paralysisTodd,s paralysis
HAEMORRHAGEHAEMORRHAGEIntracranial hge can be caused by—Intracranial hge can be caused by— Intracerebral hge {ICHIntracerebral hge {ICH} } also called parenchymal hge which also called parenchymal hge which
involves bleeding directly into brain tissue.involves bleeding directly into brain tissue. SAHSAH involves bleeding into the CSF that involves bleeding into the CSF that
surrounds the brain and the spinal cordsurrounds the brain and the spinal cord TraumaTrauma causing subdural or extradural causing subdural or extradural
haematomashaematomas
COMMONCOMMON CAUSESCAUSES HypertensionHypertension TraumaTrauma Bleeding diathesis Bleeding diathesis Amyloid angiopathyAmyloid angiopathy Illicit drug abuse {amphetamine , Illicit drug abuse {amphetamine ,
cocaine}cocaine} Vascular malformationVascular malformation Rupture of aneurysm Rupture of aneurysm VasculitisVasculitis
SUBARACHANOID HAEMORRHAGESUBARACHANOID HAEMORRHAGE
1--Bleeding from aneurysm typically located 1--Bleeding from aneurysm typically located in the anterior half of circle of willis at in the anterior half of circle of willis at the base of the brain.the base of the brain.
2—22—2ndnd commonest causes commonest causes
A/V malformationA/V malformation
bleeding diathesisbleeding diathesis
drugsdrugs
amyloid angiopathyamyloid angiopathy
COMPLICATION OF SAH DUE TOCOMPLICATION OF SAH DUE TO ANEURYSMANEURYSM
Rebleeding within 10 daysRebleeding within 10 days VasospasmVasospasm Systemic complicationsSystemic complications --hyponatremia--hyponatremia --MI--MI --CNS disturbance--CNS disturbance
TREATMENTTREATMENT Identify causeIdentify cause Prevent rebleedingPrevent rebleeding Prevent brain damage due to Prevent brain damage due to
delayed ischaemia related to delayed ischaemia related to vasoconstrictionof IC arteriesvasoconstrictionof IC arteries
--surgical removal--surgical removal --Calcium channel blocker ---Calcium channel blocker -
NimodipineNimodipine
PROGNOSISPROGNOSIS SAH from intra cranial aneurysm has a SAH from intra cranial aneurysm has a
mortality of 50%mortality of 50% Prognosis is closely related to pts Prognosis is closely related to pts
neurological condition on hospital arrivalneurological condition on hospital arrival Pts who are alert and have no major focal Pts who are alert and have no major focal
defecit have a 70-80% chances of survivaldefecit have a 70-80% chances of survival Those who are comatosed have Those who are comatosed have
90%mortality90%mortality
PROGNOSISPROGNOSIS SAH from intra cranial aneurysm has a SAH from intra cranial aneurysm has a
mortality of 50%mortality of 50% Prognosis is closely related to pts Prognosis is closely related to pts
neurological condition on hospital arrivalneurological condition on hospital arrival Pts who are alert and have no major focal Pts who are alert and have no major focal
defecit have a 70-80% chances of survivaldefecit have a 70-80% chances of survival Those who are comatosed have Those who are comatosed have
90%mortality90%mortality
INTRACERBRAL HAOMORRHAGEINTRACERBRAL HAOMORRHAGEStrongly associated with hypertensionStrongly associated with hypertensionHypertension leads to fibrinoid necrosis of arterioles Hypertension leads to fibrinoid necrosis of arterioles ++Long standing hypertension leads to hyaline changes Long standing hypertension leads to hyaline changes
in the muscular and elastic arterial layer-----leads in the muscular and elastic arterial layer-----leads to microaneurysim-----liable to ruptureto microaneurysim-----liable to rupture
Middle cerbral artery and the lenticular branches are Middle cerbral artery and the lenticular branches are prone to develop these aneurysmsprone to develop these aneurysms
Majority of ICH occur in the region of the internal Majority of ICH occur in the region of the internal capsulecapsule
FIVE COMMON AREAS OF FIVE COMMON AREAS OF HAEMORRHAGEHAEMORRHAGE
PutamenPutamen White matter or lobeWhite matter or lobe ThalamousThalamous PonsPons CerebellumCerebellum
ICH usually presents abruptly when ICH usually presents abruptly when the pt. is awakethe pt. is awake
Severe headacheSevere headache ½ of pts. Present with LOC and fits½ of pts. Present with LOC and fits Since internal capsule is involved so Since internal capsule is involved so
there is hemiplegiathere is hemiplegia Massive bleeding---increase Massive bleeding---increase
intracranial pressure---intracranial pressure---papilloedema----deep comapapilloedema----deep coma
GENERAL RULEGENERAL RULE If the bleeding is greater than 80 mls If the bleeding is greater than 80 mls
as estimated by CT scan, and is as estimated by CT scan, and is associated with deep coma------associated with deep coma------chances of survival are very poorchances of survival are very poor
ICH of moderate size >1.5 cm in ICH of moderate size >1.5 cm in diameter, surgical evacuation may diameter, surgical evacuation may be life savingbe life saving
Bleeding forms localized haematomaBleeding forms localized haematoma---spreads along the white matter---spreads along the white matter---haematoma enlarges and continues ---haematoma enlarges and continues
to growto grow---pressure surrounding it increases to ---pressure surrounding it increases to
limit its spreadlimit its spread ORORDecompresses itself into the Decompresses itself into the
ventricular system CSFventricular system CSF
Any patient with sudden onset of severe Any patient with sudden onset of severe headache should be considered to have headache should be considered to have SAH.SAH.
