chemical engineering alumni/ae news - mit.edu · chemical engineering alumni/ae news 3 by john i....

FROM THE HEAD OF THE DEPARTMENT. . .

Welcome to the 2004 edition of the department’s newsletter. It is good to have the opportunity to bring you up to date onthe department. The past two years have been particularly introspective as we have looked hard at the changes in the worldthat impact chemical engineering, and have been actively trans-lating our vision of the future into new educational and researchprograms. It has been, and continues to be, an exciting journey,which I will say more about later.

Tempering the excitement of research and education in thedepartment is the loss of several of our distinguished alumni/ae(See page 25). Particularly difficult is the passing of Dr. RalphLandau in April 2004. The department and MIT are trulygrateful for the life of service and devotion Ralph gave to theDepartment of Chemical Engineering. Ralph gave so much tous—intellectually, emotionally, and financially—over the years.It is virtually impossible to capture the enormous impact he hadon the field of chemical engineering and the department at MITin particular. He was an extraordinary visionary and a most gracious individual. It is certainly fitting that our building bearshis name as a lasting legacy to his contributions. Dr. Landau’scontributions to the department and MIT are summarized inthe article on page 25. We will all greatly miss him.

First, a few highlights: The department’s graduate and under-graduate programs were both ranked number one among chemical engineering departments in the most recent U.S. News& World Report academic survey; our faculty achieved a record$22 million research volume; we revamped our existing CourseX degree, and developed an entirely new degree program, XB. It is indeed a wonderful and an exciting time in ChemicalEngineering at MIT! (See page 27)

As I have discussed in previous newsletters, the discipline ofchemical engineering is undergoing significant and excitingchange. Although historically focused on the petrochemical sector, the chemical engineering profession has evolved to a pointwhere it is now critical to such other sectors as microelectronics,medicine, biotechnology, and new materials. While demands forwell-educated engineers have continued to grow, our educationalprograms have not kept pace—it is time for change if the profes-sion is to remain vibrant and attractive to young students andmeet the needs in the emerging technologies that depend onmolecular transformations.

HEAD see page 21

Professor Robert C. ArmstrongHead, MIT Chemical Engineering

M A S S A C H U S E T T SI N S T I T U T EO F T E C H N O L O G Y

News from the Head. . . . . . . . . . . . . . . . 1

Practice School News . . . . . . . . . . . . . . . 2

Awards Day . . . . . . . . . . . . . . . . . . . . . . 5

New Appointments & Promotions . . . . . 6

Faculty Awards Highlights. . . . . . . . . . . . 7

Faculty Distinctions . . . . . . . . . . . . . . . 10

ChemE Connection. . . . . . . . . . . . . . . 14

Named Lectures . . . . . . . . . . . . . . . . . . 15

News from Alumni/ae. . . . . . . . . . . . . . 23

Alumni/ae Donors . . . . . . . . . . . . . . . . 29

Research Highlights . . . . . . . . . . . . . . . 44

GSC-X Activities . . . . . . . . . . . . . . . . . 48

ALSO IN THIS ISSUE:

Spring 2005Course X

Chemical Engineering Alumni/ae NewsR o o m 6 6 - 3 5 0 • F a x : 6 1 7. 2 5 8 . 8 9 9 2

Landau Memorial, pg. 25

New Bioengineering Program, pg. 27

Generations mix at alumni/aeand faculty reception, pg. 24

2 Chemical Engineering Alumni/ae News

The David H. Koch School of Chemical EngineeringPractice continues to be recognized as a unique educationalopportunity within the department, attracting top studentsfrom around the country and the world. A total of 32 students attended stations during the Fall ’02 throughSummer ’03 sessions, and 30 students participated in theprogram over the past year (’03–’04). With the strong support of our hosting companies, we are able to continueto provide the diversity of experiences for our students thathas traditionally characterized our program.

Over the past year and a half since our last report, we haveoperated stations at a number of different host companies,providing a range of corporate and geographical environ-ments for our students. In Spring ’03, Mike Modell directeda station at Masterfoods, Inc., in Reno, Nev., while JohnFriedly once again ran the Cargill station just outsideMinneapolis, Minn. For the summer of 2003, we ran twostations in parallel in Minneapolis, Minn., at Cargill (JohnFriedly) for one month, and at General Mills for twomonths; the General Mills station was directed by newcom-er Claude Lupis (See below). One set of students then trav-eled overseas to Japan for two months to work at theMitsubishi Chemical Group station in Mizushima, underthe direction of Mike Modell, while the second group ofstudents went from General Mills directly to theSchenectady, N.Y., area to work on fuel cell developmentprojects at PlugPower, under the supervision of BillDalzell. In Fall ’03, we were hosted again by General Mills,this time for one month in Buffalo, N.Y., then a secondmonth just outside Chicago, Ill., with Claude Lupis incharge. The students then crossed the Atlantic to go to theBP Chemicals Saltend site near Hull in the UK for twomonths; Mike Modell ran the show this time. Because of alarger number of students than expected (some signed uplate for the program), it was necessary to run two parallelgroups through the program during the Spring ’04 session.For the first two months, one student group went to Basel,Switzerland, with Mike Modell, to tackle problems atNovartis, while the second group worked on glass-process-ing problems at Johns–Manville facilities in Toledo, Ohio,under the supervision of Claude Lupis. Both groups endedup in the Minneapolis, Minn., area, one at Cargill (JohnFriedly) and the other at General Mills (with Mike Modell).Over this past summer, students were again hosted by

Novartis, but this time closer to home, in East Hanover,N.J., where Claude Lupis has taken the helm. The finalmonth of the summer session was spent back in Cambridge,Mass., with Alkermes, Inc., directed by Bill Dalzell.

Cargill, Spring 2004 back row from L to R: Cargill Host MikeTupy,Theis Clarke, Jacob Albrecht, Dhananjay Dendukuri, andStation Director, John Friedly. Front row from L to R: SharonSoong, Amy Lewis, Mohit Rawat and Saswata Ghosh.

We continued our joint program with CambridgeUniversity under the Cambridge–MIT Institute (CMI), in which Cambridge students participate in our core courseshere at MIT, return to Cambridge, UK, for additionalcoursework and research, and then attend two months of aPractice School session alongside MIT students. Last Fall,three Cambridge students attended the General Mills station,and two students were hosted by BP Chemicals. The intakefor the 2004–05 academic year has increased to 14 students,who will be resident at MIT this Fall, and will be attendingstations next year. By all accounts, this has been a very successful collaboration, one that is looked upon by theupper CMI management as being the best in the CMI portfolio of Practice School Programs, and we look forwardto continuing it in the years to come.

BP Chemicals, UK Fall 2002 from L to R: Edward Murphyand Kerrill Titiyevskiy, U. Cambridge exchange studentsStuart Scott and Bart Hallmark, with Anna Pisania, ChadAugustine, Asst. Director Andrew Kim, U. Cambridgeexchange student Daniel Holland, and Station DirectorBarry Johnston.

The breadth of technical problems and environments provided by this large number of diverse companies affordedan excellent educational opportunity for our students. Weare certainly grateful to these companies for their hosting of our Practice School Stations.

PS see facing page

By Professor T. Alan Hatton, DirectorPractice School News

3Chemical Engineering Alumni/ae News

By John I. Mattill, Editor Emeritus,Technology Review

190 pages, 120 photographs, scores of anecdotes,and three reminiscences by alumni/ae capture thespecial passion of this audacious—and stillunique—concept that has become a world stan-dard for engineering education.

Send US $20 per copy plus $2 per

order for postage and handling

($5 foreign) to:

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Engineering

MIT, Room 66-309

Cambridge, MA 02139 US

Make Checks Payable to:

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To Order:

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Engineering Practice, 1916–1991

THE FLAGSHIP

PS from facing page

John Friedly retired from the program at the end of lastyear, having been a Station Director for more than six years,although he will fill in from time to time on an ad-hoc basiswhen we have the need for additional station directors. Wewish him and his wife, Lorue Friedly, every happiness intheir retirement, and are very thankful for all their contribu-tions to the Practice School during a long and successful second career with our program.

It is a pleasure to welcome Mike Modell and Claude Lupisto the Practice School community. Mike and Claude haveboth had distinguished careers spanning academia andindustry, and have served as independent consultants overthe years. Both have written influential thermodynamicstextbooks, and both have recently been involved in on-cam-pus teaching here at MIT. Mike was a faculty member at

MIT before branching out to start his own companiesexploiting supercritical water oxidation technologies; whileat MIT, he co-wrote the classic text, Thermodynamics and ItsApplications, with Bob Reid (the 3rd edition is the revision ofthis book by Jeff Tester). Claude’s early academic career wasat what is now called Carnegie Mellon University; aftermany years in industry and consulting, primarily in themetallurgical fields, he taught in the Materials Science andEngineering Department for a number of years before joining the Practice School; his book is titled, ChemicalThermodynamics of Materials.

This continues to be a stimulating environment for thePractice School, and we look forward to continuing ourdevelopment and testing of innovative approaches to stationoperations over the next year to ensure that our students getthe best education possible!


Class of 1936 FellowChuang-Chung Lee

Haas Family & Adel F. Sarofim FellowAndrew A. Peterson

Robert T. Haslam FellowsMai-Lan HoKangyi MaoBin PanAnna K. SchampelJanet Tse

George M. Keller ChevronFellowCurt R. Fischer

Ralph Landau FellowsAdam F. MillerMichele C. Verticchio

Jerry & Geraldine McAfeeFellowEarl Osman Pauco Solis

Reid & Williams FellowFelipe Osorno

Charles & Hilda Roddey FellowSandeep Sharma

William C. Rousseau Award forLeadership and Ethics 2002:Manish Bajaj2003:Chad Augustine

J. Edward Vivian Award 2002:Brian Anderson2003: Bernat Olle

Jefferson W. Tester Award 2002:Joseph Moritz and Ramin Haghgooie2003:Jin Zhou

Rosemary J. Wojtowicz Award2002:Joanna Yu and Soon Siong Darren Ong2003:Keith Tyo

William & MargaretHutchinson Rousseau FellowMahmooda Sultana

Keith & Helen Rumbel FellowVernella Velonie Verlin Vickerman

Arch Scurlock FellowHemantkumar Ramesh Sahoo

John C. Sluder FellowLinlin Ye

Howard Stern FellowsPanayiotis P. LemonidisLakshman Pernenkil

Frank Hall Thorp FellowGaurav Bhalla

Rosemary Wojtowicz FellowIngrid M. Berkelmans

Robert T. Billings FellowMatthew L. Cohen

John H. Grover/Haas FamilyFellowLing Chao

Tae Sup Lee FellowJu Jin An

Peter Spitz FellowSarah Virginia Petway

Alkermes FellowMinglin Ma

GEM/ATOFINA FellowAqueelah C. McKinley

Bayer FellowJames Thomas Wertman

ExxonMobil FellowsRocco P. CiccoliniBarry M. Grace

Procter & Gamble FellowJulie Cha

Dumbros FellowDaniel C. Pregibon

Dupont FellowsAnthony G. BalducciMichelle T. HardimanRyan S. Waletzko

Haslam/Presidential FellowsKristin J. MatternBrian E. MickusAndrew C. Miller

Hertz/Walsh PresidentialFellowChristopher R. Loose

NDSEG/Haslam PresidentialFellowsHelen F. ChuangScott M. Paap

NSF/Frederick Holloway FellowLily V. Tong

NSF/Edwin R. Gilliland FellowRobert Wilson Ashcraft

NSF/George M. Keller FellowAviva Presser

NSF/Walsh Presidential FellowKaren Danielle Daniel

Walsh Presidential FellowGreg M. Thurber

2003 Chemical Engineering Fellowships

Practice School Awards for Outstanding Performance


The 2004 Chemical Engineering Awards Ceremony washeld on May 10, 2004, in Gilliland Auditorium. Professorand Department Head Robert C. Armstrong presided over the event.

Armstrong began the ceremony by recognizing ChemEundergraduates who have been awarded outside scholarships. These include:

• Wei Chan, a junior from Pleasantville, N.Y., and Hana Oh, a junior from San Diego, Calif., were the recipients of Merck Fellowships for scholastic excellence.

• Peter Miller, a junior from Atlanta, Ga., was the recipient of the National Goldwater Scholarshipfor his academic excellence.

• Nnennia Ejebe, a senior from Plymouth, Minn., was chosen for the Ronald E. McNair ScholarshipAward. The scholarship, established in Dr. McNair’shonor by the Black Alumni/ae of MIT, recognizes aBlack undergraduate who has demonstrated strongacademic performance and made a considerable con-tribution to the minority community. Physicist andAstronaut Ronald E. McNair (PhD ’77), who died inthe 1986 Space Shuttle Challenger explosion, was wellknown for his involvement in the greater MIT com-munity. Ejebe was acknowledged at the MIT AwardsConvocation held on May 4th, 2004.

Armstrong then presented the following Departmental Awards:

Dow Chemical annually recognizes one junior in theDepartment of Chemical Engineering for a balanced recordof achievements in academics, participation in professionaland social organizations on campus, as well as work experi-ence. This year’s recipient of the Dow Outstanding JuniorAward was Henry Bergquist from Ellington, Conn.

The Robert T. Haslam Cup was given to senior SudhaAmarnath from Lansing, Mich., for displaying exceptionalprofessional promise in the field of chemical engineering.

The Roger de Friez Hunneman Prize is the oldest awardin the department, and is given to an undergraduate for out-standing scholarship and research. This year’s recipient wassenior Sonali Rudra from Sugar Land, Tex.

The Edward W. Merrill Outstanding Teaching Award waspresented to graduate student Saeeda Jaffar from Dubai,UAE, for her work with 10.302 during the Fall 2003 semester.

Awards DayEvery Monday, two third-year graduate students present theprogress of their research for peer evaluation as part of the10.991/2 seminar series. Two graduate students were recog-nized for their seminars. This year’s recipients of theOutstanding Seminar Awards were Brian Baynes, fromSewell, N.J., for the Fall 2003 semester; and Andre Ditsch,from Alliance, Nebr., for the Spring 2004 semester.

The Chemical Engineering Special Service Awards weregiven to members of the GSC, for their hard work organiz-ing various graduate student events. The recipients were Hal Alper, from Owings Mills, Md.; Ryan Bennett, fromLongwood, Fla.; Theis Clarke, from Valparaiso, Ind.;Malancha Gupta, from Flushing, N.Y.; Joel Moxley, fromRichmond, Va.; Jane Rempel, from Milwaukee, Wisc.;Mark Styczynski, from Freehold, N.J.; and BenjaminWang, from Santa Monica, Calif.

Senior Cindy Chung from Parsippany, N.J., was given aSpecial Service Award for her dedication and hard work asAIChE President for the past year.

The Outstanding Employee Award was given to Gwen Wilcox, an Administrative Assistant for ProfessorsJefferson W. Tester and Bernhardt L. Trout. A first-time winner, Wilcox was praised for her commitment, attentionto detail, and excellence in organizing the faculty seminars.

The Outstanding Faculty Award from the graduate students was a tie this year, and was given to ProfessorsWilliam M. Deen and Jefferson W. Tester. This award waspresented by graduate student Joel Moxley. Lecturer Jean-François Hamel received the undergraduate OutstandingFaculty Award, which was presented by Cindy Chung.

Finally, the Chemical Engineering Rock Award for outstanding athletic ability and participation, as voted on by the ChemE graduate students, was given to Mark Styczynski.

Visit us on the web at: http://web.mit.edu/cheme


NEW FACULTY APPOINTMENT

Prather Welcomed to Faculty We are very pleased to welcomenewly appointed Assistant ProfessorKristala Jones Prather, who joinedthe department this Fall. ProfessorPrather received an SB degree inchemical engineering from MIT andwas the winner of the Karl Taylor

Compton Prize. She received a PhD in chemical engineeringfrom the University of California, Berkeley, before joiningMerck, where she worked in bioprocessing research.Professor Prather was recently named as one of only ninerecipients nationwide of the Camille and Henry DreyfusNew Faculty Award. This extremely competitive award goesto both chemists and chemical engineers starting academiccareers, and recognizes her outstanding research accomplishments and bright promise. Professor Prather’s proposedresearch is concerned with methods for optimizing recombinantgene dosages to maximize productivity in the metabolic engineering of E. coli. Her addition enhances an already-out-standing group of faculty in the important area of bioprocess-ing technology.

FACULTY PROMOTIONS

Rutledge Promoted to FullProfessor, Executive Officer Gregory C. Rutledge, promoted toFull Professor and, effective July 2004,to Executive Officer for ChemicalEngineering, received a BS degree fromthe University of Virginia (1983) and a

PhD from MIT (1990). Professor Rutledge, recent pastDirector of MIT’s Interdepartmental Program in PolymerScience and Technology (PPST), aims to develop quantitativerelationships between chemical architecture and materials prop-erties on polymers and other complex molecular systems. Hisbreakthroughs include a definitive theoretical resolution of a 30-year-old problem concerning the nature of folding at the crys-tal/amorphous interface in polyethylene.

Green Promoted in 2004 toAssociate Professor with Tenure William H. Green, Jr., specializes inreactive chemical engineering: quanti-tatively predicting the time evolutionof chemical mixtures. Chemical kineticmodels are increasingly used as input

for major business and public policy decisions, ranging fromthe design of chemical process units to energy tax proposals.

Rapid advances in computer hardware and software now makeit feasible to construct truly predictive kinetic models based ona detailed understanding of the molecular processes occurringin complicated systems, rather than the very empirical interpolative models typically used today. Professor Green’sefforts are focused on the development, demonstration, andvalidation of new methods for predicting the course of chemi-cal reactions, and on the application of these methods toimportant technological and policy problems.

Trout Promoted to AssociateProfessor Bernhardt L. Trout is developingand applying molecular computationalmethods to gain insights that will leadto the design of chemical materials andprocesses. At the heart of his research

group’s methodology lies quantum mechanical methods, suchas density functional theory and molecular orbital theoriesthat include high-level correlation. These are used to computeenergies of interaction of atoms and molecules with the highestpossible accuracy.

Applications include heterogeneous catalysis on zeolites forthe synthesis of cleaner-burning fuels and olefins; high-con-version, next-generation automotive catalysts; heterogeneousstratospheric chemistry to understand the consequences ofreleasing chemicals into the atmosphere; natural gas hydratesas an abundant, clean, future fuel source; CO2 hydratesinvolved in the sequestration and storage of CO2; nucleationand crystallization of chemical pharmaceuticals and semi-conductor materials; and stabilization of therapeutic proteins.Overall, there is an emphasis on environmental research anddevelopment of more environmentally benign technologiesand on human therapeutics.

Ying Takes Charge of New Singapore Bioengineering/Nanotech Institute

Professor Jackie Y. Ying is currentlyon a professional leave from MIT toassume the Executive Director positionat Singapore’s new Institute ofBioengineering and Nanotechnology(IBN). IBN is a new national researchinstitute under the Agency of Science,

Technology, and Research–Singapore. Professor Ying is in chargeof establishing the Institute to a staff size of 250 in research areasthat include: drug delivery, genes and proteins, tissue engineer-ing, artificial organs and implants, medical devices, biologi-cal and biomedical imaging, and nanobiotechnology.

For more about IBN, visit their website: http://www.ibn.a-star.edu.sg

In the Department ofChemical EngineeringFaculty Appointments & Promotions


Merrill Merits Biomaterials Founders’ Award We’re proud to recognize EmeritusProfessor Edward W. Merrill, whowas selected as the 2003 recipientof the Founders’ Award of theSociety for Biomaterials (SFB).The SFB Founders’ Award is basedon long-term, landmark contribu-tions to the discipline of biomateri-als. Professor Merrill presented a

special address at the 29th Annual Meeting of the Society forBiomaterials in Reno, Nev., in April 2003.

Congratulations to Professor Merrill on being selected forthis important award!

For more about the SFB Founders’ Award...http://www.biomaterials.org/award_founders.htm

For more about Professor Edward W. Merrill...http://web.mit.edu/cheme/people/faculty/merrill.html

Langer Wins 2003 John FritzMedal (AASE) and Charles F.Kettering Prize (GM CancerResearch Foundation) Professor Robert S. Langer, wellknown for his contributions in thefield of controlled drug delivery sys-tems and tissue engineering, and hisdominance in the field of bioengineer-ing, was honored by the AmericanAssociation of Engineering Studies

(AAES) with the 2003 John Fritz Medal.

The John Fritz Medal is awarded for scientific or industrialachievement in any field of pure or applied science. It wasestablished in 1902 as a memorial to the great engineerwhose name it bears.

Another recent major award for Professor Langer was theGeneral Motors Cancer Research Foundation’s Charles F.Kettering Prize, one of three awards given annually by theGeneral Motors Cancer Research Foundation. The$250,000 prize recognizes the most outstanding recent con-tribution to the diagnosis or treatment of cancer. ProfessorLanger was cited for his major contributions to the develop-ment of sustained-release drug delivery systems for the treat-ment of cancer.

“I went into cancer research because I had always drawn alot of satisfaction from helping people,” Professor Langer

said. “I wanted to use my science and engineering back-ground in a way that would help people live longer andhealthier lives.”

The Charles F. Kettering Prize is given for the most out-standing recent contribution to the diagnosis or treatmentof cancer, and is named in honor of the inventor, formerGeneral Motors Director, and pioneer of the GeneralMotors Research Laboratories. Mr. Kettering was a generoussupporter of basic research in both industry and medicine.He and Alfred P. Sloan, Jr., established the Sloan–KetteringInstitute for Cancer Research in New York in 1945.

Other major awards have included the 2002 Charles StarkDraper Prize from the National Academy of Engineering,the 2002 Othmer Gold Medal from the Chemical HeritageFoundation (CHF), and the 1998 MIT–Lemelson Prize.

For more about Professor Robert S. Langer...http://web.mit.edu/cheme/people/faculty/langer.html

For more about the John Fritz Medal…http://www.aaes.org/news_center/5_5_03.asp

For more about the Charles F. Kettering Prize…http://www.gm.com/company/gmability/philanthropy/cancer_research/history.htm

Lauffenburger LandsAIChE 2002 WalkerAward The Department ofChemical Engineering wishesto congratulate ChemicalEngineering Professor Douglas A. Lauffenburger,who was awarded one of the

AIChE’s most prestigious honors, the William H. WalkerAward for Excellence in Contributions to ChemicalEngineering Literature.

Professor Lauffenburger was chosen for this award basedupon his intellectual leadership in combining chemical engineering with molecular cell biology and for developinginnovative biotechnologies based on molecular cell-leveldesign principles.

For more about Professor Douglas A. Lauffenburger...http://web.mit.edu/cheme/people/faculty/lauffenburger.html

For more about the AIChE William H. Walker Award...http://www.aiche.org/awards/awarddtl.asp?AwardID=63

Faculty Awards Highlights


particular honor to receive this recognition. “I came fromhumble origins. My father went to school only to the eighthgrade, my mother to the first grade.”

“I am a theoretician in the field of fluid mechanics,” ProfessorBrenner said. “And I was fortunate to come to this early inmy life. In high school, I had a difficult time in geometry,perhaps like many of you. But I had a wonderful teacher, Mr.Woods, who did a theorem proving that the interior angles ofa triangle added up to 180 degrees. This was a purely theoret-ical exercise, one that I had never thought about before. It washard to believe that you could use your own mind to predictsomething and then go into the world or the laboratory andmeasure it. I had a protractor because I was taking a course inmechanical engineering. After class, I drew some triangles andthey added up to 180 degrees, and I was amazed. And I havebeen amazed ever since.”

In September of next year, Professor Brenner will begin his50th year as a faculty member in Chemical Engineering. Hisresearch and educational activities have been honored bynumerous awards from professional societies, including theAmerican Institute of Chemical Engineers, the AmericanChemical Society, and the American Society ofEngineering Education. Most recently, he received theFluid Dynamics Prize of the American Physical Society.He is one of a small group of scientists and engineers electednot only to both the National Academies of Science andEngineering, but also to the American Academy of Artsand Sciences.

For more about Professor Howard Brenner...http://web.mit.edu/cheme/people/faculty/brenner.html

For more about the American Academy of Arts and Sciences...http://www.amacad.org

Hammond Honored asGreat MentorWe all know someone whoinspired, coached, or guidedus in honing our skills and inshaping our career path, ourideas about the world, andour own potential to helpshape its future. These experi-ences can spark the beginningof a lifelong path of self-growth and discovery.

In honor of NationalMentoring month, and her dedication as a mentor in theMIT and Cambridge African–American communities,

Gregory StephanopoulosElected to NAE, AIChE Board of Directors Congratulations to ProfessorGregory Stephanopoulos, BayerProfessor of Chemical Engineeringand Biotechnology, and TaplinProfessor of Health Science andTechnology, who in 2003 was elect-ed to the National Academy ofEngineering (NAE)! The NAE

cited his pioneering contributions in defining and advancingmetabolic engineering, as well as his leadership in incorpo-rating biology into chemical engineering research.

Professor Stephanopoulos was also recently elected to athree-year term on the AIChE Board of Directors.

We also congratulate 2003 NAE electee and emeritus facultymember Professor Adel F. Sarofim, now at the University of Utah. Professor Sarofim was recognized for advancing our understanding of the mechanisms and modeling ofprocesses that control radiation in and pollutant emissionsfrom combustors.

For more about Professor Gregory Stephanopoulos...http://web.mit.edu/cheme/people/faculty/steph.html

For more about Professor Adel F. Sarofim…http://www.combustion.utah.edu/People/Sarofim.html

For more about the National Academy of Engineering...http://www.nae.edu

ClarksonBestowsHonoraryDoctoralDegree uponBrenner ChemE ProfessorHoward Brennerreceived an hon-orary doctor of

science degree at Clarkson University’s 111th

Commencement on Sunday, May 9th, 2004. The degree wasawarded for “his outstanding intellectual achievements dur-ing a distinguished half-century career as a chemical engineer-ing academic, and for his boldness in questioning the mostbasic assumptions of continuum fluid mechanics.”

Addressing the more than 500 graduates, Professor Brennerexplained that as a first-generation college graduate, it was a

Faculty Awards Highlights


ChemE Professor Paula T. Hammond was named a GreatMentor by US Black Engineer online magazine in theirJanuary 2004 issue.

