cervical cancer - center for cancer research · cervical cancer not caused by hpv16/18. they...
TRANSCRIPT
![Page 1: Cervical Cancer - Center for Cancer Research · cervical cancer not caused by HPV16/18. They don’t induce regression of established HPV infections or prevent progression of HPV-induced](https://reader034.vdocuments.net/reader034/viewer/2022042322/5f0c69047e708231d435433a/html5/thumbnails/1.jpg)
Cervical Cancer
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HIV genome
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Virion
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HPV life cycle
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HPV infection
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Cancers and HPV
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HPV cancers
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Cervical cancer
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HPV carcinogenesis
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Cellular proteins
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HPV pathways
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HPV infection time line
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HPV infection
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Pap screening
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Primary prevention
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Virus like particles
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Three vaccines
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Timeline of HPV Association
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Precursor Lesions
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Efficacy of HPV Vaccine
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Gardasil-9
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Clinical Trial Evidence
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What the HPV Vaccines Don’t Do They don’t prevent infection or disease caused by
most of the other HPV types that cause 30% of
cervical cancer not caused by HPV16/18.
They don’t induce regression of established HPV
infections or prevent progression of HPV-induced
lesions.
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7 Years after vaccination
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Protection from Initial Infection
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HPC vaccine
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Safety record
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Vaccine effectiveness
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Vaccination
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CIN1 reduction
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Effectiveness
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Cervical cancer prevention
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Worldwide HPV vaccine
uptake
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US girls vaccination rate
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Increasing Uptake, Particularly
in Low Resource Settings
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One dose efficacy of Cervarix
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Cervarix after 4 years
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One dose clinical trials
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Single dose efficacy trial
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HPV vaccines
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Immune mediators of protection
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Antibody responses to VLPs
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Persistence of antibodies
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B cells recognize dense
repetitive protein arrays
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Repetitive antigen display
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Virus like particles
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Durable serum Abs
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Antibody response
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HPV achilles heal
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Cervix Ab response
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Murine model
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Basement membrane
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Antibody titers and protection
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Passive transfer
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Keratinocyte transfer
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Gardasil sera protection
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Conclusions
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Collaborators