Headache with global impairement of Headache with global impairement of conciousness is typicalconciousness is typical
Focal neurological signs are rareFocal neurological signs are rare Diplopia + cranial nerve lesion may occurDiplopia + cranial nerve lesion may occur Neck stiffnessNeck stiffness Subhyloid hgeSubhyloid hge
PUTAMENPUTAMEN Majority of hgic strokes occur in this Majority of hgic strokes occur in this
areaarea Hemiparesis or hemiplegiaHemiparesis or hemiplegia Sensory lossSensory loss Aphasia if on dominant sideAphasia if on dominant side Surgery of questionable valueSurgery of questionable value
PONSPONS Rapid loss of conciousnessRapid loss of conciousness Pin point pupilsPin point pupils Periodic respirationPeriodic respiration QuadriparesisQuadriparesis
Surgery of no valueSurgery of no value
WHITE MATTER OR LOBEWHITE MATTER OR LOBE
Same as putamin hge signsSame as putamin hge signs Distinguished only by neuroimaging Distinguished only by neuroimaging
Surgical evacuation, if suitableSurgical evacuation, if suitable
EMBOLIC STROKEEMBOLIC STROKE
Usually occur abruptlyUsually occur abruptly Occasionally present with Occasionally present with
stuttering fluctuating symptomsstuttering fluctuating symptoms Either the anterior (carotid) or Either the anterior (carotid) or
posterior (vertibobasilar ) posterior (vertibobasilar ) circulationcirculation maymay be involved be involved
CLASSIFCATION ACCORDING TOCLASSIFCATION ACCORDING TO LOBESLOBES
FRONTAL LOBEFRONTAL LOBEPersonality and emotional disordersPersonality and emotional disordersExpressive dysphasiaExpressive dysphasiaContralateral hemiparesisContralateral hemiparesisPrimitive reflexesPrimitive reflexes
PARITAL LOBEPARITAL LOBE
-Spatial disorientation-Spatial disorientation
-Apraxia +acalculia +agraphia +alexia-Apraxia +acalculia +agraphia +alexia
-Sensory inattention,neglect of non -Sensory inattention,neglect of non dominant side dominant side
-Contralateral hemisensory loss-Contralateral hemisensory loss
-Lower quadrantonopia-Lower quadrantonopia
TEMPORAL LOBETEMPORAL LOBE
-Receptive dysphasia-Receptive dysphasia-De ja vu phenomena-De ja vu phenomena-Hallucination of taste and smell-Hallucination of taste and smell-Excessive lip smacking-Excessive lip smacking-Micropsia-Micropsia-Upper quandrantonopia-Upper quandrantonopia
OCCIPITAL LOBEOCCIPITAL LOBE
-Homonymous hemianopia with -Homonymous hemianopia with sparing of the maculasparing of the macula
-Thalamic syndrome-Thalamic syndrome
LOCALIZING FEATURES OF LOCALIZING FEATURES OF MOTORMOTOR LESIONSLESIONS
CEREBRAL CORTEXCEREBRAL CORTEX
Flaccid weakness---Flaccid weakness---flexors+extensors equally flexors+extensors equally affected (globalaffected (global weakness)weakness)
INTERNAL CAPSULEINTERNAL CAPSULE Spastic weaknessSpastic weakness Extensors more than flexorsExtensors more than flexors Distal muscles affected more than Distal muscles affected more than
proximalproximal Patient looks away from the lesion Patient looks away from the lesion
(paralysis of head and eye (paralysis of head and eye movement )movement )
BRAIN STEMBRAIN STEM
--crossed hemiplegia i.e ipsilateral cranial --crossed hemiplegia i.e ipsilateral cranial nerve palsy with contralateralnerve palsy with contralateral
limb palsylimb palsy
ROOT AND PERIPHERAL LESIONROOT AND PERIPHERAL LESION
--peripheral nerve lesions usually affect both --peripheral nerve lesions usually affect both motor and sensory function in muscles and motor and sensory function in muscles and skin supplied by the nerveskin supplied by the nerve
ll
LOCALIZING ACCORDING TO BLOOD SUPPlyLOCALIZING ACCORDING TO BLOOD SUPPly
MIDDLE CEREBRAL ARTERYMIDDLE CEREBRAL ARTERY