In an illuminating interview, Professor Hammond spokeabout her inspiration to pursue chemical engineering, howshe got started in the field, and her upbringing and currentmentoring activities, both at the St. Paul AME Church herein Cambridge, Mass., and in the larger MIT community.She also described some of the exciting projects now under-way in the Hammond research group. These include cancer-fighting cell-specific nano-containers, ultra-thin films for lightweight fuel cells and related technologies, electro-chromic materials that may become usable for foldable displays, and chemical and/or bio agent sensors with multiple possible applications.

We congratulate Professor Hammond on her inspirationalrole in the Cambridge and MIT communities, serving as a needed mentor and as a role model for young African–American scholars.

For more about Professor Paula T. Hammond...http://web.mit.edu/cheme/people/faculty/hammond.html

To read the interview with Professor Paula T. Hammond...http://www.blackengineer.com/artman/publish/article_190.shtml

Stephanopoulos Wins 2003Dual AIChE HonorsProfessor George Stephanopoulos,who in 2003 returned from atwo-year stint as MitsubishiChemical Corporation’s ChiefTechnology Officer, receiveddual honors from the AIChE,garnering both the 2003Institute Lecturer and theWilliam H. Walker Awards.

These two awards are amongthe most prestigious in thefield, and Professor

Stephanopoulos’s selection for both in the same year is a fit-ting tribute to his uniquely vital and ongoing contributions.

Professor Stephanopoulos’s Institute Lecture, presented atthe 2003 National Conference in November, highlighted acharacter shift in the chemical industry, from a process to aproduct emphasis. He outlined the far-reaching ramifica-tions of this shift, found in virtually every aspect of theindustry’s operations, and in the educational preparation

of future scientists and engineers. He also used examplesfrom his experience in the rejuvenation of MitsubishiChemical’s R&D operations, and analogous activities ofother chemical companies.

The 2003 William H. Walker Award was presented toProfessor Stephanopoulos in honor of his recent outstandingcontributions to chemical engineering literature.

His work in the areas of product and process developmentand design, process operations and control, and integratedcomputer-aided environments for process systems engineeringhave also led to numerous other honors over his distinguishedcareer, including AIChE’s 1993 Computing in ChemicalEngineering Award, the 1987 and 1992 Best Paper Award,Computers and Chemical Engineering, and the 1982 Alan P.Colburn Award.


Conference on “Barrier Function of Mammalian Skin” heldin Bristol. Professor Blankschtein and his students also pre-sented talks and posters at meetings of the American Instituteof Chemical Engineers (AIChE), the Society of CosmeticChemists (SCC), the Gordon Research Conference on“Chemistry and Physics of Liquids,” and the 7th US–JapanSymposium on “Drug Delivery Systems” held in Maui,Hawaii. Professor Blankschtein continues to serve on the editorial board of Marcel Dekker’s Surfactant Science Series.

Howard Brenner prepared a paper, taught an advanced topics course entitled, “Fluid Mechanics Revisited,” and presented numerous seminars and lectures on this topic. Theunderlying theme of this controversial work asserts that thebasic foundations of continuum fluid mechanics and thermo-dynamics should, in the case of compressible fluids, be basedupon the transport of volume, rather than of mass, as is currently assumed. Professor Brenner received an honorarydoctoral degree from Clarkson University and spoke at theirgraduation ceremonies.

Charles Cooney returned from a year’s sabbatical at theUniversity of Cambridge, UK, and continues to serve as theFaculty Director of the Deshpande Center for TechnologicalInnovation and as the Co-director of the Program on thePharmaceutical Industry. During the past year, he was aCMI Fellow and co-taught the CMI pilot course, “TEEMS(Technology-based Entrepreneurship for Engineering andManagement Science Students),” for Engineering andManagement Science undergraduates. Professor Cooney wasappointed a Co-leader of the BP–MIT Projects Academy,which was created by the Sloan School of Management andthe School of Engineering.

William H. Dalzell continued as the Department ofChemical Engineering’s Environmental, Health, and Safety(EHS) Coordinator. His primary efforts this year have been toensure that all people working with chemicals or biologicalmaterials have participated in appropriate EHS training andthat all laboratories are in compliance with EHS regulatoryrequirements. He was Director of the Chemical EngineeringPractice School Station at PlugPower in Latham, N.Y., duringAugust 2003. He gave a presentation at Tokushu Kika KogyoCo., Ltd. in Tokyo, Japan, entitled, “Evaluation of NovelMixing Technology” on November 6th, 2003.

William M. Deen was an invited speaker at the FirstInternational Symposium on Albuminuria in New YorkCity, N.Y., in May 2004. Papers from his research groupalso were presented at the annual meeting of the AIChE inSan Francisco, Calif., in November 2003. In the 50th

anniversary issue of the AIChE Journal, one of his paperswas recognized as the 15th most-cited paper in the history of

Robert C. Armstrong continued as Head of theDepartment of Chemical Engineering during the academicyear 2003–04. He serves as Vice-Chair of the GoverningBoard of the Council for Chemical Research (CCR) for2004, and will chair this organization in 2005. In April, heran the CCR Annual Meeting in Tampa, Fla., on “ChemicalResearch Opportunities for the Global Energy Economy.”He has been working through CCR to organize broad dis-cussions across chemical engineering regarding the evolutionof the discipline. These discussions are driven by the signifi-cant impact of biology on research and education in chemi-cal engineering today and by the breadth of industries intowhich our graduates now go. These meetings have led to avery interesting series of curriculum workshops funded bythe National Science Foundation (NSF) to take a bold, in-depth look at the future of chemical engineering undergrad-uate education. These workshops are described in detail onthe department’s website. Professor Armstrong gave theDistinguished Lecture at the University of Texas and theHarry G. Fair Lecture at the University of Oklahoma,among other seminars. Professor Armstrong currently serveson the External Advisory Boards and/or VisitingCommittees of the respective Departments of ChemicalEngineering at Carnegie Mellon University, the GeorgiaInstitute of Technology, the University of Michigan, and theVirginia Polytechnic Institute, and in the Departments ofChemical and Biological Engineering at NorthwesternUniversity and the University of Wisconsin.

Janos Beer was presented with the US Secretary of Energy’sLowry Award at a January ceremony in Washington, D.C.The Lowry Award is the highest honor given by the USDepartment of Energy for outstanding contributions to fos-sil energy science and technology. The citation of the Awardreads: “For pioneering research and development in fossilfuel technology, inspirational teaching, and service to thegovernment and industry; for contributions in combustionscience exemplified by the development of a fundamentalunderstanding of heat transfer, NOx formation, and mineralmatter transformation in flames; and for leadership thatcontinues to be critical to the design and commercializationof high-efficiency low-NOx combustion systems widely usedin the fossil-fuel power industry.”

Daniel Blankschtein was on sabbatical leave in the Bostonarea during 2003, and continued to serve as GraduateOfficer in the department. His research group conducts fun-damental theoretical and experimental research in the areaof Colloid and Surfactant Science with emphasis on practi-cal and biomedical applications. Professor Blankschteindelivered a plenary talk at the 12th International Conferenceon “Biopartitioning and Purification” held in Vancouver,BC, and gave an invited talk at the Gordon Research

Faculty Distinctions In the Department of Chemical Engineering


that journal. As an invited speaker at the Tufts Workshop onthe Integration of Chemical and Biological Engineering inApril 2004, he shared his ideas on the teaching of transportphenomena with faculty from a number of participatinguniversities. He was the co-recipient of this year’sOutstanding Faculty Award from the graduate students inthe Department of Chemical Engineering, in recognition of his teaching. His group continued its investigations ofphysiological transport phenomena, which are supported by the National Institutes of Health. Their research topicscentered on the hindered transport of macromolecules inbiological hydrogels, water and protein filtration in kidneycapillaries, and the reaction and diffusion of nitric oxide incell culture systems used for toxicity studies.

Patrick S. Doyle received a Career Award from theNational Science Foundation to study the “dynamics ofpolymer collisions” using single molecule fluorescencemicroscopy and computer simulation. He was an invitedlecturer at several meetings, including universities and hospi-tals such as Tufts University Department of Chemical andBiological Engineering, Massachusetts General Hospital, theNew England Complex Fluids Meeting, and the LabAutomation Conference.

Karen K. Gleason completed her third year as ExecutiveOfficer for the department, gaining Institute approval for anew bachelor’s degree program, “Chemical and BiologicalEngineering–Course XB.” Professor Gleason also oversawseveral space renovations, including the refurbishment ofGilliland Auditorium (66-110), the department’s main lec-ture hall. Her group’s research on chemical vapor depositionto create ultrahydrophobic surfaces was featured in theNovember 2003 issue of Technology Review and on NBCNews programs in August 2003. Professor Gleason gave presentations at the University of California at Berkeley,Cornell University, Rennselaer Polytechnic Institute,Honeywell, Dupont, Wright–Patterson Air Force Base, andthe International Society for Plasma Chemistry in Taormina,Italy. She also continues as Chief Scientific Advisor forGVD Corporation, a company she co-founded in 2001.

William H. Green, Jr., gave invited plenary lectures at theFoundations of Molecular Modeling and SimulationsConference in Keystone Resort, Colorado, and at theInternational Bunsen-Discussion of Dynamics of MolecularPhenomena in Supercritical Fluids in Bavaria, Germany. Hereceived the American Chemical Society Fuel Division’sRichard A. Glenn award at the ACS National Meeting inPhiladelphia, Pa., in August 2004. Professor Green wasrecently promoted to Associate Professor with tenure.

Robert S. Langer received a number of awards in 2003,including the Heinz Award for Technology, Economy, andEmployment; the Harvey Prize, election to the Academy ofAchievement; and the John Fritz Award (given previously toinventors such as Thomas Edison and Orville Wright). Hewas also honored as the Founders’ Lecturer (University ofWisconsin), the Rohm and Hass Lecturer (StanfordUniversity), the Tripathy Endowed Memorial Lecturer(University of Massachusetts, Lowell), the Skinner MemorialLecturer (Northwestern University), the Maurice and YettaGlicksman Lecturer (Brown University), the FMC Lecturer(Princeton University), the Seymour J. Kreshover Lecturer(National Institutes of Health), and the Whitaker Lecturer(American Society of Artificial Organs); and he received anHonorary Doctoral degree from the University of Liverpool,England. Dr. Langer also received the General Motors CharlesF. Kettering Prize for Cancer Research (2004). ParadeMagazine (2004) selected Dr. Langer as one of six “Heroeswhose research may save your life.” He also joined the Boardof Directors for Wyeth Pharmaceuticals, Inc. in 2004.

Gregory C. Rutledge continued to serve as Director ofMIT’s interdepartmental Program in Polymer Science andTechnology, as a team leader of the Institute for SoldierNanotechnologies, and as an Editorial Board member andSpecial Editor for the journal Polymer. In July 2004, heassumed the role of Executive Officer in the Department of Chemical Engineering. Over the past year, he organizedthe third ACS workshop on “Modeling of Macromolecules,”in Hilton Head, S.C. He delivered invited talks at the“International Workshop on Thermodynamics and ComplexFluids” and at several other conferences and universities. Hisresearch entails the molecular engineering of soft matter,through the development of molecular simulations, materi-als characterization, and electrospinning of nanofibers.

Kenneth A. Smith has continued his research on the rolesof fluid mechanics and transport phenomena in a number of contexts. These include the use of the supercritical wateroxidation process for the destruction of organic wastes, a joint effort with Professor Jefferson W. Tester. WithProfessor T. Alan Hatton, he has been studying the dynamics of micellar self-assembly and the properties of a remarkable new class of photo-responsive surfactants. He is also engaged in the development of an instrument thatcan determine the size-segregated chemical composition of an aerosol in real time. This has the potential of greatlyenhancing our understanding of the origins, evolution, anddispersion of atmospheric contaminants that are found inthe submicron particle size range. He is also participating in the Molecular Engineering of Biological and ChemicalSystems (MEBCS) Program within the Singapore–MITAlliance (SMA).


George Stephanopoulos presented the 2003 AIChEInstitute Lecture at the Annual Meeting in San Francisco,Calif., in November 2003. The title of his lecture was,“Invention and Innovation in a Product-Centered ChemicalIndustry: General Trends and a Case Study.” He received the 2003 William H. Walker Award for OutstandingContributions to the Literature of Chemical Engineering.Professor Stephanopoulos was re-elected to the Board ofDirectors of Mitsubishi Chemical Corporation. He made sixpresentations in international workshops and symposia onthe “Reformation and Rejuvenation of the R&D inMitsubishi Chemical Corporation.”

Gregory Stephanopoulos continued his service on theAdvisory Boards of five academic institutions and on theBoard of Directors of the American Institute of ChemicalEngineers (AIChE), where he spearheaded the formation of the new Society for Biological Engineering (SBE). InOctober 2003, he was inducted into the National Academyof Engineering for his pioneering contributions in definingand advancing metabolic engineering as well as for his lead-ership in incorporating biology in chemical engineeringresearch and education. Professor Stephanopoulos also gavethe Cary lectures at Georgia Tech, the Holtz lectures atJohns Hopkins University, and the Centennial lecture atClarkson University. He was also a distinguished lecturer atthe University of Utah. He continued his educational andresearch activity in Bioinformatics and MetabolicEngineering and his work as Editor-in-Chief of the journalMetabolic Engineering, published by Elsevier. In addition, hecontinued to serve on the editorial boards of seven other scientific journals. He co-chaired a Gordon ResearchConference on Bioinformatics held at Queen’s College,Oxford, England, and delivered keynote lectures at theInternational Symposium of Chemical Reaction Engineering(ISCRE) in Chicago, Ill., and at the ASM IMAGEConference in Montreal, Canada. At MIT, he continued his teaching of courses on Bioinformatics and Kinetics ofChemical and Biological Reactions.

Jefferson W. Tester continues to be active in the energy andenvironmental area with both his teaching and research. Heis the Chair of the National Advisory Council of theDepartment of Energy’s (DOE) National Renewable EnergyLaboratory, and is the Co-chair of the Governor’s AdvisoryBoard for the Massachusetts Renewable Energy Trust.Professor Tester also continued as a member of the advisorygroups for the Paul Scherrer Institute, EidgenossischeTechnische Hochschule (ETH/Swiss Federal Institute ofTechnology) in Zurich, Switzerland; the Energy andEnvironmental Systems Division of the Idaho NationalEngineering and Environmental Laboratory (INEEL); theGoverning Board of the Midwest Research Institute; and the

Division of Earth and Environmental Sciences at the Los Alamos National Laboratory (LANL). He gave invited lectures at the Virginia Polytechnic Institute, at the Councilfor Chemical Research, and at MIT on various energy topics, including methane and carbon dioxide gas hydrates,transitioning to a hydrogen economy, universal heat mining,advanced drilling methods, and hydrothermal conversion ofhydrocarbons and biomass. A new 850-page textbook,Sustainable Energy—Choosing Among Options, co-authoredby Professor Tester, Professors Driscoll and Golay of NuclearEngineering, Dr. Drake of the Laboratory for Energy andthe Environment, and Dr. Peters of the Institute for SoldierNanotechnology, will be released by MIT Press this comingFall. Professor Tester received this year’s Outstanding FacultyAward from the graduate students in the Department ofChemical Engineering.

Bernhardt L. Trout was promoted to Associate Professor.He has given invited talks at Stanford University, PrincetonUniversity, and many other engineering institutes, in addition to the American Institute of Chemical Engineers(AIChE) and the American Chemical Society (ACS).Funding for his projects on chemical and process design viamolecular understanding is provided by the NationalScience Foundation (NSF), the Department of Energy(DoE), the National Aeronautics and Space Administration(NASA), the Government of Singapore, Merck, Inc., andAmgen, Inc.

Daniel I.C. Wang was the Keynote Lecturer at the Trendsin Biotechnology Conference held in Vienna, Austria, inNovember 2002. He also presented a series of lectures at the Department of Biochemical Engineering, CatholicUniversity in Valparaiso, Chile, in March 2003. At theCatholic University Valparaiso, he was bestowed anHonorary Doctoral Degree in biochemical engineering. He presented a Keynote Lecture at the Bayer’s StrategicResearch and Development Retreat in April 2003 atBeaufort, N.C. In June 2003, he was invited by theMinistry of Education, People’s Republic of China, to deliver a series of lectures in biochemical engineering andbiotechnology at Tsinghua University, Beijing, in China.

Professor Wang continues as a Faculty Fellow in the SMA Program, where he delivered his course “BioprocessEngineering” at the National University of Singapore inJanuary and March 2003. In addition, Professor Wang is theco-advisor to three PhD candidates in the SMA Program.During 2002 and 2003, he was in charge of presenting anew laboratory course, “Biological Engineering Laboratory10.28” as part of the department’s curriculum for the newcourse, “XB.”

Faculty Distinctions


Jackie Y. Ying delivered 15 invited lectures at various inter-national conferences and national meetings during the pastyear, including keynote lectures at the 10th InternationalConference on Composites/Nano Engineering, theInternational Conference on Materials for AdvancedTechnologies, the TMS Annual Meeting, and the 7th

International Conference on Nanostructured Materials. She served as a symposium organizer for the 18th NorthAmerican Catalysis Society, and is the Conference Chair forthe 1st Society of Bioengineers International Conference onBioengineering and Nanotechnology. Professor Ying was aninvited seminar speaker at the University of California,Berkeley, and at the National University of Singapore, anddelivered the Linsay Lecture at Texas A&M University. Sheserves on the Editorial Boards of eight journals/book series,as well as on the Advisory Boards of the Leibniz-Institut fürFestkörper-und Werkstoffforschung Dresden (Germany), theUniversity of Queensland Nanomaterials Centre (Australia),the National Research Council Steacie Institute forMolecular Sciences (Canada), and the Institute of MaterialsResearch and Engineering (Singapore). Professor Ying is anHonorary Professor of Chemistry of Jilin University(China), and serves on the Canvassing Committee of theAmerican Chemical Society for their Award for CreativeResearch in Homogeneous or Heterogeneous Catalysis.Professor Ying is currently on professional leave in Singaporeas the Executive Director of the Institute of Bioengineeringand Nanotechnology, a new national research instituteunder the Agency of Science, Technology, and Research.

INFINITE MILE AWARDS GO TOFIVE FROM ChemE!

The Department of Chemical Engineering is proud to commend the following staff members who have receivedMIT’s Infinite Mile Awards for Sustained Excellence:

2003 Award Winners

Robin C. Elices, Director, Administrative Services Organization

Constance J. Beal, Lab Administrator for Professor Robert S. Langer

JoAnn B. Sorrento, AdministrativeAssistant to Professor Douglas A. Lauffenburger

2004 Award Winners

Jean-François Hamel, Lecturer and Lab Supervisor

Erminia Piccinonno, Personnel Administrator,Administrative Services Organization


For the Department of Chemical Engineering, 2002–04 hasbeen a period of continued excellence and transformation.Promotions included Gregory C. Rutledge, who was pro-moted from Associate Professor to Full Professor [polymerscience and engineering, statistical thermodynamics andmolecular simulation]. Two faculty members received promotions this year from Assistant Professor to AssociateProfessor: William H. Green, Jr. [reactive chemical engi-neering], and Bernhardt L. Trout [kinetics of aqueous andbiological systems, theoretical heterogeneous catalysis,molecular-level design of products and processes, emissionscontrol and sustainable development] (See articles, page 6).

Faculty Award HighlightsOur outstanding faculty continues to garner recognitionfrom across the US and around the globe. Robert S.Langer, Germeshausen Professor of Chemical andBiomedical Engineering, received another major award in2003—the John Fritz Medal from the AmericanAssociation of Engineering Societies (See article, page 7).

The department honors Bayer Professor GregoryStephanopoulos, who in 2003 was elected to membershipin the National Academy of Engineering (NAE). Electionto the NAE is one of the highest professional distinctionsthat can be accorded an engineer! The NAE cited him forhis pioneering contributions in defining and advancingmetabolic engineering and for his leadership in incorporat-ing biology into chemical engineering research (See article,page 8).

Congratulations to Emeritus Professor Marcus Karel(PhD ’60), who received an honorable Doctorate-Ing. from the Technical University of Munich. Professor Karel’sinterests focus on food and pharmaceutical engineering and preservation.

For the second consecutive year, we are proud to announcethat the AIChE’s prestigious William H. Walker Awardfor Excellence in Contributions to Chemical EngineeringLiterature for 2003 went to one of our own—Arthur D.Little Professor George Stephanopoulos. The 2002 WalkerAward went to Professor Douglas A. Lauffenburger.Congratulations to these and all our many award-winningfaculty members!

Student Award Highlights2003 was a repeat win for ChemE students, as Grad StudentTodd C. Zion led the winning team in the MIT 50KEntrepreneurship Competition! (See article, page 28). The2001 award was also won by a team led by a ChemE duo,then grad students Edward S. Ahn and Darren D. Obrigkeitand their company, Angstrom Medica.

Congratulations to Senior Philip J. Lee, who was elected to the honorary Phi Beta Kappa Society. Membership isconferred in recognition of excellent academic performanceand a demonstrated commitment to the objectives of a liberal education.

Professor Paula T. Hammond’s lab received major pressattention in 2003, with articles in the Washington Post andthe Chemical & Engineering News, featuring collaborationswith recent PhD graduate Dean Delongchamp and withcurrent grad student Kristoffer Stokes.

Alumni/ae HighlightsBrown University faculty member Dr. Michael Lysaght ’64recently received Brown’s Elizabeth LeDuc Award forOutstanding Teaching in the Life Sciences.

Department NewsThe School of Engineering honored three ChemE staffmembers in 2003, with School-wide Infinite Mile Awardsfor Sustained Excellence going to Constance J. Beal, JoAnnB. Sorrento, and ASO Director Robin C. Elices, and in2004 with Awards going to Jean-François Hamel andErminia Piccinonno (See photos, page 13).

Changing Faces We are very pleased to announce three recent staff additions.In ChemE headquarters, Melanie L. Miller joined us asAdministrative Assistant to the Department Head. In theChemE Computing Support office, we introduced threenew staff members, Systems Administrator James Hardsog,Technical Assistant Jean Belbin, and Web Developer RickSmith. Jim and Jean’s extensive experience and expertisehave proven to be an asset to the department in this criticalarea! Special thanks to Brett Groshong and RubenMadrigale for their devoted service in these positions, andgood luck to both in their graduate studies.

We are looking forward to an exciting year of growth andimprovement in 2004–05!

ChemE Connection The Year in Review at a Glance


FRONTIERS IN BIOTECHNOLOGY LECTURE

2002 This year’s Frontiers inBiotechnology Lecturer, Dr.William H. Rastetter, presented hisseminar, “Molecules, Mechanisms,and Monoclonals” in the depart-ment’s Gilliland Auditorium onFriday, November 1st, 2002.

Dr. Rastetter guided us through ahistory of his 32-year journey in

the pharmaceutical industry, with a focus on timelines fordrug development from discovery to commercialization,using as examples Rituxan® (the first monoclonal antibodyfound to be effective and safe for the treatment of cancer inthe United States) and Zevalin [for treatment of relapsed orrefractory low-grade, follicular, or transformed B-cell non-Hodgkin’s lymphoma (NHL)]. In reflecting upon the natureof science, he outlined the differing paradigms for academiaand industry, particularly in the ways that each uses science.

Dr. William H. Rastetter, Chairman and Chief ExecutiveOfficer of IDEC Pharmaceuticals, was appointed Chairmanof the Board of Directors of the Company on May 22nd,1996. He served as President and Chief Executive Officer ofthe Company from December 1986 until January 2002. InJanuary 2002, he turned over the title of President to BillRohn. Dr. Rastetter was also Chief Financial Officer from1988 to 1993, and has served as a Director of the Companysince 1986. From 1984 to 1986, he was Director ofCorporate Ventures at Genentech. From 1982 to 1984, Dr.Rastetter served in a scientific capacity at Genentech, direct-ing the Biocatalysis and Chemical Sciences groups. From1975 to 1982, he held various positions at MIT. Dr.Rastetter received a PhD in chemistry from HarvardUniversity in 1975.

2003 Phillip A. SharpOnce dismissed as nothing morethan comic book fantasy, the devel-opment of a gene-based antiviralmiracle drug may occur soonerthan you think.

The exciting promise shown by thecontrol of gene expression throughRNAi (RNA interference) as a

means of combating viruses was the focus of the 2003Frontiers in Biotechnology Lecture, presented on Friday,October 3rd. An enthusiastic Gilliland Auditorium reception

greeted presenter MIT Biology Institute Professor andNobel Laureate Phillip A. Sharp, Director of MIT’sMcGovern Institute for Brain Research.

Speaking to an overflow crowd, Sharp said using double-stranded small RNAs to silence genes “will fundamentallychange the way we do cell biology. We have to understandhow an organism’s genes interact if we are to understandthese disease processes.” Sharp then presented a briefchronology of DNA research from the 1953 discovery ofDNA by Watson and Crick through the surge in interest ininterferon applications in 1975, and then the discovery in1998 of the RNAi principle.

Interferons are a family of proteins that human cells releasewhen invaded by a virus. Small interfering RNAs (siRNAs)are 21- to 23-nucleotide RNA molecules that can cause targeted gene silencing without triggering any interferonresponse, leading researchers on a quest to create RNA medicines to treat a host of disorders, from high cholesterolto cancer, as well as viral diseases such as AIDS.

Sharp’s longtime goal has been to silence genes in mam-malian cells. His own recent work in the field uses RNAimethods to interfere with cell surface receptors to make anindividual more resistant to viral infections like HIV. He isone of the founders of a Cambridge, Mass., company startedin 2002 that aims to use small RNAs to silence genes in disease states.

Institute Professor Phillip A. Sharp is Founding Director of MIT’s McGovern Institute for Brain Research. Much ofProfessor Sharp’s scientific work has been conducted atMIT’s Center for Cancer Research, which he joined in 1974and directed from 1985 to 1991. He subsequently led theDepartment of Biology from 1991 to 1999. His researchinterests have centered on the molecular biology of geneexpression relevant to cancer and the mechanisms of RNAsplicing; his landmark achievement was the discovery ofRNA splicing in 1977. This work provided one of the firstindications of the startling phenomenon of “discontinuousgenes” in mammalian cells. The discovery that genes containnonsense segments that are edited out by cells in the courseof utilizing genetic information is important in understand-ing the genetic causes of cancer and other diseases. ProfessorSharp’s research opened an entirely new area in molecularbiology and forever changed the field. For this work, hereceived the 1993 Nobel Prize in Physiology or Medicine.

