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TRANSCRIPT
Chapter 12:Cardiovascular Physiology
Regulation of Cardiovascular Activities
Lecture Outline•Nervous Regulation
•Humoral Regulation
•Autoregulation
Nervous Regulation
Innervation of cardiovascular system
Nervous regulation of the circulation
Cardiac mechanisms of norepinephrine
Mechanisms of norepinephrine
—increased Na+ & Ca2+ permeability
• If ↑, phase 4 spontaneous depolarization↑,
autorhythmicity ↑
• Ca2+ influx ↑, phase 0 amplitude & velocity ↑,
conductivity ↑
• Ca2+ influx ↑, Ca2+ release ↑, [Ca2+ ]i ↑, contractility ↑
Asymmetrical innervation of sympathetic nerve
Cardiac mechanisms of acetylcholine
Mechanisms of acetylcholine
—increased K+ permeability
• K+ outward ↑, |MRP| ↑, phase 4 spontaneous
depolarization ↓, autorhythmicity ↓
• Inhibition of Ca2+ channel, phase 0 amplitude &
velocity ↓, conductivity ↓
• Ca2+ influx ↓, [Ca2+ ]i ↓, contractility ↓
Cardiac effect of parasympathetic stimulation
Interaction of sympathetic and parasympathetic nerves
Predominance of autonomic nerves
Cardiovascular CenterA collection of functionally similar neurons that
help to regulate HR, SV, and blood vessel tone
Vasomotor center
Located bilaterally mainly in the reticular substance of the medulla and of the lower third of the pons
– Vasoconstrictor area– Vasodilator area– Cardioinhibitor area – dorsal nuclei of the
vagus nerves and ambiguous nucleus– Sensory area – tractus solitarius
Vasomotor center
– Reticular substance of the pons
– Mesencephalon
– Diencephalon
– Hypothalamus
– Cerebral cortex
– Cerebellum
Higher cardiovascular centers
Baroreceptor Reflexes
• Arterial baroreceptors– Carotid sinus receptor– Aortic arch receptor
• Afferent nerves (Buffer nerves)
• Cardiovascular center: medulla• Efferent nerves: cardiac sympathetic nerve,
sympathetic constrictor nerve, vagus nerve• Effector: heart & blood vessels
Baroreceptor neurons function as sensors in the homeostatic maintenance of MAP by constantly monitoring pressure in the aortic arch and carotid sinuses.
Figure 12-53
Characteristics of baroreceptors:Sensitive to stretching of the vessel walls
Proportional firing rate to increased stretching
Responding to pressures ranging from 60-180 mmHg
Receptors within the aortic arch are less sensitive than the carotid sinus receptors
The action potential frequency in baroreceptor neurons is represented here as being directly proportional to MAP.
Figure 12-54
Baroreceptor neurons deliver MAP information to the medulla oblongata’s cardiovascular control center (CVCC);the CVCC determines autonomic output to the heart.
i.e., MAP is above
homeostatic set point
i.e., reduce cardiac output
Figure 12-55
Reflex pathway
Click here to play theBaroreceptor Reflex Control
of Blood PressureFlash Animation
Typical carotid sinus reflex
Maintaining relatively
constant arterial
pressure, reducing the
variation in arterial
pressure
Physiological Significance
Other Cardiovascular Reflexes
Click here to play theChemoreceptor Reflex Control
of Blood PressureFlash Animation
Humoral Regulation
• Vasoconstrictor agents• Vasodilator agents
Renin-angiotensin system
Juxtaglomerularcell
Renin
– Constricts resistance vessels– Acts upon the adrenal cortex to release aldosterone– Stimulates the release of vasopressin– Facilitates norepinephrine release from sympathetic nerve
endings– Stimulates thirst centers within the brain
Physiological effects of angiotensin II
Epinephrine & Norepinephrine
• Sources
Epinephrine----
adrenal medulla
Norepinephrine----
adrenal medulla
sympathetic nerves
Catecholamines
Effects Epinephrine Norepinephrine
Receptor α-adrenoceptor ++ +++
β-adrenoceptor ++ +
Heart heart rate + + (in vitro)- (in vivo)
cardiac output +++ ±
Vessels constriction (skin, visceral) + +++
relaxation (SM, liver) - +++
total peripheral resistance ± +++
Blood pressure systolic +++ +++
diastolic ± ++
MAP + ++
Clinical application positive inotropic pressor agent
agent
Vasopressin (antidiuretic hormone, ADH)
Endothelium-derived vasoactive substances
•Vasodilator factors
PGI2--prostacyclin
EDRF, NO--endothelium-derived relaxing factor, nitric oxide
EDHF--endothelium-dependent hyperpolarizing factor
•Vasoconstrictor factorsEndothelin
Atrial natriuretic peptide (ANP)
•Produces natriuresis and diuresis•Decreases renin release•Reduces total peripheral resistance via vasodilatation•Decreases heart rate, cardiac output
Autoregulation
Definition:
Intrinsic ability of an organ to maintain a constant
blood flow despite changes in perfusion pressure,
independent of any neural or humoral influences
The End.