16.1GeneralConceptsinImmunity

Explainthebasicaspectsofinnate(nonspecific)andadap?ve(specificoracquired)immunity.

•  Whatarethefirstlinesofdefenseagainstpathogens?

•  Whatarethesecondlinesofdefense?

•  Whatisthethirdlineofdefenseinthebody?

ThreeLinesofDefenseintheHumanBody

•  Innateimmunity1st:Barriersatbodysurfaces–external•  Integument&mucousmembranes•  Chemicalsecre?ons•  microflora

•  3rd:Adap?veimmunity:specificimmuneresponses–  Cell‐mediated–  An?body‐mediated

2nd:Nonspecificresponses–internal

•  Phagocy?ccells•  Inflamma?on&fever

•  An?microbialproteins

InnatevsAdap?ve

•  Innate–Nonspecific– ATributeswehaveatbirth– Defendusfromallpathogens

•  Adap?ve–Acquired–Specific– Notpresentatbirth–  ImmuneresponsesthatdevelopaWerexposure

•  Vaccine,subclinicalinfec?on,clinicalinfec?on– Uniquecellsforeachspecificpathogen