A native of Kentucky, Sharp earned a BA degree fromUnion College, Ky., and a PhD in chemistry from theUniversity of Illinois, Champaign-Urbana in 1969. He didhis postdoctoral training at the California Institute of

Named Lectures In the Department of Chemical Engineering


Technology, where he studied the molecular biology of plasmids from bacteria in Professor Norman Davidson’sLaboratory. Prior to joining MIT, he was the SeniorScientist at Cold Spring Harbor Laboratory.

Professor Sharp co-founded Biogen, Inc. with ChemEInstitute Professor Daniel I.C. Wang in 1978, and is alsothe co-founder of Alnylam Pharmaceuticals (2002).

Frontiers in Biotechnology was established in 1999, toacknowledge the enabling technologies which have sustainedthe growth of biotechnology and life sciences, and to honorthe achievements of distinguished scientists and engineers inthe field. The department warmly thanks Dr. Noubar B.Afeyan ’87, whose generous donation made this visionarynew series possible.

HOYT C. HOTTEL LECTURE2002On Friday, December 6th, 2002,California Institute of TechnologyProfessor John H. Seinfeldpresented this year’s Hoyt C.Hottel Lecture on the topic“Aerosols and Climate,” inGilliland Auditorium.

Airborne particles such as shipexhaust, dust storms, forest fire

and industrial plumes; their links to human activity; and thepotential for the interaction of these particles to affect ourglobal climate were the primary focal points of ProfessorSeinfeld’s fascinating seminar.

He emphasized the importance of examining the interac-tions of different types of particles with one another andwith light, and of accounting for the numerous sources ofairborne particles worldwide. Dramatic satellite photos,showing earth-orbit views of particles and their sources,revealed their ubiquitous nature and potentially climate-altering migration patterns. Seinfeld emphasized that therole of particles stands as the single least understood factorwith regard to their effects on climate change. In closing, hemade the guarded prediction that current aerosol and green-house gas trends point to increased visible and infrared sur-face radiation in coming decades.

Professor John H. Seinfeld is widely acknowledged for hisresearch on the chemistry and physics of the atmosphere.Through both experimental and theoretical studies, he hasmade numerous contributions to the knowledge of urban

atmosphere chemistry, atmospheric aerosol formation,growth, and dynamics, and to the role of aerosols in the climate. He is one of the founders of the field of mathemati-cal modeling of the atmosphere, work that eventuallybecame written into the United States Clean Air Act. He isa member of the National Academy of Engineering and aFellow of the American Academy of Arts and Sciences.

Seinfeld received a BS degree from the University ofRochester and a PhD from Princeton University, both inchemical engineering. He joined the faculty of theCalifornia Institute of Technology in 1967.

For more about research in Professor Seinfeld’s lab…http://www.che.caltech.edu/faculty/seinfeld_j/index.html

2003Charles E. Kolb, President andCEO of Aerodyne Research

Think of crystal-blue horizons,brilliant sunsets, or the night sky’ssoaring black vault of heaven awashin twinkling astral pinpoints. Vistasof Earth’s enveloping and protectiveatmosphere easily inspire the illusion of infinite beauty—and

infinite airborne pollutant absorption capacity.

Dr. Charles E. Kolb ’67, our 2003 Hottel Lecturer, and aformer student of Professor Hottel’s, sees the atmosphere inmore quantitative terms; a complex, dynamic system with avolume of about 2.5 x 1010 km3 (stratosphere and tropo-sphere combined). Kolb captivated this year’s audience forthe October 24th lecture with his presentation, “The Impactof Combustion Emissions on the Atmosphere: New Toolsand Techniques.”

Kolb started by introducing us to cartoon character “BobbyBadair”—a sort of poster-child for the range of multipleatmosphere-related maladies—shortness of breath, acid rainburns, and skin lesions due to depleted stratospheric ozone.He then presented detailed quantifications of various typesof emissions by source, and some of the likely phenomenaassociated with their effects on the troposphere and strato-sphere. Kolb also introduced a few of the latest tools nowbeing used to gather emissions data, including Aerodyne’ssecond-generation Mobile Laboratory, which has spent significant time on the move, particularly in Mexico City,Mexico, but also in Boston, Mass., and Manchester, N.H.The Mobile Laboratory, a retrofitted delivery van boasting a

Named Lectures


state-of-the-art arsenal of tools for real-time emissions analy-sis, is used for stationary sampling, mobile sampling andmapping, and “vehicle chasing” for on-road emissions quantification under typical operating conditions.

Kolb’s systematic and lucid presentation gave us an intrigu-ing look at our atmosphere, and how an impressive array ofnew tools is yielding data and trends that can help mankindshape a healthier future. His numerous acknowledgmentsincluded a number of MIT collaborators, among themChemE’s Professor Gregory J. McRae and Nobel Laureateand former MIT EAPS Professor (now at the University ofCalifornia, San Diego) Mario Molina.

Dr. Charles E. Kolb ’67, President and CEO of AerodyneResearch, has been a prolific contributor on energy, theenvironment, and atmosphere physics. He has publishedmore than 120 papers in areas related to combustion atmos-pheric science and user physics. Kolb is a fellow of theAmerican Physical Society, the Optical Society of America,the American Geophysical Union, and the AmericanAssociation for the Advancement of Science. He has been amember of numerous government and National Academy ofSciences/National Research Council committees dealingwith atmospheric and environmental chemistry issues.

Kolb holds a BS degree in chemistry from MIT, andreceived an MS degree (1968) and a PhD from Princeton(1971). In addition to his numerous professional activities,he has been a tireless contributor to programs at MIT. His many awards include the Harold E. Lobdell ’17Distinguished Service Award and the Bronze Beaver Awardin recognition of his sustained service to MIT and the MITAlumni Association.

Kolb and his team at Aerodyne Research have served as collaborators with many researchers, including MIT facultymembers such as Professors Kenneth A. Smith, Herbert H.Sawin, and Adel F. Sarofim.

For more about Dr. Charles E. Kolb and Aerodyne Research…http://www.aerodyne.com

A video of Dr. Charles E. Kolb’s lecture is available at…http://mitworld.mit.edu/video/37/#

The Hoyt C. Hottel Lectureship was established in early1985 to recognize Professor Hottel’s contributions to theintellectual climate of the Department of ChemicalEngineering, to the encouragement of students over sixdecades, and to the foundation and direction of the FuelsResearch Laboratory. The Lectureship is intended to draw

eminent combustion and energy technology scholars toMIT for short residencies, in order to stimulate future generations of students. The inaugural Hottel Lecture waspresented in April 1985 by Professor Hottel, himself.

WARREN K. LEWIS LECTURE

2003Honeywell Specialty MaterialsPresident Dr. Nance Diccianiconducted a lively examination ofthe evolution of the US chemicalindustry as the focus of the 2003Warren K. Lewis Lecture, held onFriday, May 2nd, 2004 in 66-110.

Dr. Dicciani’s seminar,“Engineering EngineersTomorrow,” traced the industry’shistory from experimental 18th

century beginnings to its dramatic growth over the past 300years. Along the way, she detailed Honeywell’s “Triple BottomLine,” which prioritizes economic, environmental, andsocial concerns as the foundation for sustainable, responsibleindustry practices, occasionally springing “pop-quiz” questionsupon audience members to test their savvy about historicallysignificant people, places, products, and trends.

She spotlighted nanotechnol-ogy, microprocessors, andsensors as major areas of predicted growth, and therising importance of Chinato global business strategy.

Marking the passing of the Iron, Steel, and Silicon Ages, shehailed the imminent coming of the “Molecular Age.” Alongwith a concurrent rise in demand for harnessing real-worldsolutions to breakthrough molecular research outcomes, shepredicted a rise in the need for imaginative, highly skilledchemical engineers who are dedicated to the betterment ofmankind through the application of economically, environ-mentally, and socially sensitive engineering principles.

Dr. Nance Dicciani is President and CEO of SpecialtyMaterials, a strategic business group of Honeywell thatserves as a world leader in the production of nylon, poly-ester, polyethylene, fluorocarbons, caprolactam, electronicmaterials, and specialty chemicals.

“Chemistry and chemical engineering are right at theheart of all these future trends.”


Dicciani joined the company in November 2001 fromRohm and Haas, where she held the position of Senior Vice President and Business Group Executive of ChemicalSpecialties and Director, European Region. As RegionalDirector, Europe, she was responsible for the company’soperations and infrastructure in Europe, the Middle East,and Africa. Dicciani joined Rohm and Haas in 1991; andduring her tenure, she served as Vice President and GeneralManager of the Petroleum Chemicals Division and headedthe company’s worldwide monomers business.

Dicciani holds a BS degree in chemical engineering fromVillanova University, an MS degree in chemical engineeringfrom the University of Virginia, and a PhD in chemicalengineering from the University of Pennsylvania. She alsoreceived an MBA degree from the Wharton School of theUniversity of Pennsylvania.

A video of Dr. Nance Dicciani’s lecture is available at…http://mitworld.mit.edu/video/118/

2004 Frank S. Bates

On April 30th, 2004, the depart-ment welcomed alumnus FrankS. Bates, DistinguishedMcKnight University Professorand Head of Chemical andMaterials Engineering at theUniversity of Minnesota/TwinCities, as the presenter of the

2004 Warren K. Lewis Lecture. Gilliland Auditoriumhosted a capacity crowd for this year’s lecture, “PolymerScience and Engineering: Slow and Delicate.”

Introduced by his former research supervisors, ProfessorRobert E. Cohen and Professor Emeritus Edward W. Merrill,Bates first shared some memorable recollections of his workhere. He then presented a captivating survey of polymer history, crediting “Doc” Lewis’s book, Industrial Chemistryof Colloidal and Amorphous Materials, as a major influence.This was followed by a look at current directions, includinga new material for less costly CD manufacturing, a syntheticcell membrane whose applications include near-infraredmedical imaging.

Frank S. Bates received a BS degree in mathematics fromSUNY Albany in 1976, and an MS degree and an ScD inchemical engineering from MIT in 1979 and 1982, respec-tively. Between 1982 and 1989, Bates was a member of thetechnical staff at AT&T Bell Laboratories, and then joinedthe University of Minnesota as an Associate Professor. He

was promoted to Professor in 1991 and was named aDistinguished McKnight University Professor in 1996.Professor Bates conducts research on a range of topics, witha particular focus on the thermodynamics and dynamics ofblock copolymers and blends. In 1988, Bates was named aDistinguished Member of the Technical Staff at Bell Labs;in 1989, he received the Dillon Medal and in 1997 thePolymer Physics Prize, both from the American PhysicalSociety where he is a Fellow. In 2002, Bates was elected tothe US National Academy of Engineering.

For more about research in the Bates Lab…http://www2.itdean.umn.edu/faculty/detail.jsp?facultyID=18

This lecture series is a tribute to Professor Warren “Doc”Lewis, who is well known as one of the Department ofChemical Engineering’s most revered members. Also, theAIChE Warren K. Lewis Award, established in his honor,recognizes outstanding educators in chemical engineering.

ALAN S. MICHAELS LECTURE2003Leroy Hood

“After the Genome:Systems Biology” was thetitle of the 2003 Alan S.Michaels Lecture, presentedby Dr. Leroy Hood onFriday, April 25th, 2003, inthe Media Lab’s BartosTheater. Dr. Hood is the

President of the Institute for Systems Biology (ISB), ofSeattle, Wash. The mission of the ISB is twofold: the revolu-tionizing of biology through a systems approach; and pre-dictive and preventative medicine.

Introduced by Professor Robert S. Langer as the “true pioneerin protein and gene sequencers and synthesizers,” Dr. Hood,the 2003 Lemelson–MIT Program’s $500,000 prize win-ner—the world’s largest single cash prize for invention—presented an engaging exploration of the past, present, andfuture of the relatively new discipline of systems biology.

Systems biology emerged out of three forces: the Internet,the Human Genome Project, and cross-disciplinary science.A systems approach to biology analyzes a living thing as awhole, rather than one gene or one protein at a time.According to Hood, it holds the secret to understanding diseases at the molecular level, which will have a profoundeffect on the practice of medicine within the next 10 or 15

Named Lectures


years. In 2000, Hood and two colleagues recognized theneed to formalize the study of systems biology, and foundedthe Institute for Systems Biology (ISB).

Hood predicts that the practice of medicine will shift fromtoday’s reactive approach—diagnosing and treating a diseaseafter it has manifested itself—to a predictive and preventiveapproach. Predictive medicine will enable the detection ofgenes that predispose humans to disease, such as cancer andcardiovascular disease; while preventive medicine will enablethe isolation of the problem gene, and design medicine toblock the effects of the defective gene.

Dr. Leroy Hood is one of the world’s leading scientists inmolecular biotechnology and genomics. Dr. Hood earnedan MD from Johns Hopkins University in 1964 and a PhDin biochemistry from the California Institute of Technologyin 1968. Dr. Hood has published more than 500 peer-reviewed papers and has co-authored textbooks in biochem-istry, immunology, molecular biology, and genetics. He alsoco-edited Code of Codes, a book discussing the scientific,social, and ethical issues raised by genetic research. Dr.Hood is a member of the National Academy of Sciences, theAmerican Philosophical Society, and the AmericanAssociation of Arts and Sciences.

His professional career began at Caltech, where he and colleagues pioneered four instruments that constitute thetechnological foundation for contemporary molecular biology.One of the instruments has revolutionized genomics byallowing the rapid automated sequencing of DNA. Dr. Hoodalso was one of the first advocates of, and is a key player in,the Human Genome Project—the quest to decipher thesequence of human DNA.

Dr. Hood joined the University of Washington in 1992 tocreate the Department of Molecular Biotechnology, and in2000 he founded the Institute of Systems Biology.

For more about Dr. Leroy Hood and the Institute forSystems Biology...http://www.systemsbiology.org

2004 Noubar B. Afeyan

This year’s Alan S. MichaelsLecturer, Dr. Noubar B.Afeyan, was a returning alumnusand is the sponsor of ChemE’sFrontiers in Biotechnologylecture series launched in1999. An enthusiastic reception

greeted Dr. Afeyan’s intriguing presentation, “BioSystemsEngineer: Harnessing the Logic of Life,” which took placeon Friday, April 16th, 2004, in Bartos Theater.

Dr. Noubar B. Afeyan, Senior Managing Director and CEOof Flagship Ventures, is a recognized technologist and entre-preneur. He is a Senior Lecturer at MIT’s Sloan School ofManagement, and is a frequent guest speaker at technologyforums throughout the country. Dr. Afeyan has authorednumerous scientific publications and patents. He earned aBS degree in chemical engineering from McGill Universityin Montreal, Canada, and a PhD in biochemical engineer-ing from MIT.

Prior to co-founding Flagship Ventures in 1999, Dr. Afeyanwas the Founder, Chairman, and CEO of PerSeptiveBiosystems, a leader in the bio-instrumentation field thatmerged with Applera Corp. in 1998. During 1996 and1997, he also served as Chairman of the Board ofChemGenics Pharmaceuticals, a privately held companyspun out of PerSeptive and acquired by MillenniumPharmaceuticals in 1997. Until August 1999, he was SeniorVice President and Chief Business Officer of AppleraCorporation, where he initiated and oversaw the creation of Applera’s subsidiary, Celera Genomics. He has also been a founding team member, investor, and active BoardMember/Advisor of Antigenics, Color Kinetics, andEXACT Sciences.

Dr. Noubar B. Afeyan currently serves as a Director for several Flagship portfolio companies, and he continues toserve on the boards of Antigenics and Color Kinetics. Inaddition, he serves on Advisory Boards for BostonUniversity Medical School, the Whitehead Institute at MIT,the McGowan Institute at the University of Pittsburgh, theCenter for Bits and Atoms at MIT’s Media Lab, and theFaculty of Engineering at McGill University.

This Lectureship has been established as part of an endowment fund donated in honor of Alan S. Michaels, a distinguished leader in bioengineering. The series providesa forum for annual lectures dedicated to bringing distin-guished engineers from academia and industry to share their views on research and development in medical andbiological engineering.


GETTING DOWN TO BUSINESS:GRADUATION ARRIVES FOR FIRSTPHDCEP CLASS

In Fall 1999, we proudly announced a new PhD programcombining rigorous research and chemical engineering practice elements, with an intensive year of managementeducation. In Fall 2000, with the entry of our first class ofstudents to the newly minted PhD in Chemical EngineeringPractice (PhDCEP) Program, this exciting new venture wasat last underway.

One Student’s Journey

After three challengingyears of ChemicalEngineering courseworkand research, currentPhDCEP student PremV. Pavoor recently com-pleted the managementportion of his curriculumthrough the SloanSchool, which he beganin Fall 2003.

Reflecting upon his expe-riences in the program,Pavoor remarked, “Iwanted a program inwhich I could combinegroundbreaking researchwith practical manage-ment training. I foundthat in the PhDCEPProgram, which is offered

only at MIT. I’ve been able to do really interesting polymerresearch for biomedical applications, and this Fall will beginclasses at Sloan... . The Practice School part of the programwas intense. I worked for two companies: Alkermes here inCambridge, Mass., and Mitsubishi in Japan. It taught me alot about working with deadlines, group dynamics, and howto frame a problem. In textbooks, the problems are all laidout for you to solve; but in the real world, you have to identify and define the problem boundaries before you startto work on them. It was a very valuable experience.”

The Business End of the ProgramFacing the start of his management studies in Fall 2003,Pavoor reflected upon the exciting and demanding changesthat will arise with the start of his management course ofstudy. Although he expressed some regret at the shift away

from solitary lab research, he embraced the importance of management skill building and networking as critical elements of the innovative PhDCEP Program.

Pavoor expressed keen interest in learning more aboutstrategic marketing and the process of finding your “niche.”He anticipates that post-graduation plans will involve apply-ing his new skills toward either joining or building a startupfirm, or developing a consulting practice.

We look forward to hearing more about Pavoor and ourother PhDCEP students as their careers develop, enrichingthe workforce with a unique combination of analyticalexpertise and foundational business leadership skills.

The PhDCEP Program entails a four-yearcourse of study, having three main parts plus a fourth integrative element:

1. The first year focuses on MSCEP comple-tion, in addition to taking and passing thedoctoral qualifying exams and completingthe thesis selection process.

2. The second and third years consist of thesisresearch, which must lead to original, independent research publishable in archival journals.

3. The fourth year consists of the first-year coreof the Sloan School MBA Program.

4. The IAP of the fourth year and the finalsummer is spent with the thesis supervisorwriting a “capstone” paper that might, for example, deal with the business opportunities or potential market impact of the technology studied in the year-twoand year-three thesis research. This is incorporated as the final component of thestudent’s thesis.


Effective July 1st, 2004, Professor Karen K. Gleason decidedto step down as the Executive Officer in the department.During Professor Gleason’s three-year tenure as ExecutiveOfficer, she achieved major accomplishments in both educa-tion and space, two traditional focal points for the ExecutiveOfficer. Educational accomplishments included the completereview and revamping of our Course X degree and the creationof the first new undergraduate degree in the department, theSB in Chemical–Biological Engineering (XB), since the 1950s.Examples of space accomplishments are evident to anyonewho walks around Building 66 and admires and enjoys thenewly renovated spaces on the first floor (GillilandAuditorium) and on the second floor (graduate student officesand Walker Lounge). In addition, this past year she has drivena major study of existing chemical engineering space and ourspace needs for the future. This study will be invaluable to usin our future space planning and development.

Also effective July 1st, 2004, Professor Gregory C. Rutledgebecame Executive Officer in the department. ProfessorRutledge brings invaluable experience to the ExecutiveOffice, having just served as the Director of MIT’s Programin Polymer Science and Technology (PPST) and prior tothat as ChemE’s Graduate Admissions Officer. He has taughtwidely in our curriculum, and has been an active participantand a thoughtful voice in curriculum discussions.

With the academic year that ended in June 2004, we againproduced outstanding graduates at both the undergraduate-and graduate-degree levels. We awarded 41 SB degrees inchemical engineering, 70% to women. The 41 bachelor’sdegrees awarded this year represent the lowest number since1987. Sophomore class sizes have been increasing for thepast three years, with this coming Fall’s rising sophomoreclass comprised of more than 80 students. Also, during theacademic year just ended, we granted 36 master’s degrees inchemical engineering (most of those in the Practice School)and 28 doctoral degrees.

For this coming Fall, we admitted over 70 new graduate students to study in one or both of the Practice School anddoctoral programs. The quality of the students is excellent,as measured by the large number of applicants to our program,the high degree of selectivity exercised in our admissionsprocess, and our unusually high yield (i.e., the percentage ofadmitted students who accept our offer). We are grateful toProfessor K. Dane Wittrup and the Graduate AdmissionsCommittee for their hard work in recruiting these outstand-ing students. After three years of exceptional leadership ingraduate recruiting, Professor Wittrup handed over the reinsof the Graduate Admissions Committee to Professor PaulaT. Hammond for 2005.

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HEAD from page 1

In the 1920s, a group of chemical engineers led by MIT faculty members met to create “The Literature of a Profession.”These books and the ones that followed in the 1950s and1960s, which emphasize engineering science, have becomethe cornerstones of the current Chemical Engineering curriculum. Unfortunately, these teaching materials do notreflect the dramatic advances that have occurred in theunderlying sciences of chemistry and biology, nor do theycapture the exciting frontiers of research in modern chemicalengineering. Over the past two years, MIT has once againbeen active in leading discussion on the directions of ourdiscipline and its educational programs. Last year, threeworkshops entitled, “Frontiers in Chemical EngineeringEducation,” were held to assess our curriculum. Facultyfrom more than 53 universities and industry representativesfrom five companies reached strong consensus that there is aneed for change, and that extensive change is needed ratherthan the incremental evolution of the existing curriculum.

Through this process, broad consensus has been developedregarding the basic principles for chemical engineering under-graduate education in the future, which will address the fundamental knowledge, skills and attributes, and methods ofengagement with the students. From these principles, a newset of organizing principles emerged: molecular transforma-tions, broadly interpreted to include chemical and biologicalsystems and physical as well as chemical structural changes;multiscale analysis, from submolecular through supermacro-scopic scales for physical, chemical, and biological processes;and a systems approach, addressed to all scales and supplyingtools to deal with the dynamics, complexity, uncertainty, andexternal factors. This set of organizing principles provides aflexible platform for educating chemical engineers for thefuture, when coupled with carefully selected supporting subjects from other fields, an appropriate freshman experience,and extensive laboratory experiences.

I expect it will be a decade-long effort to fully realize a com-plete restructuring of the Chemical Engineering curriculum,but I believe the rewards will be great. I invite you to readmore about this curriculum effort on our websitehttp://mit.edu/che-curriculum/.

As a more immediate response to the need to incorporate biology into our curriculum as a core molecular science alongwith chemistry, we have introduced a new SB degree, XB inChemical–Biological Engineering. The definition of the intel-lectual content of this degree and its movement through theMIT approval process has been accomplished over the last yearand a half under the guidance of Professors Karen K. Gleasonand K. Dane Wittrup. We are indebted to both of them forthis Herculean task (See page 27 for details).

From the Head of the Department


continued from previous page

An essential asset in our effort to attract the very best studentsto our department is the generous external support to thePractice School and our doctoral program by our alumni/ae,through the endowed and continuing support of graduatefellowships. We are truly indebted to you for your ongoingcommitment and support. Beyond its value as a recruitingtool, funding for graduate fellowships is an essential elementof our graduate educational philosophy.

By targeting fellowship support on Practice School studentsand beginning doctoral students, we can have these studentsbegin their graduate program focused on the core subjects ofChemical Engineering. This not only provides all studentswith in-depth study of the fundamentals that underlie what-ever specialty they pursue in chemical engineering, but alsoprovides doctoral students with the important opportunity tolearn more about the breadth of research opportunities in thedepartment before choosing a thesis topic. This model foreducating graduate-level chemical engineers goes hand inhand with the picture of modern chemical engineering as thecentral engineering discipline embraced by our department.

In the past year, there have also been several significantchanges in the faculty, especially in the areas of tenure andpromotion. This academic year, Professor William H.Green, Jr., received tenure. Last academic year, ProfessorGregory C. Rutledge was promoted to Full Professor, andProfessor Bernhardt L. Trout was promoted to AssociateProfessor of Chemical Engineering in the department. Weare very proud of the accomplishments of these importantmembers of our department (See page 6 for details).

I am also pleased to report that the department hired onenew junior faculty member last year, Dr. Kristala JonesPrather, and one new junior faculty member this year, Dr.Narendra Maheshri. Dr. Prather received an SB degree inchemical engineering from MIT and was the winner of theKarl Taylor Compton Prize. She received a PhD in chemicalengineering from the University of California, Berkeley,before joining Merck, where she worked in bioprocessingresearch until the beginning of this summer. She joined thedepartment in August 2004. Dr. Maheshri, who will join usin the Spring of 2006, received SB degrees in chemical engi-neering and in biology from MIT, where he was a Phi BetaKappa scholar. He received a PhD in chemical engineeringfrom the University of California, Berkeley, under the direc-tion of alumnus Professor David Schaffer. Before joiningthe faculty here, Dr. Maheshri will do postdoctoral researchwith Professor Erin O’Shea at UCSF. Dr. Maheshri’s focusarea is cell signaling. The addition of these two outstandingjunior faculty members will bolster our already accom-plished bioengineering faculty.

During 2003-04 we had from the University of Alberta,Visiting Professor Janet Elliott. During the Fall 2003 semester, Professor Elliot co-taught the sophomore thermo-dynamics subject with Professor T. Alan Hatton. Professorand University Scholar at the University of Illinois atUrbana-Champaign Richard Braatz spent a sabbatical withus last year and taught the Systems Engineering subject during the Spring 2003 term. We are also pleased to welcomeProfessor George Stephanopoulos back from a leave ofabsence. Professor Stephanopoulos was Executive ManagingOfficer and Chief Technology Officer at MitsubishiChemical in Tokyo, Japan.