Supplies majority of the internal capsule, Supplies majority of the internal capsule, larger part of frontal , parietal and larger part of frontal , parietal and temporal lobe)temporal lobe)
Contralateral spastic weaknessContralateral spastic weakness HemianopiaHemianopia May have signs of frontal , temporal or May have signs of frontal , temporal or
parietal lobesparietal lobes
ANTRIOR CEREBRAL ARTERYANTRIOR CEREBRAL ARTERY(Supplies the frontal lobe , superior (Supplies the frontal lobe , superior
portion of cerebral cortex and portion of cerebral cortex and anterior portion of internal capsule)anterior portion of internal capsule)
--Motor dysphasia--Motor dysphasia--Cortical flaccid weakness of the --Cortical flaccid weakness of the
opposite legopposite leg--Cortical sensory loss in opposite leg--Cortical sensory loss in opposite leg--Frontal lobe signs--Frontal lobe signs
POSTERIOR CEREBRAL ARTERYPOSTERIOR CEREBRAL ARTERY
(supplies occipital lobe, branch to thalamous (supplies occipital lobe, branch to thalamous and mid brain)and mid brain)
--homonomous hemianopia with sparing of --homonomous hemianopia with sparing of the maculathe macula
--thalamic syndrome--thalamic syndrome
--if both cerebral arteries are occluded—--if both cerebral arteries are occluded—cortical blindness (pt is blind but all the cortical blindness (pt is blind but all the pupillary reflexes are intactpupillary reflexes are intact
CNS LOCALIZATIONCNS LOCALIZATION HEMIPLEGIAHEMIPLEGIA CORTICALCORTICAL speech disturbancesspeech disturbances UMNL 7UMNL 7thth N palsy N palsySUBCORTICALSUBCORTICAL multiple cranial nerve multiple cranial nerve palsypalsy
SPINAL CORDSPINAL CORD Bilateral pyramidal signsBilateral pyramidal signs Higher function intactHigher function intact No cranial nerve palsy apart from No cranial nerve palsy apart from
occasional 11occasional 11thth nerve palsy nerve palsy
WEAKNESS OF LOWER LIMBSWEAKNESS OF LOWER LIMBS With pyramidal signsWith pyramidal signs cord lesion cord lesion MNDMND Without pyramidal signsWithout pyramidal signs neuropathy either sensory or neuropathy either sensory or motormotor muscle diseasemuscle disease
CRANIAL NERVESCRANIAL NERVES Single Single
DM or Bell,s palsyDM or Bell,s palsy Multiple Multiple
brain stem , with or without brain stem , with or without
long tract signs----SOLlong tract signs----SOL
----vascular----vascular
EXTRAPYRAMIDALEXTRAPYRAMIDAL
With pyramidal signsWith pyramidal signs
vascular like atherosclerosisvascular like atherosclerosis Without pyramidal signsWithout pyramidal signs
degenarative groupdegenarative group
CEREBELLARCEREBELLAR WingsWings look for pes cavuslook for pes cavus Tract signsTract signs SOL (acoustic neuroma) SOL (acoustic neuroma) PICAPICAMUSCLESMUSCLES DystrophiesDystrophies
CEREBELLUMCEREBELLUM HeadacheHeadache VertigoVertigo AtxiaAtxia LethargyLethargy No focal weaknessNo focal weaknessSurgical evacuation for all except smallSurgical evacuation for all except smallhaemorrhageshaemorrhages
CLASSIFICATIONCLASSIFICATION
Within the cavernous sinus Within the cavernous sinus (infraclinoid)(infraclinoid)
It may compress structures like 3,4,5 It may compress structures like 3,4,5 and 6and 6thth nerve palsy nerve palsy
----dilated pupil----dilated pupil
----facial pain----facial pain
----variable loss of facial sensation----variable loss of facial sensation
Above the cavernous sinusAbove the cavernous sinus ((supraclinoid)supraclinoid)
Most frequently compress the Most frequently compress the occulomotor nerve , optic tracts and occulomotor nerve , optic tracts and chiasmchiasm
May extend into the frontal lobeMay extend into the frontal lobe
6th year