che5480 summer 2005
DESCRIPTION
CHE5480 Summer 2005. Dendrimers June 14, 2005. Starburst Dendrimers. What is a dendrimer? Branched polymers ( dendron = tree in Greek) Functionality = 3 (Nitrogen). Silicon, Si, functionalty f=4. Rose bengal inside PPI dendrimer. Dendrimers:. 1. Manufacture 2. Structure - PowerPoint PPT PresentationTRANSCRIPT
CHE5480 Summer 2005CHE5480 Summer 2005
Dendrimers
June 14, 2005
Starburst DendrimersStarburst Dendrimers
What is a dendrimer? What is a dendrimer? Branched polymersBranched polymers
((dendron dendron = tree in Greek)= tree in Greek)
Functionality = 3 (Nitrogen)= 3 (Nitrogen)
Silicon, Si,
functionalty f=4
Rose bengal inside PPI dendrimer.Rose bengal inside PPI dendrimer.
Dendrimers:Dendrimers:
1. Manufacture2. Structure3. Characterization4. Applications
Manufacture:Manufacture:
(i) Divergent Method(ii) Convergent Method
Methods of Synthesis:Methods of Synthesis:
(i) Divergent Growth(i) Divergent Growth
Methods of Synthesis:Methods of Synthesis:
(ii) Convergent Growth(ii) Convergent Growth
Comparison: Comparison: Divergent vs. ConvergentDivergent vs. Convergent
Structure:Structure:
Generations of DendrimersGenerations of Dendrimers
2nd gen.
4th gen.
5th gen.
PAMAM Dendrimer PAMAM Dendrimer (polyamidoamine)(polyamidoamine)
Alternating
(B)-AB-AB-AB-...Ethylenediamine (B)H2N-C-C-NH2
Methylacrylate (A)C=C-CO-OCH3
PAMAM Moieties:PAMAM Moieties:
Acryla
te
Diami
ne
NH3 or
Diamin
e
Characterization:Characterization:
f=3 fc=3
Spacer b
123
generations
Construction of Generations:Construction of Generations:
Core: Ethylenediamine (Moiety B = D)
“Michael Addition” of 4 Methylacrylates (A= O)
Amidization: add 4 ethyldiamines (D)
Result: Generation “0”
Continue Branching:Continue Branching:Generation “1”:
Generation “2”:Generation “2”:
Calculations:Calculations:Note that Core functionality (2
nitrogens): fc = 4 Branch functionality
(nitrogen): f=3
No. of Spacers (A+B): b=2
Generation = G
Number of Branches: Number of Branches: NNbrbr
Number of Mers (A+B): Number of Mers (A+B): NNmermer
Applications of DendrimersApplications of Dendrimers
Gas and chemical sensorsCatalystsDrug delivery and gene therapySurface modifiers (tribology, and
information storage)Bio compatible materialsElectronic devices and antennae
Size of PAMAM DendrimersSize of PAMAM Dendrimers
Generation M.W. Angstrom (dia.) End GpsGeneration M.W. Angstrom (dia.) End Gps
(1 nm = 10 Angstroms)
Equivalent Sizes with Cells:Equivalent Sizes with Cells:
Dendrimer: PAMAMDendrimer: PAMAM
2. Nanostructured materials: 2. Nanostructured materials: Gas adsorption in dendrimersGas adsorption in dendrimers