And finally, our faculty members continue to distinguishthemselves, as the past two years have produced yet anotherextensive list of faculty honors and awards. To name just a few notable achievements, in 2003 Professor Robert S.Langer received the Heinz Award for Technology, Economy,and Employment; the Harvey Prize; election to theAcademy of Achievement; and the John Fritz Award (givenpreviously to inventors such as Thomas Edison and OrvilleWright). In 2004, Professor Langer won the General MotorsKettering Award for Cancer Research (2004). Parade Magazine(2004) selected Professor Langer as one of six “Heroeswhose research may save your life.” In 2004, ProfessorGregory Stephanopoulos was elected into the NationalAcademy of Engineering (NAE) for his pioneering contribu-tions in defining and advancing metabolic engineering andfor his leadership in incorporating biology into chemicalengineering research and education. Professor Emeritus Adel F. Sarofim was also elected to the NAE for advancingour understanding of the mechanisms and modeling ofprocesses that control radiation in and pollutant emissionsfrom combustors. Professor George Stephanopoulosreceived two major AIChE Awards in one year. He receivedthe 2003 AIChE William H. Walker Award for excellence in research publications and was the 2003 Institute Lecturerfor AIChE. In January 2004, the US Secretary of Energypresented the Lowry Award of the US Department ofEnergy (DoE) to Professor Emeritus Janos Beer, at aWashington, D.C., ceremony. The Lowry Award is thehighest honor given by the DoE for outstanding contribu-tions to fossil energy science and technology. As you cantell, our faculty, in addition to their dedication to researchand teaching, are also highly regarded and respected by theirpeers in the discipline.

I hope that you enjoy this issue of the newsletter, and Iencourage you to write to us and let us know how you aredoing. Thank you all for your support, and best wishes forthe coming year!

From the Head of the Department

Al Armendariz ’93 has recently been appointed the J.Lindsay Embrey Assistant Professor of Engineering in theDepartment of Environmental and Civil Engineering atSouthern Methodist University in Dallas, Tex.

Curtis F. Gerald ’41 is pleased to report that the 7th edition of his textbook, Applied NumericalAnalysis, is complete and willsoon be available! [PUB: Addison-Wesley]

Gus Griffin ’39 presented a paper detailing the principlesof his Carbon-Free Fuel Cell design, at the 16th InternationalForum on Applied Electrochemistry, held in November2002 in Amelia Island Plantation, Fla.

The department thanks John Grover ’48, whose recentdonation funded a new Endowed Fellowship in the depart-ment. The funds generated by this endowment will helpsupport graduate students for years into the future.

Prentiss Lobdell ’33 is doing well in the Florida Keys, and would love to hear from any classmates who might livenearby—[email protected].

Joseph B. Marx ’37 has enjoyed living in Lincoln, Nebr.,after moving there in 1992 to be closer to his son David, aprofessor of statistics at the University of Nebraska. Happilymarried now for over 60 years, he’s proud to report that inhis family he’s known as father, grandfather, and, mostrecently, great-grandfather! Marx retired in 1977 after a 40-year career at Hercules, Inc., as their Manager for ChemicalEngineering Research.


Hats off to Professor Nicholas A.Peppas (ScD ’74) of the Universityof Texas/Austin, and MIT ChemEProfessor Robert S. Langer (ScD’74), whose jointly authoredAIChE Journal article, “Advances inBiomaterials, Drug Delivery, andBionanotechnology,” recently madehistory! Appearing in the December

2003 issue of the American Institute of Chemical Engineers’AIChE Journal, this article is the first AIChE Journal articleto make the 10 Most Requested Papers List maintained by theChemistry and Related Sciences Division of the AmericanChemical Society (ACS) on their “Science Spotlight” website.

Web browsers in the MIT domain can read the article at nocharge via the MIT Libraries VERA E-Journals website...http://river.mit.edu/mitlibweb/FMPro?-db=RS_Items.fp5&-Lay=web&-format=ro_search.htm&-findany.

Clyde K. Smith ’35, having retired from Bechtel Corporationin 1977, reports that—at 91 years of age—he’s still in fairlydecent shape.

Otto J. Solis (SM ’78) is President of Serlienaca, a servicescompany in his hometown of Maracaibo, Venezuela.

The newest book by Peter H. Spitz’48, The Chemical Industry at theMillennium: The maturing of com-modity and specialty chemicals, wasreleased in September 2003 by theChemical Heritage Foundation.This work examines the industry’sevolution from the post oil-shock

years of the late 1970s through the emergence of “reengi-neering,” environmentally sensitive “Responsible Care” prac-tices, and the impacts of information technology proliferationand market globalization. This is a follow-up to Spitz’s 1988book, Petrochemicals: The Rise of an Industry, which coveredthe unusually rapid growth of the petrochemical industryfrom the 1920s to the 1970s.

By T. Alan Hatton, Director News from Alumni/ae

Jim (’54) and ConnieBrown relaxing atthe 2004 ChemEAlumni/ae Reception

2004 ChemE Alumni/ae Reunion visitors From L to R:Prof. Daniel Blankschtein, with Saverio Greco ’51 andPhil Townsend ’64.


In a recent review, Alex Tullo of Chemical and EngineeringNews commented, “Few major events of the past 30 years areomitted in the book. Spitz throws in everything—including thekitchen sink—or at least the McDonald’s polystyrene clamshellsandwich container. …Spitz has a tremendous ability to distillevents down to their essence.”

After a busy career in the industry, most recently as co-founder of ChemSystems, Spitz now works as a consultantfor IBM. ChemSystems, co-founded by Spitz and Bob Davisof Scientific Design, was a $20M company by the mid-1990s, and in 1998 was acquired by IBM Consulting.

IN MEMORIAM

Lead-Free Gasoline Pioneer, Vladimir Haensel Dies at 88

UMass/Amherst Emeritus ProfessorVladimir Haensel (MS ’37), whomade lead-free gasoline possible, diedlast Sunday in Amherst, Mass.Haensel invented and developed aprocess in 1947, known as “platform-ing”—short for platinum-reform-ing—which uses a platinum-basedcatalyst to convert petroleum into

cleaner-burning fuel by increasing octane and eliminatingthe need to add lead.

This process became the key to lead-free fuel for automo-biles, which facilitated major strides in improving engineefficiency.

Haensel earned a master’s degree in chemical engineering atMIT, between stints at Northwestern University where heearned his undergraduate (’35) and doctoral (’42) degrees.His career in industry began with a summer position atUniversal Oil Products (UOP) in Des Plaines, Ill., workingwith chemist Vladimir Ipatieff who became Haensel’s men-tor. Haensel retired from Universal in 1981, dedicating him-self to a second career as a professor from which he thenretired in 1998. He became known for his skill at makingpeople feel at ease, his receptiveness to ideas from studentsand colleagues, and his enthusiasm for teaching and men-toring graduate students.

Among Haensel’s honors is the Charles Stark DraperPrize, sometimes referred to as the “Nobel Prize forEngineering,” which he was awarded in 1997 nearly 50years after the advent of his new platforming process. Otherhonors included the American Institute of ChemistsChemical Pioneer Award and the Society of ChemicalIndustry Perkin Medal (American Section), both for 1967;the National Medal of Science in 1973; the NationalAcademy of Sciences Award for Chemistry in Service toSociety in 1991; and the UMass Chancellor’s OutstandingTeacher Award for 1994.

Professor Haensel held about 145 US patents and 400 foreign patents, which was impressive to his students butless so to the man himself. “One of the lab technicians atUOP, a guy who only completed two years of communitycollege, had more than 50 patents, too,” he said. “That’sbecause nobody oppressed him for not having the right ini-tials after his name, and it’s because he got invited to all thedepartment meetings and presentations just like everyone

News from Alumni/ae

2003 ChemE Reunion Spans Generations From L to R:Karen Hladik ’78, Prof. C. Michael Mohr, Eric Reiner ’83,Emeritus Prof. Charles Satterfield, Suresh Gupta ’78,Javit Drake ’94, Zulfikar Tejpar ’78, Cordelia Price ’78,Natalya Eliashberg ’93, and Prof. Robert C. Armstrong(Head).

Alex Diaz ’91 (L) gets a warm reception fromChemE Events CoordinatorArline Benford (R).


else. I tell my students and remind them, ‘Don’t denigrate anybody.’”

John J. O’Neill, Jr. (ScD ’51), formerly of Spartanburg,S.C., died in Atlanta, Ga., on October 12th, 2001. Johngraduated from LSU in 1943 with a BS degree in chemicalengineering. He served as a Captain in the Army, on activeduty from 1943 to 1946. From 1951 to 1965, he workedfor du Pont and was involved in Research and Development.From 1965 to 1996, John was a Research Director and thena Consultant for Milliken & Company in Spartanburg, S.C.

John was an active member of the Industrial ResearchInstitute and the American Institute of Chemical Engineers,and was the founder of the Western Carolina Section of the AIChE. He served on Advisory Boards at Rose-HulmanInstitute of Technology, the Textile Research Institute,Georgia Institute of Technology, Tulane UniversityChemical Engineering Department, and ClemsonUniversity Department of Mechanical Engineering. He was an Educational Counselor representing MIT in theSpartanburg, S.C., area for many years.

Arch C. Scurlock ’43, Solid-Fuel Rocket, R & D Pioneer

The department regrets to announce the death of researchand development/solid-fuel rocket pioneer, Arch C. Scurlock(SM ’43, PhD ’48).

Atlantic Research Corporation(ARC), co-founded by Scurlockand Arthur W. Sloan in 1949, iscredited with advances in solid-rocket propellant technology, which helped ensure our nation’ssecurity throughout the height of the Cold War era and into themodern era.

Shortly after the founding of ARC,Scurlock was joined by fellow MIT alumnus, John H.Grover ’49, with whom he remained close for most of his50-plus–year professional career.

Scurlock was admired for his uniquely energetic and progressive leadership style. His most recent post had been as President and Chairman of Halifax Corporation, aVirginia-based managed services company. In addition toAtlantic Research, his career included the startup of severalother successful ventures such as TransTechnologyCorporation, a manufacturer of aerospace defense andother industrial products; and Research Industries, a private investment firm.

Also, Scurlock generously established graduate fellowships at both the University of Texas and MIT. We salute ArchScurlock’s energetic spirit and pivotal role as a scientist, philanthropist, and business leader, and hope that his example will continue to serve as an inspiration to others.

For further reading about Scurlock and AtlanticResearch Corporation...A fascinating, in-depth history of the founding and rise of Atlantic Research Corporation is recorded in the book,The Rocket Scientists: Achievement in Science, Technology, andIndustry at Atlantic Research Corporation, by Philip KeyReily (©1999 Vantage Press, Inc., New York, N.Y.).

RALPH LANDAU (SCD’41)

With deep regret, we commem-orate the recent passing ofRalph Landau (ScD ’41), oneof our most distinguished alum-ni/ae. Landau’s unsurpassedlegacy as an innovative entre-preneur, celebrated intellectual,industry leader, and uncom-monly dedicated alumnus, hasleft an indelible mark on ourdepartment. Perhaps the mostvisible symbol of his decades ofsupport is ChemE’s now-familiar1976 Landau Building. Also

critical, though less visible, have been such contributions as his sponsorship of a departmental Graduate Fellowship, participation on the department’s Visiting Committee, andhis role as a tireless champion of the department and itsPractice School.

Early PromiseDuring his high school years in Depression-era Philadelphia,Pa., Landau was a serious and hard-working student whobecame captivated by a newspaper article citing chemicalengineering as the new “glamour field.” His career path thenbecame clear. As a scholarship student at the University ofPennsylvania, he majored in chemical engineering and thenearned his doctorate at MIT in 1941.

Career BeginningsHe then worked for M.W. Kellogg Company, one of thefirst engineering firms that specialized in design and devel-opment for the oil refining and chemical industries. As headof Kellogg’s successor company, Kellex, he was asked tobuild a large-scale facility for the Manhattan Project in Oak


Ridge, Tenn., to separate uranium 235, which was neededfor the atomic bomb, from the predominant isotope urani-um 238. Landau was given the responsibility of designingthe equipment to produce fluorine, a highly reactive sub-stance needed to make the uranium hexafluoride used in thegaseous diffusion process. He also oversaw the production of the fluorinated compounds used to protect surfaces incontact with the uranium hexafluoride.

After the war, he and a construction engineer he had met atOak Ridge, Harry Rehnberg, started Scientific Designwith the objective of improving petrochemical productionprocesses. Much of their business in the early days wasabroad, and one of their first successes was an improvedmethod of producing terepthalic acid—the main raw ingredient in polyester fiber—by bromine-assisted oxidationof paraxylene. Worldwide rights for this process were pur-chased by Standard Oil of Indiana (now Amoco). Anothertriumph was an improved process for producing propyleneoxide, a substance used in polyurethane foams and in rigidpolymers; in this case, the partner in the new corporation,called Oxirane, was Atlantic Richfield (ARCO).

Scientific Design and its successor companies, HalconInternational, Inc. and Halcon SD group, became leadingsources of modern petrochemical technology around theworld. Through Dr. Landau’s leadership and innovation, hiscompanies developed processes for producing ethylene glycol by thermal hydration—the chief component ofantifreeze and used in the process of making Dacron® poly-ester fiber—and components in other commercial productssuch as insecticides, fiberglass, and nylon 66. He earnednumerous patents in his own right, in addition to morethan 1,400 held by Halcon and its subsidiaries.

Faculty AppointmentsAfter Halcon’s sale of its interest in Oxirane to ARCOin 1980, and the sale of Halcon to the Texas EasternCorporation in 1982, Ralph Landau embarked on a secondcareer—that of academic scholar and advisor. Motivated byhis long-standing interest in education and research, heserved on Visiting and Advisory Committees at PrincetonUniversity, the University of Pennsylvania, the CaliforniaInstitute of Technology, and MIT.

More recently, as a faculty member of the EconomicsDepartment at Stanford University and a Fellow at HarvardUniversity’s John F. Kennedy School of Government,Landau focused on understanding the political and economicenvironment necessary to encourage technological innova-tion—the lifeblood of a successful economy. He has alsoserved as a Senior Fellow in Stanford’s Institute for

Economic Research, and his MIT responsibilities have beennumerous, serving for several decades as a Life Member ofthe MIT Corporation and as a Member of the VisitingCommittees for ChemE and other departments.

AwardsLandau has been globally recognized for his many significantprofessional papers, speaking at the invitation of chemicalindustry groups from all over the world, and receiving morethan 50 prestigious awards. These include the 1981 PerkinMedal from the Society of Chemical Industry, and the 1987John Fritz Medal of the American Association ofEngineering Societies. In 1985, President Ronald Reaganpresented Landau with the country’s National Medal ofTechnology; and in 1997, he became the first recipient ofthe Chemical Heritage Foundation’s Othmer Gold Medal.

BooksLandau authored and edited a number of volumes, with a particular focus on exploring the connections between technology and economics. These include an authoritativebook on chemical plants, and his co-authorship of ThePositive Sum Strategy (PUB: National Academy Press, 1986)on harnessing technology for economic growth.

Honorary AppointmentsA fellow of the American Academy of Arts and Sciences, he also served as Vice President of the National Academy ofEngineering, to which he was elected in 1972. He served onthe National Research Council’s Governing Board, was a fellow of the New York Academy of Sciences, and in 1996was elected to the American Philosophical Society. He was aretired director of the Aluminum Company of America, anda former trustee of Cold Spring Harbor Laboratory.

Chairman of Listowel, Incorporated in New York City,N.Y., Dr. Landau more recently was a Consulting Professorof Economics at Stanford University and a Senior Fellow at the Stanford Institute for Economic Policy Research, positions he clearly enjoyed and to which he brought hiskeen intellect and his enormous creative energy, in no waydiminished by the passing years. As recently as 1997, he wasa Research Fellow at Harvard University.

To MIT’s good fortune, Ralph Landau brought his perseverance, keen observation, and powerful intellect to his service on the Corporation. He became a member of the Corporation in 1972 and was elected a Life Member in 1976. He was the Chair of the 50th AnniversaryConvocation of the Department of Chemical Engineeringin 1970, and a member on the national sponsoring commit-tee for the new chemical engineering building, which was

News from Alumni/ae


designed by MIT alumnus and former Corporation memberI.M. Pei. Dr. Landau’s work on both projects culminated in1976 with the naming of the new building in his honor, citing his “illustrious example.” That same year, he was oneof the first to receive the MIT Leadership Award.

Ralph Landau served on the Chemical Engineering VisitingCommittee from 1965 until his death: actively for 26 years,and as a guest for an additional 13 years. His participationon the Economics Visiting Committee spanned 19 years,from 1983 until 2002. At various times throughout hisCorporation tenure, he chaired the Visiting Committees forthe Center for International Studies, the Department ofMaterials Science and Engineering, and the Department ofNutrition and Food Science. He also served a five-year termon the Membership Committee, and was a member of theDevelopment Committee from 1966 and an HonoraryMember from 1990. In 1978–79, he served on thePresidential Search Committee, whose work resulted in theselection of Paul E. Gray as MIT’s 14th President.

Dr. Landau’s distinguished career and professional successreflected great credit on his alma mater. His dedication andhis personal generosity helped in significant ways to advancethe cause of engineering education. In particular, he was anindefatigable champion of the MIT Department of ChemicalEngineering and of its Practice School. Through his ownexample, he did much to encourage private and corporatesupport of higher education in our country. As a valuedcounselor to MIT Chairs and Presidents, one who alwaystook the long view, he was wise, insightful, discerning,and forthright.

Ralph Landau’s many colleagues mourn the loss of thisindomitable man whose legacy of entrepreneurship andinnovation exemplify the best of what the Institute strivesfor in its alumni/ae. His firm resolve, his acute perceptionsof the world, his prodigious energy, and his creative spiritwill be sorely missed by those whose lives he touched. Hewill be long remembered for his exemplary service to MITand to its governing body.

Dr. Ralph Landau is survived by his wife, Claire, and hisdaughter, Dr. Laurie J. Landau.

DEPARTMENT BOOSTS BIOENGINEERINGDEGREE AND COURSE OFFERINGS

New Course SB in Chem–Bio Engineering Approved A major addition to the undergraduate education inChemical Engineering is the new SB Degree inChemical–Biological Engineering: Course XB, approvedby the Institute Faculty in 2003 and offered for the firsttime in Fall 2004. The educational opportunity afforded bythe new XB degree reflects the long-standing recognition ofthe importance of biology as a fundamental science in bio-medical and industrial applications by the Department ofChemical Engineering at MIT, dating back 35 years to thefirst Biomedical Engineering class at MIT, taught by ProfessorEmeritus Edward W. Merrill. Interest in biology has beengrowing among the undergraduate Chemical Engineeringstudents in recent years, as reflected by a significant numberof X/VII double majors and students completing theBiomedical Engineering (BME) Minor. The new XBProgram provides clear acknowledgment of the educationthat students receive in both Chemical Engineering andBiology within the units required for a single SB degree.

Students graduating with the XB degree will be well prepared for industrial employment in the life sciencesindustries, engineering graduate studies, and professionaldegrees in medicine.

New Chem-Bio Engineering Course XB Brings Curriculum and Facilities Enhancements

Related to the new XB curriculum will be 10.28 BiologicalEngineering Laboratory, started in Fall 2003, and 10.29Biological Engineering Projects Laboratory, new forSpring 2005. Either Lab will fulfill a requirement for thisnew course of study.

10.28 Biological Engineering Laboratory introduces thecomplete design of the bioprocess: from vector selection toproduction, separation, and characterization of recombinantproducts. With the bioreactor at the core of the experiments,students study cell metabolism and biological pathways,kinetics of cell growth and product formation, oxygen masstransport, scale-up, and techniques for the design of processcontrol loops. Also introduced are novel bioreactors, power-ful analytical instrumentation, downstream processing, andrecombinant product purification. For all students, thesemester is split: One half of each class section studies themicrobial process, while the other half studies vaccine production. At semester mid-point, the halves swap places,allowing all students to experience equal emphasis of theseinterdependent phases.


10.29 Biological Engineering Projects Laboratory, taughtby Professor Clark K. Colton and Lecturer Jean-FrançoisHamel, is offered in the Spring. In 10.29, students work inteams on a single project for the entire term. These projects,often suggested by local industry, serve as the basis for train-ing in research planning and project management, executionof experimental work, data analysis, oral presentation skillsand report writing, and team building.

The department is deeply grateful to alumnus James Brown’54, whose generous donation provided critical new bioreac-tors and related equipment for use in these courses. His particularly timely gift facilitated a 250% jump in 10.28enrollment from Fall 2003 to 2004!

ZION TEAM WINS 2003 MIT 50K!

A new tradition in ChemE may be on the rise as anothermember of our department has led a winning team in theprestigious MIT 50K Entrepreneurship Contest!

ChemE Grad Student Todd C. Zion is a lead member ofthe Grand Prize-winning SmartCells team, which consistsof five graduate researchers and business students who planto commercialize the use of nanoparticles to treat diabetes.This team has already filed a provisional patent application,and now plans to secure a license from MIT to commercial-ize the technology. The SmartCells team also includes SloanSchool graduate student John Hebert; Harvard BusinessSchool (HBS) students Martin Curiel and TsafrirVanounou; and Robert Bruch, a graduate student at theSloan School.

SmartCells technology bonds insulin molecules and sugar-sensitive proteins to a biodegradable polymer and injects thenanoparticles into a repository under the skin. Zionexplained, “The nanoparticles detect a diabetic’s glucose lev-els and release appropriate amounts of insulin to keep bloodsugar levels steady.”

continued from previous page

The particles themselves can be anywhere from 80 nanome-ters to 1 micron in size, Zion said. Because they monitorand react to glucose levels on their own, diabetics couldadminister the treatment with only one daily injection,rather than the several pinprick glucose tests and insulinshots that diabetics now use.

Winning the 50K Contest is a coup of the highest order.Aside from the $30,000 grand prize (the other $20,000 issplit between two runners-up), winners get invaluable expo-sure to venture capitalists, researchers, and business execu-tives. Almost all finalists, regardless of whether they win,proceed to mold their ideas into startup businesses anyway.

Zion, a doctoral candidate in chemical engineering, developedthe technology while working at MIT’s NanostructuredMaterials Research Lab with Professor Jackie Y. Ying.“People have been looking at this for years,” Zion said.“It was very difficult.”

SmartCells would sell the nanoparticles—dubbed “SmartInsulin”—at a premium, so the cost of the drug would bemore expensive than what the nation’s 17 million diabeticspay today. But the total cost of caring for diabetes would be lower, since the expense of blood testing and insulininjections would be eliminated.

SmartCells has already done preliminary tests in the petridish, and is now conducting animal tests at the JoslinDiabetes Center in Boston, Mass.

In 2001, a ChemE team led by Edward S. Ahn (PhD ’01)won the top prize in that year’s 50K Contest for their company, Angstrom Medica, which is now developing a new bone-healing technology.

MIT ChemE congratulates Todd Zion and the SmartCellsteam on this remarkable accomplishment!

before after

Smartlnsulin

SmartlnsulinCapillary

Sugar

Insulin

Skin

SmartlnsulinNanoparticles

Capillaries


Michael J. Abadi ’78Robert F. Abbanat ’50James D. Abbott ’32James R. Abbott ’93Claudia M. Abendroth ’93Jeff I. Abes ’03Stanley Abkowitz ’48Lily Ablondi ’82Leah C. Abraham ’93Harold L. Abroms ’48David E. Acker ’38Robert C. Ackerberg ’56Robert G. Ackerley ’80Cynthia M. Adams ’04David D. Adams ’50Akinlabi A. Adewole ’68David G. Adler ’60Noubar B. Afeyan ’87Sumit Agarwal ’98Kevin A. Agatstein ’97Peter P. Agoston ’45Ronald D. Agronin ’60Berit S. Ahmad ’97Naina S. Ahmad ’03Edward S. Ahn ’97Bernardine D. Ai-Kuo ’88Bukola Aina ’03Gordon Aitken ’54Mohammad M. Akhavein ’56Yaw Akoto ’74John J. Alam ’82Charles F. Albright, Jr. ’80Joo H. Albritton ’79Haim H. Alcalay ’61William R. Alcorn ’57James S. Alder ’72Collin H. Alexander ’39Richard G. Alexander ’49Paschalis Alexandridis ’90George Alexopoulos ’92Jorge Alfert ’58Montgomery M. Alger ’78Ernest J. Allard, Jr. ’53Herbert K. Allbright ’31

For the period July 1, 2002 through June 30, 2004Thank you for all of your generous support throughout the year!

