Charcot Arthropathy.

Dr. Saima Hashim KhanDept. of Diabetes & Endocrinology

HMC. PGMI

Case History : 1

• 55yrs old married female

• Type2 diabetic 25yrs

• HTN 7yrs

• Swelling right foot >1month, treated as cellulitus with antibiotics

INVESTIGATION• Hb 10.8g/dl, TLC 9900/cmm

• S.creatinine 0.7mg/dl

• S.uric acid 4.0mg/dl

• X ray foot.

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MRI Foot

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Case History : 2

• 45yrs old married female

• DM2 15yrs (Retinopathy: PRP, Nephropathy: crt clr 103 )

• HTN 5yrs

• Post amputation RT big toe 3yrs

• Swelling LT foot 2 months, treated as cellulitis with antibiotics

Investigations

• Hb:9.5 gm/dl, TLC 9600/cmm

• URIC ACID 4.2mg/dl

• CREATININE 1.02mg/dl

• DOPPLER U/S LT FOOT : no DVT normal arterial flow and subcutaneous edema.

• Xray Foot:

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X Ray Foot

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Tragic “Rule of 15”

• 15% of diabetes Foot ulcer in lifetime of patients

• 15% of foot ulcers Osteomyelitis

• 15% of foot ulcers Amputation

Clinical Care of the Diabetic Foot, 2005

• 50% ofamputations

• 50% of patients

• 50% of patients

Tragic “Rule of 50”

Transfemoral/Transfemoral/transtibial leveltranstibial level

22ndnd amputation in amputation in 5 years 5 years

Die in Die in 5 years 5 years

ClinicalClinical CareCare ofof thethe DiabeticDiabetic FootFoot, 2005, 2005

History of charcot foot

Mitchell,1831: The first association between joints and neurological diseases.

Charcot 1868: Arthropathy and tabes dorsalis.

Jordan 1936: Neuritic manifestation of DM

Charcot’s Foot A Neuropathic Arthropathy

Caused by repetitive trauma in the setting of:

• Diminished sensation & proprioception• Motor neuropathy results in muscle

imbalance & abnormal weight bearing.• “Rocker Bottom Deformity” a convex deformity of the foot’s plantar

aspect caused by the collapse of metatarsal bones

http://bjsm.bmjjournals.com/content/vol37/issue1/images/large/sm022279.f9.jpeg

Etiology

Peripheral sensory neuropathy is always present +/- motor.

Autonomic neuropathy leads to increased blood flow.

Trauma may be an important precipitating factor, although 2/3rd of patients don’t remember any injury.

Bone metabolism both osteoblastic and osteoclastic activities are increased.

Epidemiology

Incidence : 0.1 – 0.5 % . General: Increased in patients with neuropathy.Diabetics: 3-5%Common in the 4th or 5th decades of life.Bilateral in 30 % of patients. Sex difference : NoType 1 or type 2: Both are at risk.Majority: in the mid foot but any bone or

joint in the foot or ankle can be affected.

Clinical Features and Diagnosis

Acute Charcot Warm, inflamed and swollen. Misdiagnosed as cellulitis, osteomyelitis or

inflammatory arthropathy as gouty or septic.Although sensory neuropathy, pain is

common feature followed by discomfort.Diagnosis by exclusion as investigations in

early stages are negative.

Clinical Features and Diagnosis

High index of suspicion is necessary so that appropriate treatment is immediately instituted to prevent severe deformity!

Clinical Features and Diagnosis

Chronic Charcot, may be months, painless, without temperature difference and deformed.

Reactivation by further trauma is frequent.Patients are at high risk of ulceration and

amputation, so long term follow up is recommended.

InvestigationsX-ray : Early; absent or subtle finding. Late; bone and joint destruction,

fragmentation. bone scan: Increased bone uptake.In labeled leucocytes scan to differentiate

from osteomyelitis.MRI: Bone marrow edema is the earliest

sign.

Treatment

1. Immobilization

2. Pharmacological Treatment.

3. Surgical Treatment.

Treatment

1. Immobilization:

Almost 16 weeks (3-6 months) but may be more.

(temp gradient less than 1 on 2 occasions or serial radiology).

Treatment

1. Immobilization:

• Bed rest

• Half-shoes

• Crutches, Walkers and Wheelchairs

• Total contact cast (TCC) -gold standard

• Prefabricated pneumatic walking brace ( Air cast )

Total contact cast

Air cast

Half shoe

Modified/custom shoes/orthoses

Treatment

3. Pharmacological Treatment.

Pilot study first using pamidronate,1994. Other Bisphosphonates were used to decrease

disease activity and bone turnover markers. Calcitonin were also used. Given for 12 weeks or till temp gradient is less than 2

on 2 consecutive visits.

Treatment

4. Surgical treatment: No role in acute. Later may be to remove bony deformities or

constructive surgeries to achieve a stable shape.

Techniques include; Arthrodesis, exostectomies, reconstruction and Achilles tendon lengthening.

Take Home Message

High degree of suspicion to diagnose acute Charcot arthropathy.

High risk categorization.ImmobilizationBisphosphonate.Customized Foot Wear

Thank You