Please direct corrections to: Gregory Sands, EditorEmail: [email protected] • Phone: (617) 253-0949 • Fax: (617) 258-8559

Jonathan O. Allen ’93Kenneth D. Allen ’86Phillip B. Allen ’60Scott W. Allison ’62W. L. Allison ’50Timothy B. Alosi ’90Diana M. Altrichter ’80John F. Alvarez ’73Maureen C. Alvarez ’75Sudha R. Amarnath ’04Allen C. Amdur ’48Illa L. Amerson ’91Sanjay I. Amin ’75Paul R. Ammann ’57Charles D. Anderson ’62David J. Anderson ’86Diane L. Anderson ’93Eric W. Anderson ’79James S. Anderson ’62John E. Anderson ’50Steven J. Anderson ’78Robert L. Andrews ’61Laura C. Angotti ’86Robert E. Anslow ’54Alfred J. Antos ’82Kaoru Aou ’00Minas R. Apelian ’88Henry R. Appelbaum ’80Gerald M. Appelstein ’80Juris I. Apse ’73Webster J. Arceneaux, Jr. ’55Debra B. Arenare ’87Antonio A. Armenante ’49William A. Arnold ’94Richard S. Arold ’65Akua A. Asa-Awuku ’03Afua A. Asante ’03Baffour Asante-Abedi ’00Wesley L. Asbury, Jr. ’80Arjang A. Assad ’71Frederick F. Assmann ’36Vassiliki Athanassiou ’96Cynthia S. Atherton ’85Kenneth J. Auer ’58

Debra T. Auguste ’99Joao P. Aumond ’96Anne H. Aunins ’91John G. Aunins ’89Harold R. Austin ’55Henry Avery ’41George C. Avgerinos ’82Ricardo Avila Araujo ’72Seema M. Awatramani ’01Oliver H. Axtell, Jr. ’47Alfred B. Babcock, Jr. ’43William L. Babcock ’41Robert B. Bacastow ’52Brett W. Bader ’95Jamie B. Bader ’80Kamran Badizadegan ’88Tina Bahadori ’84Anna Bailey ’54Todd C. Bailey ’98James H. Baird ’40James L. Baird ’40Joseph S. Baker, Jr. ’48Marshall E. Baker ’48Marvin L. Baker ’51Warren E. Baker ’64Bhavik R. Bakshi ’89Peter G. Balbus ’82R. R. Balcarcel ’99Robert J. Balcius ’85Lionel V. Baldwin ’55Natalie J. Banas ’98Brian J. Banaszak ’97Jean F. Bandy ’80Austin P. Banks ’81Eric T. Banks ’84Donn W. Barber ’42Robert R. Barbolini ’59George C. Barclay, Jr. ’53Karen G. Bardeen ’87Aaron A. Barlow ’86Donald W. Barnby ’56James H. Barnes, Jr. ’44James W. Barnett, Jr. ’56Robert E. Baron ’81

Alumni/ae Donors


Michael D. Barrera ’90Rodolfo F. Barrera ’49Hope M. Barrett ’98Richard L. Barrett ’48Thomas S. Barrows ’48Chester T. Barry ’83Roger Bart ’46Mark P. Bartilucci ’85Alfred P. Barton ’40Thomas M. Bartos ’85Osman A. Basaran ’78Louis Basel ’49Jesse N. Baskir ’88David H. Bass ’83Ephraim M. Bassan ’83Alan G. Bates ’50Claude P. Battu ’70William H. Battye ’77Ronald O. Baukol ’60Alfred G. Baum ’48Stephen H. Baum ’64Yvette V. Baxter-Drayton ’91Douglas M. Bea ’88Malcolm C. Beaverstock ’63Curt B. Beck ’45William C. Beck, Jr. ’62William F. Beck ’64Henry A. Becker ’61David R. Beckerman ’60Lloyd S. Beckett, Jr. ’56Norman Beecher ’44George J. Beerli ’57William C. Behrmann ’60Myron W. Belaga ’52Louis S. Belknap ’53Norton Belknap ’50Alexis T. Bell ’64Nancy E. Bell ’75Samuel A. Bell ’33Barbara A. Belt ’77Luca F. Bencini-Tibo ’74Douglas F. Bender ’70Lewis H. Bender ’81Kevin E. Bennet ’76Robert F. Bennett, Jr. ’71Thomas M. Bennett ’43Bernard A. Benson ’56George K. Benson ’51Paul F. Bente ’68George R. Berbeco ’66Scott A. Berceli ’85

Richard A. Berg ’89Scott A. Berger ’78Joseph J. Berghammer ’91James E. Bergholt ’59Allan H. Bergman ’58Richard I. Bergman ’55Michael L. Berins ’60David P. Berkowitz ’84Edwin L. Berkowitz ’56Leonard Berkowitz ’58Howard S. Berman ’82Juan R. Bernal ’63Peter F. Bernhardt ’82Alan M. Bernstein ’68Howard Bernstein ’85Pamela C. Berry ’79Frank W. Berryman ’56William H. Bertolet III ’48Robert J. Best ’40Albert W. Beucker ’40Thomas E. Beutel ’67Martha R. Beverage Black ’87Edmund M. Bevington ’49Stefan K. Bewley ’01Nazir A. Bhagat ’66Sue A. Bidstrup ’81Wayne W. Bidstrup ’88Robert F. Biehl ’56Jeffrey C. Bigler ’87Patrick C. Bigot ’81Brian P. Bilello ’97Charles J. Billerbeck ’55Bradley C. Billetdeaux ’72Charles W. Billings ’83Robert A. Bingel ’92Tara F. Bishop ’97Thomas W. Bither ’82James D. Bittner ’81Harris J. Bixler ’53Kathleen M. Black ’50Donald S. Blackford ’57James J. Blake ’58Owen W. Blake, Jr. ’65Joanna D. Blanchard ’99John P. Bleeg ’36Saul Blinder ’55Gary S. Bliss ’76Jose G. Bloch ’69Ellen F. Block ’95Lawrence W. Blodgett ’56William D. Bloebaum, Jr. ’62

Lloyd M. Bloom ’82Daniel F. Blossey ’64Malcolm R. Blotner ’56Emanuel M. Blue ’37Paul N. Blumberg ’65Robert L. Blumberg ’64Richard R. Blumenfeld ’82Theresa Bly ’01Charles K. Boatin ’01Thomas C. Boberg ’56James A. Bock ’43Richard E. Bockrath ’82Herman N. Bockstruck ’50Theodore H. Bodner ’53Norman W. Boe ’70John T. Boepple ’71Nelson T. Bogart, Jr. ’39George E. Bohlig ’57William H. Bohlke ’65Robert E. Bohman ’77Douglas G. Bohn ’98Vivek Bohra ’96Michael P. Bohrer ’75Richard C. Boland ’80Justin C. Bolger ’61Richard N. Bolles ’50Andra S. Bolotin ’94Christian C. Bolta ’51Andreas S. Bommarius ’82George W. Bond ’57Leo W. Bonnell ’77Francis J. Bonner ’55John S. Bonner ’50Joanna C. Bonventre ’02Merson Booth ’55James R. Boots ’80Walter E. Borden III ’45Daniel B. Borenstein ’57David E. Borenstein ’54Michael L. Boroson ’87George H. Borrmann ’57Edward D. Boston ’49Nicole A. Botcheos ’00Gregory D. Botsaris ’59Van T. Boughton, Jr. ’49Alain L. Bourhis ’89Jewell R. Bowen ’56Lee S. Bowers III ’68Walker H. Bowman ’51Craig H. Boyce ’96Thomas J. Boyle ’57

Carl R. Bozzuto ’69Ralph Braccio ’81Walter D. Braddock ’58John M. Bradley ’47George B. Bradshaw, Jr. ’40Eugene G. Branca ’31Eric K. Brandt ’84James C. Bray ’72Bruce B. Bredehoft ’56Kristen A. Breslin ’94Christopher M. Brewer ’83Barry W. Brian ’77P. L. T. Brian ’56Charles R. Bridges, Jr. ’85Henry S. Brightman ’42Amiel W. Brinkley, Jr. ’50Akbar F. Brinsmade ’42Norman F. Brockmeier ’66James J. Broderick ’50Mitchell B. Brodkin ’61Leslie G. Bromwell ’61James C. Bronfenbrenner ’70Barry R. Bronfin ’60Mary-Ellin Brooks ’94Steven W. Brostoff ’64Daniel L. Brown ’55Douglas R. Brown ’75Frances S. Brown ’79Frank R. Brown ’60Henry T. Brown ’56James W. Brown ’54John J. Brown ’32Kevin C. Brown ’83Malcolm K. Brown ’66Pamela A. Brown ’79Patricia M. Brown ’78Paul S. Brown ’59Peter Brown ’62Richard F. Brown ’82Robert E. Brown ’61Rodney F. Brown ’78Roy W. Brown ’40Stephanie J. Browning ’98James S. Bruce ’39Scott R. Brundage ’80Raymond F. Brunsberg ’86Robert L. Bryan ’39Gina M. Buccellato ’86Evan Buck ’61Walter F. Buck ’55Walter M. Buehl, Jr. ’59

Alumni/ae Donors


James B. Bunnell ’72Heidi E. Burch ’01Gordon M. Burck ’75Maria K. Burka ’69James L. Burns ’47William A. Burns ’61Joseph T. Burval ’58Claudia W. Buser ’81Ellen R. Bush ’81Rhonda L. Bush ’00Harold W. Butler ’38James C. Butler ’86Mark L. Bye ’78Joseph Byrne ’50Lucia J. Byrne ’95Rodney D. Cadanau ’80William P. Cadogan ’41Colin S. Caldwell ’51Wayman L. Calhoun ’49Charles W. Calkins ’81Frank M. Calkins ’50James R. Calkins ’50Donald A. Cameron ’57David A. Campanella ’76Alice E. Campbell ’78Calvin A. Campbell ’59Pat C. Campbell ’81Thomas D. Canby ’52Edward B. Cantey, Jr. ’50Matthew Capeci ’03Mark C. Capone ’91Anthony R. Cappuccio ’48John C. Card ’81Rudolf Carl ’47John T. Carleton ’42Alfred Carlson ’75Edwin A. Carlson ’62Harrison C. Carlson ’34Thomas W. Carmody ’44James M. Carr ’78John Carrier ’95Hilary B. Carter ’00Renee O. Carter ’77Thomas J. Carter, Jr. ’57William E. Carter ’66Brian C. Carty ’85Robert J. Casadonte ’94Robert B. Case ’43Pierre D. Casimir-Lambert ’55Marion A. Casserberg ’94John R. Castle ’61

Lawrence H. Cater ’80Luigi A. Cazzaniga ’91William H. Ceckler ’61Joseph Cerami ’86Albert P. Chadourne, Jr. ’58Heeyeop Chae ’00Charmaine W. Chan ’95Irene Y. Chan ’76Jennifer M. Chan ’92Joyce Chan ’03Lawrence S. Chan ’81Sonia S. Chan ’03Leonard B. Chandler ’36Celestine Chang ’00Chiechun J. Chang ’83Julia L. Chang ’04Karen L. Chang ’79Nancy T. Chang ’87Thomas S. Chang ’81I-Hwa M. Chang-Mateu ’79D. R. Channing ’62Steven H. Chansky ’67Enoch I. Chao ’76Warren H. Chapman ’46Stanley E. Charm ’52Henry C. Chau ’84Anita L. Chaudhuri ’01Tommy J. Chavez ’87Marc J. Chelemer ’81Jennifer C. Chen ’85John C. Chen ’84Nai Y. Chen ’59Nora Chen ’97Shiao-Chiu A. Chen ’58Zee-Puu Chen ’77Weiyang Cheong ’98Eric G. Cheslek ’04Martin R. Chetron ’56Bo K. Chi ’79Chang W. Chi ’61Edward S. Chian ’67Elta M. Chian Ratliff ’94John L. Chiappetta ’64John S. Child, Jr. ’67James L. Childs, Jr. ’82Catherine Chiles ’78Allan Chin ’52Arthur A. Chin ’80Michael Q. Chin ’79Patrick K. Chin ’85Vicki I. Chin ’99

Morris A. Chomitz ’46David H. Chorlian ’54Martha A. Choroszy-Marshall ’79Howard W. Chou ’76Oscar K. Chow ’78Katherine S. Chrien ’80Don A. Christensen ’52David Christison ’42Daniel R. Christman ’76Jane H. Chronis ’80Michael P. Chrzanowski ’71Karen I. Chu ’94Paul Chuberka ’61Matthew B. Chun ’99Cindy Chung ’04Joyce A. Chung ’85Michael K. Chung ’94Taemoon Chung ’00Dudley F. Church ’47Anna B. Chwang ’95Jack J. Cinque ’53Stanley W. Clark ’57Jennifer L. Clarke ’03Donald K. Clarkson ’75Frank A. Clauson ’43Russell T. Clay ’94David D. Claypool ’63Don A. Clayton ’83Frank L. Cleary ’56Timothy P. Cleary ’81Fred B. Clemens ’50George F. Clifford ’48Jason A. Cline ’97Leslie W. Cline, Jr. ’49Herschel Clopper ’62Joseph A. Clumpner ’55James T. Cobb, Jr. ’60Benjamin P. Coe ’53Jerome T. Coe ’42Jerry A. Cogan, Jr. ’58Alan P. Cohen ’75Edward S. Cohen ’50Harold Cohen ’87Stephen I. Cohen ’60Steven Cohen ’68Elaine A. Cohen Hubal ’88Jerald A. Cole ’82Jerry L. Cole ’78Randolph P. Cole ’69Scott H. Coleman ’96Frederick L. Colhoun ’95

Jeffrey L. Collett ’84David J. Collins ’86Alain L. Colomb ’56Grace E. Colon ’95Kim Colon ’90Stewart L. Colten ’64Clark K. Colton ’69Michael J. Colucci ’82Albert R. Colville ’59James M. Colville, Jr. ’73Lloyd N. Combs ’33Kathryn J. Comer ’91Ann R. Comfort ’88James H. Comfort ’88Winthrop D. Comley ’37John P. Congalidis ’81Donald J. Conklin ’74Catherine D. Conley ’96Michael J. Connair ’48Richard A. Conti ’84Edward T. Cook ’40Garth Coombs ’51Sharonda E. Cooper ’97Stuart L. Cooper ’63William W. Cooper ’63Steven S. Cooperman ’87Terry M. Copeland ’78Bruce C. Copley ’78George A. Corbin ’83Jennifer E. Corbin ’81John A. Cornell ’44Gerardo Corona ’97Daniel G. Coronell ’93Douglas H. Cortez ’69Claude Corty ’44John D. Corwin ’50Eric J. Costa ’82John L. Costello ’62Richard G. Cosway ’81David B. Cotton ’58Robert H. Cotton ’39Henry R. Couch, Jr. ’59Margaret M. Coughlan ’90Arthur Cowen ’57John O. Cowles ’56Benjamin D. Cowley ’49Chandler K. Coyle, Sr. ’61Gordon S. Craig ’89Joseph J. Cramer ’68John L. Crandall ’42Bruce E. Crocker ’64


Burton B. Crocker ’47James C. Cross ’87Robert A. Cross ’59Matthew S. Croughan ’88Thomas S. Crow ’47Dolores Cruz ’00Jeffrey J. Csernica ’89Orlando D. Cucchiara ’55Daniel L. Cummings ’73Thomas F. Cummings ’47Philip D. Cunningham ’62Tiffany P. Cunningham ’98James A. Curme ’82Thomas A. Curtis ’80Linda M. Custer ’83Brian A. D’Amato ’96John F. D’Amico ’54Joseph C. D’Amore ’77Zaven A. Dadekian ’55David E. Dahlke ’88Carol A. Daigle ’80George A. Dainis ’81Charles B. Dale ’43Elizabeth L. Dale ’01Irene M. Dale ’81Margaux E. Daly ’04Robert H. Damon ’52Robert A. Dangel ’70Selam Daniel ’03Joseph P. Dankese ’54Alexander H. Danzberger ’53James R. Datesh ’77Thonet C. Dauphine’ ’35Jeremy David ’99Marc G. Davidson ’88Dwight A. Davis ’71Gershon J. Davis ’56Rebecca A. Davis ’87Robert W. Davis ’50Sheila J. Davis ’85Stephen G. Dawson ’75John R. Day III ’66Steven G. De Cicco ’77Richard P. De Filippi ’59Aida E. De Garcia ’88Eleanor M. De Groot ’90Jean B. De Hemptinne ’90Robert L. De Jong ’58Jaime H. De Sola ’60Thomas J. DeBoissiere ’81Edward G. DeLaney ’48

Robert D. DeWitt ’82Vivian M. de Zengotita ’94Sheldon W. Dean, Jr. ’58Pablo G. Debenedetti ’85Louis P. Deis, Jr. ’52Bernard E. Deitrick ’81Freddie A. Delavega ’53Joseph A. Dellorto ’79Duncan J. del Toro ’66John J. Demo ’35Douglas Denholm ’78Clifford M. Denker ’84Kathleen A. Dennison ’86Richard A. Denton ’36Andre C. Deprez ’55Michael W. Derden ’96Daniel J. Dershowitz ’76Mark S. Dershowitz ’78Vikram J. Desai ’73Naresh V. Desireddi ’96Patrice Desvigne-Nickens ’76John M. Deutch ’61Donald J. Devine, Jr. ’79Bradley Dewey, Jr. ’40Piero D. Di Capua ’74Anthony J. Di Leo ’83Sebastian M. Di Palma ’52Peter N. DiGiovanni ’67Fiore D. DiGiovine ’51Francis A. DiTaranto ’83Brian P. DiVasta ’95William A. Dickens ’56Joseph W. Dickey ’66Robert P. Dickey ’62Dana L. Dickinson ’73Ronald A. Dictor ’79Steffen F. Dieckmann ’47Albert C. Dierckes, Jr. ’60Albert G. Dietz ’92Edward F. Dillon ’47Richard S. Dillon ’67Dimitrios G. Dimitriou ’50Ali K. Dincer ’75Minh H. Dinh ’98Steven M. Dinh ’81Keith E. Dionne ’90John H. Dise ’03Joseph M. Ditz ’68Robert K. Dix ’43Amos T. Dixon, Jr. ’52Daniel G. Dobryn ’85

Gonzalo C. Docal ’44Stephen C. Dodd ’76William G. Dodge ’31William W. Doerr ’79John F. Dolan ’80Thomas J. Dolan ’43Joseph D. Domine ’64John E. Donahue ’48Xiang D. Dong ’95Mark J. Donnelly ’82Timothy J. Donnelly ’89Charles M. Donohue ’61James H. Donovan ’89Joanne M. Donovan ’77William P. Dooley ’40Kevin D. Dorfman ’01Earl M. Douglas ’83Laurence E. Dowd ’44Mason L. Downing ’41Thomas S. Doyle ’95Cyril W. Draffin, Jr. ’72Edna L. Dragsdorf ’49Elisabeth M. Drake ’58Geoffrey Drake ’56Javit A. Drake ’94James A. Drobile ’50James M. Druding ’85John W. Dryden ’61Beth P. Dubeck ’02Andrew D. Dubner ’85Chase E. Duclos-Orsello ’00David R. Dudek ’88Scott G. Dudevoir ’85Barrett S. Duff ’50Norman B. Duffett ’40Bruce R. Duggar ’62George S. Dundon ’48Deirdre K. Dunn ’99Dorsey C. Dunn ’61William W. Dunn ’52Louis J. Durlofsky ’86Preston L. Durrill ’57Arunava Dutta ’85Wieske S. Duyvesteyn ’94Jay S. Dweck ’77James L. Dwyer ’54Thomas J. Dwyer ’57David K. Dyck ’81John C. Dyer ’56Matthew Dyer ’95Peter D. Dyke ’56

Richard W. Dykstra ’79James C. Eagleton ’77Donald D. Easson ’61Brian E. Eaton ’77Carl D. Eben ’61Walter S. Eberhard ’42Thomas G. Eccles ’86Ana T. Echaniz ’96Matthew E. Edstrom ’95Robert G. Edwards ’59Timothy W. Eggert ’80Christopher Egolf ’66John R. Ehrenfeld ’53Ernest P. Eich ’65Ronald S. Eisinger ’70David M. Eissenberg ’52Eduardo F. Elejalde-Arena ’70Daniel L. Ellig ’81Stephen J. Elliott ’83Sandra C. Eltringham ’94Tracy A. Embree ’95Cherry L. Emerson ’41Leonard C. Emma ’60Steven S. Emmer ’72Arthur F. Emmett ’61Leonard L. Eng ’58William K. Engmann ’96Lea W. Engst ’02Mark A. Ensio ’84Bruce R. Entwistle ’82Thomas H. Epps ’98Pablo Epstein ’51Shilpi Epstein ’94Harold G. Erichs ’58John E. Ertel ’50Richard H. Eshbaugh ’35Clifford J. Eskey ’85Ramon L. Espino ’68Louis Essandoh ’77Oscar C. Eubank ’50James M. Evans ’56Timothy W. Evans ’73Carl B. Everett ’69Christine Evron ’77James M. Ewell ’37William Eykamp ’65Wilhelmina Fader ’85Charles S. Fadley ’63Malcolm P. Fairbairn ’84Michael Falco ’59James R. Falender ’65

Alumni/ae Donors


David M. Falk ’43Gary L. Falkenstein ’59Gary J. Fallick ’58Kevin J. Fallon ’78Louis A. Falvo ’63Martin L. Falxa ’61Yolanda T. Fan ’02Robert H. Fariss ’51Marguerite L. Farnsworth ’46John Farquhar III ’54Roger D. Farr ’79Joseph B. Farrell ’47Marc-Kuesi T. Farrell ’03Michael J. Farrell ’98Peter C. Farrell ’67Richard J. Farrell ’53Paul J. Farris ’60William H. Farrow ’44John E. Fay II ’71Susan L. Feindt ’83Alan S. Feitelberg ’90Valerie A. Feliberti ’89Lowell L. Fellinger ’41Daniel W. Felten ’84Flora W. Feng ’90James H. Ferguson ’78Joao P. Ferreira ’93Mary T. Ferris ’81Theodore V. Ferris ’41John A. Feyk ’50Theodore R. Fick ’52Hunter H. Ficke ’77Edwin L. Field ’50Leslie A. Field ’78Allison A. Fielder ’02Rober Filiba ’73Francis E. Finch ’89Michael J. Fink ’81Stan N. Finkelstein ’71James L. Fischer ’55Elizabeth A. Fisher ’80Robert E. Fisher ’66Warren C. Fisher ’49Ellen L. Fitch ’84James H. FitzGerald ’47Gerald L. Fitzgerald ’82Bridget A. Fitzpatrick ’87Daniel L. Flamm ’64Michael E. Flanagan ’85William M. Flarsheim ’81Raymond K. Flege ’32

Cathy A. Fleischer ’84Frederick L. Fletcher ’49James M. Flink ’64Susan E. Flint Barr ’81Theresa M. Flood ’87Daniel F. Flores, Jr. ’85Trinidad Flores ’92Nathaniel Florian ’60William E. Flowers ’88Tamara M. Floyd ’98Ethan A. Fode ’96Harry G. Foden ’50Stephen K. Fok ’80Roopa M. Foley ’92Ivan K. Fong ’83Wing S. Fong ’54Thomas Foo ’85Kenneth J. Ford ’97John Forgrieve ’50J. C. Forman ’53Carl A. Fortin ’91Nancy H. Foster ’95George N. Fountas ’48Richard P. Fowler ’49Daniel C. Fox ’90William K. Fraizer ’80Warren C. Francis ’40Cheryl B. Francisco ’93Constantinos S. Frangoulis ’66Raymond F. Frankel ’43Howard D. Franklin ’80Rufus M. Franklin ’47William D. Franklin ’72Darryl M. Fraser ’80Leslye M. Fraser ’78Malcolm D. Fraser ’60Albert H. Frazier, Jr. ’78Hyman M. Freedman ’40Richard W. Freedman ’76Reed H. Freeman ’61John J. Freer ’58Frank E. French, Jr. ’43Paul H. Fricke ’61Robert P. Fried ’46Malcolm P. Friedman ’59Robert S. Friedman ’48Shinya Fukuda ’95George J. Fuld ’53Cindy W. Fung ’96David L. Fung ’85Andrew P. Furman ’85

Richard C. Furman ’72Shintaro Furusaki ’64Morris I. Gabel ’40Henry L. Gabelnick ’61Calvin T. Gabriel ’83David C. Gagne ’81Michael Gagne ’96William D. Gaherty ’84Lewis H. Gaines ’66Sean A. Gallagher ’84Peter M. Galland ’63Lawrence B. Galpin ’67Frederick W. Gander ’42Manfred Gans ’51Charles J. Garbarini ’60Robert A. Garber ’04Anthony G. Garcia ’99Joaquin Garcia Barcena ’58Robert A. Gardella ’54William M. Gardner, Jr. ’53Thomas F. Garrett ’52Angel R. Garron-Torrez ’77Brett V. Gaspers ’87Joseph F. Gassette ’81Joseph V. Gaven, Jr. ’52Lee M. Gavens ’78Thomas H. Gawronski ’62Kenneth S. Gayer ’98Christopher T. Geary ’78Adam G. Gebauer ’56Brendan J. Geelan ’67David J. Geiser ’79David H. Geisler ’60Fred Gelbard ’74Lars H. Genieser ’94Frank T. Gentile ’88Gregory S. George ’79Gregory E. Georges ’83Michael M. Gerardi ’81Fariborz K. Ghadar ’68Anastasios E. Gianakakos ’94David A. Gibbs ’60Richard A. Giberti ’67Samuel P. Gido ’93John D. Gignac ’56Douglas J. Gilbert ’78Bruce D. Giles ’51Frank Gilliland ’52Christian A. Gimre, Jr. ’58Kymus K. Ginwala ’52Gerard H. Gizinski ’67

George B. Glackin ’79Richard E. Gladstone ’40John H. Glaser ’58Donald M. Glass ’79Werner B. Glass ’56Karen K. Gleason ’82Nathaniel J. Gleason ’98Roland D. Glenn ’33Michael J. Glodek ’83John J. Glover ’49Simon E. Gluck ’43Richard A. Gnecco ’50Michael R. Gobler ’89Nadir B. Godrej ’73Ankur K. Goel ’03George A. Goepfert, Jr. ’55Gary J. Goetz ’73Cobb S. Goff ’70Kent E. Goklen ’86Robert H. Goldey ’44Morton I. Goldman ’50Andrew H. Goldsmith ’67Jonathan M. Goldstein ’83Robert W. Goldsworthy ’58Maribel Gomez ’02Jaime J. Gonzalez-Duke ’66Elizabeth M. Goodrich ’89Anil Gopala ’96Rafael Gordin ’69Neal F. Gordon ’89Brian S. Gorin ’86George D. Gould ’47Rene Goutte ’61Thomas R. Gow, Jr. ’80Richard L. Graff ’39Christine J. Graham ’92Gustavo E. Grampp ’92Henry R. Grane ’48William J. Grant ’48Maurice F. Granville ’39John L. Graumann ’54Charles A. Gray ’66David C. Gray ’89Frank R. Graziano ’77Catherine I. Greany ’78Milton J. Grebler ’63Saverio G. Greco ’51Eric Green ’03Harry J. Green, Jr. ’38Sheldon L. Green ’48George Greenbaum ’39


Robert J. Greenberg ’78Robert H. Greene ’56Wayne M. Greene ’84Robert B. Greenes ’42Sidney H. Greenfeld ’45Norman L. Greenman ’44Gail Greenwald ’75Ronald Greenwald ’51Roy F. Greenwald ’75Frank F. Greer ’97Clarence L. Gregory, Jr. ’51Gus M. Griffin ’39Thomas P. Griffin ’80Kenton A. Griffis ’66Steven W. Griffiths ’02Charles O. Grigsby ’89Donald A. Grindstaff ’69Debra Gross ’77Irwin C. Gross ’56Marc S. Gross ’55Marta E. Gross ’80Philip M. Gross ’63Frederick B. Grosselfinger ’38John H. Grover ’48Philip M. Grover ’57Reginald B. Grover ’57Martin J. Gruber ’59Philip E. Gruber, Jr. ’55Eugene L. Grumer ’64Irwin J. Gruverman ’55Raymond G. Gruwell ’51Kristopher R. Grymonpre ’03Paul F. Gubanc ’82Thomas A. Gubiotti ’96Ernest A. Gudath ’60David C. Guell ’91Amrita Guha ’00Frank A. Gulla ’74David M. Gunn ’84David A. Gunter ’77Heinz H. Gunther ’52John R. Gunther ’43Frank E. Guptill ’48Robert N. Gurnitz ’60David E. Gushee ’50Samuel Gusman ’46Catherine Gutierrez ’01Efren Gutierrez ’03Edgar B. Gutoff ’52John C. Haas ’42Robert A. Haass ’50

Austin G. Habib ’57Donald C. Habib ’82Nicholas Habibe ’56David S. Hacker ’50Mark Hagan ’04Mark P. Hagemeister ’84William H. Hagenbuch ’40P. F. Hagerty ’46Wilburt E. Haggerty ’50Aaron F. Hahn ’45Chris K. Hahn ’58Raymond E. Hahn ’43Eddy R. Hair ’54Mohammadreza Hajaligol ’81Daniel J. Halbert ’81Ledyard P. Hale II ’48David J. Haley ’91Benjamin D. Halpern ’43Michael E. Halpern ’55Bruce K. Hamilton ’69Ogden H. Hammond ’68Paula T. Hammond ’84Philip G. Hampton ’77Julie J. Han ’94Robert H. Handler ’43Jason Handwerker ’97Robert T. Hanlon ’85John N. Hanson ’64Jon C. Hanson ’65Robert A. Hard ’57Michelle T. Hardiman ’00Nicholas J. Haritatos ’52John B. Harkness ’71Kenneth G. Harms ’51George S. Harrington ’41George M. Harriott ’83Peter Harriott ’52Elaine J. Harris ’78Grady W. Harris ’61Leonard Harris ’44Marvin S. Harris ’55Ray W. Harris ’50Brian M. Harrison ’97William J. Hart ’48Samantha L. Hartemink ’98Lynn F. Harth ’85Gary L. Harting ’60John S. Hartman ’65Christine M. Hartmann ’98Mark A. Hartney ’82Heidi E. Harvey ’81

William H. Haslett, Jr. ’61James A. Hasse ’79Eric H. Hasseltine ’59William Y. Hata ’81Robert L. Hatch ’47Gary R. Hattery ’78Robert W. Hausslein ’58Robert H. Havlin ’63Robert D. Hawthorn ’54Althea T. Haylett ’85Hal P. Headley ’37Frank J. Hearl ’80Robin A. Heath ’89Ralph L. Hegner ’39Adel E. Heiba ’79Edward W. Heinle ’82Robert W. Heinze ’68Richard E. Heitman ’52Joseph J. Helble, Jr. ’87Mark G. Helder ’84John D. Helferich ’79Daniel S. Helgesen ’97Steven Heller ’43Richard K. Helling ’86Kelly L. Hellmuth ’00Kenneth G. Hellyar ’80Mary Jane J. Hellyar ’82Andrew J. Heman ’72Paul J. Hemley ’74Charles B. Henderson ’52James H. Henderson, Jr. ’42Donald L. Hendrickson ’50Carol A. Henry ’91D. B. Henschel ’67David C. Herak ’89Mark J. Herbst ’73Albert R. Hernandez ’95Gilbert R. Hernandez ’95Jorge C. Herrera ’81Eduardo F. Herrerias ’43Jill M. Herrick ’95Rebecca D. Herrin ’90Howard J. Herzog ’74Stanley Herzog ’64Sidney W. Hess ’53Bedrich V. Hettich ’43William B. Hetzel ’93Robert C. Hewitt ’67Eve J. Higginbotham-Williams ’75Harold B. Higgins ’44Arthur E. Higinbotham ’60

Arthur S. Hill ’63Charles G. Hill, Jr. ’59Howard D. Hill ’53John S. Hill ’67David W. Hills ’81David A. Himmelblau ’72Robert J. Hinds ’53Thomas J. Hirasuna ’76Peter M. Hirsch ’79Henry E. Hirschland ’49Sidney Hirshon ’37Karen J. Hladik ’78Anthony W. Ho ’96Chester S. Ho ’87Eugene Ho ’71Henry Ho ’52Kwok-Lun Ho ’92William Hoagland ’73Robert M. Hodges ’60Allan S. Hoffman ’53Stephen M. Hoffman ’66Thomas R. Hoffman ’87Thomas S. Hoffman ’56Wilburn H. Hoffman ’46John E. Hofmann ’56Henry G. Hohorst ’52Stanley E. Holbrook ’44Henry R. Holgate ’89William D. Holland ’58Edward H. Hollister III ’50Charles R. Holman ’36Pamela L. Holmes ’92Benjamin M. Holt ’37Robert P. Holton ’57Michael J. Holtz ’74Stephanie S. Homer ’00Charles A. Homsy ’53Paul T. Homsy ’80Caroline C. Hon ’01Robert W. Hone ’79Glenn T. Hong ’81Joonkee Hong ’84Kristy H. Hong ’99Wan-Jen Hong ’01Thomas Hooker ’40John W. Hoopes, Jr. ’44Kenneth R. Hootnick ’61Lloyd N. Hoover ’56Harold B. Hopfenberg ’60Harvey C. Hopkins, Jr. ’51Joanne Hopmeyer ’91

Alumni/ae Donors


Bernd P. Hopp ’63Allen F. Horn ’84Jeffrey M. Horne ’89William B. Horner ’52Robert V. Horrigan ’44Jane F. Hortelano ’94William E. Horton ’56Hillary B. Hotelling ’85Anne K. Hou ’83Richard H. Hough ’58Patrick A. Houghton ’88Patrick B. Houghton ’82James J. Hourihan, Jr. ’48Keith L. House ’78William B. Householder ’83Bradford Houston ’95Chanelle J. Howe ’02John H. Howell ’35Edward L. Hoyt ’57Richard D. Hoyt ’57Frank J. Hrach ’84Janet Hsiao ’03Sherry H. Hsiung ’95Christine Hsu ’03Jennifer Y. Hsu ’97Joseph K. Hsu ’85Noel Y. Hsu ’82Shih-Liang Hsu ’60Benjamin V. Hu ’79Edward S. Huang ’00Evelyn Y. Huang ’99Mengchien C. Huang ’54Nganfong Huang ’02Dennis J. Huber ’74Robert T. Hucks, Jr. ’51Timothy G. Hueston ’84John E. Hueter ’71George A. Huff, Jr. ’82Robert L. Huffman, Sr. ’42Donald P. Hug ’47Mark D. Hughes ’79Thomas P. Hui ’75Lewis W. Hull ’38Robert D. Hulse ’68Ralph A. Hulseman ’80Evelyn W. Hum ’01Edward C. Hume ’83Albert S. Humphrey ’49Dean E. Humphrey ’49Edwin P. Hunger ’54Catherine M. Hunter ’81

Jean B. Hunter ’76Julia A. Hunter ’84Kim L. Hunter ’86Gilbert L. Huppert ’89Robert H. Hurt ’87Albert G. Hutchins III ’53Richard R. Hydeman ’47Nola M. Hylton-Watson ’79Daniel Hyman ’52Brian Hynes ’95Tomoko Iida ’02Hiroshi Iino ’67Princess Imoukhuede ’02Kristin M. Imsande ’95Robert R. Imsande ’42Tetsu Inada ’97Samuel W. Ing, Jr. ’53Margaret N. Ingalls ’83Thomas B. Irwin ’80James J. Isenberg ’75Allan B. Isham ’56Shingo Ishikawa ’79Frank J. Iskra ’48John M. Iwasyk ’60Susan D. Izatt ’83Jean-Pierre G. Jacks ’71Kingsbury T. Jackson ’40Norman A. Jacobs ’59Ralph L. Jacobson ’35Lawrence A. Jacowitz ’56Thomas A. Jadwin ’69Joseph C. Jaeger ’74Frederick L. Jaggi ’57Hugh R. James ’74Peter A. James ’67Vincent W. James ’78James M. Jamieson ’70Alice Jang ’00Christine J. Jang ’93Frederick J. Jao ’98Lawrence A. Jarnagin ’58Mottlene Jarvis ’74Donald M. Jassowski ’57Sarah E. Jatko ’98Alwyne C. Jealous ’42Dara T. Jeffries ’02David M. Jenkins ’59Robert D. Jenkins ’48Rodman Jenkins ’46Earp F. Jennings, Jr. ’39James T. Jensen ’50

Peter L. Jensen ’73Stanley E. Jensen ’48Lewis T. Jester ’72Vinod K. Jhunjhunwala ’65Barbara I. Jimenez ’99Neil Jochelson ’68Adrian E. Johnson, Jr. ’49Charles T. Johnson, Jr. ’73Dana E. Johnson ’88Douglas L. Johnson ’53Eric H. Johnson ’83Geoffrey B. Johnson ’97Harry E. Johnson ’83Hugo C. Johnson, Jr. ’46Ivette M. Johnson ’96John R. Johnson, Jr. ’60Robert A. Johnson ’62Warne P. Johnson ’42Willard C. Johnson ’59Robert H. Johnston ’45Jennifer G. Jonas Stahr ’78David H. Jones ’65David H. Jones ’81Deverraux A. Jones ’03Robert E. Jones ’54Russell L. Jones ’72Stephen F. Jones ’76Thomas C. Jones ’66Warren C. Jones ’59James C. Jorgensen ’01Luis G. Juarbe Osorio ’87Arnold S. Judson ’47Burton F. Judson ’48Nikola M. Juhasz ’92Susan G. Juncosa ’82Lisa B. Jungherr ’80Beth H. Junker ’89John F. Kaar ’69Suparna B. Kadam ’02Nicholas C. Kafes ’55Naomi J. Kagetsu ’82Burton H. Kahn ’47Morley D. Kahn ’51Christina G. Kaiser ’04Robert Kaiser ’56Theodore Kalina ’58Robert J. Kallal ’49Mauritz J. Kallerud ’62Elsa Kam-Lum ’74Harold W. Kamins ’78John R. Kancavicus, Sr. ’61

Edward D. Kane ’47Eugene W. Kane ’47Shantaram G. Kane ’71Rahra Kang ’01Shin G. Kang ’91Henry S. Kao ’67Muneera R. Kapadia ’98Amy B. Karger ’98David A. Karohl ’85Orhan I. Karsligil ’00Brian R. Kashiwagi ’64Stanley Kasper ’48I. M. Kasser ’60Mark J. Kastantin ’03Stacy D. Katchman ’87David A. Katz ’80Gerald Katz ’59William E. Katz ’48James R. Katzer ’70Lara I. Kauchak ’96Arnold F. Kaulakis ’38William J. Kausch, Jr. ’78Pascale E. Kavanagh ’88Herbert Kay ’47William C. Kay ’31Nancy D. Kayvanfar ’85Mitchell F. Keamy ’47Andrew H. Kean, Jr. ’43John R. Kearney ’48Ifiyenia Kececioglu ’79James B. Keeler ’81James J. Keenan ’48George T. Keene ’52Ephraim Kehat ’60Jeb E. Keiper ’99Nishla H. Keiser ’99Caroline L. Keller ’97George M. Keller ’48Michelle B. Keller ’84John S. Kellett ’47Franklin R. Kellogg ’50Robert M. Kemper II ’65James S. Kempner ’68Delbert W. Kendall ’24C. T. Kennedy ’42William E. Kennel ’47Vernon W. Kenney ’51Colin J. Kerwin ’82David S. Keselica ’83Michael G. Kesler ’51Donna L. Kessel ’89


Gregory H. Keuroghlian ’67Fadilah A. Khan ’02Malik Z. Khan ’78Samer S. Khanachet ’72Bhupendra N. Khetani ’60Hans W. Khimm ’72Roger T. Kiley ’60Donna M. Kilian ’80Byung J. Kim ’77Edward J. Kim ’87Hose Kim ’81In Ho H. Kim ’56Joo C. Kim ’61Miral E. Kim-E. ’85Robert M. Kimmel ’64William O. Kincannon, Jr. ’50Cary J. King III ’58Robert C. King, Jr. ’88Terry S. King ’79William C. King ’48George S. Kingsley ’83Thomas A. Kinney ’88Erdogan Kiran ’69Kenneth A. Kirk ’81Thomas A. Kirkham ’48Wylie C. Kirkpatrick ’40Sameer M. Kirtane ’98Thomas P. Kisala ’85Linda D. Kiss ’87Robert D. Kiss ’87William R. Kittredge ’43Kazuo Kiyonaga ’50Mitchell Klausner ’84Howard W. Klee, Jr. ’72Gary G. Klein ’74Max M. Klein ’81David E. Kleinschmidt ’76Hans A. Klemm ’75William A. Klemm ’46Allen L. Klibanoff ’56Douglas F. Kline ’93Richard W. Kline ’64David H. Klipstein ’56Norman R. Klivans ’40Stuart R. Knapp ’31Chester E. Knight, Jr. ’64Joseph K. Knight ’40Heather L. Knoedler ’94John A. Knowlton, Jr. ’49David H. Koch ’62Gayle S. Koch ’82

Robert W. Koch ’50Wendy S. Koegler ’00Kenneth C. Koehlert ’83Han-Jong Koh ’86Henry H. Kohl ’48Alison D. Kohler ’78Edward Kohler ’95Jo-Anne M. Kokoski ’96Frederick J. Kolb, Jr. ’38James D. Kolb ’53Mobil W. Kolbon ’85Paul C. Kolosick ’86Yoko Kondo ’94Amy K. Koo ’95George P. Koo ’60Harry L. Kopp ’48Paul M. Koppel ’54Kenneth D. Kopple ’51Ernest I. Korchak ’61Theodore H. Korelitz ’56Sally C. Kornfeld ’79Michael A. Kornitzky ’62Richard G. Kotosky ’81Robert W. Koucky ’56Kenneth L. Kovach ’83Eugene J. Kovary ’54Nikolas O. Kozy ’00Anibor Kragha ’03Robert F. Kratz ’44Lawrence R. Kravitz ’60Louis F. Kreek ’48David W. Kress ’67Theodore A. Kreuser ’58Michael J. Kreuze ’93John N. Krikelis ’97Hannes B. Kristinsson ’51Elizabeth J. Kroeker ’91Adam D. Kroft ’00Charles L. Kroll ’49Thomas P. Kronenberger ’88David F. Kronholm ’97Dean E. Kross ’73Charles W. Krueger ’87John A. Krueger ’70Richard T. Krueger ’48Richard M. Kruger ’76Steven A. Kruger ’70Gilbert K. Krulee ’44George C. Krusen ’50Larry J. Krussel ’73Audrey Kuang ’96

Yu Kuang ’98Yuji Kubo ’01Joseph D. Kuhach, Jr. ’83Norman G. Kulgein ’55Alexander M. Kulinowski ’83Douglas H. Kuller ’84Dennis Y. Kuo ’84Ronald T. Kurnik ’81Stuart J. Kurtz ’63Charles L. Kusik ’56Chi S. Kwan ’52Gerald K. Kwentus ’67Lily F. Kwok ’80Concetta LaMarca ’81William J. LaPoint, Jr. ’84Catherine B. Labelle ’96Aaron J. Labrocca ’98Arthur J. Lacroix ’45Robert A. Lafyatis ’78Arthur P. Lagace ’60James Lago ’47Chiu-Kin S. Lai ’86Chung J. Lai ’73Weil R. Lai ’04Michael W. Laird ’69Robert I. Lait ’54David S. Laity ’50Frederick W. Lam ’89Lorenzo A. Lamadrid ’44Harry W. Lambe ’49Paul E. Lambert ’63Gerard C. Lammers ’48Gay V. Land ’44Robert E. Lander ’52Mary E. Landrum ’87Stanley C. Lane ’25Suzanne T. Lane ’85J. H. Laning ’40Berton M. Lapidus ’59Ana I. Laplaza ’94Cheryl A. Larrivee-Elkins ’87Howland A. Larsen ’50Jason K. Larsen ’99Paul R. Larson ’54Paul Z. Larson ’58Vijay K. Lathi ’94Albert K. Lau ’72Edmund K. Lau ’75Amy B. Laverdiere ’99Hugh P. Lavery ’73Stephen D. Laveson ’60

James S. Law ’72Andrew S. Lawing ’97John V. Lawler ’86Leroy E. Layton ’50Howard S. Lazar ’82Melanie L. Lazaro Flores ’92Hong-Van M. Le ’00Francis N. Le Baron ’44Jeffrey B. LeBlanc ’98Shirley C. LeMay ’89Steven R. LeMott ’72Donald C. Lea ’50Kathleen J. Leach ’92Benjamin L. Lebron ’03Joel A. Lederman ’77Andrew W. Lee ’76Arthur Lee ’85Barbara A. Lee ’87Chun-Hyuk Lee ’94Chung M. Lee ’87David S. Lee ’94David S. S. Lee ’98Dek S. Lee ’80Eun J. Lee ’04George Lee ’52Heather M. Lee ’95Helen H. Lee ’02Ivan H. Lee ’98Jean H. Lee ’87Jenny C. Lee ’96Jeong S. Lee ’80Karen L. Lee ’93Lester A. Lee ’55Mary K. Lee ’82Max N. Lee ’58Philip J. Lee ’03Robert Lee ’82Yung B. Lee ’81Ronald P. Leemhuis ’72Steven J. Lefkowitz ’00Jean P. Leinroth, Jr. ’48Jorge R. Leis ’86Susan M. Leite ’93Joseph E. Leitgeb ’57Robert S. Leithiser ’55Frank B. Leitz, Jr. ’55Robert B. Lennox ’83Stephen T. Lentz ’86Edward F. Leonard ’53Donato R. Leone ’59Sai B. Leong ’80

Alumni/ae Donors


Sing Leong ’45Richard N. Leslie ’66Gerald A. Lessells ’50Alan Letton ’80John S. Lettow ’02James C. Leu, Jr. ’85Alice M. Leung ’93James C. Leung ’75Joseph E. Levangie ’67Joseph C. Levesque ’95Robert S. Levine ’46James A. Levitan ’45Roy N. Levitch ’66Charles Levy ’50Gerard G. Levy ’64Karl B. Levy ’83Peter F. Levy ’79Lawrence J. Lewandowski ’69Philip C. Lewellen ’75Peter J. Lewis ’65Robert W. Lewis ’61George T. Li ’89Marlene M. Li ’89James W. Libby, Jr. ’35Frank H. Libman ’40William R. Licht ’87Robert A. Licklider ’78Nathan G. Lieberson ’51William E. Lifson ’41Bruce D. Lilly ’93Larry J. Lilly ’65Fredric J. Lim ’83Kenneth J. Lim ’70Kirk W. Limbach ’89Allie Lin ’99David Y. Lin ’98Gene C. Lin ’95Henry H. Lin ’83Nelson P. Lin ’91Rita H. Lin ’00Selina Lin ’84Tanya P. Lin ’96Wendy W. Lin ’84Danielle J. Lin Reese ’98John W. Lincoln ’55Peter G. Linde ’88Christine M. Lindsey ’04Carl A. Lindstrom ’49Richard S. Lindstrom ’53William Lintner, Jr. ’53John R. Linton ’84

W. H. Linton, Jr. ’47Malcolm J. Lipson ’50Charles C. Littlefield, Jr. ’44Stuart L. Litwin ’80Perry Liu ’80Theresa M. Liu ’97Fred P. Lobban ’40Prentiss Lobdell ’33Paul A. Lobo ’50Barbara E. Locke ’80George O. Lof ’40Jordan Loftus ’50William C. Long ’59John M. Longoria ’86John P. Longwell ’43Emilio M. Lopez ’87Francisco J. Lopez ’02Viorica Lopez-Avila ’79Daniel F. Lord ’44Richard A. Loring ’62Jeremiah A. Lott ’48Otway Louie ’93Bertrand C. Louvet ’62Richard N. Lovett ’43Robert F. Lovezzola ’48Robert E. Lueders ’55John M. Luger ’51Andrew L. Lui ’78Jeffrey C. Lukas ’82James A. Luker ’46John W. Lum ’72Walter J. Lunsmann ’91Robert M. Lurie ’52Martiel A. Luther ’82Stella C. Lymberis ’95Christine M. Lyons ’86Michael J. Lysaght ’64Yi H. Ma ’67Justine E. MacDonald ’80David S. MacKay ’84Alan L. MacLean ’44Andrei D. Maces ’04Marc Machbitz ’78Anthony C. Mack ’62Arnold Mackintosh ’44Dale A. Madden ’55Robert P. Madrulli ’51Robert D. Maher ’44Louis E. Mahoney III ’54William F. Mahoney ’89Thomas O. Maier ’67

Donald A. Mains ’47Daniel S. Maisel ’47Jennifer M. Majernik ’96Alex S. Malaspina ’52Gregory S. Malkin ’76Francis M. Mallee ’74Victor K. Mallet ’02Arvind Mallik ’98James A. Malloch ’43John B. Malloy ’50Robert L. Malster ’56David A. Manalan ’65Gerald Mandel ’77James L. Manganaro ’61Ivan Mankowich ’33Albert R. Manner ’79Brian A. Mannion ’84Eileen M. Mannix ’79Frank A. March ’67Frances K. Marchand ’90James K. Marchetti ’96Jan W. Mares ’60Jill R. Margetts ’00Stanley V. Margolin ’49Geoffrey Margolis ’69Mark E. Marinan ’81Linda C. Marinilli Kristal ’87Charles P. Marion ’52Guy T. Marion ’71Amy L. Markel ’85Catherine L. Markham ’81Alan B. Marks ’70Jerold S. Marks ’79Stanley Marple, Jr. ’41Andre V. Marrou ’62Henry N. Marsh ’51Harry A. Marshall ’65Mark E. Marshall ’80Xavier K. Marshall ’85John E. Marsland, Jr. ’57Alvin D. Martin, Jr. ’61Geo H. Martin ’53Reynold W. Martin II ’68Agustin Martinez ’95Boni P. Martinez ’46Wade S. Martinson ’00Prisca C. Marvin ’85Curtis L. Marx ’68Ben Y. Mason ’44Edward A. Mason ’50Thomas A. Massaro ’63

Chris A. Mastro ’98David K. Matsumoto ’88John L. Mattana ’51Christian J. Matthew ’43Diana J. Matthews ’92John W. Matthews ’44Philippe J. Matthys ’90David J. Mawer ’62John V. Maxham ’69Bruce H. Mayer ’44Jerome F. Mayer ’74Robert H. Mayer ’69Siegfried T. Mayr ’70Annmarie M. McAninch ’96James K. McCauley ’51David N. McClanahan ’43Hugh E. McCollum ’65Douglas D. McConnell, Jr. ’42Kenneth H. McCorkle, Jr. ’51Donald C. McCulloch ’63Charles W. McCutchen ’49Crawford McDonald ’48James R. McDonald ’01Lindsay J. McFadden ’96Clifton J. McFarland ’80Carl L. McGinnis ’42Robert G. McGrath ’53John D. McGrew ’51Joseph R. McHugh ’42Robert A. McIlroy ’58Winnette McIntosh ’98Robert V. McIntyre ’98Richard G. McKee ’54John T. McKenna, Jr. ’50Richard C. McKern ’94Derrick B. McKie ’74Julian T. McKinnon, Jr. ’89Mary A. McLaughlin ’58Gerald S. McMahon ’36Lee P. McMaster ’69James D. McMillan ’90Robert L. McMurtrie ’52James B. McNeely ’57James D. McNitt ’41Kenneth J. McNulty ’73Bryant R. Mclaughlin ’00John J. Mealy ’51Hendrik J. Meerman ’84Neville Z. Mehenti ’01Eugene F. Mehr ’01Herbert J. Meiselman ’66


Edward O. Meisner ’47Jerry H. Meldon ’73Peter Melnik ’52Diane T. Melo ’96Henry M. Meltzer ’56Marco A. Mena ’99Alejandro Menchaca ’85Michael P. Mendez ’93Burt Mendlin ’49Raghu K. Menon ’91Robert B. Meny ’44Tushar P. Merchant ’95Peter B. Merkle ’84Edward W. Merrill ’47William W. Merrill ’83Carla M. Merritt ’01Noelle M. Merritt ’85Richard T. Merritt ’42Raymond M. Merz ’82Amir A. Mesarwi ’00Janet C. Metsa ’79Arthur B. Metzner ’51Jerry C. Meyer ’93Juan M. Meyer ’68Paul G. Meyer ’87Robert E. Meyer ’46Albert C. Meyerer ’70Amy S. Meyers ’89Stephen L. Michaels ’76Jacques H. Michel ’68Laurent P. Michel ’47Richard C. Michel ’75Robert C. Michel ’50Stephen S. Mickel ’80Harold S. Mickley ’46Richard G. Miekka ’58Theodoros G. Mihopoulos ’94Marlo T. Miksche ’93Glen A. Miles ’59Aristides Miliotes ’54Irwin W. Millen ’50Bayen L. Miller ’02David R. Miller ’48James A. Miller ’50James D. Miller ’62Kimberley R. Miller ’83Stephen J. Miller ’48Wayne E. Miller ’44Howard P. Milleville ’40William H. Millick III ’49Clare L. Milton ’40

Sachiyo Minegishi ’99David R. Ming ’85Mark A. Mintun ’77Leon Mir ’61Floro D. Miraldi ’53Mary Beth E. Miranda ’88Andre J. Misk ’53Richard T. Miskinis ’53Angela M. Mislowsky ’99Lisa Misterka-Benati ’91Robert L. Mitchell, Jr. ’43Samuel L. Mitchell ’52William J. Mitchell ’53Samir S. Mitragotri ’96Thomas W. Mix ’56Helen E. Miyasaki ’78Wang-Tsee T. Mo ’88Michael Modell ’60Wm D. Mohr ’50Lingfung Mok ’80Brian V. Mokler ’60Thomas E. Molnar ’54Charles W. Monroe ’55Craig C. Monsell ’77Jose H. Montero ’82Cecilia I. Montes de Oca ’98Timothy L. Montgomery ’74Steven S. Moor ’77Albert L. Moore ’58Arthur W. Moore ’59James W. Moore ’78Elizabeth Morales ’96Joel Morales ’99Allan C. Morgan ’60Dale F. Morgan ’38Dean T. Morgan ’57John H. Morgenthaler ’51Timothy I. Morgenthaler ’80Brian R. Moroney ’82Eric M. Morrel ’87Joyce C. Morrill ’84Stephen R. Morris ’82William C. Morris ’60George M. Morrow III ’41David C. Morse ’56Merton Morse ’51Kenneth P. Mortensen ’77Peter C. Moss ’59Johnson Mossman ’50John A. Moulson ’62Angela R. Mtungwa ’97

Joan T. Muellerleile ’85Kanae Mukai ’98Debi P. Mukherjee ’69Antonio Mulet ’80James A. Mulholland ’58Lorenz A. Muller ’87Allan U. Munck ’48Paul S. Munn ’46Richard L. Murdock ’58Charles F. Murphy ’51Regina M. Murphy ’78Thomas P. Murphy ’54Gilman Y. Murray ’44Robert M. Murray ’48William M. Murray, Jr. ’55Jeffrey A. Muss ’83Michael Mutsakis ’72David F. Myers ’81Henry J. Myers ’53Kenneth L. Myers ’98Edward M. Myskowski ’62Gerald J. Nacamuli ’67Vanessa A. Nadal ’04Fred S. Nadel ’58Robert S. Nahas ’56Paul R. Nahass ’83Gabriel H. Nahigian ’96Hareesh V. Nair ’03Edward G. Najjar ’56Duane T. Nakahata ’81Stacey T. Nakamura ’80Rita Nanda ’93Walter C. Nason, Jr. ’45Elba A. Nazario ’95Russell S. Negin ’97Anil K. Nehru ’63Lita L. Nelsen ’64Celeste M. Nelson ’98Gordon R. Nelson ’51Gregory N. Nelson ’02Stuart M. Nemser ’66Lisette L. Nenninger ’90Noble M. Nerheim ’61Michael A. Neschleba ’69Paul H. Netherwood ’33Christine M. Neumann ’00George W. Neuner ’66Joseph P. Neville ’56Allison H. Newcombe ’51Bruce H. Newell ’82Robyn S. Newell ’84

Barry A. Newman ’79Robert W. Newman ’36Andrew S. Ng ’73Christine S. Ng ’97Theresa Ng ’99Ying Y. Ng ’01Hau Yee Ng-Lo ’84Shih-Tung Ngiam ’91Tuan Nguyen-Duy ’78Hong Bin Ni ’92James F. Nichols ’56William B. Nichols ’50Benjamin F. Nicholson ’03Edward W. Nicholson ’36William J. Nicholson ’60David E. Nickles ’62Christopher T. Nidel ’95William J. Nieckarz, Jr. ’61Matthew E. Nilsson ’01Reynold B. Nippe, Sr. ’56Kemal M. Nisancioglu ’68James J. Noble ’68Kirk T. Noda ’94Susan C. Noe ’87James P. Nolan, Jr. ’51Ronald A. Norelli ’67Edward M. Norin ’68Robert G. Norton ’51Verrill M. Norwood, Jr. ’53Richard M. Novo ’82James P. Noyes ’53Amechi E. Nwachuku ’95Catherine Nyarady ’93Scott L. Nyberg ’82David C. O’Brien ’53John B. O’Brien ’64John P. O’Connell ’61Joseph E. O’Connell ’60William J. O’Connell ’65Robert J. O’Donnell ’46Analeah O’Neill ’00Marguerite E. O’Neill ’93William O. O’Neill ’43Janet A. Oatway Quirey ’78Christiana O Obiaya ’04Ryan M. Ochylski ’01Stephen A. Odio ’90Jeffrey C. Oehler ’81Mary C. Oehler ’82Siegbert J. Oettinger ’39Larry M. Ogden ’58

Alumni/ae Donors


Oludare Ogunyemi ’00Edwin M. Oh ’84Minna M. Oh ’03Myongsook S. Oh ’85Young D. Oh ’89Stephanie B. Ohshita ’88David T. Okamoto ’85Donald R. Olander ’58Jessica R. Oleson ’96Emily L. Oliphant ’03James D. Oliver ’81Robert C. Oliver ’53James M. Olivo ’82Sven A. Olund ’51Raymond L. Oransky ’49Robert D. Orlandi ’74William F. Orr ’41Ronald G. Ort ’71David E. Ortman ’79Atsushi E. Osawa ’92Marlon A. Osbourne ’98Martine M. Osias ’90Mark I. Ostler ’69David J. Ostlund ’04Steven G. Oston ’59Ravinder K. Oswal ’80Jeffrey Ou ’94Shukong Ou ’76Alfred J. Oxenham ’45Olayiwola O. Oyeleye ’90Rudolph J. Ozol ’36Jeffrey D. Paarz ’63Walter J. Paciorek, Jr. ’65Richard D. Packard, Sr. ’51Laura Y. Padilla ’97George W. Page, Jr. ’78Philip F. Palmedo ’61Louis C. Palmer ’50Nicole A. Palmer ’02Tuomas A. Paloposki ’88Anna Pan ’97Carolyn K. Pan ’03Mark A. Panarusky ’85Neil A. Panzier ’52Theodore G. Papastavros ’55Paul C. Pape ’79James J. Pappas ’52Chandrasekar Papudesu ’98Natesh Parashurama ’94Trueman D. Parish ’63Chan D. Park ’75

Keum J. Park ’93Rachel R. Parke-Houben ’03Melahn L. Parker ’01Reginald Parker ’92Rienzi B. Parker, Jr. ’59Russell F. Parker, Jr. ’51Porshia S. Parkinson ’95Leonard J. Parsons ’64Stephen H. Pasternak ’87Chandra Patel ’94Bernard J. Patnode ’56Jennie R. Patrick ’79Richard S. Paul ’52Houston K. Payne ’56Donald W. Peaceman ’51William E. Peak ’74Frank G. Pearce ’46Cornell Pearcy ’79Benjamin R. Pease ’90Kerone N. Peat ’00George C. Pedersen ’62Jorge A. Pefaure ’76Abigail H. Pelcyger ’01Wardner G. Penberthy ’81William B. Penn ’37Janice G. People ’75Miguel Perales ’93Edward Perez ’95Roger C. Perkins ’85Samuel E. Perkins II ’50George P. Perkinson ’65Charles W. Perry ’35Christopher D. Perry ’98Leland H. Perry ’63Steven D. Perry ’87Rolph A. Person ’52Ervin Peter ’98David F. Petherbridge ’67Kavas N. Petigara ’72Robert P. Petrich ’63Dimitrios P. Petridis ’91Philip J. Philliou, Sr. ’55John J. Phillips, Jr. ’38Ronald J. Phillips ’90Wallace C. Philoon, Jr. ’47Donald L. Phipps, Jr. ’61David G. Pickering ’85Rudolph W. Pierce ’50Thomas H. Pigford ’48John J. Piret ’85John S. Pitcher ’87

James A. Pitcock ’51Denise L. Plaskett ’80Sharon E. Plon ’79Dirk A. Plummer ’52Joseph A. Polack ’43Jason W. Politi ’98John G. Polk ’53Bryan S. Poltilove ’97Michael J. Pomianek ’90Arturo Ponce Alcala ’47Karen Ponchner ’02Brian W. Pontius ’83Olapeju A. Popoola ’96Jill E. Porter ’85Katie M. Porter ’95Neil S. Portnoff ’73Jane H. Potter ’80J. L. Powell ’47Kevin T. Powell ’89Lakisha N. Powell ’95Robert W. Powell ’70Arthur J. Power ’42Puriwana Pradipasena ’03Sutikshan Prakash ’65Kristala J. Prather ’94Mark R. Pratt ’60Randall N. Pratt ’44Stuart W. Pratt, Jr. ’51Anthony Praznik ’56Paul M. Premo ’65Paal Prestegaard ’61John L. Preston, Jr. ’68Rosalyn F. Preston ’82Jeffrey D. Pribble ’89Cordelia M. Price ’78Robert C. Price ’83John R. Priest ’60John J. Prior ’97David N. Prugh ’82James M. Prusko ’86Douglas A. Prybylowski ’83William B. Pryor ’58Andrzej B. Przedpelski ’46John C. Putman, Jr. ’47George C. Putnam ’36Gordon B. Pye ’55Annemarie L. Quaadgras ’85H. M. Quackenbos ’41Richard J. Quann ’82Robert H. Quick ’53Waqar R. Qureshi ’90

Henry H. Rachford, Jr. ’50Frederick A. Radville ’48Sang-Chun Rah ’84Reza S. Rahaman ’89Shehry Rahman ’95William P. Raiford ’89Dilip Rajagopalan ’91Gokaraju K. Raju ’89Julie A. Rakestraw ’90Scott L. Rakestraw ’90Suresh Ramalingam ’90Carlos A. Ramirez ’79David M. Ramirez ’93Desiree L. Ramirez ’02Alonso R. Ramos Vaca ’78George A. Randall ’66Kendall B. Randolph ’56Betty R. Ransohoff ’84Thomas C. Ransohoff ’84Derek T. Ransom ’98Maggie A. Raphael ’96William J. Rapoport ’46Gerald S. Rau ’83Carl W. Rausch ’74Lori A. Ray ’93Martin L. Ray ’46Willis B. Reals ’47Stephen A. Reber ’75William H. Redlien, Jr. ’46Jefferson M. Reece ’68Carleton M. Reed ’70Charles E. Reed ’37Charles L. Reed ’61David W. Reed ’61Keith G. Reed ’04Stanley D. Reed ’74William A. Reed ’43Winthrop B. Reed ’39John H. Rees ’47Stacey L. Reeves ’93Carolyn A. Reeves Saarinen ’86Carlonda L. Reilly ’90Peter M. Reilly ’80Ronald A. Reimer ’69Eric S. Reiner ’83Ralph I. Reis ’48Toby R. Reitzen-Sachen ’78Edward G. Remmers ’52Neil S. Renninger ’96Todd M. Renshaw ’87Timothy J. Resch ’95


Hyman Resnick ’49Richard H. Reuther ’51Conrad S. Revak ’58Albert B. Reynolds ’53Richard B. Reznik ’64Judson C. Rhode ’40Frank J. Rhodes ’81Lockwood Rianhard ’54Harold A. Ricards, Jr. ’41James W. Rice ’57William L. Rice ’53David C. Rich ’92Edwin T. Richard ’51Robert L. Richards, Jr. ’51Steven O. Richardson ’79William S. Richardson ’44Bradford D. Ricketson ’97Royal C. Riedinger ’54Herbert Riegel ’49John E. Riley ’39Lynn C. Riley ’84Auguste E. Rimpel, Jr. ’60Peter M. Rinaldo ’44Irven H. Rinard ’57Alvin E. Ring ’48Jose A. Rionda, Jr. ’62James B. Risser ’57Kimberly E. Ritrievi ’85John E. Ritter ’82Heriberto Rivas ’98Sandra J. Roadcap ’81Lester E. Robb ’47Andrew M. Robbins ’83James D. Roberge ’84John H. Roberts ’56Cynthia S. Robertson ’55Geoffrey Robillard ’44Norman A. Robins ’55John M. Robinson ’81Sarah M. Robinson ’93John M. Roblin ’55Stanley B. Roboff ’43Richard K. Rockstroh ’50Avital A. Rodal ’97Otha C. Roddey ’51Stephen D. Rodgers ’96Maritza L. Rodriguez ’03Phyllis W. Rodriguez ’00Theodore B. Roessel ’44Bethany M. Rogers ’97Joseph E. Rogers ’73

Reginald E. Rogers, Jr. ’01Edward Rolfe ’51R. J. Rollbuhler ’54Florence R. Rolston ’88Philip B. Romanik ’82Michael J. Romney ’66Peter J. Ronco ’92Edwin G. Roos ’44Douglass E. Root, Jr. ’44Emma M. Root ’64Stephen C. Root ’62Thatcher W. Root ’79Robert L. Rorschach ’43Peter J. Rosamilia ’83Stephen H. Rose ’71David Rosen ’58Martin N. Rosen ’62H. J. Rosenberg ’45Robert E. Rosenberger ’67Ronald E. Rosensweig ’56Barnet L. Rosenthal ’30Murray W. Rosenthal ’53Richard S. Rosera ’70Alexander G. Ross ’61Frederick J. Ross ’46John M. Ross ’56John R. Ross ’67Joel N. Rossen ’48A.D. Rossin ’55Philip M. Roth ’60Stan R. Roth ’75Burton M. Rothleder ’53Paul H. Rothschild ’58Edwin C. Rothstein ’56Margaret H. Rousseau ’37William C. Rousseau ’36Robert J. Roy ’82David B. Rubin ’75Steven H. Rubin ’71Bennett L. Rudorfer ’82Loring W. Rue, Jr. ’53Tina C. Rulevich ’92Frank E. Rush, Jr. ’44Ridwan D. Rusli ’93Allen P. Russell ’82Charles D. Russell ’57Jack A. Russell ’68Morley E. Russell ’53Leonard W. Russum ’47Christian L. Rust ’51Gregory C. Rutledge ’90

Philip A. Ruziska ’62James M. Ryan ’58Lisa M. Ryan ’81James E. Ryder ’49Arthur R. Ryrholm ’46Dewey D. Ryu ’61Abdul Ghani M. Saad ’01Daniel G. Sabanosh ’94Robert B. Sackheim ’39Shafik E. Sadek ’66Robert F. Sadowski ’50Stanley J. Sadowski ’53Tracy M. Sadowski ’99Basil C. Safos ’80Suchitra N. Sairam ’93Hiroshi H. Saito ’91Jeffrey B. Sakaguchi ’82Shelly E. Sakiyama-Elbert ’96Morris Salame ’60Todd R. Salamon ’96Vasilios S. Salapatas ’66Norman I. Salas ’69Miren C. Salsamendi ’82Dominick A. Sama ’54Rafael Sanabria ’79Gilbert W. Sanchez ’75Robert L. Sandel ’64Rola K. Sangodeyi ’98Vishak Sankaran ’90Cynthia S. Santillan ’96John T. Santini ’99Salvatore L. Santo ’51Pedro M. Saraiva ’93Behrooz Satvat ’80Gerald K. Saul ’57Deborah E. Savage ’92Edward E. Savard ’87Elliot Savitz ’63Christine M. Sawka ’90Raymond M. Sawka ’91Craig D. Sawyer ’60Clifford M. Sayre, Jr. ’52Elizabeth A. Scarito ’74Edgar M. Scattergood ’58Kirk D. Scattergood ’79Martin J. Schad ’83Eugene J. Schaefer ’85Albert R. Schallenmuller ’56Eric G. Scharin ’90Walter S. Scheib, Jr. ’52Herbert I. Scher ’51

Arthur Schiff ’46George F. Schlaudecker ’39Fred H. Schlesinger ’83Mark J. Schmaier ’82Frank G. Schmaltz, Jr. ’59Michael R. Schmid ’57Frederick W. Schmidt ’61John P. Schmidt ’63William J. Schmitt ’85George A. Schnabel ’60Dean A. Schneider ’69George R. Schneider ’56Gia D. Schneider ’99S. B. Schneiderman ’58Carol A. Schnepper ’84Leonard J. Schnetzer, Jr. ’59Jay J. Schnitzer ’83Fritz Schnorf ’52Bern J. Schnyder ’60David E. Schoeffel ’51Cassandra S. Schoessow ’99James E. Schonblom ’56Sarah E. Schott ’83Robert J. Schrader ’43Alan P. Schreiber ’39Brent M. Schreiber ’03Gerald L. Schroeder ’59Dale S. Schultz ’84Theodore F. Schultz ’59Barbara J. Schultze ’02Robert B. Schulz ’79Stephen R. Schulze ’66Carl P. Schumacher ’51Arthur Schwartz ’47Scott B. Schwartz ’81Eric G. Schwarz ’53Hugh W. Schwarz ’42Stephen Schwed ’83Richard W. Schweizer ’50Daniel M. Schwendenman ’83Howard E. Schwiebert ’40Chris E. Schwier ’84Arthur D. Schwope ’72Steven F. Sciamanna ’81Jocelyn E. Scott ’84Stewart Scott III ’50Eugene Scoville ’78Bruce E. Scruggs ’88Robert N. Secord ’42Leonard A. Seder ’37Rodolfo E. Segovia Salas ’58

Alumni/ae Donors


Arnold Seid ’73Andrew Seidenfeld ’68Howard W. Seidler ’80Roy L. Seikel ’47George R. Seiler ’57William A. Selke ’43Charles W. Selvidge ’63Luwam G. Semere ’01Suren A. Semonian ’50Michael A. Serio ’84William R. Seuren ’47Stephen D. Severson ’76Lawrence R. Sewell ’72John D. Sewer ’00Ray W. Shade ’49Mona K. Shah ’00Pauravi M. Shah ’02Paul M. Shain ’81John C. Shambaugh ’61Erica S. Shane ’86Frank G. Shanklin ’52Jennifer R. Shapiro ’01Paul S. Shapiro ’63Stephen I. Shapiro ’66Alfred C. Sharon ’76Deborah S. Sharpe ’76Robert G. Shaver ’52Rhonda J. Shaw ’83Thomas E. Shea ’86James F. Sheehan, Jr. ’48Linda M. Sheehan ’85Seymour J. Sheinkopf ’39Jack L. Shelton ’58Charlene C. Shen ’80Emil W. Shen ’78Yen Shen ’42Rahul A. Shendure ’95Norman F. Sheppard, Jr. ’78Jesse M. Shereff ’63David C. Sherman ’85Albert E. Sherwood ’52John W. Shield ’89Ashley K. Shih ’91Paul J. Shim ’84Hyunkook Shin ’62Annette D. Shine ’83Gregory B. Shinn ’83Duane E. Shinnick ’70Deborah R. Shnek ’89Kiyoshi Shohara ’53Lloyd G. Shore ’41

Adam L. Shrier ’60Joseph Shrier ’44Ruchi Shrivastava ’01Aarti Shukla ’94Kenneth R. Sidman ’67Donald H. Siefkes ’64Robert E. Siegfried ’47William L. Sifleet ’75Charles A. Siletti ’89Jeffrey E. Silliman ’72Ronald A. Sills ’70Richard S. Silver ’63Peter M. Silverberg ’60Peter L. Silveston ’51Harsono S. Simka ’98John A. Simmons ’53Irwin B. Simon ’68Valeria M. Simone ’97Vinson R. Simpson ’50James A. Sinclair ’64Mansour Sindi ’01Jean E. Singer ’79Marvin I. Singer ’63Paul A. Siock, Jr. ’65Arthur L. Sirkin ’56Ricardo Sitchin ’80Hoi Man Siu ’87Nicole M. Skaf ’97George T. Skaperdas ’38Richard E. Skavdahl ’56Andrew D. Skibo ’67Benjamin L. Skinner ’42Carl P. Slenk ’56John E. Slifer ’44Robert L. Slifer ’50Melvin R. Sline ’69Bernard Slosberg ’63Theodore J. Slosek ’54Robert S. Slott ’58Amy A. Smiley ’84Brian R. Smiley ’83Barbara J. Smith ’89Douglas S. Smith ’86Frank G. Smith ’81Frederick C. Smith ’43George C. Smith, Jr. ’49Joe M. Smith ’43Kenneth A. Smith ’58Kristin D. Smith ’04Louis C. Smith ’36Mark D. Smith ’00

Michael J. Smith ’59Rebecca E. Smith ’89Robert F. Smith ’58Robert S. Smith ’47Verity C. Smith ’48Stanley C. Smock, Jr. ’44Cecilia C. Smolinski ’84John M. Smyser ’35Robert A. Snedeker ’50Steven J. Snider ’82Elizabeth M. Snoeyink ’81Jeffrey P. Snow ’78Michael J. Snow ’86Richard A. Snow ’48Jay E. Sobel ’61Charles R. Solenberger ’57Janet A. Sollod ’96Daniel I. Solomon ’82George S. Somekh ’56Steven R. Sommer ’77Maria R. Sondhaus ’87Yihhong L. Song ’78Claudio Sonino ’58Scott G. Sontheimer ’84Jasjeet S. Sood ’80Musta Fa I. Soylemez ’64Patrick S. Spangler ’60Kevin A. Sparks ’91Gordon D. Specht ’54Herschel Specter ’57Karen Y. Spencer ’86Barry M. Speyer ’61Stephen H. Spiegelberg ’93Peter H. Spitz ’48Thomas M. Spitznagel ’88Herbert L. Spivack ’49Joia K. Spooner-Wyman ’01Kimberley J. Sprague ’83Dennis L. Sprecher ’74Katherine A. Squire ’97Arthur L. Squyres ’53Manakan B. Srichai ’94Tina Srivastava Dear ’92Thomas M. St. Louis ’85Kevin E. St. Onge ’85Richard L. Stadterman ’75James J. Staikos ’50Jeffrey D. Stamler ’00Arnold F. Stancell ’62Michael D. Stanfield ’53Robert B. Stanfield ’57

Walter T. Stanley ’75Louis E. Stark ’47Brian C. Starzec ’95Anthony Stathoplos ’51John E. Stauffer ’57David K. Steckler ’87Robert A. Steel ’38Olaf Steen, Jr. ’50Edward R. Stefaniak ’51Nelson E. Stefany ’61Robert K. Steidlitz ’79Harold A. Stein ’56Theodore W. Stein ’51Robert M. Steinberg ’81Don Steiner ’60Peter L. Steinhagen ’79Reed C. Steinmetz ’87Harvey G. Stenger, Jr. ’84David A. Stern ’79Howard S. Stern ’53Robert L. Stern ’48William R. Stern ’40Robert V. Sternberg ’39Douglas M. Stevens ’83Robert L. Stevens ’49William B. Stevenson ’35Mark W. Stewart ’98Warren E. Stewart ’51Kenneth W. Stickney ’48Ted J. Stoecker ’82Thomas J. Stohlman, Jr. ’76Thibaud S. Stoll ’90Herbert L. Stone ’53Bayard T. Storey ’55Dimitrios Stratikopoulos ’97Richard A. Strauss ’60Justin A. Strittmatter ’95Pieter Stroeve ’73Robert J. Struble ’85Richard S. Strzelecki ’53Nathan V. Stuart ’92Harold A. Stubing ’55Michael C. Sudol, Jr. ’58Tzeng J. Suen ’35Sarosh P. Sukhia ’66Andrew D. Sullivan ’92William H. Sun ’79Warren E. Sundstrom ’35Cynthia Sung ’89Jean C. Sung ’98Wei F. Sung ’77


David C. Surber ’82Harry D. Surline ’64Frank E. Surma, Jr. ’66Norman F. Surprenant ’49Eric M. Suuberg ’73Akira Suzuki ’63Jahnavi Swamy ’95David E. Swanberg ’40David C. Swanson ’79David S. Swanson ’53Dennis V. Swanson ’68Eric F. Swart ’03James R. Swartz ’78Jason T. Sweeney ’03Linda E. Sweeney ’83Maxwell P. Sweeney ’50Darius Sweet ’81William A. Sweet ’77Robert F. Sykes ’44Wendell G. Sykes ’50Min-Nan Sze ’70Morgan C. Sze ’39Andrea M. Tabor ’82William Taggart ’59Nazbeh R. Taghizadeh ’02Raj V. Tahil ’81Hsin-Chien Tai ’93Luther Tai ’70Robert W. Tait ’80Jack C. Tang ’49Bernard Y. Tao ’76James F. Tao ’59Frank A. Tapparo ’60Oded Tavory ’51Sew-Wah Tay ’86Douglas J. Taylor ’39John M. Taylor ’84Joshua D. Taylor ’98Katherine L. Taylor ’95Thomas R. Taylor ’38James H. TeStrake ’62Catherine E. Teague Sigal ’81Ted B. Teitelman ’84Donato R. Telesca ’48Kwaku O. Temeng ’79Leonard R. Tenner ’60Philip D. Terpandjian ’76Jefferson W. Tester ’71Evan W. Thayer ’91Michael P. Thien ’88Edward F. Thode ’42

Alan C. Thomas ’79Valarie D. Thomas ’92Edward T. Thompson ’49Keith M. Thompson ’64Kimberly M. Thompson ’88Louis S. Thompson ’63Suzanne M. Thompson ’81Robert T. Thomson ’84Ellen A. Thorne Lane ’88Barbara A. Thornton ’77Rachel M. Thornton ’92Kathrine R. Threefoot ’84Anna M. Thuer ’82George M. Thurlow ’54Jean Tilly ’83William J. Timson ’50David T. Ting ’99Robert Tischbein ’38Simon Tisminezky ’00Elaine R. Tobias ’79Jean W. Tom ’84Jeanne E. Tomaszewski ’00Peter A. Tomlinson ’67Hsueh-Rong Tong ’81Sonja L. Tong ’01Jose V. Tormo ’81Edward C. Torres ’93Juan E. Torres ’82Luisa K. Torrielli ’98Warren L. Towle ’34Robert M. Train ’75Richard T. Traskos ’66Olev Trass ’58Harvey C. Travers ’49David R. Treadwell ’33David P. Trempel ’85Charles A. Trilling ’49Debasish Tripathy ’81Edwin P. Tripp III ’67Richard H. Tromel ’58Robert J. Tronnier ’73Martin J. Troster ’51Bernhardt L. Trout ’90Theodore D. Trowbridge ’59George A. Truskey ’85Margaret C. Tsai ’99Mun C. Tsang ’79Tat P. Tsang ’81Konstantinos G. Tsiveriotis ’88Mosum E. Tsui ’82Tsu-Man P. Tu ’86

Edward L. Tucker ’61W. H. Tucker ’46Glenn A. Tuckman ’77Antonio Tuells Juan ’65Lisa A. Tung ’88Shao E. Tung ’54Howard T. Tupper ’52Anthony Turano, Jr. ’54Seymour B. Turetzky ’61Frederica C. Turner ’95Lawrence C. Turnock ’41Anthony C. Turrisi ’56Robert S. Tutunjian ’72Chaplin Tyler ’23Jeffrey J. Tyrrell ’80Edye C. Udell ’89Nkereuwem I. Udofia ’83Page S. Ufford, Jr. ’44John C. Uhrmacher ’64John G. Ullman ’47Akaniyene E. Umoh ’01Jacqueline T. Underberg ’01Kevin D. Uptain ’99Angela L. Urdanoff ’82Carlos Uribe ’63Debra A. Utko ’80David H. Vahlsing ’58Jaime A. Valencia-Chavez ’78Amy S. Vallely ’04Marketa Valterova ’00Irvin B. Van Horn ’59Walter L. Van Nostrand, Jr. ’50William T. van Ravenswaay ’44William D. Van Vorst ’43Jon Van Winkle ’53Kenneth A. Van Wormer, Jr. ’61Arthur P. Vasen ’83Steven N. Vaslef ’80Victor C. Vaughen ’56Craig B. Vaughn ’88Robert E. Vaughn ’52Patrick J. Vayn ’69Jesus Velazquez, Jr. ’84Sandra Velez van Dongeren ’93Dell F. Venarde ’55Sivakami Venkatachalam ’99Rajesh Venkataramani ’00David P. Ventola ’91Frank J. Venuti ’74Michele C. Verticchio ’02Nancy P. Vespoli ’79

Gerard F. Vetromile ’63Vincent L. Vilker ’76James D. Virosco ’79Susan A. Visser ’86Chitra Viswanathan ’95Valerie J. Vitale ’81Henry C. Vogel ’41David E. Voit ’68Laura J. Vojvodich ’95Kathleen G. Vokes ’00David Volfson ’85Robert L. Von Berg ’44George F. Von Fuchs ’59Antonia J. Von Gottberg ’92Friedrich K. Von Gottberg ’92Susanne M. von Rosenberg ’83John C. Vyverberg, Jr. ’39David L. Wagger ’92Heidi L. Wald ’92Zwi H. Waldman ’57Raymond J. Waldmann ’60Charles M. Walker ’49William W. Walker, Jr. ’70Jesse T. Wallace ’58Robert R. Walsh ’85Glynis A. Walton ’87Stephen P. Walton ’00Albert E. Walz, Jr. ’54Hans G. Walz ’43Eva C. Wan ’81Mona M. Wan ’84Stephen S. Wan ’82Albert Y. Wang ’85Beatrice Wang ’99Jack Wang ’00Kenneth W. Wang ’79Mei-Hui Wang ’86Peggy J. Wang ’02Richard D. Wang ’78Wechung M. Wang ’04Kenneth L. Warden, Jr. ’43Margaret F. Ware ’98Robert A. Ware ’84Charles E. Warford ’63Robert T. Wargo ’78Douglass J. Warner ’59Huber R. Warner ’58Donald C. Warren, Jr. ’76Steven L. Warsof ’73Arthur A. Wasserman ’51Paul Watkins ’49

Alumni/ae Donors


Dawn E. Watkins-Chow ’92Delonia A. Watson ’78Ross O. Watson ’49George H. Waugh ’57James B. Weaver ’44Robert P. Webb ’51Vincent A. Webb ’89Richard M. Webber ’86Richard P. Weber ’03Alfred E. Wechsler ’55David S. Weddell ’41Christopher P. Wedig ’73Norman E. Weeks ’63Herbert Wegener, Sr. ’61James C. Wei ’54Ronald J. Weigel ’80Robert F. Weimer ’61Mark Weinberg ’81Peter C. Weinert ’36Naomi L. Weinless ’78Randy D. Weinstein ’98Samantha A. Weinstein ’02Kenneth A. Weisel ’71Kenneth R. Weisshaar ’72Stephen Weisskoff ’57Abraham Weitzberg ’57Jeffrey P. Welch ’91Martin A. Welt ’57Ralph L. Wentworth ’48Jason A. Wertheim ’96Jennifer L. West ’92Jessica L. West ’98Theresa A. Weston ’80Otto K. Wetzel ’48Lennard Wharton ’55Michael P. Whelan ’80Nicholas H. Wheless, Jr. ’38William B. Whiston ’51Michael T. Whitaker ’71Chiquita V. White ’85Gary L. White ’77Herbert M. White ’44William P. White ’64Lawson E. Whitesides, Jr. ’71Charles A. Whiting ’84Richard H. Wick ’58David A. Wickham ’84Carl V. Wikstrom ’90Christina M. Wilbert ’01David S. Wilbourn ’55Richard J. Wilcox ’85

Ross P. Wilcox ’77William R. Wilcox ’42George T. Wildman ’73David E. Wilfong ’82Jeffrey A. Wilke ’93John A. Wilkens ’77Lucile S. Wilkens ’77Roland F. Wilkinson ’44John A. Willard, Jr. ’50Laura B. Willett ’79Corrine M. Williams ’01Curtis C. Williams III ’50James E. Williams ’81Laura A. Williams ’00Peter M. Williams ’57Pyam W. Williams ’36Rosemarie D. Williams ’81W. G. Williams ’65David V. Williamson ’53David A. Willis ’60William Willoughby II ’54Gary N. Willson ’85Richard C. Willson ’88R. S. Wilson ’80Robert E. Wilson ’50Steven R. Wilson ’75Terri A. Wilson ’99Todd D. Wilson ’88Eugene B. Wilusz ’68Leonard Wimpfheimer ’54R. N. Wimpress ’39Max Winer ’34Richard C. Wingerson ’52Charles E. Winters ’39Richard B. Winters ’76William T. Wise ’48Marc B. Wisnudel ’91Robert H. Wittenauer ’49Harvey J. Woehlck ’81Graham A. Woerner ’76Byron B. Woertz ’39Carl F. Wolf ’53Clarence W. Wolf, Jr. ’62J. H. Wolf, Jr. ’51Arthur E. Wolters ’50Stanley M. Womack ’82Aaron K. Wong ’98Eric W. Wong ’81John P. Wong ’78Patrick M. Wong ’78Patrick S. Wong ’62

Yun-Ling Wong ’04Pang T. Woo ’51Benjamin H. Wood, Jr. ’62Elwood S. Wood III ’56Frank Wood, Jr. ’55Paul J. Wood ’73Clifford C. Woods, Jr. ’46W. K. Woods ’36Eugene E. Woodward ’49Morton P. Woodward ’22Kim C. Worley ’84Mary J. Wornat ’88George R. Worrell ’48Walter F. Worth ’68Edward E. Wright, Jr. ’58Wesley Wright, Jr. ’57Donna T. Wrublewski ’00Aileen J. Wu ’03Michelle H. Wu ’02Mario R. Wunderlich ’45Richard A. Wuopio ’60Larkin T. Wyers, Jr. ’43George M. Wyman ’62Jirong Xiao ’90Liangzhi Xie ’97Ye Xu ’99Vijay M. Yabannavar ’88Hiroshi Yagi ’79Kayoko Yamamoto ’93Hiroshi Yanagioka ’66Daniel Yang ’98Linda Yang ’85Ioannis V. Yannas ’59Bruce S. Yarmoska ’79Kenji Yasuda ’79Michael J. Yaszemski ’95St. Clair P. Yates ’38John A. Yeabower, Jr. ’79Linda H. Yeh ’89Por-Wun Yeh ’84Arline S. Yen ’85I-Kuen Yen ’56Lin-Chi Yen ’98Pao M. Yen ’44Stephen J. Yeretsky ’59Johnny C. Yeung ’77Reginald S. Yeung ’59David Yin ’03Yu-Lan Mary Ying ’98Jessica Y. Yip ’02John E. Yocom ’47

Mark I. Yogman ’66En S. Yoon ’82Hyung J. Yoon ’90John R. Young ’48Kai W. Young ’58Lester W. Young ’65Richard E. Young ’56Charles R. Youngson, Jr. ’72Lily H. Youtt ’97Adrian P. Yovanovich ’83Eric T. Yu ’84Michael Yu ’93Stephen K. Yu ’80Wendy H. Yuan ’80William W. Yuan ’59Pak K. Yuet ’96Alan Yung ’78Mark W. Zacharias ’79Russell E. Zagrodzky ’61Aina Zahari ’02Joseph G. Zahka ’71Domenic A. Zambuto ’85Howard B. Zasloff ’52Michael Zeltkevic ’98Jorge Zemella Frea ’63Lei Zhang ’95Xinjin Zhao ’90Hong Zhong ’96Yizu Zhu ’92Allyn J. Ziegenhagen ’59Harry J. Zimmer ’51Nora A. Zirps ’82Samuel Znaimer ’81Irwin S. Zonis ’52Paul M. Zorn ’50Craig A. Zupke ’93Eric L. Zweigel ’76Melinda L. Zwickert ’77Andrew L. Zydney ’85


TOXICITY OF ENDOGENOUS NITRIC OXIDEPROFESSOR WILLIAM M. DEEN

Researchers in numerous branches of medicine and physiol-ogy have discovered in recent years that nitric oxide (NO) isroutinely synthesized by cells throughout the body, and thatmaintaining proper concentrations of it is essential for goodhealth. It helps regulate blood pressure, affects clotting,assists the communication among neurons, and plays a rolein the immune response to infections, among other benefi-cial actions. But, unfortunately, NO is both toxic and muta-genic if present in excess, and there are situations in whichits production is apparently overstimulated. The sustained,high rate of NO synthesis by immune cells during chronicinflammations provides an example, and may explain thestatistical link between persistent inflammations and certainforms of cancer. Chemical damage to cellular proteins,lipids, and DNA results not so much from NO itself, butfrom a variety of trace nitrogen oxides formed when NO isoxidized in biological fluids.

Professor Deen’s group has been investigating the funda-mental aspects of the production and fate of NO and relatednitrogen oxides in biological systems in collaboration withseveral faculty in the Biological Engineering Division. Toassess health risks and design interventions, one needs toknow which compounds actually mediate the various harmful effects of excess NO. Underlying that effort is theneed to know what their concentrations are near an NOsource (e.g., an activated macrophage), and over what distances those concentrations remain elevated. A chemicalengineering problem emerges: The concentration fields must reflect the interplay between rates of reaction and diffusion. The modeling problems are made challenging bythe complex chemistry, which includes enzymatic sourcesand sinks for NO, a network of inorganic oxidations thatyield other reactive nitrogen oxides, and the interactions of the nitrogen oxides with soluble or structural biomole-cules. The geometric complexity of tissues, and even of cell culture systems used to study NO toxicity, adds its own difficulties. Experimentally, few of the compounds of interest are present at measurable concentrations, andtheir levels must be inferred from analyses of oxidation end products and of biomarkers (e.g., trace levels of nitrogen oxide-modified proteins).

This work in Professor Deen’s group has yielded severalrecent insights. A reaction-diffusion model developed todescribe the fate of NO released by macrophages culturedon plates revealed that some species will be present only inthe immediate vicinity of the cells, but others will existthroughout the culture medium. Accordingly, various chemical reactions will be spatially segregated, even in

extracellular fluid. Experiments varying the depth of the liquid medium indicated that NO strongly inhibits its ownsynthesis by macrophages, a phenomenon that had beendemonstrated previously with isolated enzymes but not withintact cells. An analysis of the kinetics of NO productionand consumption in macrophages suggested that the maxi-mum NO concentration that can be achieved at any cellnumber density is about 1 µM. This was the first indicationof a possible upper limit for NO concentrations at sites ofinflammation. Knowing better what to mimic, an apparatuswas designed to permit “target cells” (cells that do not produce NO) to be exposed to controlled, micromolecularlevels of NO for up to several days. In collaboration withProfessor Gerald N. Wogan of the Biological EngineeringDivision, the effects of NO concentration and total dose(area under the concentration-time curve) were then charac-terized in terms of cell survival and several types of cellulardamage. It was found that there are dual thresholds for NOtoxicity. Toxic effects were not seen unless a minimum con-centration and a minimum dose were both exceeded. Theconcentration threshold for the cell lines used was about 0.5µM (about half the inferred physiological maximum). Thisis the first quantitative demonstration of toxicity thresholdsfor NO, and is stimulating a new round of experiments toexamine the underlying intracellular events. An importantobjective in the next few years is to develop reaction-diffusionmodels for tissues that will provide a rational means toextrapolate kinetic, diffusional, and cell culture data topathophysiological conditions in the body.

TWO-DIMENSIONAL PROTEIN CRYSTALS:PHYSICS LESSONS FROM NATUREPROFESSOR ALICE P. GAST

The surfaces of many prokaryotic cells (bacteria and archae)are fully enveloped with an organized layer of proteins. The purpose of these ordered protein coats is not fullyunderstood, although it is postulated that they play a role in the physical integrity and protection of the cell or in sieving materials passing through the membrane. These fascinating structures in nature motivated the Gast group to study model systems of proteins on lipid monolayers orbilayers. In addition to the interesting, naturally occurringassemblies, ordered arrays of proteins on lipid supports are a useful system to study protein structure and interactions.Lipid monolayers and bilayer membranes serve as simplifiedmodels to the complex and inhomogeneous properties ofactual cell membranes. Appropriately cloaked liposomes alsohave potential uses as carriers for targeted drug delivery.

Several years ago, we began studying a model system, called streptavidin, a tetrameric globular protein having an

Research Highlights From the Department of Chemical Engineering


unusually high binding affinity for biotin. We studied thecrystallization of streptavidin attached to lipid monolayersspread at the air-water interface. By changing the solutionpH, we were able to provoke different crystalline symmetriesand shapes due to the changing intermolecular interactionsbetween proteins. We tested our understanding of thesemolecular interactions by creating point mutations thataltered the surface of the protein-enhancing attractions orrepulsions and driving the crystallization behavior. The ability to alter single amino acids in this way provides apowerful link to molecular models of protein-protein inter-actions. These studies have enabled us to learn much moreabout the two-dimensional crystallization process and howwe can tailor lattice structure and crystal morphologythrough manipulating intermolecular forces.

Our interest in naturally occurring protein crystals such asthose enveloping archae led us to create giant unilamellarvesicles as model membranes. We were able to study thesame crystallization phenomena on these vesicles of about50–100 micrometers in diameter through confocal fluores-cence microscopy. We find that crystals grow on these sur-faces even under conditions of very low ionic strength andin the presence of sugar solutions. A typical series of imagesshows fluorescently labeled background protein surroundingdark regions of streptavidin crystals.

We collaborated with R. Merkel in the Sackmann groupin Munich, Germany, to study the effect of a surfacecrystalline protein layer on the mechanical properties of the membrane. In particular, we used micropipetteaspiration to probe the membrane responses and materialproperties of bare vesicles and those coated with either an amorphous or a crystalline protein layer. The presenceof crystals on the vesicle surface transformed them intoroughened spheres and prolate ellipsoids. The coatedvesicles have a plastic response to deformation as seen in the structure set by aspiration with a pipette shownbelow. The composite protein-lipid membrane combinesthe solid characteristics of two-dimensional crystals withthe fluid elastic behavior of lipid bilayers to yield a thin,rigid, yet viscoelastic structure. The nature of the protein-lipid and protein-protein interactions plays a key role in determining the overall properties of the composite membrane.

Crystallizing proteins on giant bilayer vesicles provides uswith a well-defined system that is easy to study and manipu-late. The unique properties of these structures facilitate afundamental understanding of molecular self-assembly andprotein-membrane interactions.

DESIGN OF THERAPEUTIC PROTEINFORMULATIONS VIA QUANTUM MECHANICSAND STATISTICAL MECHANICSPROFESSOR BERNHARDT L. TROUT

Therapeutic proteins encompass a significant and growingfraction of the pharmaceutical market. An example isAmgen’s G-CSF, which has annual sales of $2 billion and is used to treat complications arising from chemotherapy.Designing therapeutic proteins like G-CSF and processes tomanufacture them are great accomplishments but they are

not enough. In order for therapeuticproteins to be useful and to beapproved by the FDA, they must bestable for two years in a form that canbe conveniently and safely injected intoa patient. Typically, this form is anaqueous solution, consisting of water

and a variety of cosolutes, such as salts, sugars, surfactants,amino acids, and others.

The major problem in developing the solution formulationis that no one knows how to do it for a particular protein,aside from using heuristics and trial-and-error experimenta-tion. This “Edisonian” approach has failed in many cases, sothat there are numerous therapeutic proteins that have thepotential to save lives and enhance the quality of lives butthat cannot be used because they are not stable in storage.Furthermore, in cases where the Edisonian approach succeeds,it does so after many experiments, the number of whichwould be sharply reduced if the underlying chemicalprocesses involved in destabilization and stabilization wereunderstood. A major reason why they are not understood isthat it is almost impossible using current experimental tech-nology to isolate the individual interactions and reactionsamong chemical species that lead to destabilization or stabi-lization. This is because many trillions (actually, roughly1023) of chemical processes are occurring during any single

Streptavidin Crystals

Coated Vesiclest = 0s t = 0.9s


experiment, and multiple, very clever and very accurateexperiments would need to be performed in order to isolatethe chemical processes of interest. Alternatively, accuratemathematical models of the systems would allow the studyof the most important chemical events isolated from the lessimportant ones.

The Trout group is developing and solving mathematicalmodels for the design of solutions that will stabilize thera-peutic proteins against oxidation and aggregation, the twomost common routes of degradation of therapeutic proteins.For these models to be accurate, they must include eachatom explicitly and for the most important regions of theprotein and solution, each electron explicitly. The latter isessential for the accurate treatment of the breaking and for-mation of chemical bonds, and requires the use of approach-es based on quantum mechanics.

Having an accurate model is not enough. This is because themodels that we develop are exceedingly complex, and wemust devise clever ways of extracting the information thatwe want from these models efficiently and with a minimumof numerical noise. In order to accomplish this task, we usesophisticated simulation approaches, some of which aredeveloped in our laboratory. These approaches are based onstatistical mechanics, which gives us physical insight intowhich numerical regions of our model we should focus on.Even using these statistical mechanical methods, each datapoint takes more than a billion trillion (1015) computations.Together with these computational approaches, we are per-forming experiments on well-defined model systems in orderto validate our theoretical/computational approaches.

In terms of specific results, we have isolated the essentialreaction pathway that leads to the oxidation of sulfur siteson methionine residues and demonstrated that the rate ofoxidation is proportional to the number of water moleculesin the vicinity of the sulfur site. If one can keep water awayfrom the sulfur sites, even with a large amount of oxidizingcomponents present in the system, the sulfur will not beoxidized. We are currently designing chemicals, called excip-ients, which selectively surround those sulfur sites and blockthem from water. Our computational modeling approachgives us unique insight into what is happening at the sulfursites and what properties of the excipients are necessary sothat the excipient surrounds the target site selectively.

In the area of aggregation, we have validated our models forthe computation of the change in stability of proteins, suchas RNase, in the presence of sugars, polyols, and urea. Wehave also developed a quantitative theory of what the essen-tial properties of an excipient are that makes it a stabilizer.Using this theory, we are designing new molecules that

should function better than currently used excipients, andare developing computational methods to aid in the designof these new molecules, in addition to experimental proto-cols to test them.

RESEARCH ON ENERGYAND THE ENVIRONMENTPROFESSOR JEFFERSON W. TESTER

Several important problems face us in transitioning to amore sustainable energy system. One set of problems relatesto the environmental impacts created by the currentapproach, which relies heavily on fossil fuels—these rangeacross scales from local to regional effects caused by particu-late, and sulfur and nitrogen oxide emissions from combus-tion to global concerns over carbon dioxide. Another impor-tant aspect is the maldistribution and depletion of fossilresources (oil, natural gas, and coal). All of this suggests thatwe should diversify our energy supply options while we seekto minimize the environmental effects associated with fossilfuel use. So far, progress has been slow, in part because thetechnologies associated with renewable energy capture andrecovery cannot compete economically with today’s low-costfossil fuels. A significant fraction of research in theDepartment of Chemical Engineering is addressing many ofthese problems. For example, several investigations areaimed at producing cleaner fuels and renewable biomass andgeothermal energy systems, while others are focused onprocesses to remediate environmentally contaminated areas.

Professor Tester’s research group—in collaboration withother faculty in chemical engineering, nuclear engineering,and materials science—has been developing a range ofexperimental and theoretical methods to probe kinetics andtransport phenomena in compressed and supercriticalmedia. For example, measurements of reaction rates andproduct distributions have successfully been linked to abinitio quantum chemical calculations to quantify the effec-tiveness of reforming and oxidation processes in supercriticalwater to detoxify chemical and military wastes. Improvedfundamental understanding of the role of supercriticalwater, both as a solvent and as a reactant, has been obtainedfor a number of model wastes ranging from methylene chlo-ride to methyl tert-butyl ether (MTBE) to methyl phos-phoric acid (MPA).

Synthetic pathways are also being pursued using mixtures ofcompressed and supercritical fluids in a collaborative pro-gram with Professor Rick Danheiser in Chemistry andProfessor Andrew Holmes at Cambridge University, UK.The key idea involves a green chemistry approach whereenvironmentally benign solvents such as water and carbon

Research Highlights


dioxide are used as the media to carry out selective carbon-carbon bond forming cyclo-addition reactions for producingpharmaceutical intermediates and specialty chemicals. So far,we have been successful in demonstrating the use of powerultra sound to produce emulsified bi-phasic mixtures ofnear-critical carbon dioxide and water that enhance reactionrates between model Diels-Alder reactants.

In separate studies, Professor Tester, in collaboration withProfessor Trout, has developed a refined statistical mechani-cal model for solid gas hydrates or water clathrates. The goalhas been to develop a physically consistent model for use inpredicting the properties of important hydrate systems, suchas those involving carbon dioxide and methane, which havedirect applications to carbon sequestration in the deep oceanand natural gas recovery from permafrost and marine sedi-ments. Ab initio calculations are coupled to a statisticalmechanical model to capture the effects of intermolecularinteractions between water host molecules and enclathratedguest molecules. This first principles approach has success-fully predicted the equilibrium and transport properties inmultiphase systems containing solid hydrates and funda-mentally differs from earlier work, which has relied heavilyon fitting parameters to robust experimental data.

Figure 1: Illustration of the multi-scale nature of theinvestigation of carbon dioxide sequestration. A key question is whether the rate of nucleation of carbondioxide hydrate can be controlled.

Molecular

Dropformation

Plumemodeling

Ocean

600m

1500–3000m

>3600m

Coupled ab initiocalculations to a statistical mechanical model

Macroscopiclevel transportmodeling

“A significant fraction of theresearch in MIT ChemE isaddressing the problems facingus in the effort to transition to amore sustainable energy system”

The third area under investigation is the development of anew approach to drilling ultra deep holes in the earth usingthermal spallation and fusion rather than the conventionalcutting and grinding approach.

Earlier work in our group has quantitatively characterizedrock spallation phenomena using supersonic combustionflame jets at low pressures and fluid densities in shallow hole drilling to show that they will penetrate very hard rockat about 5 to 10 times the rate of conventional bits with little or no wear. Ultra deep drilling to 10+ km will require having an intense heat source at high pressures of 1 kbar or more. Building on our experience operating in high-pres-sure, supercritical water environments, we are analyzing the feasibility of using hydrothermal flames as a heat source to spall and melt rock in confined bore holes. Using conventional drilling technology, an exponentialdependence of drilling cost on well depth results in partfrom the inherent wear to drilling equipment and the needfor drill bit replacements.

If the thermal method works, we are optimistic that the cur-rent exponential dependence would be replaced with a lineardependence of cost on depth. Such technology would drasti-cally improve the economics of geothermal energy recoveryfrom very deep reservoirs, thus making heat mining fromthe deep earth a universally accessible energy source.

GSC-X ActivitiesHowzit from your friends at GSC-X! Things got kicking last August with the Freedom Festival Barbeque to kick off asizzle-dizzle year. Professor Armstrong took a few plunges inthe dunking booth, and we washed down the barbeque withthe largest Legal Seafood clam chowder order since TheEagles rolled through town. Before the semester started, wecrowned a department putting champion at the Caddyshackwelcomepicnic for the First-Years.

We all know that the GSC-X pulls out all the stops for theDecember holiday party, and 2003 did not disappoint. Sureenough, the First-Years came out of the gates with somesolid skits and the Nth-Years did their best to follow. Therewas even a rumor that Professor Deen cracked a half smileat several points, but I will never believe it. Afterwards, theparty moved to 66 where we could discuss the latest facultyjokes and enjoy a veritable feast. And if you have not holidaycaroled with the ChemE’s, you just haven’t lived.

Hopefully, the GSC-X succeeded in easing a bit of the First-Years’ pain of impending Quals Exams with bags of candy, apost-test lunch, and critiquing practice oral qualifer presen-tations. As always, they pulled through. Later that month,in celebration of Adam Vinateri’s Super Bowl-clinchingkick, we all ate “Vinateriyaki” chicken subs and practicedfield goals at the February TG. Some BioEngineering staffwere not too amped about the footballs flying to and fro in

Gregory Sands, Editor Department of Chemical Engineering

Massachusetts Institute of TechnologyDepartment of Chemical Engineering77 Massachusetts Avenue, Room 66-350Cambridge, MA 02139-4307 USA

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Chemical Engineering Alumni/ae News is an annualpublication of MIT’s Department of Chemical Engineering.

the hall, but this failed to dampen our spirits and a depart-ment place-kicking champion was determined in a suddendeath playoff.

March is recruitment month! What better way to attractbright young minds to our department than butchering classics on karaoke, or flailing limbs on Dance DanceRevolution (DDR)—a pad where you dance to club musicfollowing instructions on the monitor. The three recruitingTGs in March pretty much tuckered us out, but we musteredup the energy to hold the First Annual ChemE Semiformalin April, which revived every bad reminder of high schooldances, including the balloon arch, and took our dates tothe Western Sizzler afterwards.

In intramural sports, ChemE’s continued to dominate outside 66 capping off an exciting year. Thanks for stoppingby. Stay classy, Chem E’s!

By Joel Forrest Moxley, GSC-X Staff

“ChemE’s continued to dominate outside building 66, capping off an exciting year!”

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